Changes in interoception after alcohol administration correlate with expectancies and subjective effects

2021 ◽  
Author(s):  
Mateo Leganes‐Fonteneau ◽  
Marsha E. Bates ◽  
Shahriar Islam ◽  
Jennifer F. Buckman
Keyword(s):  
Subjective Effects ◽  
Alcohol Administration

Changes in interoception after alcohol administration correlate with expectancies and subjective effects

2020 ◽  
Author(s):  
Mateo Leganes-Fonteneau ◽  
Jennifer Buckman ◽  
Shahriar Islam ◽  
Marsha Bates
Keyword(s):  
Subjective Effects ◽  
Drinking Behavior ◽  
Alcohol Expectancies ◽  
Subjective Feeling ◽  
Placebo Condition ◽  
Alcohol Administration ◽  
Interoceptive Sensitivity ◽  
Interoceptive Accuracy ◽  
Bodily States ◽  
Induced Changes

Interoceptive signals give rise to subjective feeling states that can drive motivational and behavioral responses. In the context of alcohol use behaviors, interoceptive signals may shape subjective alcohol experiences, and thereby support bio-behavioral mechanisms of drinking behavior change. This study examined the acute effects of alcohol on participants’ interoceptive sensitivity, and determined whether pharmacologically induced changes in heart beat detection correlate with subjective alcohol effects, craving and expectancies.Participants completed a two-session, double-blind placebo controlled experiment (n=31). Participants consumed a beverage containing 0.4g/kg of alcohol or a placebo. They also completed measurements of alcohol expectancies at baseline, and alcohol-induced changes in mood, craving and light-headedness. Interoceptive sensitivity was measured using the heartbeat discrimination task prior to and following beverage administration, yielding indices of interoceptive accuracy, confidence and meta-cognition. Alcohol administration increased interoceptive accuracy compared to baseline and placebo; and those changes in interoception negatively correlated with negative alcohol expectancies. Further, changes in interoception positively correlated with perceived light-headedness and positive mood after alcohol administration, whereas null effects were found for craving. In the placebo condition, null results were obtained. Alcohol is well established to change bodily states, and here we find that the extent to which alcohol increases participants’ sensitivity to bodily states impacts their subjective drinking experiences. This was observed in relation to mood and light-headedness, but also on prospective alcohol expectancies. We posit that over successive alcohol experiences, changes in bodily states may feed into the development of alcohol expectancies that could in turn predict future drinking behaviors.

Characterization of tobacco withdrawal: Physiological and subjective effects.

1985 ◽  
Author(s):  
Dorothy K. Hatsukami ◽  
John R. Hughes ◽  
Roy W. Pickens
Keyword(s):  
Subjective Effects ◽  
Tobacco Withdrawal

THE INFLUENCE OF VITAMIN C ON EOSINOPHIL RESPONSE TO ACUTE ALCOHOL INTOXICATION IN RATS

1960 ◽  
Vol XXXV (IV) ◽  
pp. 585-593 ◽  
Author(s):  
T. P. J. Vanha-Perttula
Keyword(s):  
Vitamin C ◽  
Ethyl Alcohol ◽  
Intraperitoneal Injection ◽  
Alcohol Intoxication ◽  
Albino Rats ◽  
Acute Alcohol Intoxication ◽  
Alcohol Administration ◽  
Initial Values

ABSTRACT The effect of ethyl alcohol on the circulating eosinophil cells has been studied in female albino rats. An intoxicating dose of alcohol caused a marked depletion of circulating eosinophils which was most clearly evident four hours after the administration of the alcohol. The initial values were not reached before 24 hours had elapsed. Intraperitoneal injection of vitamin C 12 hours prior to the alcohol administration very effectively prevented this eosinopenic reaction. The mechanism of regulation of the eosinophil cells in the circulation has been discussed in the light of previous results and of those obtained in this study.

