Are Korotkoff sounds reliable markers for accurate estimation of systolic and diastolic pressure using brachial cuff sphygmomanometry

2021 ◽  
pp. 1-1
Author(s):  
Branko George Celler ◽  
Mark Butlin ◽  
Ahmadreza Argha ◽  
Isabella Tan ◽  
Andy Sze Chiang Yong ◽  
...  
Keyword(s):  
Diastolic Pressure ◽  
Accurate Estimation ◽  
Korotkoff Sounds

Criteria for Diastolic Pressure: Revolution, Counterrevolution, and Now a Compromise

PEDIATRICS ◽  
1983 ◽  
Vol 71 (5) ◽  
pp. 854-855
Author(s):  
ARTHUR J. MOSS
Keyword(s):  
Great Britain ◽  
American Heart Association ◽  
American Heart ◽  
Diastolic Pressure ◽  
Heart Association ◽  
International Committee ◽  
Reliable Index ◽  
Korotkoff Sounds ◽  
Cardiac Society

In 1967, an editorial entitled, "The Criterion for Diastolic Pressure: Revolution and Counterrevolution" appeared in a cardiology journal.1 The comments centered on deliberations of three committees appointed through the years by the American Heart Association. The charge of these committees was, among other things, to resolve the issue of whether the fourth phase of Korotkoff sounds (muffling) or the fifth phase (cessation) is the proper index of diastolic pressure. In 1939, the American Heart Association, together with the Cardiac Society of Great Britain and Ireland, recommended quite definitely that the fourth phase should be considered the index of diastolic pressure.2 REVOLUTION In 1951, a second committee of the American Heart Association reversed the recommendation of the 1939 International Committee and stated that the fifth phase was to be regarded as the more reliable index of diastolic pressure.3

An Efficient Statistic for Determining the Diameter of Thin Sectioned Uniform Spheres from Measurements of Biological Samples

1974 ◽  
Vol 32 ◽  
pp. 114-115
Author(s):  
W. R. Schucany ◽  
G. H. Kelsoe ◽  
V. F. Allison
Keyword(s):  
Biological Samples ◽  
Traditional Method ◽  
Cell Types ◽  
Accurate Estimation ◽  
Morphological Identification ◽  
Sectioned Material ◽  
Maximal Diameter ◽  
Similar Cell

Accurate estimation of the size of spheroid organelles from thin sectioned material is often necessary, as uniquely homogenous populations of organelles such as vessicles, granules, or nuclei often are critically important in the morphological identification of similar cell types. However, the difficulty in obtaining accurate diameter measurements of thin sectioned organelles is well known. This difficulty is due to the extreme tenuity of the sectioned material as compared to the size of the intact organelle. In populations where low variance is suspected the traditional method of diameter estimation has been to measure literally hundreds of profiles and to describe the “largest” as representative of the “approximate maximal diameter”.

Under- and Over-Estimation

2011 ◽  
Vol 58 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Virginie Crollen ◽  
Julie Castronovo ◽  
Xavier Seron
Keyword(s):  
Empirical Data ◽  
Accurate Estimation ◽  
Numerical Estimation ◽  
Production Task ◽  
Estimation Task ◽  
Reproduction Task ◽  
Perception Task ◽  
Adult Participants ◽  
Mapping Hypothesis ◽  
Task Perception

Over the last 30 years, numerical estimation has been largely studied. Recently, Castronovo and Seron (2007) proposed the bi-directional mapping hypothesis in order to account for the finding that dependent on the type of estimation task (perception vs. production of numerosities), reverse patterns of performance are found (i.e., under- and over-estimation, respectively). Here, we further investigated this hypothesis by submitting adult participants to three types of numerical estimation task: (1) a perception task, in which participants had to estimate the numerosity of a non-symbolic collection; (2) a production task, in which participants had to approximately produce the numerosity of a symbolic numerical input; and (3) a reproduction task, in which participants had to reproduce the numerosity of a non-symbolic numerical input. Our results gave further support to the finding that different patterns of performance are found according to the type of estimation task: (1) under-estimation in the perception task; (2) over-estimation in the production task; and (3) accurate estimation in the reproduction task. Moreover, correlation analyses revealed that the more a participant under-estimated in the perception task, the more he/she over-estimated in the production task. We discussed these empirical data by showing how they can be accounted by the bi-directional mapping hypothesis ( Castronovo & Seron, 2007 ).

LABORATORY TESTS OF THYROID FUNCTION IN HYPERTHYROIDISM II.

