Microfluidic Channel Network Analysis of a Lab-on-a-Chip Device Using Electrical Circuit Analogy

Abstract Low temperature co-fired ceramic (LTCC) based microfluidic sensors have been developed for biomedical and environmental sensing systems. This paper introduces a microfluidic chamber based on impedance spectroscopy measurements using LTCC technology for wireless Lab-On-A-Chip (LOC) applications. To overcome the channel sagging during the fabrication process, we used sacrificial carbon tapes as solid inserts, thus guiding the LTCC to follow their shape upon lamination and then formed micro-channels. The measurement chamber was a parallel-plate capacitive structure with 85 μm gap. This platform requires a small fluid sample of less than 4 μL. The sensor formed by the microfluidic channel and capacitance structure was characterized using different dielectric materials such as air, water and acetone. We hereby present the capability of LTCC-based systems in fluid identification by detecting their electrical permittivity using capacitance measurement.

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Effect of Slit Channel Width of a Shim Embedded in Slot-Die Head on High-Density Stripe Coating for OLEDs

Coatings ◽

10.3390/coatings10080772 ◽

2020 ◽

Vol 10 (8) ◽

pp. 772

Author(s):

Dongkyun Shin ◽

Jinyoung Lee ◽

Jongwoon Park

Keyword(s):

Electric Circuit ◽

Electrical Circuit ◽

High Density ◽

Voltage Source ◽

Light Emitting ◽

Slot Die ◽

Potential Applications ◽

Circuit Analogy ◽

Wide Slit ◽

Fine Organic

With an attempt to achieve high-density fine organic stripes for potential applications in solution-processable organic light-emitting diodes (OLEDs), we have performed slot-die coatings using a shim with slit channels in various shapes (rectangular-shaped narrow, rectangular-shaped wide, and reversely tapered channels) in the presence of narrow µ-tips. Based on hydraulic-electric circuit analogy, we have analyzed the fluid dynamics of an aqueous poly (3,4-ethylenedioxythiophene): poly (4-styrenesulfonate) (PEDOT:PSS). It is observed that the coating speed can be increased and the stripe width can be reduced using a shim with rectangular-shaped wide slit channels. It is attributed that the hydraulic resistance is decreased and thus more fluid can reach a substrate through µ-tips. This behavior is consistent with the simulation result of the equivalent electrical circuit with a DC voltage source representing a pressure source. Using the shim with 150-µm-wide slit channels, we have successfully fabricated 200 PEDOT:PSS stripes within the effective coating width (150 mm) and 160 OLED stripes (34 stripes per inch) with the luminance of 325 cd/m2 at 5 V.

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Lab on a chip imaging and quantitative phase contrast in turbid microfluidic channel

Frontiers in Optics 2012/Laser Science XXVIII ◽

10.1364/fio.2012.ftu5c.4 ◽

2012 ◽

Author(s):

Melania Paturzo ◽

Andrea Finizio ◽

Pasquale Memmolo ◽

Roberto Puglisi ◽

Donatella Balduzzi ◽

...

Keyword(s):

Phase Contrast ◽

Microfluidic Channel ◽

Lab On A Chip ◽

Quantitative Phase

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Particle Manipulation Inside a Grooved Microfluidic Channel

ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 3 ◽

10.1115/mnhmt2009-18394 ◽

2009 ◽

Author(s):

Hsiu-hung Chen ◽

Dayong Gao

Keyword(s):

