Recent advances in cutaneous melanoma: towards a molecular model and targeted treatment

2013 ◽  
Vol 54 (3) ◽  
pp. 163-172 ◽  
Author(s):  
Jazlyn Read
Keyword(s):  
Cutaneous Melanoma ◽  
Molecular Model ◽  
Targeted Treatment ◽  
Recent Advances

scholarly journals Targeted Treatment for Erythrodermic Psoriasis: Rationale and Recent Advances

Drugs ◽  
2020 ◽  
Vol 80 (6) ◽  
pp. 525-534 ◽  
Author(s):  
Shuai Shao ◽  
Gang Wang ◽  
Emanual Maverakis ◽  
Johann E. Gudjonsson
Keyword(s):  
Targeted Treatment ◽  
Recent Advances ◽  
Erythrodermic Psoriasis

Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Yi-Ping Chou ◽  
Yin-Ku Lin ◽  
Chun-Han Chen ◽  
Jia-You Fang
Keyword(s):  
Cutaneous Melanoma ◽  
Recent Advances

scholarly journals Recent Advances on Drug-Loaded Mesenchymal Stem Cells With Anti-neoplastic Agents for Targeted Treatment of Cancer

2020 ◽  
Vol 8 ◽  
Author(s):  
Amirhesam Babajani ◽  
Pegah Soltani ◽  
Elham Jamshidi ◽  
Mohammad Hadi Farjoo ◽  
Hassan Niknejad
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Targeted Treatment ◽  
Recent Advances

scholarly journals Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment

2017 ◽  
Vol 46 (16) ◽  
pp. 5110-5127 ◽  
Author(s):  
Jevan Medlock ◽  
Anupam A. K. Das ◽  
Leigh A. Madden ◽  
David J. Allsup ◽  
Vesselin N. Paunov
Keyword(s):  
Cell Shape ◽  
Shape Recognition ◽  
Targeted Treatment ◽  
Recent Advances ◽  
Cell Selectivity ◽  
Wide Range ◽  
Alternative Modality

We review the recent advances in a wide range of bioimprinting techniques which may provide an alternative modality for cell selectivity in separation, diagnosis and targeted treatment of cancer.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Toward an alignment of the actin molecule within the actin filament

1983 ◽  
Vol 41 ◽  
pp. 450-451
Author(s):  
P.R. Smith ◽  
W.E. Fowler ◽  
U. Aebi
Keyword(s):  
Actin Filament ◽  
Diffraction Data ◽  
Quantitative Estimate ◽  
Molecular Model ◽  
Quantitative Comparison ◽  
Regulatory Proteins ◽  
Essential Information ◽  
X Ray ◽  
Maximum Resolution ◽  
Lack Of Information

An understanding of the specific interactions of actin with regulatory proteins has been limited by the lack of information about the structure of the actin filament. Molecular actin has been studied in actin-DNase I complexes by single crystal X-ray analysis, to a resolution of about 0.6nm, and in the electron microscope where two dimensional actin sheets have been reconstructed to a maximum resolution of 1.5nm. While these studies have shown something of the structure of individual actin molecules, essential information about the orientation of actin in the filament is still unavailable.The work of Egelman & DeRosier has, however, suggested a method which could be used to provide an initial quantitative estimate of the orientation of actin within the filament. This method involves the quantitative comparison of computed diffraction data from single actin filaments with diffraction data derived from synthetic filaments constructed using the molecular model of actin as a building block. Their preliminary work was conducted using a model consisting of two juxtaposed spheres of equal size.

Exploration of cell wall architecture with the rapid-freeze deep-etch technique

1993 ◽  
Vol 51 ◽  
pp. 128-129
Author(s):  
Béatrice Satiat-Jeunemaitre ◽  
Chris Hawes
Keyword(s):  
Plant Cell ◽  
Cell Walls ◽  
Cell Biology ◽  
Molecular Model ◽  
Three Dimensional ◽  
Secretory Activity ◽  
Wall Structure ◽  
Specimen Preparation ◽  
Molecular Architecture ◽  
Plant Cell Walls

The comprehension of the molecular architecture of plant cell walls is one of the best examples in cell biology which illustrates how developments in microscopy have extended the frontiers of a topic. Indeed from the first electron microscope observation of cell walls it has become apparent that our understanding of wall structure has advanced hand in hand with improvements in the technology of specimen preparation for electron microscopy. Cell walls are sub-cellular compartments outside the peripheral plasma membrane, the construction of which depends on a complex cellular biosynthetic and secretory activity (1). They are composed of interwoven polymers, synthesised independently, which together perform a number of varied functions. Biochemical studies have provided us with much data on the varied molecular composition of plant cell walls. However, the detailed intermolecular relationships and the three dimensional arrangement of the polymers in situ remains a mystery. The difficulty in establishing a general molecular model for plant cell walls is also complicated by the vast diversity in wall composition among plant species.

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Cutaneous melanoma in a patient with neurofibromatosis

1979 ◽  
Vol 115 (7) ◽  
pp. 864-865 ◽  
Author(s):  
M. J. Mastrangelo
Keyword(s):  
Cutaneous Melanoma
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