LABORATORY TESTS OF THYROID FUNCTION IN HYPERTHYROIDISM II.

1969 ◽  
Vol 62 (4_Suppla) ◽  
pp. S23-S35
Author(s):  
B.-A. Lamberg ◽  
O. P. Heinonen ◽  
K. Liewendahl ◽  
G. Kvist ◽  
M. Viherkoski ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Laboratory Tests ◽  
Goodness Of Fit ◽  
Point Of View ◽  
Accurate Estimation ◽  
Diagnostic Efficiency ◽  
Normal Limits ◽  
Significant Difference ◽  
Crossing Point ◽  
Hyperthyroid Patients

ABSTRACT The distributions of 13 variables based on 10 laboratory tests measuring thyroid function were studied in euthyroid controls and in patients with toxic diffuse or toxic multinodular goitre. Density functions were fitted to the empirical data and the goodness of fit was evaluated by the use of the χ2-test. In a few instances there was a significant difference but the material available was in some respects too small to allow a very accurate estimation. The normal limits for each variable was defined by the 2.5 and 97.5 percentiles. It appears that in some instances these limits are too rigorous from the practical point of view. It is emphasized that the crossing point of the functions for euthyroid controls and hyperthyroid patients may be a better limit to use. In a preliminary analysis of the diagnostic efficiency the variables of total or free hormone concentration in the blood proved clearily superior to all other variables.

Neutrophil chemotaxis, random migration, and adherence in patients with hyperthyroidism

1989 ◽  
Vol 121 (6) ◽  
pp. 817-820 ◽  
Author(s):  
B. Wolach ◽  
B. Lebanon ◽  
A. Jedeikin ◽  
M. S. Shapiro ◽  
L. Shenkman
Keyword(s):  
Thyroid Function ◽  
Chemotactic Activity ◽  
Neutrophil Chemotaxis ◽  
Phagocytic Cells ◽  
Random Migration ◽  
Significant Difference ◽  
Neutrophil Adherence ◽  
Hyperthyroid Patients ◽  
Normal Controls ◽  
Neutrophil Chemotactic Activity

Abstract. We have examined neutrophil adherence, chemotactic activity, and random migration in 35 hyperthyroid patients with Graves' disease and 106 normal volunteers. No statistically significant differences were found between granulocyte adherence of 17 hyperthyroid subjects (67 ± 15.6%) and 81 healthy volunteers (63.1 ± 17%). In 3 thyrotoxic patients, impaired neutrophil adherence was found, which resolved when thyroid function returned to normal. The neutrophil chemotactic activity of 32 normal controls was 107.5 ± 21.4 cells, and the random migration 36 ± 15.5 cells. No statistically significant difference was demonstrated in 13 hyperthyroid patients who had a neutrophil chemotactic activity of 102 ± 14.6 cells and a random migration of 31.2 ± 13.2 cells. Defective chemotactic activity and random migration was found in 2 patients. Neutrophil functions returned to normal in one of the two subjects who were re-evaluated when thyroid function recovered. In summary, 14% of hyperthyroid patients had impaired leukocyte functions. However, severe pyogenic infections are quite rare in hyperthyroid patients, indicating that the observed alterations in function of phagocytic cells are not clinically important.

scholarly journals ANALYSIS ON WHOLE BLOOD, SGOT, SGPT, AND TNF-a EXAMINATION IN PATIENTS WITH NON-DENGUE AND POSITIVE DENGUE FEVER (DF/DHF)

2013 ◽  
Vol 4 (4) ◽  
pp. 46
Author(s):  
Rahayu Anggraini ◽  
Nasronudin Nasronudin
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Whole Blood ◽  
Laboratory Tests ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Normal Value ◽  
Normal Limits ◽  
Significant Difference

