Multivariate Multilinear Regression

2012 ◽  
Vol 42 (6) ◽  
pp. 1560-1573 ◽  
Author(s):  
Ya Su ◽  
Xinbo Gao ◽  
Xuelong Li ◽  
Dacheng Tao
Keyword(s):  
Multilinear Regression

scholarly journals Identification of Anti-SARS-CoV-2 Compounds from Food Using QSAR-Based Virtual Screening, Molecular Docking, and Molecular Dynamics Simulation Analysis

2021 ◽  
Vol 14 (4) ◽  
pp. 357
Author(s):  
Magdi E. A. Zaki ◽  
Sami A. Al-Hussain ◽  
Vijay H. Masand ◽  
Siddhartha Akasapu ◽  
Sumit O. Bajaj ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Molecular Docking ◽  
Virtual Screening ◽  
Simulation Analysis ◽  
Qsar Model ◽  
Quantitative Structure Activity Relationship ◽  
Dynamics Simulation ◽  
Multilinear Regression ◽  
Qsar Analysis ◽  
Main Protease

Due to the genetic similarity between SARS-CoV-2 and SARS-CoV, the present work endeavored to derive a balanced Quantitative Structure−Activity Relationship (QSAR) model, molecular docking, and molecular dynamics (MD) simulation studies to identify novel molecules having inhibitory potential against the main protease (Mpro) of SARS-CoV-2. The QSAR analysis developed on multivariate GA–MLR (Genetic Algorithm–Multilinear Regression) model with acceptable statistical performance (R2 = 0.898, Q2loo = 0.859, etc.). QSAR analysis attributed the good correlation with different types of atoms like non-ring Carbons and Nitrogens, amide Nitrogen, sp2-hybridized Carbons, etc. Thus, the QSAR model has a good balance of qualitative and quantitative requirements (balanced QSAR model) and satisfies the Organisation for Economic Co-operation and Development (OECD) guidelines. After that, a QSAR-based virtual screening of 26,467 food compounds and 360 heterocyclic variants of molecule 1 (benzotriazole–indole hybrid molecule) helped to identify promising hits. Furthermore, the molecular docking and molecular dynamics (MD) simulations of Mpro with molecule 1 recognized the structural motifs with significant stability. Molecular docking and QSAR provided consensus and complementary results. The validated analyses are capable of optimizing a drug/lead candidate for better inhibitory activity against the main protease of SARS-CoV-2.

scholarly journals School Dropout Intention and Self-esteem in Immigrant and Native Students Living in Poverty: The Protective Role of Peer Acceptance at School

2021 ◽  
Author(s):  
Dora Bianchi ◽  
Elisa Cavicchiolo ◽  
Fabio Lucidi ◽  
Sara Manganelli ◽  
Laura Girelli ◽  
...  
Keyword(s):  
Developmental Psychology ◽  
Immigrant Students ◽  
Peer Acceptance ◽  
School Dropout ◽  
Well Being ◽  
Self Esteem ◽  
Protective Role ◽  
Drop Out ◽  
Multilinear Regression ◽  
Immigrant Background

AbstractThe psychological well-being at school of immigrant students living in poverty is currently an understudied topic in developmental psychology. This is an important shortcoming because this population, which is rapidly increasing in many western countries, is in a double minority condition and has a greater risk of experiencing psychological distress at school, in comparison with their native peers. In order to improve our understanding on this issue, the present two-wave study investigated the prospective relationships between peer acceptance and two aspects of well-being at school—intention to drop out of school and negative self-esteem—specifically focusing on the differential effect of having (vs. not having) an immigrant background. The participants were 249 preadolescents and adolescents living in poverty (Mage = 12.76; SDage = 2.34; 41.8% girls; 19.3% immigrants) who were attending educational centres for disadvantaged minors. The poverty status of the participants was an inclusion criterion. A multilinear regression model with multigroup analysis was tested. As expected, the results showed that peer acceptance had a significant negative association with school dropout intentions and negative self-esteem only for immigrants, but not for natives. For immigrant students, the protective effect of peer acceptance was comparable to the stability over time of dropout intention and self-esteem, a result that has promising implications for prevention programs. The applied implications of the study for educational and clinical contexts are discussed.

scholarly journals Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2(300,000 IU)

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
A. Sankaralingam ◽  
R. Roplekar ◽  
C. Turner ◽  
R. N. Dalton ◽  
G. Hampson
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Inverse Correlation ◽  
Loading Dose ◽  
Multilinear Regression ◽  
Significant Inverse Correlation ◽  
Blood Samples ◽  
Multilinear Regression Analysis ◽  
Wnt Inhibitors ◽  
Dickkopf 1

Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain.Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin andDKK1.Subjects and Methods. We measured serum sclerostin andDKK1in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D2(300,000 IU) intramuscularly. Blood samples were taken at baseline and serially up to 3 months.Results. Serum 1,25 (OH)2vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L,P<0.001). There was a significant correlation between sclerostin andDKK1at baseline (r=0.504, P=0.002) and at 3 months (r=0.42, P=0.013). A significant inverse correlation was observed between sclerostin and eGFR at 3 months (r=-0.494, P=0.007). Sclerostin increased significantly at 3 months (P=0.033). In a multilinear regression analysis with % change in sclerostin andDKK1as dependent variable, a positive significant association was observed with % change in 1,25 (OH)2vitamin D (P=0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR.Conclusions. Supraphysiological concentration in 1,25 (OH)2vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling. This may have detrimental effects on bone.

The Effect of Hospital Resource Unavailability and Ambulance Diversions on the EMS System

1994 ◽  
Vol 9 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Keith W. Neely ◽  
Robert L. Norton ◽  
Gary P. Young
Keyword(s):  
Prospective Observational Study ◽  
Trauma System ◽  
Base Station ◽  
Computed Tomography Scan ◽  
Hospital Resource ◽  
Multilinear Regression ◽  
Number Of Patients ◽  
The Impact ◽  
Tomography Scan ◽  
Intended Destination

AbstractHypotheses:1) There is no increase in transport or scene time of diverted patients and no increase in distances traveled; 2) hospital resource shortages bear no relationship to the number of patients diverted; and 3) paramedics are able to match their patient correctly with the resources available at a given hospital.Methods:This was a five-month, prospective, observational study in an urban area with a population of 600,000 comparing all 9-1-1 ambulance diversions against a randomly selected sample of 5% of all other 9-1-1 originated patients. All patient diversions that originated from the 9-1-1 center are included in the study.Results:Hospitals identify their diversion status on a community-wide computer system monitored at the 9-1-1 center and base station. Accepted categories include: 1) diversion of all patients through the 9-1-1 center from the emergency department (ED); 2) trauma system patients (T); 3) psychiatric secure beds (PSB); 4) general acute ward beds (AW); 5) critical care (CC); 6) computed tomography scan (CT); 7) labor and delivery (LD); and 8) pediatric beds (PEDS). Data were abstracted from 481 patients' records. A total of 111 were diverted from their intended destination. Transport times were longer and diverted patients traveled further (p <.002). Hospitals showing ED and LD diversion categories were more likely to have patients diverted away (r2 = .895, multilinear regression, p <.001). Of the 111 patients, 21 (19%) were diverted because of CC unavailability. Six of these (28%) were inappropriate because they did not fit the CC definition.Conclusions:In this system, hospital diversions increase transport times and distances traveled. Diversion of patients correlated strongly to unavailability of specific categories. Paramedics make errors in determining appropriate CC diversions. Systems reviewing their diversion problems need to assess the impact of longer out-of-hospital times and of certain diversion categories, and to clarify definitions.

Fiber-Content Measurement of Wool–Cashmere Blends Using Near-Infrared Spectroscopy

2017 ◽  
Vol 71 (10) ◽  
pp. 2367-2376 ◽  
Author(s):  
Jinfeng Zhou ◽  
Rongwu Wang ◽  
Xiongying Wu ◽  
Bugao Xu
Keyword(s):  
Near Infrared ◽  
Nir Spectroscopy ◽  
Chemical Bonds ◽  
Multilinear Regression ◽  
Textile Production ◽  
Protein Fibers ◽  
Characteristic Wavelength ◽  
Product Classification ◽  
Band Assignment ◽  
Blend Ratios

Cashmere and wool are two protein fibers with analogous geometrical attributes, but distinct physical properties. Due to its scarcity and unique features, cashmere is a much more expensive fiber than wool. In the textile production, cashmere is often intentionally blended with fine wool in order to reduce the material cost. To identify the fiber contents of a wool–cashmere blend is important to quality control and product classification. The goal of this study is to develop a reliable method for estimating fiber contents in wool–cashmere blends based on near-infrared (NIR) spectroscopy. In this study, we prepared two sets of cashmere–wool blends by using either whole fibers or fiber snippets in 11 different blend ratios of the two fibers and collected the NIR spectra of all the 22 samples. Of the 11 samples in each set, six were used as a subset for calibration and five as a subset for validation. By referencing the NIR band assignment to chemical bonds in protein, we identified six characteristic wavelength bands where the NIR absorbance powers of the two fibers were significantly different. We then performed the chemometric analysis with two multilinear regression (MLR) equations to predict the cashmere content (CC) in a blended sample. The experiment with these samples demonstrated that the predicted CCs from the MLR models were consistent with the CCs given in the preparations of the two sample sets (whole fiber or snippet), and the errors of the predicted CCs could be limited to 0.5% if the testing was performed over at least 25 locations. The MLR models seem to be reliable and accurate enough for estimating the cashmere content in a wool–cashmere blend and have potential to be used for tackling the cashmere adulteration problem.

