γδT cell as a potential candidate contributing to the development of psoriatic cardiovascular disease

2021 ◽  
Author(s):  
Q. Xu ◽  
J. Zheng
Keyword(s):  
Cardiovascular Disease ◽  
Potential Candidate ◽  
Γδt Cell

5234KAND567, the first selective small molecule CX3CR1 antagonist in clinical development, mediates anti-inflammatory cardioprotective effects in rodent models of atherosclerosis and myocardial infarction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Abdelmoaty ◽  
H Arthur ◽  
I Spyridopoulos ◽  
M Wagberg ◽  
R Fritsche Danielson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Infarct Size ◽  
Small Molecule ◽  
Atherosclerotic Plaque ◽  
Vehicle Group ◽  
Potential Candidate ◽  
Rodent Models ◽  
Anti Inflammatory

Abstract Background Fractalkine is a chemokine that mediates recruitment and extravasation of CX3CR1-expressing subsets of leukocytes and monocytes and has been implicated in the inflammation-driven pathology of cardiovascular disease. More specifically, fractalkine signaling has been proposed to contribute to increased infarct size and enhanced atherosclerotic plaque vulnerability in patients and experimental models. Blocking fractalkine/CX3CR1 signaling is suggested as a promising anti-inflammatory strategy for the treatment of both acute and chronic cardiovascular disease. KAND567 is a small molecule, selective, non-competitive, allosteric antagonist of the fractalkine receptor CX3CR1, that is under preparation for a clinical phase IIa study in AMI patients. Purpose To explore the therapeutic effects of the short and long term administration of KAND567 in experimental rodent models of acute myocardial infarction and atherosclerosis, respectively. Methods Myocardial infarction was induced in Wistar rats (N=6–8 per group) by ligation of the left anterior descending (LAD) coronary artery for 30 minutes followed by 2 h of reperfusion. The drug or vehicle infusion started either 5 min before or 30 min after start of reperfusion and continued during the remainder of the experiment. Hearts were collected and subjected to triphenyl tetrazolium chlorine (TTC) staining and the infarction area/area at risk of the left ventricle was determined by planimetry and compared against vehicle group. Atherosclerosis-prone LDL-receptor deficient mice on a high-cholesterol diet, (N=15–25 per group) were treated with KAND567 for 15–23 weeks. Atherosclerotic plaque development in the thoracic arch was determined by ultrasound imaging and histology. Immunohistochemistry was used to follow changes in the cellular composition in the atherosclerotic lesions. Results In the acute myocardial infarction study, the infusion of KAND567 before the start of reperfusion significantly reduced infarcted/risk area (by up to 50%) as compared to the vehicle group. However, the infusion had no effect on the infarct size when administration was initiated 30 min after start of reperfusion. In the atherogenesis study, oral treatment with KAND567 significantly reduced vascular macrophage infiltration by 50% and reduced intima media thickness. Furthermore, reduced plaque volume and a more stable plaque phenotype was noted following treatment with KAND567. KAND567 experimental results Conclusion Specific inhibition of fractalkine-driven inflammation by KAND567 provides cardioprotective, anti-atherosclerotic and plaque stabilizing effects via mechanisms related to immune cell infiltration, in rodent models. Further studies should be initiated to test if KAND567 is a potential candidate drug, targeting the excessive inflammatory injury associated with ischemia/reperfusion in myocardial infarction and providing plaque stabilization by reducing inflammatory risk for recurrent coronary events.

