scholarly journals Growth factor expression is enhanced and extracellular matrix proteins are depressed in healing skin wounds in septic patients compared with healthy controls

Apmis ◽  
2021 ◽  
Author(s):  
Henna Jaurila ◽  
Marjo Koskela ◽  
Vesa Koivukangas ◽  
Fiia Gäddnäs ◽  
Tuula Salo ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Healthy Controls ◽  
Skin Wounds ◽  
Factor Expression ◽  
Growth Factor Expression

scholarly journals Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1356 ◽  
Author(s):  
Milito ◽  
Brancaccio ◽  
D’Argenio ◽  
Castellano
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

Liver fibrosis is a pathophysiologic process involving the accumulation of extracellular matrix proteins as collagen deposition. Advanced liver fibrosis can evolve in cirrhosis, portal hypertension and often requires liver transplantation. At the cellular level, hepatic fibrosis involves the activation of hepatic stellate cells and their transdifferentiation into myofibroblasts. Numerous pro-fibrogenic mediators including the transforming growth factor-β1, the platelet-derived growth factor, endothelin-1, toll-like receptor 4, and reactive oxygen species are key players in this process. Knowledge of the cellular and molecular mechanisms underlying hepatic fibrosis development need to be extended to find novel therapeutic strategies. Antifibrotic therapies aim to inhibit the accumulation of fibrogenic cells and/or prevent the deposition of extracellular matrix proteins. Natural products from terrestrial and marine sources, including sulfur-containing compounds, exhibit promising activities for the treatment of fibrotic pathology. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans are largely unknown. This review aims to provide a reference collection on experimentally tested natural anti-fibrotic compounds, with particular attention on sulfur-containing molecules. Their chemical structure, sources, mode of action, molecular targets, and pharmacological activity in the treatment of liver disease will be discussed.

Vascular Endothelial Growth Factor Induces Extracellular Matrix Proteins and Osteopontin in the Umbilical Artery

2008 ◽  
Vol 22 (2) ◽  
pp. 273-284 ◽  
Author(s):  
Manfred Infanger ◽  
Jirka Grosse ◽  
Kriss Westphal ◽  
Annekatrin Leder ◽  
Claudia Ulbrich ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Umbilical Artery ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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