scholarly journals Pengaruh Kualitas Layanan dalam Menciptakan Kepuasan Publik di Kantor Pelayanan Publik, Jakarta Utara

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Janny Rowena ◽  
Fuji Rahayu Wilujeng ◽  
Glisina Dwinoor Rembulan
Keyword(s):  
Provincial Government ◽  
Political Life ◽  
Multilinear Regression ◽  
Urban District ◽  
Exogenous Variables ◽  
District Office ◽  
Service Support ◽  
The North ◽  
Information Time

One indicator that shows the quality of government performance is the quality of public service offices. Public services in Indonesia have an important role in economic and political life. The magnitude of the role of the district office in providing services around population bureaucracy issues, especially in the province of DKI Jakarta, is still often getting complaints from the public. This study aims to assess the level of community satisfaction with the quality of district office services in the Jakarta province, specifically the North Jakarta municipality. This study uses multilinear regression and uses the T-test to find out the significant level of influence of independent variables on the dependent. The study used five exogenous variables (procedures, information, time, facilities, and infrastructure, and environmental comfort) and 1 endogenous variable (satisfaction). The results of this study are all exogenous variables that have a positive and significant effect on the satisfaction of Jakarta citizens, which means that urban district office services have a positive and significant effect on the satisfaction of Jakarta citizens when viewed from procedures, information, time, facilities, and infrastructure as well as environmental comfort. The provincial government of DKI Jakarta must maintain and improve existing service procedures, some attributes of information that are already very good, good values regarding the certainty of the time of completion of services, several aspects of facilities and infrastructure, and comfortable environmental conditions, both in the service office or in the service support facilities.

scholarly journals Cervical mismatch: the normative value of T1 slope minus cervical lordosis and its ability to predict ideal cervical lordosis

2019 ◽  
Vol 30 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Blake N. Staub ◽  
Renaud Lafage ◽  
Han Jo Kim ◽  
Christopher I. Shaffrey ◽  
Gregory M. Mundis ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Pelvic Incidence ◽  
Linear Regression Analysis ◽  
Cervical Lordosis ◽  
Multilinear Regression ◽  
Normative Database ◽  
T1 Slope ◽  
Horizontal Gaze ◽  
Normative Value

OBJECTIVENumerous studies have attempted to delineate the normative value for T1S−CL (T1 slope minus cervical lordosis) as a marker for both cervical deformity and a goal for correction similar to how PI-LL (pelvic incidence–lumbar lordosis) mismatch informs decision making in thoracolumbar adult spinal deformity (ASD). The goal of this study was to define the relationship between T1 slope (T1S) and cervical lordosis (CL).METHODSThis is a retrospective review of a prospective database. Surgical ASD cases were initially analyzed. Analysis across the sagittal parameters was performed. Linear regression analysis based on T1S was used to provide a clinically applicable equation to predict CL. Findings were validated using the postoperative alignment of the ASD patients. Further validation was then performed using a second, normative database. The range of normal alignment associated with horizontal gaze was derived from a multilinear regression on data from asymptomatic patients.RESULTSA total of 103 patients (mean age 54.7 years) were included. Analysis revealed a strong correlation between T1S and C0–7 lordosis (r = 0.886), C2–7 lordosis (r = 0.815), and C0–2 lordosis (r = 0.732). There was no significant correlation between T1S and T1S−CL. Linear regression analysis revealed that T1S−CL assumed a constant value of 16.5° (R2 = 0.664, standard error 2°). These findings were validated on the postoperative imaging (mean absolute error [MAE] 5.9°). The equation was then applied to the normative database (MAE 6.7° controlling for McGregor slope [MGS] between −5° and 15°). A multilinear regression between C2–7, T1S, and MGS demonstrated a range of T1S−CL between 14.5° and 26.5° was necessary to maintain horizontal gaze.CONCLUSIONSNormative CL can be predicted via the formula CL = T1S − 16.5° ± 2°. This implies a threshold of deformity and aids in providing a goal for surgical correction. Just as pelvic incidence (PI) can be used to determine the ideal LL, T1S can be used to predict ideal CL. This formula also implies that a kyphotic cervical alignment is to be expected for individuals with a T1S < 16.5°.

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