Cardioprotective molecule and bioactive compounds of some selected vegetables available in Bangladesh

2018 ◽  
Vol 16 (1) ◽  
pp. 82-87
Author(s):  
Md Arif Sakil ◽  
Mohammed Arif Sadik Polash ◽  
Md Tahjib Ul Arif ◽  
Md Afzal Hossain ◽  
Md Alamgir Hossain
Keyword(s):  
Cardiovascular Disease ◽  
Bioactive Compounds ◽  
Research Work ◽  
Beta Carotene ◽  
Nitrate Content ◽  
Potential Candidate ◽  
Dietary Nitrate ◽  
Household Level ◽  
Anti Oxidant ◽  
Cardio Protection

Cardiovascular disease (CVD) is one of the leading causes of death and morbidity as well as imposing a huge economic burden at both country and household level. Upto 90% cardiovascular disease may be preventable if established risk factors are avoided. In this context, dietary nitrate from vegetables was highlighted as a potential candidate for cardio protection. Hence, by supplying dietary nitrate and other bio-active compounds to ease the risk of cardiovascular disease, present research work was carried out. Among the tested vegetables, the highest nitrate content (745 mg/100g) was determined in Indian spinach. In addition, Indian spinach also possesses more chlorophyll (150mg/100g), beta carotene (40mg/100g) and lycopene (34mg/100g) than other tested vegetables in the current study. In case of anti-oxidant content, Indian spinach showed the highest (103mg/100g) vitamin C content. Taken all together, Indian spinach may be a good and cheapest source of cardio protective molecule (nitrate) bioactive compounds to avoid risk of cardiovascular disease.J. Bangladesh Agril. Univ. 16(1): 82-87, April 2018

Abstract 13770: Experiences of Ethnic Discrimination and COMT Val158Met Polymorphism Are Associated With Depressive Symptoms in Hispanic Adults at Risk for Cardiovascular Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Kaitlin V Key ◽  
Steven Estus ◽  
Terry A Lennie ◽  
Ana Maria Linares ◽  
Gia Mudd-martin
Keyword(s):  
Cardiovascular Disease ◽  
Depressive Symptoms ◽  
Ethnic Discrimination ◽  
Potential Candidate ◽  
Cvd Risk ◽  
Moderation Effect ◽  
Val158met Polymorphism ◽  
Increased Risk ◽  
Hispanic Adults ◽  
The Impact

Introduction: There is emerging evidence that ethnic discrimination, commonly experienced among U.S. Hispanics, is associated with depressive symptoms, increasing cardiovascular disease (CVD) risk. Genetic variants in dopaminergic pathways may moderate this association. The catechol-O-methyltransferase Val158Met polymorphism is a potential candidate because the Met allele is associated with increased risk for depressive symptoms. The purposes of this study were to examine associations among ethnic discrimination, Val158Met polymorphism, and depressive symptoms, and to explore if Val158Met moderates the association between discrimination and depressive symptoms in Hispanic adults. Methods: Participants were 124 Hispanic adults with 2+ CVD risk factors. Ethnic discrimination was measured with the Experiences of Discrimination instrument, which measures discrimination experiences across 9 settings (e.g. at work). Scores range from 0 to 45; higher scores indicate more experiences of discrimination. Depressive symptoms were measured using the Patient Health Questionnaire-8. Scores range from 0 to 21; higher scores indicate more depressive symptoms. DNA was isolated from saliva and analyzed for Val158Met genotype. A hierarchical linear regression was conducted adjusting for sex, age, income, education, acculturation, and years in the U.S. Discrimination was entered in Step 1 and Val158Met in Step 2 to examine the association with depressive symptoms. To assess moderation, a discrimination*Val158Met interaction term was entered in Step 3. Results: Participants were aged 40.2 ± 9.3 years and mostly female (74.2%). Discrimination was positively associated with depressive symptoms (p = 0.041). Participants with at least one Met allele at the Val158Met polymorphism had more depressive symptoms than those with a Val-Val genotype (p = 0.049). No moderation effect was found. Conclusion: Findings suggest that discrimination and Val158Met genotype independently influence depression in Hispanic adults, which may increase risk for depression and CVD in certain individuals. This highlights the need to explore mechanisms underpinning these associations, and to address the impact of discrimination on depression and CVD disparities.

scholarly journals Cardioprotective Effects of Honey and Its Constituent: An Evidence-Based Review of Laboratory Studies and Clinical Trials