Background: In Indonesia has four serotypes, the DEN-1, DEN-2, DEN-3 and DEN-4. The management of Dengue virus becomes difficult because the patients were infected with different clinical profiles depending on the serotypes and genotypes of infecting dengue virus. Consequently, the diagnosis and treatment becomes difficult. Aim: The purpose of this study was to identify the difference between the results of laboratory tests between non-dengue fever and positive dengue fever. Method: This study was an observational cross-sectional study. Fifteen samples were diagnosed with dengue fever and fifteen samples with negative dengue fever on NS1, IgM / IgG-anti-DHF strip test results. Laboratory tests comprising whole blood, SGOT, SGPT, and TNFa were first examined when the patient came to the hospital. The collected data were analyzed by Chi-Square test SPSS version 13 for Windows. Result: The results of the study in two groups regarding sex, age, days of fever, grade, hemoglobin levels, leukocytes count, platelet count, hematocrit percentage, SGOT levels, and TNFa level were not significantly different with p > 0.050, whereas the SGPT level in non-dengue increased 3 x of normal value of 66.7%, n = 10/15 and in positive dengue fever the SGPT level was within normal limits, found in 60%, n = 9/15, so there was significant difference with p = 0.022 (p < 0.05). Conclusion: in non-dengue SGOT and SGPT levels increased of 1–3 times the normal value. In positive dengue fever SGOT levels increased 1–3 x normal value, but SGPT levels was within normal value, so SGPT levels can be used as a predictive factor for distinguishing the two types of fever.

The Influence of the Thyroid Function on the Metabolic Rate of Prothrombin, Factor VII, and Factor X in the Rat

1976 ◽  
Vol 35 (03) ◽  
pp. 607-619 ◽  
Author(s):  
Allan T. van Oosterom ◽  
Herman Mattie ◽  
Wim Th Hermens ◽  
Jan J. Veltkamp
Keyword(s):  
Metabolic Rate ◽  
Thyroid Function ◽  
Coagulation Factors ◽  
Biologically Active ◽  
Factor Vii ◽  
Synthesis Rate ◽  
Apparent Difference ◽  
Vitamin K1 ◽  
Factor X ◽  
Significant Difference

SummaryThe influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and X was studied in the rat. Disappearance rates of the three coagulation factors were measured after synthesis had been blocked with appropriate doses of warfarin, and reappearance rates were assessed upon induction of synthesis by high doses of vitamin K1 injected into rats displaying coumarin induced hypocoagulability.No statistically significant difference in the disappearance and production rates of any of the factors could be found between normal euthyroid rats and thyroxin-treated hypothyroid rats proven to be euthyroid. The differences between the two euthyroid groups and the hypothyroid group were highly significant, however: hypothyroidism results in an approximately 50% decrease of the metabolic rates of the three coagulation factors under study.The reappearance of the three factors, under euthyroid as well as hypothyroid conditions, showed a biphasic pattern: in the first two hours after vitamin K1 administration to warfarin treated rats, a rapid reappearance was observed, to the same extent for all three factors, in hypo- as well as euthyroid rats. This finding suggests that in vitamin K1 deficiency an intracellular accumulation of precursor proteins (PIVKAs) occurs, which after rapid conversion into biologically active coagulation factors by vitamin K1 are shed into circulation.The subsequent phase of reappearance is much slower and reflects the synthesis rate of coagulation enzymes. It is characteristic for each factor and clearly slower in hypothyroid rats than in euthyroid rats. From this an influence of thyroid function on the synthesis rate of the protein moiety of coagulation factors can be inferred.An apparent difference between disappearance and reappearance rate of the coagulation factors in the plasma, particularly pronounced for factors VII and X in euthyroid rats, could theoretically be explained as the consequence of the model used for derivation of these rates.