1969 ◽  
Vol 62 (4_Suppla) ◽  
pp. S23-S35
Author(s):  
B.-A. Lamberg ◽  
O. P. Heinonen ◽  
K. Liewendahl ◽  
G. Kvist ◽  
M. Viherkoski ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Laboratory Tests ◽  
Goodness Of Fit ◽  
Point Of View ◽  
Accurate Estimation ◽  
Diagnostic Efficiency ◽  
Normal Limits ◽  
Significant Difference ◽  
Crossing Point ◽  
Hyperthyroid Patients

ABSTRACT The distributions of 13 variables based on 10 laboratory tests measuring thyroid function were studied in euthyroid controls and in patients with toxic diffuse or toxic multinodular goitre. Density functions were fitted to the empirical data and the goodness of fit was evaluated by the use of the χ2-test. In a few instances there was a significant difference but the material available was in some respects too small to allow a very accurate estimation. The normal limits for each variable was defined by the 2.5 and 97.5 percentiles. It appears that in some instances these limits are too rigorous from the practical point of view. It is emphasized that the crossing point of the functions for euthyroid controls and hyperthyroid patients may be a better limit to use. In a preliminary analysis of the diagnostic efficiency the variables of total or free hormone concentration in the blood proved clearily superior to all other variables.

Acute Changes in Left Ventricular End Diastolic Pressure following the Transcatheter Closure of an Atrial Septal Defect in Adults

2016 ◽  
Vol 19 (3) ◽  
pp. 145 ◽  
Author(s):  
Young Hwa Kong ◽  
Jinyoung Song ◽  
Kyung Hee Kim ◽  
June Huh ◽  
I-Seok Kang
Keyword(s):  
Elderly Patients ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Transcatheter Closure ◽  
Diastolic Pressure ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Device Closure ◽  
Acute Changes ◽  
Asd Closure

<strong>Background:</strong> Acute changes in left ventricular diastolic function shortly after ASD closure in elderly patients have not been well known. We aimed to investigate acute changes in left ventricular end diastolic pressure (LVEDP) in elderly patients following transcatheter closure of atrial septal defect (ASD). <br /><strong>Methods:</strong> All 19 adults with ASDs who underwent transcatheter closure between June 2013 and December 2014 were enrolled. LVEDP was measured prior to device closure and compared with that immediately following device closure and 15 minutes after device closure. <br /><strong>Results:</strong> The median age of the patients was 48 years old. The baseline E/e’ and LVEDP values were 8.3 ± 2.8 and 13 ± 3 mmHg. The LVEDP value immediately following closure was 19 ± 4 mmHg, and 15 minutes after closure was 16 ± 4 mmHg. The median increase in the LVEDP value immediately following closure was 6 mmHg, which significantly differed from that prior to closure. The LVEDP 15 minutes after closure decreased but remained significantly higher than the value observed immediately after closure. No significant changes were observed with regard to E/e’ at either 1 day or 3 months following closure. The LVEDP value <br />15 minutes after device closure was significantly correlated with those observed before closure and immediately following closure; however, no significant correlations were observed with regard to patient age, Qp/Qs, E/e’ before closure, or E/e’ 3 months after device closure.<br /><strong>Conclusion:</strong> LVEDP in adults with ASDs significantly increases following device closure. LVEDP before closure predicts LVEDP following device closure.

RELATIVE CONTRIBUTIONS OF FIBROSIS AND CONNEXIN CHANGES TOTHE ATRIAL FIBRILLATION SUBSTRATE DURING THE DEVELOPMENT AND REVERSAL OF CONGESTIVEHEART FAILURE

2008 ◽  
Vol 31 (4) ◽  
pp. 5
Author(s):  
Brett Burstein ◽  
Kunihiro Nishida ◽  
Philippe Comtois ◽  
Louis Villenuve ◽  
Yung-Hsin Yeh ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Potential Model ◽  
Diastolic Pressure ◽  
Recovery Period ◽  
Left Ventricular ◽  
Muscle Bundle ◽  
Protein Ratio ◽  
Conduction Disturbances ◽  
Conduction Abnormalities ◽  
Mrna And Protein Expression

