scholarly journals Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023850
Author(s):  
Catherine S Wall ◽  
Rose S Bono ◽  
Rebecca C Lester ◽  
Cosima Hoetger ◽  
Thokozeni Lipato ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Subjective Effects ◽  
Latin Square ◽  
Abuse Liability ◽  
Smoke Inhalation ◽  
Nicotine Concentration ◽  
The Past ◽  
The Usa ◽  
Behavioural Economic ◽  
Scientific Meetings

IntroductionIn the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Flavourings may mask the taste of tobacco and enhance smoke inhalation, influencing toxicant exposure and abuse liability among novice tobacco users. Using clinical laboratory methods, this study investigates how flavour availability affects measures of abuse liability in young adult cigarette smokers. The specific aims are to evaluate the effect of cigar flavours on nicotine exposure, and behavioural and subjective measures of abuse liability.Methods and analysesParticipants (projected n=25) are healthy smokers of five or more cigarettes per day over the past 3 months, 18–25 years old, naive to cigar use (lifetime use of 50 or fewer cigar products and no more than 10 cigars smoked in the past 30 days) and without a desire to quit cigarette smoking in the next 30 days. Participants complete five laboratory sessions in a Latin square design with either their own brand cigarette or a session-specific Black & Mild cigar differing in flavour (apple, cream, original and wine). Participants are single-blinded to cigar flavours. Each session consists of two 10-puff smoking bouts (30 s interpuff interval) separated by 1 hour. Primary outcomes include saliva nicotine concentration, behavioural economic task performance and response to various questionnaire items assessing subjective effects predictive of abuse liability. Differences in outcomes across own brand cigarette and flavoured cigar conditions will be tested using linear mixed models.Ethics and disseminationThe Virginia Commonwealth University Institutional Review Board approved the study (VCU IRB: HM20007848). Dissemination channels for study findings include scientific journals, scientific meetings, and policy briefs.Trial registration numberNCT02937051.

Cross-culture outcomes of a brazilian professor Fulbright in the USA

2017 ◽  
Vol 26 (50) ◽  
pp. 115
Author(s):  
Marcelo Da Silva Leite ◽  
Celeste Gaia
Keyword(s):  
Higher Education ◽  
Low Cost ◽  
Cross Culture ◽  
College And University ◽  
Governmental Agencies ◽  
The Past ◽  
University Curriculum ◽  
Fulbright Scholar ◽  
The Usa ◽  
Higher Education Costs

Over the past decade due the expansion of globalization there has been an increasing emphasis on internationalization among faculty, administration and accrediting agencies in the Higher Education.  Although to promote internationalization in the Higher Education, costs are a big challenge, one way to have the international actions with low cost, it is seeking for grants from different governmental agencies and foundations.The Fulbright Scholar program provides a long-standing and externally-funded means for internationalizing college and university curriculum. This article is going to share the perspective   of a Brazilian Fulbright Scholar at an American college and the institution perspective of the Fulbright scholar participation at the College.

scholarly journals Bioinsecticides based on plant essential oils: a short overview

2020 ◽  
Vol 75 (7-8) ◽  
pp. 179-182
Author(s):  
Murray B. Isman
Keyword(s):  
Essential Oils ◽  
Crop Protection ◽  
Large Body ◽  
Regulatory Agencies ◽  
The European Union ◽  
Plant Essential Oils ◽  
The Past ◽  
Wide Range ◽  
The Usa ◽  
Regulatory Challenges

AbstractInterest in the discovery and development of plant essential oils for use as bioinsecticides has grown enormously in the past 20 years. However, successful commercialization and utilization of crop protection products based on essential oils has thus far lagged far behind their promise based on this large body of research, most notably because with the exceptions of the USA and Australia, such products receive no special status from regulatory agencies that approve new pesticides for use. Essential oil-based insecticides have now been used in the USA for well over a decade, and more recently have seen use in the European Union (EU), Korea, and about a dozen other countries, with demonstrated efficacy against a wide range of pests and in numerous crop systems. For the most part these products are based on commodity essential oils developed as flavor and fragrance agents for the food and cosmetic industries, as there are formidable logistic, economic, and regulatory challenges to the use of many other essential oils that otherwise possess potentially useful bioactivity against pests. In spite of these limitations, the overall prospects for biopesticides, including those based on essential oils, are encouraging as the demand for sustainably-produced and/or organic food continues to increase worldwide.