Compensated 131I-therapy of solitary autonomous thyroid nodules: effect on thyroid size and early hypothyroidism

1986 ◽  
Vol 113 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Laszlo Hegedüs ◽  
Dagmar Veiergang ◽  
Steen Karstrup ◽  
Jens Mølholm Hansen
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Nodules ◽  
Thyroid Volume ◽  
131I Therapy ◽  
Important Place ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
One Year ◽  
Hyperthyroid Patients

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

scholarly journals Using Wearable Cameras to Assess Foods and Beverages Omitted in 24 Hour Dietary Recalls and a Text Entry Food Record App

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1806
Author(s):  
Virginia Chan ◽  
Alyse Davies ◽  
Lyndal Wellard-Cole ◽  
Silvia Lu ◽  
Hoi Ng ◽  
...  
Keyword(s):  
Dietary Assessment ◽  
Fats And Oils ◽  
Point Of View ◽  
Self Report ◽  
Smartphone App ◽  
Food Record ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Post Hoc ◽  
Paired T Test

Technology-enhanced methods of dietary assessment may still face common limitations of self-report. This study aimed to assess foods and beverages omitted when both a 24 h recall and a smartphone app were used to assess dietary intake compared with camera images. For three consecutive days, young adults (18–30 years) wore an Autographer camera that took point-of-view images every 30 seconds. Over the same period, participants reported their diet in the app and completed daily 24 h recalls. Camera images were reviewed for food and beverages, then matched to the items reported in the 24 h recall and app. ANOVA (with post hoc analysis using Tukey Honest Significant Difference) and paired t-test were conducted. Discretionary snacks were frequently omitted by both methods (p < 0.001). Water was omitted more frequently in the app than in the camera images (p < 0.001) and 24 h recall (p < 0.001). Dairy and alternatives (p = 0.001), sugar-based products (p = 0.007), savoury sauces and condiments (p < 0.001), fats and oils (p < 0.001) and alcohol (p = 0.002) were more frequently omitted in the app than in the 24 h recall. The use of traditional self-report methods of assessing diet remains problematic even with the addition of technology and finding new objective methods that are not intrusive and are of low burden to participants remains a challenge.

scholarly journals LARGE QUANTUM GRAVITY EFFECTS: CYLINDRICAL WAVES IN FOUR DIMENSIONS

2000 ◽  
Vol 09 (06) ◽  
pp. 669-686 ◽  
Author(s):  
MARÍA E. ANGULO ◽  
GUILLERMO A. MENA MARUGÁN
Keyword(s):  
Quantum Gravity ◽  
Symmetry Axis ◽  
Point Of View ◽  
Three Dimensions ◽  
Asymptotic Region ◽  
Four Dimensions ◽  
Cylindrical Waves ◽  
Significant Difference ◽  
Gravity Effects ◽  
Linearly Polarized

Linearly polarized cylindrical waves in four-dimensional vacuum gravity are mathematically equivalent to rotationally symmetric gravity coupled to a Maxwell (or Klein–Gordon) field in three dimensions. The quantization of this latter system was performed by Ashtekar and Pierri in a recent work. Employing that quantization, we obtain here a complete quantum theory which describes the four-dimensional geometry of the Einstein–Rosen waves. In particular, we construct regularized operators to represent the metric. It is shown that the results achieved by Ashtekar about the existence of important quantum gravity effects in the Einstein–Maxwell system at large distances from the symmetry axis continue to be valid from a four-dimensional point of view. The only significant difference is that, in order to admit an approximate classical description in the asymptotic region, states that are coherent in the Maxwell field need not contain a large number of photons anymore. We also analyze the metric fluctuations on the symmetry axis and argue that they are generally relevant for all of the coherent states.