Background: Connexin alterations occur in various atrial fibrillation (AF) paradigms, but their functional significance remains unclear. No data are available regarding the effects of CHF on atrial connexin expression and phosphorylation. We therefore analyzed connexin changes and their contribution to the AF substrate during the development and reversal ofCHF. Methods and Results: Dogs were allocated to three groups: CHF induced by 2-week ventricular tachypacing (CHF, n=15); CHF dogs allowed to recover for 4 weeks after 2-week tachypacing (REC, n=15) and non-paced shams (CTL, n=11). Left ventricular end-diastolic pressure increased with CHF (14.5±1.0*** vs.3.7±0.7, ***P < 0.001 vs. CTL) and normalized upon CHF recovery (5.1±1.0^†††, ^††† P < 0.001 vs. CHF). Real-time PCR and Western-blot analyses revealed connexin43 (Cx43) and connexin40 (Cx40) mRNA and protein expression to be unchanged by CHF and REC. However, CHF caused Cx43 dephosphorylation(by ~73%***) and increased Cx40/Cx43 protein ratio (by ~35%***), with both alterations completely reversing in REC. Immunofluorescent confocal microscopy confirmed connexin protein trends, with a reduction in phosphorylated Cx43 (by ~68%*** in CHF) that returned to control in REC. CHF caused conduction abnormalities (phasedelay-range and heterogeneity index, both P < 0.01) and burst pacing-induced AF prolongation (CTL 22±7s, CHF 1100±171s***, REC 884±220s***) which persisted in the recovery period, along with residual fibrosis (CTL 3.6±0.7%, CHF 14.7±1.5%***, REC13.3±2.3%***). Fibrosis physically interrupted muscle bundle continuity and anionically-based action potential model of canine atrium showed that fibrosiswas able to account for the observed conduction abnormalities. Conclusions: CHF causes connexin-dephosphorylation and Cx40/Cx43ratio increases. With CHF reversal, atrial connexin alterations recover completely, but tissue fibrosis, conduction abnormalities and a substrate forAF remain with fibrosis accounting for conduction abnormalities. Thus, althougha trial connexin changes occur with CHF, they are not essential for conduction disturbances and AF promotion, which appear rather to be related primarily tofibrotic interruption of muscle-bundle continuity.

Napfmarathon versus Stadtmarathon: Eine Annäherung an das Konzept des Leistungskilometers

2015 ◽  
Vol 63 (1) ◽  
Keyword(s):  
Accurate Estimation ◽  
Horizontal Distance ◽  
First Approximation ◽  
The City

The aim of this study was to investigate differences in course times of a mountainmarathon (Napfmarathon) versus a city Marathon. Therefore all participants of Napfmarathon were screened concerning a double participation on a city marathon (Zürich, Winterthur, Lausanne, Luzern) and the course time were compared. Of key interest was the influence of ascents and descents which were quantified according to ­guidelines of Youth & Sport (Jugend + Sport / Jeunesse et Sport), whereby in first approximation 100 meter of ascent, 150 meter of descent (more than 20%) and 1 km of horizontal distance were taken as a simallar performance correlat. For the identified double starter different average times per km resulted. For the city marathon with an average time of 4 min 52 sec and for the Napfmarathon with 4 min 28 sec. If speed per km was calculated only with ascent and horizontal distances having performance relevance an average time of 4 min 56 sec per km was identified. This effect seems to be independet from distance absolved, resulting for Halbmarathon on an average time of distance of 4 min 13 sec, for Napfmarathon of 4 min 4 sec and for the performance concept only with ascent an average time per km of 4 min 16 sec. These analysis reveal, that if only ascent is taxed average course times differ less than 5 sec for both distances. For these particular reasons we recommend for running events to calculate only based on ascent and horizontal distances making necessary adjustments based on length of course, steepness of ascent and descent, character of terain (middle-country, pre-alps, alpes) for accurate estimation of course times.

THE ELASTICITY OF THE LARGE ARTERIES IN HYPERTENSION

1952 ◽  
Vol 30 (2) ◽  
pp. 125-129
Author(s):  
J. P. Adamson ◽  
J. Doupe
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Diastolic Pressure ◽  
Arterial Elasticity ◽  
Large Arteries ◽  
Wave Velocities

Intra-arterial pressures and pulse wave velocities were measured in 18 subjects whose auscultatory diastolic pressures ranged from 45 to 120 mm. Hg. Various methods were used to lower the blood pressure in the hypertensive and to raise it in nonhypertensive subjects so that pulse wave velocities might be compared in all subjects at a common diastolic pressure. The pulse wave velocities were calculated for a diastolic pressure of 80 mm. Hg. No significant differences were found between hypertensive and nonhypertensive subjects. It was concluded that a defect of arterial elasticity as gauged by pulse wave velocity is not a factor in the pathogenesis of hypertension.

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