scholarly journals Global publication trends and hotspots of molecular biomarkers in DILI from 1991 to 2020: A 30-year bibliometric analysis

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042110005
Author(s):  
Mingnan Cao ◽  
Li Wang ◽  
Lin Zhang ◽  
Jingli Duan
Keyword(s):  
Bibliometric Analysis ◽  
Research Collaboration ◽  
Citation Networks ◽  
Publication Trends ◽  
Drug Induced ◽  
Topic Area ◽  
The Past ◽  
Black Box Warnings ◽  
The Usa ◽  
Post Marketing

Drug-induced liver injury (DILI) is one of the common adverse drug reactions and the leading cause of drug development attritions, black box warnings, and post-marketing withdrawals. Current biomarkers are suboptimal in detecting DILI and predicting its outcome. This study aimed to quantitatively and qualitatively investigate the research trends on DILI biomarkers using bibliometric analysis. All relevant publications were extracted from the Web of Science database. An online analysis platform of literature metrology, bibliographic item co-occurrence matrix builder, and CiteSpace software were used to analyze the publication trends. CitNetExplorer was used to construct direct citation networks and VOSviewer was used to analyze the keywords and research hotspots. We found a total of 485 publications related to DILI biomarkers published from 1991 to 2020. Toxicological Sciences had been the most popular journal in this field over the past 30 years. The USA maintained a top position worldwide and provided a pivotal influence, followed by China. Among all the institutions, the University of Liverpool was regarded as a leader for research collaboration. Moreover, Professors Paul B. Watkins and Tsuyoshi Yokoi made great achievements in topic area. We analyzed the citation networks and keywords, therefore identified five and six research hotspot clusters, respectively. We considered the publication information regarding different countries/regions, organizations, authors, journals, et al. by summarizing the literature on DILI biomarkers over the past 30 years. Notably, the subject of DILI biomarkers is an active area of research. In addition, the investigation and discovery of novel promising biomarkers such as microRNAs, keratin18, and bile acids will be future developing hotspots.

Diverging trends in US male-female condom use by STI risk factors: a nationally representative study

2020 ◽  
pp. sextrans-2020-054642
Author(s):  
Casey E Copen ◽  
Patricia J Dittus ◽  
Jami S Leichliter ◽  
Sagar Kumar ◽  
Sevgi O Aral
Keyword(s):  
Risk Factors ◽  
Condom Use ◽  
Illicit Drugs ◽  
Female Condom ◽  
Cross Sectional ◽  
The Past ◽  
Representative Study ◽  
The Usa ◽  
Over Time ◽  
Sex Partner

ObjectiveCondom use behaviours are proximal to recent STI increases in the USA, yet it remains unclear whether the use of condoms has changed over time among unmarried, non-cohabiting young men who have sex with women (MSW) and how this variability is influenced by STI risk factors.MethodsTo examine condom use over time among MSW aged 15–29, we used three cross-sectional surveys from the 2002, 2006–2010 and 2011–2017 National Survey of Family Growth. We estimated weighted percentages, adjusted prevalence ratios (APRs) and 95% confidence intervals (CI) to assess changes in condom use, stratified by whether MSW reported any STI risk factors in the past 12 months (ie, perceived partner non-monogamy, male-to-male sex, sex in exchange for money or drugs, sex partner who injects illicit drugs, or an HIV-positive sex partner).ResultsWe observed a divergence in trends in condom use at last sex between men aged 15 –29 with STI risk factors in the past 12 months and those without such history. We saw significant declines in condom use from 2002 to 2011–2017 among men with STI risk factors (APR=0.80, 95% CI 0.68 to 0.95), specifically among those aged 15–19 (APR=0.73, 95% CI 0.57 to 0.94) or non-Hispanic white (APR=0.71, 95% CI 0.54 to 0.93). In contrast, trends in condom use among men with no STI factors remained stable or increased. Across all time periods, the most prevalent STI risk factor reported was perception of a non-monogamous female partner (23.0%–26.9%). Post-hoc analyses examined whether condom use trends changed once this variable was removed from analyses, but no different patterns were observed.ConclusionsWhile STIs have been increasing, men aged 15–29 with STI risk factors reported a decline in condom use. Rising STI rates may be sensitive to behavioural shifts in condom use among young MSW with STI risk factors.