Rapid Prototyping ◽

Microfluidic Device ◽

Microfluidic Channel ◽

Lab On A Chip ◽

Cell Suspensions ◽

Microfluidic Channels ◽

Particle Manipulation ◽

Post Processing ◽

Processing Stage ◽

Submicron Structures

The manipulation of particles and cells in micro-fluids, such as cell suspensions, is a fundamental task in Lab-on-a-Chip applications. According to their analysis purposes in either the pre- or post-processing stage, particles/cells flowing inside a microfluidic channel are handled by means of enriching, trapping, separating or sorting. In this study, we report the use of patterning flows produced by a series of grooved surfaces with different geometrical setups integrated into a microfluidic device, to continuously manipulate the flowing particles (5 to 20 μm in diameters) of comparable sizes to the depth of the channel in ways of: 1) concentrating, 2) focusing, and 3) potential separating. The device is fabricated using soft lithographic techniques and is composed of inlets, microfluidic channels, and outlets for loading, manipulating and retrieving cell suspensions, respectively. Such fabrication methods allow rapid prototyping of micron or submicron structures with multiple layers and replica molding on those fabricated features in a clear polymer. The particles are evenly distributed in the entrance of the microchannel and illustrate the enriching, focusing, or size-selective profiles after passing through the patterning grooves. We expect that the techniques of manipulating cell suspensions from this study can facilitate the development of cell-based devices on 1) the visualization of counting, 2) the visualization of sizing, and 3) the particle separating.

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Lab on a chip imaging and quantitative phase contrast in turbid microfluidic channel

IEEE Photonics Conference 2012 ◽

10.1109/ipcon.2012.6358496 ◽

2012 ◽

Author(s):

Melania Paturzo ◽

Andrea Finizio ◽

Pasquale Memmolo ◽

Roberto Puglisi ◽

Donatella Balduzzi ◽

...

Keyword(s):

Phase Contrast ◽

Microfluidic Channel ◽

Lab On A Chip ◽

Quantitative Phase

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Stream channel network analysis applied to colony-wide feeding structures in a Permian bryozoan from Greenland

Paleobiology ◽

10.1666/10008.1 ◽

2011 ◽

Vol 37 (2) ◽

pp. 287-302 ◽

Cited By ~ 4

Author(s):

Marcus M. Key ◽

Patrick N. Wyse Jackson ◽

Louis J. Vitiello

Keyword(s):

Network Analysis ◽

Stream Channel ◽

Drainage Pattern ◽

Channel Network ◽

Channel Networks ◽

Closed Basin ◽

Natural Stream ◽

Large Size ◽

Colony Surface ◽

The Law

Colony-wide feeding currents are a common feature of many bryozoan colonies. These feeding currents are centered on excurrent macular chimneys that expel previously filtered water away from the colony surface. In some bryozoans these macular chimneys consist of a branching channel network that converges at a point in the center of the chimney. The bifurcating channels of the maculae are analogous to a stream channel network in a closed basin with centripetal drainage. The classical methods of stream channel network analysis from geomorphology are here used to quantitatively analyze the number and length of macular channels in bryozoans. This approach is applied to a giant branch of the trepostome bryozoan Tabulipora from the Early Permian Kim Fjelde Formation in North Greenland. Its large size allowed 18 serial tangential peels to be made through the 8-mm-thick exozone. The peels intersected two stellate maculae as defined by contiguous exilapores. The lengths of 1460 channels radiating from the maculae were measured and their Horton-Strahler stream order and Shreve magnitude scored.We hypothesize that if fossil bryozoan maculae function as excurrent water chimneys, then they should conform to Horton's laws of stream networks and behave like closed basins with centripetal drainage. Results indicate that the stellate maculae in this bryozoan behaved liked stream channel networks exhibiting landscape maturation and stream capture. They conformed to the Law of Stream Number. They have a Bifurcation Ratio that falls within the range of natural stream channel networks. They showed a pattern opposite that expected by the Law of Stream Lengths in response to behavior characteristic of a centripetal drainage pattern in a closed basin. Thus, the stellate maculae in this bryozoan probably functioned as excurrent water chimneys with the radiating channels serving to efficiently collect the previously filtered water, conducting it to the central chimney for expulsion away from the colony surface.

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Modeling and Analysis of Opto-Fluidic Sensor for Lab-On- a-Chip Application

10.20944/preprints201711.0154.v1 ◽

2017 ◽

Author(s):

Venkatesha M. ◽

Chaya B. M. ◽

Pattnaik P. K. ◽

Narayan K.

