Capsule-Type Magnetic Microrobot Actuated by an External Magnetic Field for Selective Drug Delivery in Human Blood Vessels

2014 ◽  
Vol 50 (11) ◽  
pp. 1-4 ◽  
Author(s):  
Kyun Choi ◽  
Gunhee Jang ◽  
Seungmun Jeon ◽  
Jaekwang Nam
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Blood Vessels ◽  
Human Blood ◽  
Capsule Type

scholarly journals Magnetic micropump embedded in contact lens for on-demand drug delivery

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Wang ◽  
Jungyul Park
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Drug Release ◽  
Contact Lens ◽  
Tear Film ◽  
Check Valve ◽  
Drug Diffusion ◽  
On Demand ◽  
The Magnetic Field

AbstractIn this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized.

scholarly journals Extensional Magnetorheology of Viscoelastic Human Blood Analogues Loaded with Magnetic Particles

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6930
Author(s):  
João M. Nunes ◽  
Francisco J. Galindo-Rosales ◽  
Laura Campo-Deaño
Keyword(s):  
Magnetic Field ◽  
External Magnetic Field ◽  
Human Blood ◽  
Magnetic Particles ◽  
Volume Fraction ◽  
Flow Direction ◽  
Deborah Number ◽  
Simultaneous Application ◽  
String Structure ◽  
Breakup Time

This study represents a pioneering work on the extensional magnetorheological properties of human blood analogue fluids loaded with magnetic microparticles. Dynabeads M-270 particles were dispersed in Newtonian and viscoelastic blood analogue fluids at 5% wt. Capillary breakup experiments were performed, with and without the influence of an external magnetic field aligned with the flow direction. The presence of the particles increased the viscosity of the fluid, and that increment was larger when embedded within a polymeric matrix. The application of an external magnetic field led to an even larger increment of the viscosity of the working fluids, as the formation of small aggregates induced an increment in the effective volume fraction of particles. Regarding the liquid bridge stability, the Newtonian blood analogue fluid remained as a Newtonian liquid exhibiting a pinch-off at the breakup time in any circumstance. However, in the case of the viscoelastic blood analogue fluid, the presence of the particles and the simultaneous application of the magnetic field enhanced the formation of the beads-on-a-string structure, as the Ohnesorge number remained basically unaltered, whereas the time of the experiment increased due to its larger viscosity, which resulted in a decrease in the Deborah Number. This result was confirmed with fluids containing larger concentrations of xanthan gum.

Magnetic Equilibrium Posture of a Multibody Magnetic Microrobot Composed of Spherical Magnets Manipulated by External Magnetic Field

2013 ◽  
Author(s):  
S. M. Jeon ◽  
G. H. Jang
Keyword(s):  
Magnetic Field ◽  
External Magnetic Field ◽  
Blood Vessels ◽  
Human Body ◽  
Complex Environments ◽  
Single Body ◽  
Magnetic Microrobots ◽  
Magnetic Equilibrium

Magnetic microrobots wirelessly manipulated by external magnetic field have been widely investigated as possible surgical alternatives for cardiovascular or intraocular surgeries [1, 2]. Since the principle of manipulation is based on the external magnetic field, the microrobot can be effectively simplified and miniaturized for the application in complex environments in the human body. Several researchers have investigated various types of single-body microrobots to achieve different mechanical motions [1, 2]. However, a magnetically coupled multibody magnetic microrobot (MMM) has not been proposed to improve the mechanical and therapeutic maneuverability to navigate through the blood vessels and to treat the diseased area.

scholarly journals Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system

Gene Therapy ◽  
2010 ◽  
Vol 17 (6) ◽  
pp. 745-751 ◽  
Author(s):  
M Compte ◽  
V Alonso-Camino ◽  
P Santos-Valle ◽  
Á M Cuesta ◽  
D Sánchez-Martín ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Vessels ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Blood ◽  
Therapeutic Proteins ◽  
New Drug

scholarly journals Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1210
Author(s):  
Zhuocong Cai ◽  
Qiang Fu ◽  
Songyuan Zhang ◽  
Chunliu Fan ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Fixed Point ◽  
External Magnetic Field ◽  
Targeted Drug Delivery ◽  
Drug Application ◽  
Whole Process ◽  
Computational Fluid Dynamics Cfd ◽  
Targeted Drug ◽  
Motion Characteristics

Given that the current microrobot cannot achieve fixed-point and quantitative drug application in the gastrointestinal (GI) tract, a targeted drug delivery microrobot is proposed, and its principle and characteristics are studied. Through the control of an external magnetic field, it can actively move to the affected area to realize the targeted drug delivery function. The microrobot has a cam structure connected with a radially magnetized permanent magnet, which can realize two movement modes: movement and targeted drug delivery. Firstly, the magnetic actuated capsule microrobotic system (MACMS) is analyzed. Secondly, the dynamic model and quantitative drug delivery model of the targeted drug delivery microrobot driven by the spiral jet structure are established, and the motion characteristics of the targeted drug delivery microrobot are simulated and analyzed by the method of Computational Fluid Dynamics (CFD). Finally, the whole process of the targeted drug delivery task of the microrobot is simulated. The results show that the targeted drug delivery microrobot can realize basic movements such as forward, backward, fixed-point parking and drug delivery through external magnetic field control, which lays the foundation for gastrointestinal diagnosis and treatment.

scholarly journals Preparation of Magnetic Hybrid Microspheres with Well-Defined Yolk-Shell Structure

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Yuan Zhao ◽  
Tao Chen ◽  
Shaofa Sun ◽  
Long Zhao
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Magnetic Particles ◽  
Suspension Polymerization ◽  
Magnetic Microspheres ◽  
Vibrating Sample Magnetometry ◽  
Efficient Route ◽  
Magnetic Bioseparation ◽  
Tga Analysis

A facile and efficient route was reported to prepare a kind of yolk-shell magnetic hybrid microspheres by suspension polymerization and calcinations method. The morphology, structure, and composition of the magnetic microspheres were characterized by FTIR, XRD, TEM, SEM, and TGA analysis. The vibrating-sample magnetometry (VSM) results clearly showed that the magnetic particles were superparamagnetic with saturation magnetization of 32.82 emu/g which makes the microcomposites easily controlled by an external magnetic field. The results revealed that the magnetic hybrid microspheres might have important applications in magnetic bioseparation and drug delivery.

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