scholarly journals Pictorial health warning labels on the waterpipe device are effective in reducing smoking satisfaction, puffing behaviour and exposure to CO: first evidence from a crossover clinical laboratory study

2019 ◽  
Vol 28 (e1) ◽  
pp. e37-e42 ◽  
Author(s):  
Wasim Maziak ◽  
Ziyad Ben Taleb ◽  
Mohammad Ebrahimi Kalan ◽  
Thomas Eissenberg ◽  
James Thrasher ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Clinical Laboratory ◽  
Warning Labels ◽  
Health Warning ◽  
Before And After ◽  
Regulatory Approach ◽  
The Usa ◽  
Exhaled Carbon Monoxide ◽  
Positive Experiences ◽  
Harmful Effects

ObjectivesThis study examined the effect of pictorial health warning labels (HWLs) on the waterpipe (WP) device on smokers’ experience, puffing behaviour, harm perception and exposure to respiratory toxicants.MethodsThirty WP smokers completed two 45 min ad libitum smoking sessions (WP without HWL vs WP with HWL) in a crossover design study. Exhaled carbon monoxide (eCO) was measured before and after each smoking session. Puff topography was recorded throughout the smoking session, and participants completed survey questionnaires assessing subjective smoking experiences and harm perception.ResultsSignificant differences were observed in eCO levels between the two study conditions, with lower levels of eCO boost recorded following smoking the WP fitted with HWL (16 ppm) compared with WP without HWL (22.7 ppm). Participants had more puffs, shorter interpuff intervals and a higher total puff volume during smoking the WP without HWL relative to WP with HWL (p values <0.05). We documented enhanced reports of satisfaction, taste and puff liking following smoking the WP without HWL compared with the WP with HWL. WP harm perception was significantly higher among participants after smoking the WP with HWL compared with WP without HWL.ConclusionThis pilot study shows that placing HWL on the WP device is effective in reducing WP smoker’s positive experiences, puffing parameters and exposure to carbon monoxide. HWLs lead also to more appreciation of WP harmful effects, making them a promising regulatory approach for addressing the spread of WP smoking among young adults in the USA.

scholarly journals Trends in survival of patients with Burkitt lymphoma/leukemia in the USA: an analysis of 3691 cases

Blood ◽  
2013 ◽  
Vol 121 (24) ◽  
pp. 4861-4866 ◽  
Author(s):  
Luciano J. Costa ◽  
Ana C. Xavier ◽  
Amy E. Wahlquist ◽  
Elizabeth G. Hill
Keyword(s):  
United States ◽  
Young Adults ◽  
Burkitt Lymphoma ◽  
Unmet Need ◽  
The United States ◽  
The Past ◽  
Black Patients ◽  
Key Points ◽  
The Usa

Key Points Survival of patients with BL improved substantially in the United States during the past decade, mainly among young adults. Survival of patients with BL remains relatively low, particularly for older and black patients, identifying an unmet need.