Keyword(s):

Continuous Flow ◽

Microfluidic Channel ◽

Optical Loss ◽

Lab On A Chip ◽

Single Mode ◽

Fluidic Channel ◽

Modeling And Analysis ◽

Micro Particles ◽

Sensing Applications ◽

Integrated Optical

In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on achievement of single mode optical confinement and continuous flow of micro particles in the microfluidic channel for Lab-on-a Chip (LOC) sensing application is presented. This sensor consists of integrated optical waveguides, microfluidic channel among other integrated optical components. A continuous flow of micro particles in a narrow fluidic channel is achieved by maintaining the two sealed chambers at different temperatures and by maintaining a constant pressure of 1Pa at the centroid of narrow fluidic channel geometry. The analysis of silicon on insulator (SOI) integrated optical waveguide at an infrared wavelength of 1550nm for single mode sensing operation is presented. The optical loss is found to be 0.0005719dB/cm with an effective index of 2.2963. The model presented in this work can be effectively used to detect the nature of micro particles and continuous monitoring of pathological parameters for sensing applications.

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Elasto-Magnetic Pumps Integrated within Microfluidic Devices

Engineering Proceedings ◽

10.3390/micromachines2021-09590 ◽

2021 ◽

Vol 4 (1) ◽

pp. 48

Author(s):

Jacob L. Binsley ◽

Elizabeth L. Martin ◽

Thomas O. Myers ◽

Stefano Pagliara ◽

Feodor Y. Ogrin

Keyword(s):

Magnetic System ◽

Point Of Care ◽

Microfluidic Channel ◽

Lab On A Chip ◽

Microfluidic Devices ◽

Point Of Care Testing ◽

Ongoing Research ◽

Flow Rates ◽

Pumping System ◽

Oscillating Magnetic Field

Many lab-on-a-chip devices require a connection to an external pumping system in order to perform their function. While this is not problematic in typical laboratory environments, it is not always practical when applied to point-of-care testing, which is best utilized outside of the laboratory. Therefore, there has been a large amount of ongoing research into producing integrated microfluidic components capable of generating effective fluid flow from on-board the device. This research aims to introduce a system that can produce practical flow rates, and be easily fabricated and actuated using readily available techniques and materials. We show how an asymmetric elasto-magnetic system, inspired by Purcell’s three-link swimmer, can provide this solution through the generation of non-reciprocal motion in an enclosed environment. The device is fabricated monolithically within a microfluidic channel at the time of manufacture, and is actuated using a weak, oscillating magnetic field. The flow rate can be altered dynamically, and the direction of the resultant flow can be controlled by adjusting the frequency of the driving field. The device has been proven, experimentally and numerically, to operate effectively when applied to fluids with a range of viscosities. Such a device may be able to replace external pumping systems in portable applications.

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Band structures in a two-dimensional phononic crystal with rotational multiple scatterers

International Journal of Modern Physics B ◽

10.1142/s0217979217500382 ◽

2017 ◽

Vol 31 (06) ◽

pp. 1750038 ◽

Cited By ~ 4

Author(s):

Ailing Song ◽

Xiaopeng Wang ◽

Tianning Chen ◽

Lele Wan

Keyword(s):

Sound Pressure ◽

Phononic Crystal ◽

Low Frequency ◽

Electrical Circuit ◽

Frequency Noise ◽

Transmission Spectra ◽

Two Dimensional ◽

Band Structures ◽

Unit Cells ◽

Circuit Analogy

In this paper, the acoustic wave propagation in a two-dimensional phononic crystal composed of rotational multiple scatterers is investigated. The dispersion relationships, the transmission spectra and the acoustic modes are calculated by using finite element method. In contrast to the system composed of square tubes, there exist a low-frequency resonant bandgap and two wide Bragg bandgaps in the proposed structure, and the transmission spectra coincide with band structures. Specially, the first bandgap is based on locally resonant mechanism, and the simulation results agree well with the results of electrical circuit analogy. Additionally, increasing the rotation angle can remarkably influence the band structures due to the transfer of sound pressure between the internal and external cavities in low-order modes, and the redistribution of sound pressure in high-order modes. Wider bandgaps are obtained in arrays composed of finite unit cells with different rotation angles. The analysis results provide a good reference for tuning and obtaining wide bandgaps, and hence exploring the potential applications of the proposed phononic crystal in low-frequency noise insulation.

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