Non-invasive technique for analysis of feedback relationship between heart rate and beat-to-beat blood pressure fluctuations

Author(s):  
T. Wada ◽  
K. Narimatu
2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Elisa Mejía-Mejía ◽  
James M. May ◽  
Mohamed Elgendi ◽  
Panayiotis A. Kyriacou

AbstractHeart rate variability (HRV) utilizes the electrocardiogram (ECG) and has been widely studied as a non-invasive indicator of cardiac autonomic activity. Pulse rate variability (PRV) utilizes photoplethysmography (PPG) and recently has been used as a surrogate for HRV. Several studies have found that PRV is not entirely valid as an estimation of HRV and that several physiological factors, including the pulse transit time (PTT) and blood pressure (BP) changes, may affect PRV differently than HRV. This study aimed to assess the relationship between PRV and HRV under different BP states: hypotension, normotension, and hypertension. Using the MIMIC III database, 5 min segments of PPG and ECG signals were used to extract PRV and HRV, respectively. Several time-domain, frequency-domain, and nonlinear indices were obtained from these signals. Bland–Altman analysis, correlation analysis, and Friedman rank sum tests were used to compare HRV and PRV in each state, and PRV and HRV indices were compared among BP states using Kruskal–Wallis tests. The findings indicated that there were differences between PRV and HRV, especially in short-term and nonlinear indices, and although PRV and HRV were altered in a similar manner when there was a change in BP, PRV seemed to be more sensitive to these changes.


2011 ◽  
Vol 2-3 ◽  
pp. 595-598
Author(s):  
Fang Fang Jiang ◽  
Xu Wang ◽  
Dan Yang ◽  
Yu Hao

Ballistocardiogram signal (BCG) is a non-invasive technique for the assessment of the cardiac function. It consists mainly of heart movement and the movement of blood in aorta, arteries, and periphery, which can be used to real-time monitor the heart rate and respiration frequency at home. In our laboratory, a sitting BCG detection chair has been designed successfully, and the acquisition and analysis system based on virtual instruments is proposed in this paper. MATLAB7.0 and LabVIEW8.5 were used to simulate the operational environment, and the results show high efficiency and accuracy in displaying waveform and spectrum, extracting main characteristics of heart rate and respiratory frequency, and alerting when abnormal heart-rate occurs.


2020 ◽  
Vol 23 (2) ◽  
pp. 9-13
Author(s):  
Sushila Lama Moktan ◽  
Manan Karki

Introduction: Laryngoscopy and intubation is always associated with a short term reflex sympathetic pressor response. The perfusion index is an indirect, non-invasive, and continuous measure of peripheral perfusion by pulse oximeter which can detect the stress response to intubation similar to heart rate, systolic blood pressure and diastolic blood pressure. Methods: This prospective observational study enrolled sixty-five normotensive patients of American society of anesthesiologists physical status grade I and II scheduled for elective surgery under general anaesthesia. Tracheal intubation was performed after induction with intravenous fentanyl, propofol and vecuronium. Heart rate, Systolic and Diastolic Blood Pressure and Perfusion Index were measured before induction of anesthesia, before intubation and one minute, three minutes, five minutes after the insertion of the endotracheal tube. Increase in heart rate by ?10 beats per minute, systolic and diastolic blood pressure by ?15 millimeters of mercury and decrease in Perfusion index ?10% after endotracheal intubation as compared to preintubationvalue were considered positive haemodynamic changes. Results: Endotracheal intubation produced a significant increase in heart rate and blood pressure whereas perfusion index decreased significantly. Our study showed that perfusion index response criterion achieved 97.7% (Confidence interval 97.58-97.86) sensitivity in detecting the stress response to insertion of endotracheal tube whereas systolic and diastolic blood pressure achieved sensitivity of 90% and 92% respectively. Conclusion: Perfusion Index is easier, reliable and non-invasive alternative to conventional haemodynamic criteria for detection of stress response to endotracheal intubation.


PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259559
Author(s):  
Ryan P. Sixtus ◽  
Cholawat Pacharinsak ◽  
Clint L. Gray ◽  
Mary J. Berry ◽  
Rebecca M. Dyson

Background Non-invasive physiological monitoring can induce stress in laboratory animals. Sedation reduces the level of restraint required, thereby improving the validity of physiological signals measured. However, sedatives may alter physiological equilibrium introducing unintended bias and/or, masking the experimental outcomes of interest. We aimed to investigate the cardiorespiratory effects of four short-acting sedatives in juvenile guinea pigs. Method 12 healthy, 38 (26–46) day-old Dunkin Hartley guinea pigs were included in this blinded, randomised, crossover design study. Animals were sedated by intramuscular injection using pre-established minimum effective doses of either alfaxalone (5 mg/kg), diazepam (5 mg/kg), ketamine (30 mg/kg), or midazolam (2 mg/kg) administered in random order with a minimum washout period of 48 hours between agents. Sedative depth, a composite score comprised of five assessment criteria, was observed every 5-min from dosing until arousal. Physiological monitoring of cardiorespiratory status included measures of heart rate, blood pressure, respiratory rate, and peripheral microvascular perfusion. Results Ketamine and alfaxalone were most effective in inducing stable sedation suitable for physiological monitoring, and diazepam less-so. Midazolam was unsuitable due to excessive hypersensitivity. All sedatives significantly increased heart rate above non-sedated control rates (P<0.0001), without altering blood pressure or microvascular perfusion. Alfaxalone and ketamine reduced respiratory rate relative to their control condition (P<0.0001, P = 0.05, respectively), but within normative ranges. Conclusion Ketamine and alfaxalone are the most effective sedatives for inducing short duration, stable sedation with minimal cardiorespiratory depression in guinea pigs, while diazepam is less-so. However, alfaxalone is the most appropriate sedative for longitudinal studies requiring multiple physiological timepoints.


2021 ◽  
Vol 6 (1) ◽  
pp. 33
Author(s):  
Zubaidah Zubaidah ◽  
Insana Maria ◽  
Rusdiana Rusdiana ◽  
Iis Pusparina ◽  
Raihana Norfitri

Introduction: Hypertension is a non-communicable disease that affected on health in the adult age group. Acupressure therapy that can improve blood circulation for people with hypertension. Acupressure therapy can be an alternative treatment option to lower blood pressure and can meet the needs of society in reducing pharmacological therapy. The study was to determine the effect of Acupressure on changes in blood pressure of hypertension sufferers.Method: This study used pre-experimental design. The number of respondents was 15 people with consecutive sampling technique. The research variable is acupressure therapy. While the dependent variable is blood pressure. The data collected are primary data using observation sheets and blood pressure measured with a tensimeter and a stethoscope before and after the intervention. Therapy is done 3 times for 3 three days.Results: The results of the study showed that there was an effect of changes in blood pressure before and after being given acupressure therapy with p = 0.046 and p = 0.003.Conclusion: Acupressure is a simple non-invasive technique that nurses can perform independently. These findings suggest that acupressure can reduce systolic and diastolic blood pressure in patients with hypertension. The further research regarding acupressure therapy for other diseases besides hypertension.


2020 ◽  
Author(s):  
Felix Haidl ◽  
Christian Tronstad ◽  
Leiv Arne Rosseland ◽  
Vegard Dahl

Abstract Background: Pregnancy in general and labor in particular is associated with changes in maternal hemodynamic parameters such as increased cardiac output and heart rate, with peaks during uterine contractions. Adrenaline may be added to labor epidural solutions to enhance efficiency, but the hemodynamic fluctuations may increase. The aim of this study was to compare the hemodynamic changes of epidural drug solution with or without adrenaline 2 µg.ml -1 and to provide pilot data for a larger study. Methods: Forty-one nulliparous laboring women requesting epidural analgesia were randomized to epidural solution of bupivacaine 1mg.ml -1 , fentanyl 2 µg.ml -1 with or without adrenaline 2 µg.ml -1 . The participants were monitored with the Nexfin CC continuous non-invasive blood pressure and cardiac output monitor. The primary outcomes were changes in peak systolic blood pressure and cardiac output at uterine contraction within 30 minutes after epidural activation. The effect of adrenaline was tested statistically by a linear mixed effects model of the outcome variables’ dependency on time, adrenaline and their interaction. Results: The addition of adrenaline to the solution had no statistically significant effect on the temporal changes in peak systolic blood pressure (mean change 0.23 mmHg.min -1 95% CI [-0.17; 0.64] p=0.26), peak cardiac output (mean change 0.0029 l.min -1 .min -1 95 % CI [-0.026; 0.032] 0.84), or heart rate (mean change 0.015 beats.min -1 .min -1 95 % CI [-0.25; 0.28] p=0.91).


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