scholarly journals Impact of Long‐Term Alcohol Consumption and Relapse on Genome‐Wide DNA Methylation Changes in Alcohol‐Dependent Subjects: A Longitudinal Study

2020 ◽  
Vol 44 (7) ◽  
pp. 1356-1365
Author(s):  
Eva Friedel ◽  
Henrik Walter ◽  
Ilya M. Veer ◽  
Ulrich S. Zimmermann ◽  
Andreas Heinz ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Longitudinal Study ◽  
Alcohol Consumption ◽  
Genome Wide ◽  
Alcohol Dependent

Long-term PM2.5 Exposure, Genome-wide DNA Methylation and Lung Function in Korean Adults

2021 ◽  
Author(s):  
Ye-Eun Han ◽  
Nak-Hyeon Choi ◽  
Mi Jin Cho ◽  
Min Gu Kang ◽  
Young-Youl Kim
Keyword(s):  
Dna Methylation ◽  
Lung Function ◽  
Korean Adults ◽  
Genome Wide ◽  
Pm2.5 Exposure

scholarly journals Alcohol consumption and methylation-based measures of biological age

2021 ◽  
Author(s):  
Jacob K Kresovich ◽  
Alexandra M Martinez Lopez ◽  
Emma L Garval ◽  
Zongli Xu ◽  
Alexandra J White ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Consumption ◽  
Biological Age ◽  
Average Lifetime ◽  
Epigenetic Clock ◽  
Genome Wide ◽  
Epigenetic Age ◽  
Epigenetic Age Acceleration ◽  
The Mean ◽  
Average Consumption

Abstract Epigenetic age acceleration is considered a measure of biological aging based on genome-wide patterns of DNA methylation. Although age acceleration has been associated with incidence of diseases and death, less is known about how it is related to lifestyle behaviors. Among 2,316 women, we evaluate associations between self-reported alcohol consumption and various metrics of epigenetic age acceleration. Recent average alcohol consumption was defined as the mean number of drinks consumed per week within the past year; lifetime average consumption was estimated as the mean number of drinks per year drinking. Whole blood genome-wide DNA methylation was measured with HumanMethylation450 BeadChips and used to assess four epigenetic clocks (Hannum, Horvath, PhenoAge, GrimAge) and their corresponding metrics of epigenetic age acceleration (Hannum AgeAccel, Horvath AgeAccel, PhenoAgeAccel, GrimAgeAccel). Although alcohol consumption showed little association with most age acceleration metrics, both lifetime and recent average consumption measures were positively associated with GrimAgeAccel (lifetime, per additional 135 drinks/year: β=0.30 years, 95% CI: 0.11, 0.48, p=0.002; recent, per additional 5 drinks/week: β=0.19 years, 95% CI: 0.01, 0.37, p=0.04). In a mutually adjusted model, only average lifetime alcohol consumption remained associated with GrimAgeAccel (lifetime, per additional 135 drinks/year: β=0.27 years, 95% CI: 0.04, 0.50, p=0.02; recent, per 5 additional drinks/week: β=0.05 years, 95% CI: -0.16, 0.26, p=0.64). Although alcohol use does not appear to be strongly associated with biological age measured by most epigenetic clocks, lifetime average consumption is associated with higher biological age assessed by the GrimAge epigenetic clock.

scholarly journals Genome-wide investigation of DNA methylation in congenital adrenal hyperplasia

2019 ◽  
Author(s):  
Leif Karlsson ◽  
Michela Barbaro ◽  
Ewoud Ewing ◽  
David Gomez-Cabrero ◽  
Svetlana Lajic
Keyword(s):  
Dna Methylation ◽  
Congenital Adrenal Hyperplasia ◽  
Hdl Cholesterol ◽  
Adrenal Hyperplasia ◽  
Blood Lipid Profile ◽  
Glucocorticoid Treatment ◽  
C Peptide ◽  
Genome Wide ◽  
Metabolic Outcome