scholarly journals Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023850
Author(s):  
Catherine S Wall ◽  
Rose S Bono ◽  
Rebecca C Lester ◽  
Cosima Hoetger ◽  
Thokozeni Lipato ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Subjective Effects ◽  
Latin Square ◽  
Abuse Liability ◽  
Smoke Inhalation ◽  
Nicotine Concentration ◽  
The Past ◽  
The Usa ◽  
Behavioural Economic ◽  
Scientific Meetings

IntroductionIn the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Flavourings may mask the taste of tobacco and enhance smoke inhalation, influencing toxicant exposure and abuse liability among novice tobacco users. Using clinical laboratory methods, this study investigates how flavour availability affects measures of abuse liability in young adult cigarette smokers. The specific aims are to evaluate the effect of cigar flavours on nicotine exposure, and behavioural and subjective measures of abuse liability.Methods and analysesParticipants (projected n=25) are healthy smokers of five or more cigarettes per day over the past 3 months, 18–25 years old, naive to cigar use (lifetime use of 50 or fewer cigar products and no more than 10 cigars smoked in the past 30 days) and without a desire to quit cigarette smoking in the next 30 days. Participants complete five laboratory sessions in a Latin square design with either their own brand cigarette or a session-specific Black & Mild cigar differing in flavour (apple, cream, original and wine). Participants are single-blinded to cigar flavours. Each session consists of two 10-puff smoking bouts (30 s interpuff interval) separated by 1 hour. Primary outcomes include saliva nicotine concentration, behavioural economic task performance and response to various questionnaire items assessing subjective effects predictive of abuse liability. Differences in outcomes across own brand cigarette and flavoured cigar conditions will be tested using linear mixed models.Ethics and disseminationThe Virginia Commonwealth University Institutional Review Board approved the study (VCU IRB: HM20007848). Dissemination channels for study findings include scientific journals, scientific meetings, and policy briefs.Trial registration numberNCT02937051.

scholarly journals Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway

2021 ◽  
Vol 22 (8) ◽  
pp. 4037
Author(s):  
Su Yeon Seo ◽  
Se Kyun Bang ◽  
Suk Yun Kang ◽  
Seong Jin Cho ◽  
Kwang Ho Choi ◽  
...  
Keyword(s):  
Negative Emotions ◽  
Acupuncture Point ◽  
Repeated Administration ◽  
Ultrasonic Vocalizations ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Alcohol Administration ◽  
Heart Meridian ◽  
Mature Brain ◽  
Neurotropic Factor

The Shenmen point (acupuncture point heart 7: HT7), located in the heart meridian, is frequently used to treat mental disorders, including drug addiction, anxiety, and depression. This study aimed to determine how HT7 regulates anxiety and negative emotions caused by repeated alcohol administration, focusing on the amygdala and paraventricular nucleus (PVN). Repeated administration of alcohol (ETOH; 2 g/kg, i.p. injection, 16% v/v) for 14 days increased the corticosterone (CORT) levels, and HT7 stimulation reduced the plasma CORT levels. HT7 stimulation mitigated anxiety-like behaviors and reduced 22-kHz ultrasonic vocalizations in rats receiving repeated ETOH injections. HT7 stimulation increased the amygdala expression of mature brain-derived neurotropic factor (mBDNF) and phosphorylated tropomyosin receptor kinase B (pTrkB) and decreased the PVN corticotropin-releasing hormone (CRH) expression. Amygdala microinjections of the TrkB antagonist ANA-12 (0.1 pmol/1 μL) reversed the increase in PVN CRH levels. The reduced PVN CRH levels were regulated by CRH-expressing neurons in the amygdala, and the increased amygdala CRH levels were affected by the HT7-stimulation induced increases in mBDNF. HT7 stimulation alleviates increased stress hormone levels and mitigates anxiety and negative emotions caused by repeated ETOH administration. These results provide scientific support for the clinical use of acupuncture to treat various alcoholism-induced diseases.