Diagnostic Efficiency of the Trail Making Test as a Function of Cut-off Score, Diagnosis, and Age

1978 ◽  
Vol 47 (1) ◽  
pp. 191-195 ◽  
Author(s):  
Norman G. Gordon
Keyword(s):  
Analysis Of Covariance ◽  
Veterans Administration ◽  
Trail Making Test ◽  
Diagnostic Efficiency ◽  
Male Veterans ◽  
Significant Difference ◽  
Trail Making ◽  
Administration Hospital ◽  
Cutoff Scores ◽  
The Brain

This study is a reinvestigation of the effectiveness of the Trail Making Test in discriminating between brain-damaged ( n = 51) and pseudoneurologic ( n = 72) subjects. All subjects were hospitalized male veterans at the Allen Park Veterans Administration Hospital. An analysis of covariance showed that the pseudoneurologic subjects performed at a significantly higher level than the brain-damaged subjects. Further analysis with two different cutoff scores exhibited unequal discriminatory power throughout the whole range of Trail Making Test scores. These results suggested diagnosing only when the scores were 9 or lower and 13 or higher. This use of extreme scores resulted in an over-all hit rate of 87% in the study. Comparisons with five major subgroupings of the pseudoneurologic subjects yielded only one significant difference: more accurate discrimination with the 12 cut-off score between 10 general-medical and peripheral nerve-damaged subjects (100% correct) and 18 psychotic subjects (39% accuracy).

scholarly journals Correlation of Triiodothyronine Level with In-Hospital Cardiac Function and Long-Term Prognosis in Patients with Acute Myocardial Infarction

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jianqing She ◽  
Jiahao Feng ◽  
Yangyang Deng ◽  
Lizhe Sun ◽  
Yue Wu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Survival Analysis ◽  
Cardiac Function ◽  
Thyroid Function ◽  
Major Adverse Cardiovascular Events ◽  
Free Triiodothyronine ◽  
Kaplan Meier ◽  
Significant Difference

Objective. The pathophysiologic mechanism of how thyroid function is related to the development and prognosis of acute myocardial infarction (AMI) remains under explored, and there has been a lack of clinical investigations. In this study, we investigate the relationship between triiodothyronine (T3) level and cardiac ejection fraction (EF) as well as probrain natriuretic peptide (NT-proBNP) on admission and subsequent prognosis in AMI patients. Methods. We measured admission thyroid function, NT-proBNP, and EF by echocardiography in 345 patients diagnosed with AMI. Simple and multiregression analyses were performed to investigate the correlation between T3 level and EF as well as NT-proBNP. Major adverse cardiovascular events (MACE), including new-onset myocardial infarction, acute heart failure, and cardiac death, were documented during the follow-up. 248 participants were separated into three groups based on T3 and free triiodothyronine (FT3) levels for survival analysis during a 2-year follow-up. Results. 345 patients diagnosed with AMI were included in the initial observational analysis. 248 AMI patients were included in the follow-up survival analysis. The T3 levels were found to be significantly positively correlated with EF (R square=0.042, P<0.001) and negatively correlated with admission NT-proBNP levels (R square=0.059, P<0.001), which is the same with the correlation between FT3 and EF (R square=0.053, P<0.001) and admission NT-proBNP levels (R square=0.108, P<0.001). Kaplan-Meier survival analysis revealed no significant difference with regard to different T3 or FT3 levels at the end of follow-up. Conclusions. T3 and FT3 levels are moderately positively correlated with cardiac function on admission in AMI patients but did not predict a long-time survival rate. Further studies are needed to explain whether longer-term follow-up would further identify the prognosis effect of T3 on MACE and all-cause mortality.

scholarly journals Outcome of Fixed Dose of Radioiodine Therapy in Hyperthyroid Patients at NINMAS

2018 ◽  
Vol 20 (1) ◽  
pp. 37
Author(s):  
Sharmin Quddus ◽  
Fatima Begum ◽  
Nasreen Sultana ◽  
Rahima Perveen ◽  
Tapati Mandal ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Single Dose ◽  
Thyroid Function ◽  
Radioactive Iodine ◽  
Radioiodine Therapy ◽  
Thyroid Stimulating Hormone ◽  
Fixed Dose ◽  
Free Triiodothyronine ◽  
Toxic Goiter ◽  
Hyperthyroid Patients

