Dynamic Center Aggregation Loss with Mixed Modality for Visible-Infrared Person Re-Identification

PURPOSE: To assess long-term site-specific risks of second malignancy after Hodgkin’s disease in relation to age at treatment and other factors. PATIENTS AND METHODS: A cohort of 5,519 British patients with Hodgkin’s disease treated during 1963 through 1993 was assembled and followed-up for second malignancy and mortality. Follow-up was 97% complete. RESULTS: Three hundred twenty-two second malignancies occurred. Relative risks of gastrointestinal, lung, breast, and bone and soft tissue cancers, and of leukemia, increased significantly with younger age at first treatment. Absolute excess risks and cumulative risks of solid cancers and leukemia, however, were greater at older ages than at younger ages. Gastrointestinal cancer risk was greatest after mixed-modality treatment (relative risk [RR] = 3.3; 95% confidence interval [CI], 2.1 to 4.8); lung cancer risks were significantly increased after chemotherapy (RR = 3.3; 95% CI, 2.4 to 4.7), mixed-modality treatment (RR = 4.3; 95% CI, 2.9 to 6.2), and radiotherapy (RR = 2.9; 95% CI, 1.9 to 4.1); breast cancer risk was increased only after radiotherapy without chemotherapy (RR = 2.5; 95% CI, 1.4 to 4.0); and leukemia risk was significantly increased after chemotherapy (RR = 31.6; 95% CI, 19.7 to 47.6) and mixed-modality treatment (RR = 38.1; 95% CI, 24.6 to 55.9). These risks were generally greater after treatment at younger ages: for patients treated at ages younger than 25 years, there were RRs of 18.7 (95% CI, 5.8 to 43.5) for gastrointestinal cancer after mixed-modality treatment, 14.4 (95% CI, 5.7 to 29.3) for breast cancer after radiotherapy, and 85.2 (95% CI, 45.3 to 145.7) for leukemia after chemotherapy (with or without radiotherapy). CONCLUSION: Age at treatment has a major effect on risk of second malignancy after Hodgkin’s disease. Although absolute excess risks are greater for older patients, RRs of several important malignancies are much greater for patients who are treated when young. The increased risk of gastrointestinal cancers may relate particularly to mixed-modality treatment, and that of lung cancer to chemotherapy as well as radiotherapy; there are also well-known increased risks of breast cancer from radiotherapy and leukemia from chemotherapy. The roles of specific chemotherapeutic agents in the etiology of solid cancers after Hodgkin’s disease require detailed investigation.

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Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian–human immunodeficiency virus viraemia with protein/DNA combination

Journal of General Virology ◽

10.1099/vir.0.83384-0 ◽

2008 ◽

Vol 89 (2) ◽

pp. 540-5533 ◽

Cited By ~ 28

Author(s):

Gerrit Koopman ◽

Daniella Mortier ◽

Sam Hofman ◽

Nathalie Mathy ◽

Marguerite Koutsoukos ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Virus Replication ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Current Data ◽

Dna Immunization ◽

Immunodeficiency Virus ◽

Vaccine Antigens ◽

Mixed Modality

Current data suggest that prophylactic human immunodeficiency virus type 1 (HIV) vaccines will be most efficacious if they elicit a combination of adaptive humoral and T-cell responses. Here, we explored the use of different vaccine strategies in heterologous prime–boost regimes and evaluated the breadth and nature of immune responses in rhesus monkeys induced by epidermally delivered plasmid DNA or recombinant HIV proteins formulated in the AS02A adjuvant system. These immunogens were administered alone or as either prime or boost in mixed-modality regimes. DNA immunization alone induced cell-mediated immune (CMI) responses, with a strong bias towards Th1-type cytokines, and no detectable antibodies to the vaccine antigens. Whenever adjuvanted protein was used as a vaccine, either alone or in a regime combined with DNA, high-titre antibody responses to all vaccine antigens were detected in addition to strong Th1- and Th2-type CMI responses. As the vaccine antigens included HIV-1 Env, Nef and Tat, as well as simian immunodeficiency virus (SIV)mac239 Nef, the animals were subsequently exposed to a heterologous, pathogenic simian–human immunodeficiency virus (SHIV)89.6p challenge. Protection against sustained high virus load was observed to some degree in all vaccinated groups. Suppression of virus replication to levels below detection was observed most frequently in the group immunized with protein followed by DNA immunization, and similarly in the group immunized with DNA alone. Interestingly, control of virus replication was associated with increased SIV Nef- and Gag-specific gamma interferon responses observed immediately following challenge.