2020 ◽  
Vol 17 (10) ◽  
pp. 3613 ◽  
Author(s):  
Ruszymah Bt Hj Idrus ◽  
Nur Qisya Afifah Veronica Sainik ◽  
Abid Nordin ◽  
Aminuddin Bin Saim ◽  
Nadiah Sulaiman
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Myocardial Infarct ◽  
Toxic Metabolite ◽  
Potential Candidate ◽  
Eligibility Criteria ◽  
Public Health Burden ◽  
Area Reduction ◽  
Geological Origin ◽  
Pressure Modulation

Cardiovascular disease is a major public health burden worldwide. Myocardial infarction is the most common form of cardiovascular disease resulting from low blood supply to the heart. It can lead to further complications such as cardiac arrhythmia, toxic metabolite accumulation, and permanently infarcted areas. Honey is one of the most prized medicinal remedies used since ancient times. There is evidence that indicates honey can function as a cardioprotective agent in cardiovascular diseases. The present review compiles and discusses the available evidence on the effect of honey on cardiovascular diseases. Three electronic databases, namely, PubMed, Scopus, and MEDLINE via EBSCOhost, were searched between January 1959 and March 2020 to identify reports on the cardioprotective effect of honey. Based on the pre-set eligibility criteria, 25 qualified articles were selected and discussed in this review. Honey investigated in the studies included varieties according to their geological origin. Honey protects the heart via lipid metabolism improvement, antioxidative activity, blood pressure modulation, heartbeat restoration, myocardial infarct area reduction, antiaging properties, and cell apoptosis attenuation. This review establishes honey as a potential candidate to be explored further as a natural and dietary alternative to the management of cardiovascular disease.

Conditions for atomic imaging of mullite

1989 ◽  
Vol 47 ◽  
pp. 418-419
Author(s):  
T. A. Epicier ◽  
G. Thomas
Keyword(s):  
Oxygen Vacancies ◽  
High Resolution Electron Microscopy ◽  
Ceramic Materials ◽  
Work Conditions ◽  
Real Space ◽  
Potential Candidate ◽  
Silicate Mineral ◽  
Resolution Electron ◽  
The Subject ◽  
Aluminium Silicate

Mullite is an aluminium-silicate mineral of current interest since it is a potential candidate for high temperature applications in the ceramic materials field.In the present work, conditions under which the structure of mullite can be optimally imaged by means of High Resolution Electron Microscopy (HREM) have been investigated. Special reference is made to the Atomic Resolution Microscope at Berkeley which allows real space information up to ≈ 0.17 nm to be directly transferred; numerous multislice calculations (conducted with the CEMPAS programs) as well as extensive experimental through-focus series taken from a commercial “3:2” mullite at 800 kV clearly show that a resolution of at least 0.19 nm is required if one wants to get a straightforward confirmation of atomic models of mullite, which is known to undergo non-stoichiometry associated with the presence of oxygen vacancies.Indeed the composition of mullite ranges from approximatively 3Al2O3-2SiO2 (referred here as 3:2-mullite) to 2Al2O3-1SiO2, and its structure is still the subject of refinements (see, for example, refs. 4, 5, 6).

Cardiovascular Disease: Effects Upon Cognition and Communication

ASHA Leader ◽  
2006 ◽  
Vol 11 (7) ◽  
pp. 10-23 ◽  
Author(s):  
Laura Murray
Keyword(s):  
Cardiovascular Disease

Cardiovascular disease and risk factors in persons with type 2 diabetes diagnosed in a large population screening: The Nord-Trondelag Diabetes Study, Norway

2000 ◽  
Vol 248 (6) ◽  
pp. 492-500 ◽  
Author(s):  
T. Claudi ◽  
K. Midthjell ◽  
J. Holmen ◽  
K. Fougner ◽  
O. Kruger ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Large Population ◽  
Population Screening

M.614 Homocysteine as an independent risk factor for cardiovascular disease

2004 ◽  
Vol 5 (1) ◽  
pp. 142
Author(s):  
S PAXIMADAS
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Independent Risk Factor
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