DemCure: A Technology-oriented solution for Assisting Caretakers and Dementia Patients with Mild Cognitive Impairment

2020 ◽  
Author(s):  
Amirita Dewani ◽  
Mehdi Raza Lakho ◽  
Ghulam Haider Buledi ◽  
Urooj Samoo ◽  
Naila Anwer ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Dementia Patients

Abstract 1122‐000036: Demographic and Pharmacological Characteristics of Alzheimer Dementia Patients with Mild Cognitive Impairment stratified by Gender

2021 ◽  
Vol 1 (S1) ◽  
Author(s):  
Oreoluwa O Coker‐Ayo ◽  
Samuel Nathaniel ◽  
Chika Onuoha ◽  
Nneoma Madubuike ◽  
Lidadi Agbomi ◽  
...  
Keyword(s):  
Gender Differences ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Regression Models ◽  
Operating Characteristic ◽  
Management Strategies ◽  
Roc Curve Analysis ◽  
Alzheimer Dementia ◽  
Dementia Patients ◽  
Specific Factors

Introduction : The role that specific clinical factors play in contributing to gender differences in Alzheimer’s patients with mild cognitive impairment (MCI) is not yet fully understood. In this study, we tested the hypothesis that pharmacological, demographic, and risk factors may contribute to gender difference in Alzheimer’s patients with MCI. Methods : Methods Data collected for 5 years was analyzed using a retrospective data analytical approach on 33,064 Alzheimer patients, including 13,569 men and 19,495 women that presented with MCI. Receiver operating characteristic (ROC) curve analysis and multivariate regression models were used to identify specific factors that contribute to gender differences in MCI patients. Results : Results Our records indicate that women that presented with MCI were more likely to be taking Buspirone (OR = 0.767, 95% CI, 0.683‐0.861, P<0.001) while men within this population were more likely to be taking Galantamine (OR = 0.559, 95% CI, 0.382‐0.818, P<0.001). ETOH use was associated with MCI in both men (OR = 0.696, 95% CI, 0.638‐0.760, P<0.001) and women with Alzheimer’s Dementia (OR = 0.484, 95% CI, 0.442‐0.529, P<0.001). Conclusions : Conclusion Our findings reveal gender differences in men and women that presented with MCI. Management strategies should consider identified factors to provide better care for Alzheimer patients with MCI.

Digit Span Forward as a Performance Validity Test in Dementia Evaluations: Specificity in Mild Cognitive Impairment, Mild Dementia, and Moderate Dementia

2019 ◽  
Vol 34 (6) ◽  
pp. 837-837
Author(s):  
H Clark ◽  
P Martin ◽  
R Schroeder
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Digit Span ◽  
Future Research ◽  
Performance Validity ◽  
Mild Dementia ◽  
Dementia Patients ◽  
Moderate Dementia ◽  
Neuropsychological Evaluations ◽  
Validity Tests

Abstract Objective Traditional performance validity tests (PVTs) often yield high false positive rates in dementia evaluations. The current study examined the frequency of extremely low scores (≤ 2 percentile) on WAIS-IV Digit Span Forward (DSF) in older adults with Mild Cognitive Impairment (MCI) or dementia to evaluate its possible utility as a PVT in these populations. Method Archival data from outpatient neuropsychological evaluations were analyzed. Individuals who were not diagnosed with a neurocognitive disorder, had missing data, or were believed to be invalidly performing were excluded. Participants (n = 195; mean age = 72.8; mean education = 13.2 years) were classified according to their evaluation diagnosis of MCI (n = 72; mean RBANS Total Score = 86.8) or dementia. Dementia patients were further divided by MoCA score into groups of mild dementia (n = 90; MoCA≥15; mean RBANS Total Score = 71.0) or moderate dementia (n = 33; MoCA < 15; mean RBANS Total Score = 55.9). Frequencies of scaled scores were analyzed to calculate specificity values for each group. Results A WAIS-IV DSF scaled score of ≤4 (≤ 2 percentile) resulted in specificity values of 0.99 and 0.94 in MCI and mild dementia, respectively. Conversely, in moderate dementia, ≥0.90 specificity was achieved only when using a more conservative cutoff of ≤2. Conclusions Low DSF scaled scores occurred infrequently in MCI and mild dementia, indicating strong specificity and potential utility as a PVT in these populations. However, in moderate dementia, low DSF scores were more common, requiring use of a more stringent cutoff. Future research should examine DSF sensitivity to invalid performance, as well as DSF specificity according to specific etiologies of MCI and dementia.

Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project

2021 ◽  
pp. 1-13
Author(s):  
Naoko Nakahata ◽  
Takumi Nakamura ◽  
Takeshi Kawarabayashi ◽  
Yusuke Seino ◽  
Sadanobu Ichii ◽  
...  
Keyword(s):  
Health Promotion ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Educational History ◽  
Dementia Patients ◽  
Age Related ◽  
Age Related Cognitive Decline

Background: The Iwaki Health Promotion Project (IHPP) is a community-based study for the prevention of lifestyle-related diseases and improvement of quality of life. Objective: Between 2014 and 2017, a total of 4,442 Iwaki town residents from 19 to 93 years of age participated in annual surveys to clarify the natural course of age-related cognitive decline and mild cognitive impairment (MCI). Methods: Modified OLD and SED-11Q questionnaires, MMSE, Logical Memory II, educational history, and APOE genotypes were examined at the first screening. MCI and dementia were diagnosed at the second examination by detailed neurological examination, CDR, and MRI, and followed for 3 years. Spline regression analyses based on a linear mixed model was adopted for statistical analysis. Results: MMSE scores declined with age from 55 to 64 years. There was also interaction between levels of education and ages. At the second examination, 56 MCI and 5 dementia patients were identified. None of the MCI cases progressed to dementia during the 3 years. During follow-up examinations, 13 cases showed improved MMSE scores (0.95 point/year), 5 remained stable, and 7 deteriorated (–0.83 point/year). Five cases showed improved CDR-SOB scores (–0.28 point/year), 9 remained stable, and 6 deteriorated (0.3 point/year). Conclusion: IHPP revealed that age- and education-related cognitive decline began and advanced from 55 years of age. The prevalence of MCI and dementia was estimated to be 5.9%in the Iwaki town cohort over 60 yeas of age. About 30%of MCI cases showed progression of cognitive decline.

The Mini-Mental State Examination: Czech Norms and Cutoffs for Mild Dementia and Mild Cognitive Impairment due to Alzheimer's Disease

2016 ◽  
Vol 42 (1-2) ◽  
pp. 50-57 ◽  
Author(s):  
Ales Bartos ◽  
Miloslava Raisova
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Mild Dementia ◽  
Dementia Patients ◽  
Early Alzheimer’S Disease ◽  
State Examination

Background: There is a lack of normative studies of the Mini-Mental State Examination (MMSE) for comparison with early Alzheimer's disease (AD) according to new diagnostic criteria. Participants and Methods: We administered the MMSE to normal elderly Czechs and to patients with mild cognitive impairment (MCI) and mild dementia due to AD according to NIA-AA criteria. Results: We established percentile- and standard deviation-based norms for the MMSE from 650 normal seniors (age 69 ± 8 years, education 14 ± 3 years, MMSE score 28 ± 2 points) stratified by education and age. Dementia patients scored significantly lower than the MCI patients and both groups (110 early AD patients) had significantly lower MMSE scores than the normal seniors (22 ± 5 or 25 ± 3 vs. 28 ± 2 points) (p < 0.01). The optimal cutoff was ≤27 points with sensitivity of 86% and specificity of 79% for early detection of AD patients. Conclusion: We provided MMSE norms, several cutoffs, and higher cutoff scores for early AD using recent guidelines.

scholarly journals The Positivity Effect on the Intensity of Experienced Emotion and Memory Performance in Mild Cognitive Impairment and Dementia