Para-diplomacy: Concept and the Context

2017 ◽  
Vol 73 (4) ◽  
pp. 375-394 ◽  
Author(s):  
Rakhahari Chatterji ◽  
Swagata Saha
Keyword(s):  
Sovereign State ◽  
The Past ◽  
The Usa ◽  
Control Versus ◽  
International Interaction ◽  
Sphere Of Influence ◽  
Past Experiences ◽  
Regional Imbalance ◽  
Institutional Space ◽  
India And China

Globalisation and market reforms have made foreign policymaking a more inclusive and multilayered process. Para-diplomacy and emergence of empowered federating/component units engaging in international interaction call for recalibration of theories and understating of International Relations. The debate over central control versus unit autonomy raised the concern: whether para-diplomacy will turn out to be an asset or a threat for the sovereign state. While state may reap benefits of economic development, para-diplomacy may yet lead to regional imbalance, ethnic mobilisation and separatism. With the focus being shifted to Asia with respect to expanding market and sphere of influence, this article analyses the experience of para-diplomacy between India and China as well as of both with the USA. In doing so, reference is drawn to the past experiences of the West to understand how para-diplomacy took root and how is it practised in different contexts. Considering the economic, political and social implications of para-diplomatic practices in specific contexts, the article concludes with an attempt to find out the institutional space it may tread and the policy options it may hold out especially for India.

Small-colony Variants (SCVs) of Staphylococci: A Role in Foreign Body-associated Infections

2007 ◽  
Vol 30 (9) ◽  
pp. 778-785 ◽  
Author(s):  
C. Von Eiff ◽  
K. Becker
Keyword(s):  
Foreign Body ◽  
Defense Mechanisms ◽  
Susceptibility Testing ◽  
Slow Growth ◽  
Clinical Laboratory ◽  
Coagulase Negative Staphylococci ◽  
Small Colony Variants ◽  
The Past ◽  
Small Colony ◽  
Antibacterial Chemotherapy

Staphylococci have various strategies for resisting therapy that extend beyond classic mechanisms. Clinical experience with device-associated infections as well as with infections due to small-colony variants (SCVs) clearly shows that both antibacterial chemotherapy and host defense mechanisms are often unable to eliminate the pathogens and cure these infections. Of particular interest is the fact that in the past few years an increasing number of various foreign body-related infections due to staphylococcal SCVs have been reported. In this overview, the characteristics of SCVs recovered from clinical specimens and of defined mutants displaying the SCV phenotype are described. Their slow growth and changing biochemical and physiological features represent a challenge to clinical laboratory personnel, because recovery, identification, as well as susceptibility testing of these variants need particular efforts. In addition, the reduced susceptibility to aminoglycosides and the ability of SCVs to persist intracellularly require specific attention for the treatment of these infections. Thus, special efforts to search for these variants formed by Staphylococcus aureus or by coagulase-negative staphylococci should be considered when an infection is particularly resistant to therapy, persists for a long period or fails to respond to apparently adequate therapy with antimicrobial compounds.

Bausteine zu einer Geographie des Kapitalismus

2003 ◽  
Vol 47 (1) ◽  
Author(s):  
Christian Zeller
Keyword(s):  
Economic Geography ◽  
Research Agenda ◽  
Power Relations ◽  
Political Power ◽  
Global Scale ◽  
The Political ◽  
Reciprocal Effects ◽  
The Past ◽  
The Usa ◽  
Socially Relevant

Elements of a geography of capitalism. Despite the variety of new approaches economic geography developed rather one-sided in the past decade. The regional and the firm lenses hardly enabled to recognize how economic processes and political power relations interact on different scales. These empirical deficits also express a restricted theoretical base. The approaches of the new “regional orthodoxy” claim to explain conditions of an improved competitiveness of firms and of regions. However, many socially relevant and spatially differentiated problems are ignored. In contrast, this paper argues for an integrative understanding of the capitalist economy in its historical dynamics and with its reciprocal effects for actors on various scales. In the course of neoliberal deregulation policies and globalization processes, a finance-dominated accumulation regime emerged in the USA which shapes the economy on a global scale. Institutional investors gained decisive control over investments. The political power relations and hierarchies between states remain important. Therefore, the paper suggests a shift of economic geographical research. In the perspective of an integrative geography of capitalism the paper outlines a research agenda of a geography of accumulation, a geography of production as well as a geography of power

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