Individualized Degradation Modeling and Prognostics in a Heterogeneous Group via Incorporating Intrinsic Covariate Information

Author(s):  
Minhee Kim ◽  
Changyue Song ◽  
Kaibo Liu
Author(s):  
CHAITHRA KALKUR ◽  
NILOFER HALIM ◽  
ANUSHA RANGARE ◽  
Rumisha .

Ectodermal dysplasia is a heterogeneous group of inherited disorder affecting two or more ectodermally derived tissues such as skin, hair, nails, eccrine glands and teeth. The disorder is of two types: Hypohydrotic ectodermal dysplasia/Christ seimens –Touraine syndrome and Hydrotic ectodermal dysplasia/clousten syndrome. Commonly associated signs include hypohidrosis, anomalous dentition, onychodysplasia, hypotrichosis. Multidisciplinary approaches are required for optimal treatment3. Here, we present two cases of 19 and 13 year old male siblings who were diagnosed with the disorder based upon their clinical features. Key Words: ectodermal dysplasia, hypodontia; anomalous dentition.


2019 ◽  
Vol 25 (39) ◽  
pp. 5327-5346 ◽  
Author(s):  
Konstantin P. Volcho ◽  
Sergey S. Laev ◽  
Ghulam Md Ashraf ◽  
Gjumrakch Aliev ◽  
Nariman F. Salakhutdinov

Neurodegenerative disorders (NDDs) like Alzheimer's disease, Parkinson’s disease and Huntington’s disease are a heterogeneous group of disorders with the progressive and severe loss of neurons. There are no full proof cures for these diseases, and only medicines are available that can alleviate some of the symptoms. Developing effective treatments for the NDDs is a difficult but necessary task. Hence, the investigation of monoterpenoids which modulate targets applicable to many NDDs is highly relevant. Many monoterpenoids have demonstrated promising neuroprotective activity mediated by various systems. It can form the basis for elaboration of agents which will be useful both for the alleviation of symptoms of NDDs and for the treatment of diseases progression and also for prevention of neurodegeneration. The further developments including detections of monoterpenoids and their derivatives with high neuroprotective or neurotrophic activity as well as the results of qualified clinical trials are needed to draw solid conclusions regarding the efficacy of these agents.


2021 ◽  
pp. 1-21
Author(s):  
Anne Mette L. Würtz ◽  
Mette D. Hansen ◽  
Anne Tjønneland ◽  
Eric B. Rimm ◽  
Erik B. Schmidt ◽  
...  

ABSTRACT Intake of vegetables is recommended for the prevention of myocardial infarction (MI). However, vegetables make up a heterogeneous group, and subgroups of vegetables may be differentially associated with MI. The aim of this study was to examine replacement of potatoes with other vegetables or subgroups of other vegetables and the risk of MI. Substitutions between subgroups of other vegetables and risk of MI were also investigated. We followed 29,142 women and 26,029 men aged 50-64 years in the Danish Diet, Cancer and Health cohort. Diet was assessed at baseline by using a detailed validated FFQ. Hazards ratios (HR) with 95% CI for the incidence of MI were calculated using Cox proportional hazards regression. During 13.6 years of follow-up, 656 female and 1,694 male cases were identified. Among women, the adjusted HR for MI was 1.02 (95% CI: 0.93, 1.13) per 500 g/week replacement of potatoes with other vegetables. For vegetable subgroups, the HR was 0.93 (95% CI: 0.77, 1.13) for replacement of potatoes with fruiting vegetables and 0.91 (95% CI: 0.77, 1.07) for replacement of potatoes with other root vegetables. A higher intake of cabbage replacing other vegetable subgroups was associated with a statistically non-significant higher risk of MI. A similar pattern of associations was found when intake was expressed in kcal/week. Among men, the pattern of associations was overall found to be similar to that for women. This study supports food-based dietary guidelines recommending to consume a variety of vegetables from all subgroups.


Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2266
Author(s):  
Marta Cuenca ◽  
Victor Peperzak

B-cell malignancies arise from different stages of B-cell differentiation and constitute a heterogeneous group of cancers including B-cell lymphomas, B-cell leukemias, and plasma cell dyscrasias [...]


Diversity ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 132
Author(s):  
Maël Grosse ◽  
Anna Zhadan ◽  
Joachim Langeneck ◽  
Dieter Fiege ◽  
Alejandro Martínez

Sedentarian annelids are a diverse and heterogeneous group of marine worms representing more than 8600 species gathered in ca. 43 families. The attention brought to these organisms is unevenly distributed among these families, and the knowledge about them sometimes scarce. We review here the current knowledge about the families Acrocirridae, Cirratulidae (including Ctenodrilidae), Cossuridae, Longosomatidae, Paraonidae, and Sternaspidae in terms of biodiversity as well as the evolution of the taxonomy and systematics of each group. We present the challenges faced when studying these organisms and compare methodologies across groups and perspectives in future research.


Mathematics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 93
Author(s):  
Marcelo Loor ◽  
Ana Tapia-Rosero ◽  
Guy De Tré

A flexible attribute-set group decision-making (FAST-GDM) problem consists in finding the most suitable option(s) out of the options under consideration, with a general agreement among a heterogeneous group of experts who can focus on different attributes to evaluate those options. An open challenge in FAST-GDM problems is to design consensus reaching processes (CRPs) by which the participants can perform evaluations with a high level of consensus. To address this challenge, a novel algorithm for reaching consensus is proposed in this paper. By means of the algorithm, called FAST-CR-XMIS, a participant can reconsider his/her evaluations after studying the most influential samples that have been shared by others through contextualized evaluations. Since exchanging those samples may make participants’ understandings more like each other, an increase of the level of consensus is expected. A simulation of a CRP where contextualized evaluations of newswire stories are characterized as augmented intuitionistic fuzzy sets (AIFS) shows how FAST-CR-XMIS can increase the level of consensus among the participants during the CRP.


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