A Novel Design and Analysis of High-Sensitivity Biosensor Based on Nano-Cavity for Detection of Blood Component, Diabetes, Cancer and Glucose Concentration

In this work, a novel structure of an all-optical biosensor based on glass resonance cavities with high detection accuracy and sensitivity in two-dimensional photon crystal is designed and simulated. The free spectral range in which the structure performs well is about FSR = 630 nm. This sensor measures the concentration of glucose in human urine. Analyses to determine the glucose concentration in urine for a normal range (0~15 mg/dL) and urine despite glucose concentrations of 0.625, 1.25, 2.5, 5 and 10 g/dL in the wavelength range 1.326404~1.326426 μm have been conducted. The detection range is RIU = 0.2 × 10−7. The average bandwidth of the output resonance wavelengths is 0.34 nm in the lowest case. In the worst case, the percentage of optical signal power transmission is 77% with an amplitude of 1.303241 and, in the best case, 100% with an amplitude of 1.326404. The overall dimensions of the biosensor are 102.6 µm2 and the sensitivity is equal to S = 1360.02 nm/RIU and the important parameter of the Figure of Merit (FOM) for the proposed biosensor structure is equal to FOM = 1320.23 RIU−1.

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Effects of CF4 Plasma Treatment on Indium Gallium Oxide and Ti-doped Indium Gallium Oxide Sensing Membranes in Electrolyte–Insulator–Semiconductors

Crystals ◽

10.3390/cryst10090810 ◽

2020 ◽

Vol 10 (9) ◽

pp. 810

Author(s):

Chyuan-Haur Kao ◽

Yen-Lin Su ◽

Wei-Jen Liao ◽

Ming-Hsien Li ◽

Wei-Lun Chan ◽

...

Keyword(s):

Plasma Treatment ◽

Gallium Oxide ◽

Sol Gel ◽

Chemical Vapor ◽

High Sensitivity ◽

Ph Sensing ◽

Ion Sensing ◽

Indium Gallium ◽

Optical Applications ◽

Novel Design

Electrolyte–insulator–semiconductor (EIS) sensors, used in applications such as pH sensing and sodium ion sensing, are the most basic type of ion-sensitive field-effect transistor (ISFET) membranes. Currently, some of the most popular techniques for synthesizing such sensors are chemical vapor deposition, reactive sputtering and sol-gel deposition. However, there are certain limitations on such techniques, such as reliability concerns and isolation problems. In this research, a novel design of an EIS membrane consisting of an optical material of indium gallium oxide (IGO) was demonstrated. Compared with conventional treatment such as annealing, Ti doping and CF4 plasma treatment were incorporated in the fabrication of the film. Because of the effective treatment of doping and plasma treatment, the defects were mitigated and the membrane capacitance was boosted. Therefore, the pH sensitivity can be increased up to 60.8 mV/pH. In addition, the hysteresis voltage can be improved down to 2.1 mV, and the drift voltage can be suppressed to as low as 0.23 mV/h. IGO-based membranes are promising for future high-sensitivity and -stability devices integrated with optical applications.

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Preparation of Ni(OH)2 nanosheets on Ni foam via a direct precipitation method for a highly sensitive non-enzymatic glucose sensor

RSC Advances ◽

10.1039/c5ra06664f ◽

2015 ◽

Vol 5 (66) ◽

pp. 53665-53670 ◽

Cited By ~ 17

Author(s):

Yudong Zhao ◽

Gaochen Gu ◽

Shengquan You ◽

Renhua Ji ◽

Hui Suo ◽

...

Keyword(s):

Glucose Concentration ◽

Glucose Sensor ◽

High Sensitivity ◽

Precipitation Method ◽

Ni Foam ◽

Direct Precipitation ◽

Highly Sensitive ◽

Direct Precipitation Method

Ni(OH)2 nanosheets on Ni foam was prepared by the direct precipitation method. This electrode shows high sensitivity with 1130 μA mM−1 cm−2 at the glucose concentration range of 2 μM to 40 μM and 1097 μA mM−1 cm−2 at the range of 0.1 mM to 2.5 mM.