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A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1715124115 ◽

2017 ◽

Vol 115 (4) ◽

pp. E668-E675 ◽

Cited By ~ 30

Author(s):

Lieselot L. G. Carrette ◽

Chen-Yu Wang ◽

Chunyao Wei ◽

William Press ◽

Weiyuan Ma ◽

...

Keyword(s):

Rett Syndrome ◽

Noncoding Rna ◽

Cultured Cells ◽

Fragile X ◽

Specific Treatment ◽

Disease Genes ◽

X Chromosomes ◽

Modality Approach ◽

Mixed Modality

The X-chromosome harbors hundreds of disease genes whose associated diseases predominantly affect males. However, a subset, including neurodevelopmental disorders, Rett syndrome (RTT), fragile X syndrome, and CDKL5 syndrome, also affects females. These disorders lack disease-specific treatment. Because female cells carry two X chromosomes, an emerging treatment strategy has been to reawaken the healthy allele on the inactive X (Xi). Here, we focus on methyl-CpG binding protein 2 (MECP2) restoration for RTT and combinatorially target factors in the interactome of Xist, the noncoding RNA responsible for X inactivation. We identify a mixed modality approach combining an Xist antisense oligonucleotide and a small-molecule inhibitor of DNA methylation, which, together, achieve 30,000-fold MECP2 up-regulation from the Xi in cultured cells. Combining a brain-specific genetic Xist ablation with short-term 5-aza-2′-deoxycytidine (Aza) treatment models the synergy in vivo without evident toxicity. The Xi is selectively reactivated. These experiments provide proof of concept for a mixed modality approach for treating X-linked disorders in females.

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Mixed-modality psychophysical scaling: Double cross-modality matching for “difficult” continua

Perception & Psychophysics ◽

10.3758/bf03207069 ◽

1986 ◽

Vol 39 (6) ◽

pp. 407-417 ◽

Cited By ~ 16

Author(s):

Lawrence M. Ward

Keyword(s):

Psychophysical Scaling ◽

Mixed Modality ◽

Double Cross

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Diagnóstico que permita detectar fortalezas y debilidades para ofrecer la modalidad mixta en el Instituto Tecnológico de Altamira

Revista de Políticas Universitarias ◽

10.35429/jup.2019.8.3.7.18 ◽

2019 ◽

pp. 7-18

Author(s):

Ángela Liliana Castillo-Flores ◽

Olimpia Danáe Arellano-Briones ◽

Luis Alfredo Ángeles-Reséndiz ◽

Luis Guillermo Fernández-García

Keyword(s):

Latin America ◽

Target Population ◽

Technological Institute ◽

Social Demand ◽

Coverage Gap ◽

Percentage Points ◽

Educational Processes ◽

The Social ◽

The Caribbean ◽

Mixed Modality

Currently our country has a coverage of 38.4%, leaving ten points below the average for Latin America and the Caribbean (UNESCO, 2018), that means that so far only a little more than a third of the social demand has been met or target population. With respect to the state of Tamaulipas, in 2017 it was below average, widening its coverage gap by 15.5 percentage points (ANUIES, 2018). One way to increase coverage is to use innovative educational processes (Mortis Lozoya, Del Hierro Parra, García López, & Manig Valenzuela, 2015). The objectives of this work are: Make a diagnosis to detect strengths and weaknesses to offer the mixed modality at the Technological Institute of Altamira. For this, a survey will be carried out on the actors involved in this process, the students, the teachers, and the authorities.