341 Acute effects of seltorexant, a selective orexin-2 antagonist (JNJ- 42847922), on driving after bedtime administration

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A136-A136
Author(s):  
S Brooks ◽  
R G J A Zuiker ◽  
G E Jacobs ◽  
I Kezic ◽  
A Savitz ◽  
...  
Keyword(s):  
Postural Stability ◽  
Driving Simulator ◽  
Motor Vehicle ◽  
Subjective Effects ◽  
Driving Ability ◽  
Post Dose ◽  
Double Blind ◽  
Increased Risk ◽  
Subjective Sleepiness ◽  
The Difference

Abstract Introduction Seltorexant (JNJ-42847922), a potent and selective antagonist of the human orexin-2 receptor, is being developed for the treatment of major depressive disorder. Seltorexant also has sleep-promoting properties. Investigating the effects of sleep-promoting medications on driving is important because some of these agents (e.g. GABAA receptor agonists) may be associated with increased risk of motor vehicle accidents. We evaluated the effect of seltorexant on driving after forced awakening at night, using a validated driving simulator. Methods This double-blind, placebo and active-controlled, randomized, 3-way cross-over study was conducted in 18 male and 18 female healthy subjects. All subjects received seltorexant 40 mg, zolpidem 10 mg, or placebo 15 minutes before bedtime. Eighteen subjects were awakened at 2- and 6-hours post-dose, and the other 18 at 4- and 8-hours post-dose. At those timepoints, pharmacokinetics, objective (standard deviation of the lateral position [SDLP]) and subjective effects (using Perceived Driving Quality and Effort Scales) on driving ability, postural stability and subjective sleepiness were assessed. Results For seltorexant, the SDLP difference from placebo (95% confidence interval) at 2-, 4-, 6- and 8-hours post-dose was 3.9 cm (1.26, 6.60), 0.9 cm (-1.08, 2.92), 1.1 cm (-0.42, 2.63), and 0.6 cm (-2.75, 1.55), respectively vs. 9.6 cm (6.97, 12.38), 6.6 cm (3.53, 9.60), 4.7 cm (1.46, 7.85), and 1.3cm (-1.16, 3.80), respectively for zolpidem. The difference from placebo was significant at 2-hours after taking seltorexant, while the difference from placebo was significant at 2, 4 and 6-hours after zolpidem. Subjective driving quality was decreased for both drugs at all time points and driving effort was increased up to 4-hours post-dose for both medications. Subjective sleepiness showed a significant increase compared to placebo 2- and 4-hours after administration of either drug. Postural stability was decreased up to 2-hours after administration of seltorexant, and up to 4-hours after administration of zolpidem. Conclusion Compared to zolpidem, objective effects on driving performance were more transient after seltorexant administration and largely normalized by 4–6 hours post-dose. Support (if any) This work was sponsored by Janssen R&D.

scholarly journals Subjective Effects of Inhaling Kuromoji Tea Aroma

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 575
Author(s):  
Eri Matsubara ◽  
Takeshi Morikawa ◽  
Norihisa Kusumoto ◽  
Koh Hashida ◽  
Naoyuki Matsui ◽  
...  
Keyword(s):  
Core Body Temperature ◽  
Subjective Effects ◽  
Subjective Feeling ◽  
Beneficial Effects ◽  
Saliva Secretion ◽  
Subjective Assessments ◽  
Long Time ◽  
Production Areas ◽  
Core Body ◽  
Deciduous Shrub

Teas and various herbal teas are well-known beverages and are commonly consumed around the world. In this study, we focused on kuromoji tea. Kuromoji is a deciduous shrub of the Lauraceae family, and the plucked leaves and branches have been drunk as a tea in production areas for a long time. However, no studies have investigated the subjective and physiological effects of kuromoji tea. In this study, the effects of kuromoji tea were examined on the basis of the measurements of heart rate variability and cerebral blood flow, core body temperature and subjective assessments. Moreover, the results of this study showed that a pleasant subjective feeling could be obtained by sniffing the aroma of kuromoji teas, especially tea leaves. It was also found that the aroma of kuromoji teas has the potential to stimulate saliva secretion and increase subjective and physiological excitements in the oral cavity. 1,8-Cineole, linalool, terpinen-4-ol, carvone and geraniol were determined in both kuromoji leaves and branches. In this study, the beneficial effects of kuromoji teas when drunk conventionally were investigated.

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