<p><strong>Objective:</strong> The modified fixed doses of radioactive iodine (RAI) in different types of hyperthyroidism had been practiced at National Institute of Nuclear Medicine &amp; Allied Science (NINMAS) according to Society of Nuclear Medicine Bangladesh (SNMB) protocol since 2002 which was upgraded in 2015. The objective of the study was to observe the treatment outcome in modified fixed dose on previous protocol. Patients and Methods: In the present study the outcome of radioiodine therapy of hyperthyroid patients was retrospectively evaluated in 1349 consecutive primary hyperthyroid patients treated from January 2010 to December 2014 at NINMAS. Diagnosis of hyperthyroidism was done by thyroid function test; thyroid stimulating hormone (TSH), free triiodothyronine (FT3)   &amp; free thyroxine (FT4), 99m Technetium scan, thyroid radioiodine uptake and ultrasound imaging of thyroid gland. All patients received a fixed dose (8-29 m Ci) of radioactive iodine (RAI) depending on types of hyperthyroidism, visual assessment of gland size and severity of disease at diagnosis. They were followed up at 2 months of therapy, then every three months intervals for first year and thereafter 6 monthly up to 5 years or as needed during fluctuation of thyroid function.</p><p><strong>Results:</strong> Among the study population, 832 patients had diffuse toxic goiter (Graves’ disease), 369 patients were diagnosed as toxic multinodular goiter and 148 patients with single toxic nodule. At one year follow-up, permanent hypothyroidism occurred in 61.62% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.25% after 5 years. Cure or success of RAI therapy was considered as attainment of euthyroid state or hypothyroid state. About 11.26 % patients received more than single dose.</p><p><strong>Conclusion:</strong> Fixed dose RAI therapy is very much cost effective mode of treatment for primary hyperthyroidism with ~89% success by giving single dose.</p><p>Bangladesh J. Nuclear Med. 20(1): 37-40, January 2017</p>

scholarly journals Capture efficiency for small dominant mesozooplankters (Copepoda, Appendicularia) off Buenos Aires Province (34ºS-41ºS), Argentine Sea, using two plankton mesh sizes

2009 ◽  
Vol 57 (3) ◽  
pp. 205-214 ◽  
Author(s):  
Rosana Di Mauro ◽  
Fabiana Capitanio ◽  
María Delia Viñas
Keyword(s):  
Buenos Aires ◽  
Developmental Stages ◽  
Fish Larvae ◽  
Abundant Species ◽  
Accurate Estimation ◽  
Buenos Aires Province ◽  
Oikopleura Dioica ◽  
Great Loss ◽  
Argentine Sea ◽  
Significant Difference

Two plankton mesh sizes of 67 µm and 220 µm were compared to evaluate their efficiency in the capture of the smallest copepods and appendicularians present in the Buenos Aires coastal area (Argentine Sea). A total of 12 copepod species and one appendicularian species were recorded in this study. The copepods were separated into 4 groups: harpacticoids, cyclopoids, small calanoids and large calanoids and their developmental stages. Among the cyclopoids, Oithona nana was the most abundant species, being 96.29 % underestimated by the 220 µm mesh, whereas Microsetella norvegica dominated the harpacticoids and was captured exclusively by the smaller mesh. Similar results were found for copepodites I-III of small calanoids, whose net sampled underestimation reached 99.70%. On the other hand, no significant difference between meshes was found for adults and copepodites IV-V of small calanoids or any of the developmental stages of large calanoids. A great loss of biomass was observed for O. nana when applying the larger mesh. In regards to the appendicularian Oikopleura dioica, all size ranges below 1,000 µm length were better estimated by the 67 µm mesh in terms of abundance and biomass. Our results clearly show that the 67 µm mesh was more efficient in the capture of early stages of small copepods thus providing a more accurate estimation of the fish larvae prey field.

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