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Changes in pulmonary function after long-duration adventure racing in adolescent athletes

International Journal of Sports Medicine ◽

10.1055/a-1715-7199 ◽

2021 ◽

Author(s):

Anthony Birat ◽

Yoann Garnier ◽

Alexandre Dodu ◽

Claire Grossoeuvre ◽

Anne-Charlotte Dupont ◽

...

Keyword(s):

Pulmonary Function ◽

Respiratory Muscle ◽

Forced Expiratory Volume ◽

Adolescent Athletes ◽

Respiratory Muscle Fatigue ◽

Male Adolescents ◽

Long Duration ◽

Mouth Pressure ◽

Pressure Meter ◽

Mixed Modality

The present study investigated the acute effects of a mixed-modality, long-duration adventure race on pulmonary function in adolescent athletes. Twenty male adolescents aged 14 to 17 years volunteered to participate in a wilderness adventure race of 68.5-km. Expiratory function was evaluated before, immediately after, and 24 h after race completion. Measurements included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF). Maximal inspiratory and expiratory mouth static pressures (MIP and MEP, respectively) were also measured using a portable hand-held mouth pressure meter across the same time points. The mean completion time of the race was 05:38 ± 00:20 hours. A significant post-race decrease in FVC was observed immediately after the race (-5.2%, p = 0.01). However, no significant changes were observed for FEV1, PEF and the FEV1/FVC and FEV1/PEF ratios. In addition, estimates of respiratory muscle strength (MIP and MEP) were unaffected by the race. The long-duration adventure race induced no marked reduction in expiratory pulmonary function and this response was associated with no apparent respiratory muscle fatigue. Therefore, the pulmonary system of trained adolescent athletes was sufficiently robust to sustain the mixed-modality, long-duration adventure race of ∽5-6 h.

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Changes in pulmonary function after long-duration adventure racing in adolescent athletes

10.22541/au.161512728.83009771/v1 ◽

2021 ◽

Author(s):

Anthony BIRAT ◽

Yoann GARNIER ◽

Pierre BOURDIER ◽

Alexis DUPUY ◽

Alexandre DODU ◽

...

Keyword(s):

Pulmonary Function ◽

Respiratory Muscle ◽

Substantial Reduction ◽

Forced Expiratory Volume ◽

Adolescent Athletes ◽

Respiratory Muscle Fatigue ◽

Long Duration ◽

Expiratory Flow ◽

Pressure Meter ◽

Mixed Modality

Objective: The present study investigated the acute effects of a mixed-modality, long-duration adventure race on pulmonary function in adolescent athletes. Methods: Twenty male adolescents aged 14 to 17 years volunteered to participate in a simulated competitive wilderness adventure race of 68.5-km. Expiratory function was evaluated by spirometry with an Ergocard CPX Clinical system before, immediately after, and 24 h after race completion. Measurements included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), forced expiratory flows at 25%, 50% and 75% of FVC (FEF25, FEF50, FEF75, respectively) and peak expiratory flow (PEF). Maximal inspiratory and expiratory mouth static pressures (MIP and MEP, respectively) were also measured using a portable hand-held mouth pressure meter across the same time points. Results: The mean completion time of the race was 05:38 ± 00:20 hours. A significant post-race decrease in FVC was observed immediately after the race (-5.2%, p < 0.05). However, no significant changes were observed for FEV1, PEF or the FEV1/FVC and FEV1/PEF ratios. The results also showed no significant modifications in the maximal expiratory flow-volume curves irrespectively of FVC percentages (FEF25, FEF50, FEF75). In addition, estimates of respiratory muscle strength (MIP and MEP) were unaffected by the race. Conclusion: The long-duration adventure race induced no substantial reduction in expiratory pulmonary function and this response was associated with no apparent respiratory muscle fatigue. Therefore, the pulmonary system of trained adolescent athletes was sufficiently robust to endure the mixed-modality, long-duration adventure race of ∼5-6 h.

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