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Synthesis and Characterization of Ru-MOFs on Microelectrode for Trace Mercury Detection

Sensors ◽

10.3390/s20226686 ◽

2020 ◽

Vol 20 (22) ◽

pp. 6686

Author(s):

Chenyu Xiong ◽

Yuhao Xu ◽

Chao Bian ◽

Ri Wang ◽

Yong Xie ◽

...

Keyword(s):

Limit Of Detection ◽

Water Environment ◽

High Sensitivity ◽

Deposition Process ◽

Mercury Ions ◽

Covered Area ◽

Gold Microelectrode ◽

Novel Design ◽

Test Process

Mercury ions (Hg2+) pollution in the water environment can cause serious harm to human health. Trace Hg2+ detection is of vital importance for environmental monitoring. Herein, we report a novel design of Ru-MOFs modified gold microelectrode for Hg2+ determination. Ru-MOFs are synthesized directly by the cathodic method on gold microelectrode, with the covered area accurately controlled. Cathodic synthesized Ru-MOFs show good conductivity and are suitable to be used as the electrode surface material directly. The synergy of the pre-deposition process and the adsorption process of Ru-MOFs can effectively improves the performance of the sensor. The results show good linearity (R2 = 0.996) from 0.1 ppb to 5 ppb, with a high sensitivity of 0.583 μA ppb−1 mm−2. The limit of detection is found to be 0.08 ppb and the test process is within 6 min. Most importantly, the senor has a good anti-interference ability and the recoveries are satisfactory. This miniature electrochemical sensor has the potential for on-site detection of trace mercury in the field.

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A fluorescent biosensor of lysozyme-stabilized copper nanoclusters for the selective detection of glucose

RSC Advances ◽

10.1039/c5ra19421k ◽

2015 ◽

Vol 5 (123) ◽

pp. 101599-101606 ◽

Cited By ~ 31

Author(s):

Chan Wang ◽

Shili Shu ◽

Yagang Yao ◽

Qijun Song

Keyword(s):

Blood Glucose ◽

Glucose Concentration ◽

High Sensitivity ◽

Selective Detection ◽

Copper Nanoclusters ◽

Fluorescent Biosensor ◽

Simple Detection

Fluorescent copper nanoclusters (Lys-CuNCs) were synthesized using lysozyme as a template, displaying smart response to glucose concentration with high sensitivity. The visualization variation of Lys-CuNCs may further enable the rapid and simple detection of blood glucose.

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3D Shape Classification Based on Spectral Function and MDS Mapping

Journal of Computing and Information Science in Engineering ◽

10.1115/1.3290769 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Zhanqing Chen ◽

Kai Tang

Keyword(s):

Spectral Function ◽

Euclidean Plane ◽

High Sensitivity ◽

Shape Classification ◽

The Novel ◽

Feature Points ◽

3D Shape ◽

And Topology ◽

3D Shapes ◽

Novel Design

This paper reports a new method for 3D shape classification. Given a 3D shape M, we first define a spectral function at every point on M that is a weighted summation of the geodesics from the point to a set of curvature-sensitive feature points on M. Based on this spectral field, a real-valued square matrix is defined that correlates the topology (the spectral field) with the geometry (the maximum geodesic) of M, and the eigenvalues of this matrix are then taken as the fingerprint of M. This fingerprint enjoys several favorable characteristics desired for 3D shape classification, such as high sensitivity to intrinsic features on M (because of the feature points and the correlation) and good immunity to geometric noise on M (because of the novel design of the weights and the overall integration of geodesics). As an integral part of the work, we finally apply the classical multidimensional scaling method to the fingerprints of the 3D shapes to be classified. In all, our classification algorithm maps 3D shapes into clusters in a Euclidean plane that possess high fidelity to intrinsic features—in both geometry and topology—of the original shapes. We demonstrate the versatility of our approach through various classification examples.

