Chemical composition, bioactive compounds extraction, and observed biological activities from jussara ( Euterpe edulis ): The exotic and endangered Brazilian superfruit

Munronia is a genus in the Meliaceae family, which consists of over 17 species that are distributed in the subtropical and tropical area of Asia, including southern China, Vietnam, Myanmar, Sri Lanka, India, Indonesia, and the Philippines. It is known that these plants contain valuable bioactive compounds. Since the first isolation of new stigmastane steroid was reported in 2003, researchers have been able to study the chemical composition of these plants, especially the largest secondary metabolite obtained, limonoid. About 97 compounds were isolated successfully and characterized. The reported compounds showed various biological activities, such as antifeedant, antimicrobial, antiangiogenic, cytotoxic against several cancer cell lines, inducing apoptosis, and anti-tobacco mosaic virus activities. Therefore, the results suggest that the use of this plant as a source of bioactive compounds is promising for the medicinal chemistry field.

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Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds

Journal of Functional Foods ◽

10.1016/j.jff.2019.02.037 ◽

2019 ◽

Vol 55 ◽

pp. 325-332 ◽

Cited By ~ 9

Author(s):

Jéssica A.A. Garcia ◽

Rúbia C.G. Corrêa ◽

Lillian Barros ◽

Carla Pereira ◽

Rui M.V. Abreu ◽

...

Keyword(s):

Chemical Composition ◽

Biological Activities ◽

Added Value ◽

Euterpe Edulis ◽

Euterpe Edulis Martius ◽

By Products

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Pharmacologically potentials of different substituted coumarin derivatives

10.31221/osf.io/w6hdg ◽

2019 ◽

Cited By ~ 1

Author(s):

Chem Int

Keyword(s):

Benzene Ring ◽

Bioactive Compounds ◽

Biological Activities ◽

Pharmacological Properties ◽

Coumarin Derivatives ◽

Wide Range ◽

Anti Oxidant ◽

Anti Inflammatory ◽

Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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Extraction of Essential Oils from Medicinal Plants and their Utilization as Food Antioxidants

Current Pharmaceutical Design ◽

10.2174/1381612826666200121092018 ◽

2020 ◽

Vol 26 (5) ◽

pp. 519-541 ◽

Cited By ~ 3

Author(s):

Giovanna Ferrentino ◽

Ksenia Morozova ◽

Christine Horn ◽

Matteo Scampicchio

Keyword(s):

Chemical Composition ◽

Medicinal Plants ◽

Beneficial Effect ◽

Essential Oils ◽

Bioactive Compounds ◽

Antimicrobial Properties ◽

Food Products ◽

Human Diseases ◽

Present Review ◽

Green Technologies

Background: The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of essential oils extracted from medicinal plants to cure human diseases such as hypertension, diabetes, or obesity. However, to preserve their bioactivity, the use of appropriate extraction technologies is required. Method: The present review aims to describe the studies published so far on the essential oils focusing on their sources and chemical composition, the technologies used for their recovery and their application as antioxidants in food products. Results: The review has been structured in three parts. In the first part, the main compounds present in essential oils extracted from medicinal plants have been listed and described. In the second part, the most important technologies used for extraction and distillation, have been presented. In detail, conventional methods have been described and compared with innovative and green technologies. Finally, in the last part, the studies related to the application of essential oils as antioxidants in food products have been reviewed and the main findings discussed in detail. Conclusions: In summary, an overview of the aforementioned subjects is presented by discussing the results of the most recent published studies.

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Comparative Analysis of In-Vitro Biological Activities of Methyl Eugenol Rich Cymbopogon khasianus Hack., Leaf Essential Oil with Pure Methyl Eugenol Compound

Current Pharmaceutical Biotechnology ◽

10.2174/1389201021666200217113921 ◽

2020 ◽

Vol 21 (10) ◽

pp. 927-938 ◽

Cited By ~ 7

Author(s):

Roktim Gogoi ◽

Rikraj Loying ◽

Neelav Sarma ◽

Twahira Begum ◽

Sudin K. Pandey ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Biological Activities ◽

Methyl Eugenol ◽

Dpph Assay ◽

Pure Compound ◽

Allium Cepa Assay ◽

Anti Inflammatory ◽

Lemongrass Essential Oil

Background: The essential oil of methyl eugenol rich Cymbopogon khasianus Hack. was evaluated and its bioactivities were compared with pure methyl eugenol. So far, methyl eugenol rich essential oil of lemongrass was not studied for any biological activities; hence, the present study was conducted. Objective: This study examined the chemical composition of essential oil of methyl eugenol rich Cymbopogon khasianus Hack., and evaluated its antioxidant, anti-inflammatory, antimicrobial, and herbicidal properties and genotoxicity, which were compared with pure compound, methyl eugenol. Material and Methods: Methyl eugenol rich variety of Cymbopogon khasianus Hack., with registration no. INGR18037 (c.v. Jor Lab L-9) was collected from experimental farm CSIR-NEIST, Jorhat, Assam (26.7378°N, 94.1570°E). The essential oil wasobtained by hydro-distillation using a Clevenger apparatus. The chemical composition of the essential oil was evaluated using GC/MS analysis and its antioxidant (DPPH assay, reducing power assay), anti-inflammatory (Egg albumin denaturation assay), and antimicrobial (Disc diffusion assay, MIC) properties, seed germination effect and genotoxicity (Allium cepa assay) were studied and compared with pure Methyl Eugenol compound (ME). Results: Major components detected in the Essential Oil (EO) through Gas chromatography/mass spectroscopy analysis were methyl eugenol (73.17%) and β-myrcene (8.58%). A total of 35components were detected with a total identified area percentage of 98.34%. DPPH assay revealed considerable antioxidant activity of methyl eugenol rich lemongrass essential oil (IC50= 2.263 μg/mL), which is lower than standard ascorbic acid (IC50 2.58 μg/mL), and higher than standard Methyl Eugenol (ME) (IC50 2.253 μg/mL). Methyl eugenol rich lemongrass EO showed IC50 38.00 μg/mL, ME 36.44 μg/mL, and sodium diclofenac 22.76 μg/mL, in in-vitro anti-inflammatory test. Moderate antimicrobial activity towards the 8 tested microbes was shown by methyl eugenol rich lemongrass essential oil whose effectiveness against the microbes was less as compared to pure ME standard. Seed germination assay further revealed the herbicidal properties of methyl eugenol rich essential oil. Moreover, Allium cepa assay revealed moderate genotoxicity of the essential oil. Conclusion: This paper compared the antioxidant, anti-inflammatory, antimicrobial, genotoxicity and herbicidal activities of methyl eugenol rich lemongrass with pure methyl eugenol. This methyl eugenol rich lemongrass variety can be used as an alternative of methyl eugenol pure compound. Hence, the essential oil of this variety has the potential of developing cost-effective, easily available antioxidative/ antimicrobial drugs but its use should be under the safety range of methyl eugenol and needs further clinical trials.

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Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽

10.3390/md19050241 ◽

2021 ◽

Vol 19 (5) ◽

pp. 241

Author(s):

Shaden A. M. Khalifa ◽

Eslam S. Shedid ◽

Essa M. Saied ◽

Amir Reza Jassbi ◽

Fatemeh H. Jamebozorgi ◽

...

Keyword(s):

Bioactive Compounds ◽

Biomedical Applications ◽

Large Scale ◽

Biological Activities ◽

Scale Production ◽

Pharmacological Activities ◽

Large Scale Production ◽

Marine Products ◽

Hiv 1 ◽

Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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