AbstractBackgroundPatients with congenital adrenal hyperplasia (CAH) are at risk of long-term cognitive and metabolic sequelae with some of the effects being attributed to the chronic glucocorticoid treatment that they receive. This study investigates genome-wide DNA methylation in patients with CAH to determine whether there is evidence for epigenomic reprogramming as well as any relationship to patient outcome.MethodsWe analysed CD4+ T cell DNA from 28 patients with CAH (mean age=18.5 ±6.5 years [y]) and 37 population controls (mean age=17.0 ±6.1 y) with the Infinium-HumanMethylation450 BeadChip array to measure genome-wide locus-specific DNA methylation levels. Effects of CAH, phenotype and CYP21A2 genotype on methylation were investigated as well as the association between differentially methylated CpGs, glucose homeostasis, blood lipid profile and cognitive functions. In addition, we report data on a small cohort of 11 patients (mean age=19.1, ±6.0 y) with CAH who were treated prenatally with dexamethasone (DEX) in addition to postnatal glucocorticoid treatment.ResultsWe identified two CpGs to be associated with patient phenotype: cg18486102 (located in the FAIM2 gene; rho=0.58, adjusted p=0.027) and cg02404636 (located in the SFI1 gene; rho=0.58, adjusted p=0.038). cg02404636 was also associated with genotype (rho=0.59, adjusted p=0.024). Higher levels of serum C-peptide was also observed in patients with CAH (p=0.044). Additionally, levels of C-peptide and HbA1c were positively correlated with patient phenotype (p=0.044 and p=0.034) and genotype (p=0.044 and p=0.033), respectively. No significant association was found between FAIM2 methylation and cognitive or metabolic outcome. However, SFI1 TSS methylation was associated with fasting plasma HDL cholesterol levels (p=0.035).ConclusionIn conclusion, higher methylation levels in CpG sites covering FAIM2 and SFI1 were associated with disease severity. Hypermethylation in these genes may have implications for long-term cognitive and metabolic outcome in patients with CAH.

scholarly journals Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study

2020 ◽  
Vol 128 (6) ◽  
pp. 067003
Author(s):  
Ikenna C. Eze ◽  
Ayoung Jeong ◽  
Emmanuel Schaffner ◽  
Faisal I. Rezwan ◽  
Akram Ghantous ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Peripheral Blood ◽  
Transportation Noise ◽  
Genome Wide

scholarly journals Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Kyeong Lee ◽  
◽  
Cheng-Jian Xu ◽  
Megan U. Carnes ◽  
Cody E. Nichols ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Korean Adults ◽  
Genome Wide ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

2018 ◽  
Vol 126 (2) ◽  
pp. 027004 ◽  
Author(s):  
Ana Julia de F.C. Lichtenfels ◽  
Diana A. van der Plaat ◽  
Kim de Jong ◽  
Cleo C. van Diemen ◽  
Dirkje S. Postma ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Cohort Study ◽  
Lung Function ◽  
Genome Wide ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Effects of Alcohol Consumption and Smoking on the Onset of Hypertension in a Long-Term Longitudinal Study in a Male Workers’ Cohort

2021 ◽  
Vol 18 (22) ◽  
pp. 11781
Author(s):  
Tamotsu Nagao ◽  
Kazuhiro Nogawa ◽  
Koichi Sakata ◽  
Hideki Morimoto ◽  
Kotaro Morita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Longitudinal Study ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Antihypertensive Drugs ◽  
Annual Survey ◽  
Habitual Exercise ◽  
Prevention Of Hypertension ◽  
Male Workers

Aim: To determine the effects of alcohol consumption and smoking on the onset of hypertension in a long-term longitudinal study. Methods: 7511 non-hypertensive male workers were enrolled. This cohort study was performed over an 8-year period using the results of the annual workers-health screening. The end-point was defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or use of antihypertensive drugs. For alcohol consumption, weekly alcohol intake (g ethanol/week) was estimated (1 “gou” = 22 g ethanol). Annual survey data were analyzed by pooled logistic regression that included alcohol consumption, smoking, age, body mass index, job schedule types, habitual exercise, and blood test measurements into the statistical model. Results: A significant positive dose–response relationship between alcohol consumption and onset of hypertension was observed, with synergistic health effects present. Compared with abstainers and nonsmokers, the adjusted odds ratios (95% confidence interval) for the onset of hypertension were: 1.51 (1.27–1.79) for 154 g ethanol/week and nonsmokers, and 1.81 (1.54–2.11) for 154 g ethanol/week and smokers. An interaction between alcohol and smoking was confirmed. Conclusions: This study provided information useful to the prevention of hypertension. By reducing alcohol consumption and smoking simultaneously, the risk of hypertension may be considerably lowered.

Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study

Epigenomics ◽  
2021 ◽  
Author(s):  
Meng Lu ◽  
Qin Xueying ◽  
Peng Hexiang ◽  
Gao Wenjing ◽  
Sara Hägg ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Consumption ◽  
Twin Study ◽  
Alcohol Intake ◽  
Entire Sample ◽  
Cpg Sites ◽  
Infinium Humanmethylation450 Beadchip ◽  
Twin Registry ◽  
Genome Wide ◽  
Mz Twins

Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials & methods: In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Results: Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. Conclusion: The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.

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