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Novel Design and Fabrication of High Sensitivity MEMS Capacitive Sensor Array for Fingerprint Imaging

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.74.239 ◽

2009 ◽

Vol 74 ◽

pp. 239-242 ◽

Cited By ~ 2

Author(s):

Mitra Damghanian ◽

Burhanuddin Yeop Majlis

Keyword(s):

Pressure Sensor ◽

Sensor Array ◽

Fem Analysis ◽

High Sensitivity ◽

Capacitive Sensor ◽

Capacitive Pressure Sensor ◽

Structural Modifications ◽

Enhanced Sensitivity ◽

Sensor Structure ◽

Novel Design

A novel MEMS capacitive pressure sensor array is designed and fabricated for fingerprint acquisition application. Based on analytical investigations and FEM analysis, the designed structure of pressure sensor cells assist from an aluminum clamped-clamped wide beam as the movable electrode of variant capacitor, instead of usual membrane structure. A rectangular base T-shape protrusion is also used on top of the deflecting electrode to concentrate pressure and increase the sensitivity. Proven by the real test of the fabricated sensor structure, this design has enhanced sensitivity and linearity of the device compared to all membrane based reported prototypes without crossing the dpi limits. Structural modifications have resulted in a simpler fabrication process as well.

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Multichannel Electrical Impedance Spectroscopy Analyzer with Microfluidic Sensors

Sensors ◽

10.3390/s19081891 ◽

2019 ◽

Vol 19 (8) ◽

pp. 1891 ◽

Cited By ~ 2

Author(s):

Jaan Ojarand ◽

Mart Min ◽

Ants Koel

Keyword(s):

Impedance Spectroscopy ◽

Mechanical Design ◽

Point Of Care ◽

High Sensitivity ◽

Electrical Impedance Spectroscopy ◽

Signal Acquisition ◽

Biological Matter ◽

Microfluidic Sensors ◽

Passive Electrical Properties ◽

Novel Design

Impedance spectroscopy is a common approach in assessing passive electrical properties of biological matter. However, several problems appear in microfluidic devices in connection with the requirement for high sensitivity of signal acquisition from small volume sensors. The developed compact and inexpensive analyzer provides impedance spectroscopy measurement from three sensors, both connected in direct and differential modes. Measurement deficiencies are reduced with a novel design of sensors, measurement method, optimized electronics, signal processing, and mechanical design of the analyzer. Proposed solutions are targeted to the creation of reliable point-of-care (POC) diagnostic and monitoring appliances, including lab-on-a-chip type devices in the next steps of development. The test results show the good working ability of the developed analyzer; however, also limitations and problems that require attention and further improvement are appointed.

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Novel Design of an Extremely Miniaturized Accelerometer Based on Quantum Tunneling Effect

Proceedings ◽

10.3390/proceedings2131045 ◽

2018 ◽

Vol 2 (13) ◽

pp. 1045

Author(s):

Michael Haub ◽

Sebastian Hummel ◽

Martin Bogner ◽

Hermann Sandmaier

Keyword(s):

Focused Ion Beam ◽

Ion Beam ◽

High Sensitivity ◽

Tunneling Effect ◽

The Novel ◽

Electrostatic Actuators ◽

Operational Conditions ◽

Sensor Structure ◽

Constant Distance ◽

Novel Design

This paper presents the design of an extremely miniaturized accelerometer based on the tunneling effect. Because of its high sensitivity the tunneling effect allows the detection of smallest deflections. The aim of the novel design is a large geometric miniaturization at the lowest possible natural frequency with a nominal acceleration of +/−1 g corresponding to a deflection of +/−9.36 Å. The poly-silicon (PolySi) sensor structure with a size (L × W) of 98 µm × 85 µm is designed in a way that the main displacement operates just in one direction. To lead the sensor into operational conditions, control a constant distance between the tunneling electrodes and perform self-test actuations two electrodes are placed below the sensor structure. The tunneling tip is deposited by a focused ion beam (FIB) to provide the tunneling section with a third pad on the substrate. Within this paper the focus is on the functional implementation of the structure, the investigation of the electrostatic actuators and the deposition of the tunneling tip by the FIB.

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