2015 ◽  
Vol 5 (2) ◽  
pp. 233-243 ◽  
Author(s):  
Lina Gorenc-Mahmutaj ◽  
Christina Degen ◽  
Petra Wetzel ◽  
Nadja Urbanowitsch ◽  
Joachim Funke ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Performance ◽  
Emotional Valence ◽  
Positivity Effect ◽  
Healthy Elderly ◽  
Dementia Patients ◽  
Moderate Dementia ◽  
Emotion And Memory ◽  
Experienced Emotion

Aims: We examined the ‘positivity effect' on memory performance in mild cognitive impairment (MCI) and dementia patients. Methods: In 109 subjects (28 controls, 32 with MCI, 27 with mild and 32 with moderate dementia), we investigated free recalls (immediate and delayed) and recognition of 12 pictures. Moreover, the emotional valence of the pictures perceived and the emotions evoked in the subjects were evaluated. Results: Patients with mild and moderate dementia recalled fewer pictures than those with MCI or the healthy controls. Across the groups, the positive pictures were better memorized and induced a higher arousal than the negative or neutral ones. Conclusions: Our findings indicate a positivity effect on memory performance and intensity of experience not only in healthy elderly patients but also in those with MCI or mild and moderate dementia. This effect does not refer to the compliance of the patients investigated since they perceived and experienced the pictures in the expected way.

Memory Complaints in Mild Cognitive Impairment, Worried Well, and Semantic Dementia Patients

2008 ◽  
Vol 22 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Samrah Ahmed ◽  
Joanna Mitchell ◽  
Robert Arnold ◽  
Kate Dawson ◽  
Peter J. Nestor ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Semantic Dementia ◽  
Memory Complaints ◽  
Dementia Patients

scholarly journals Relation of Secondhand Smoking to Mild Cognitive Impairment in Older Inpatients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Giuseppe Orsitto ◽  
Vincenzo Turi ◽  
Amedeo Venezia ◽  
Francesco Fulvio ◽  
Cosimo Manca
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older Patients ◽  
Cross Sectional Study ◽  
Smoking History ◽  
Cross Sectional ◽  
Secondhand Smoking ◽  
Dementia Patients ◽  
Older Inpatients ◽  
Never Smokers

Up to now, controversy still exists regarding the role of secondhand smoking (SHS) in developing cognitive impairment. This study aimed to evaluate the prevalence of SHS in hospitalized older patients with cognitive deficit, particularly in those with mild cognitive impairment (MCI). Smoking history was classified into four groups: never smokers, former-active smokers/no SHS, active smokers, and secondhand smokers, and cognitive function into three levels: normal cognition (C), MCI, and dementia. A total of 933 older subjects with diagnoses of MCI (n=98), dementia (n=124), or C (n=711) were enrolled in this cross-sectional study. As expected, patients with dementia had significantly higher frequency of former-active smokers than cognitively normal. Moreover, patients with MCI showed a significantly higher frequency of active and secondhand smokers than patients with dementia or C. A smoking history is very frequent in older patients with dementia. Patients with MCI had even higher rate of exposure to active or secondhand smoking.

scholarly journals Depression and Conversion to Dementia in Mild Cognitive Impairment

2021 ◽  
Vol 3 (1) ◽  
pp. 149-154
Author(s):  
Fithry Rahma
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Deficits ◽  
Memory Loss ◽  
The Elderly ◽  
Review Article ◽  
Dementia Patients ◽  
Diagnosis Criteria ◽  
Cognitive Deficiencies ◽  
The Relationship

Mild cognitive impairment (MCI) is a stage of aging that occurs between normal aging and dementia (precedes dementia). Patients with MCI have memory loss who is otherwise functioning normally and does not match the clinical diagnosis criteria for dementia.  MCI is frequently accompanied by cognitive deficits and non-cognitive. One of the most frequent non-cognitive deficiencies is depression. Depression and mild cognitive impairment are closely associate particularly in the elderly and can progress into neurodegenerative disorders like dementia. This indicates that there is a connection that needs to be explored further. Through this review article, a theoretical review of the relationship between MCI with depression and its conversion to dementia.

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