The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation

2013 ◽  
Vol 38 (5) ◽  
pp. 2684-2692 ◽  
Author(s):  
Maik M. A. Worlitzer ◽  
Thomas Viel ◽  
Andreas H. Jacobs ◽  
Jens C. Schwamborn
Keyword(s):  
Substantia Nigra ◽  
Adult Mouse ◽  
Low Levels

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson’s Disease

2017 ◽  
Vol 55 (1) ◽  
pp. 804-821 ◽  
Author(s):  
Debashis Dutta ◽  
Nilufar Ali ◽  
Emili Banerjee ◽  
Raghavendra Singh ◽  
Amit Naskar ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Low Levels

Transferrin in foetal and adult mouse tissues: synthesis, storage and secretion

Development ◽  
1985 ◽  
Vol 86 (1) ◽  
pp. 205-218
Author(s):  
Jennifer Meek ◽  
Eileen D. Adamson
Keyword(s):  
Spinal Cord ◽  
Adult Mouse ◽  
Adult Brain ◽  
Rib Cage ◽  
Muscle Tissues ◽  
Mouse Tissues ◽  
Visceral Yolk Sac ◽  
Growth Promoting ◽  
Low Levels ◽  
The Brain

Transferrin is an important growth-promoting serum glycoprotein synthesized chiefly in the liver in adults. The transferrin found in the mouse foetus is thought to be wholly a product of the foetus itself and its synthesis starts at least as early as the 7th day of gestation. The major sites of synthesis in mouse foetuses are the visceral yolk sac (VYS) and liver (Adamson, 1982). We now report that other murine foetal tissues synthesize readily detectable amounts, namely lung, spleen, spinal cord and rib cage. Very low levels are also synthesized by the brain, muscle and pancreas. We can detect no synthesis of transferrin in late foetal thymus, heart or skin although mid-gestation foetal skin may make a very small amount. No synthesis of transferrin can be detected in adult brain, lung and spleen, but approximately equal rates of synthesis are detected in adult liver and adult ear pinna. Transferrin is accumulated by foetal and adult tissues in widely varying amounts and these have been measured by enzyme-linked immunosorbent assays of extracts. In addition to VYS and liver, high levels of transferrin are found in foetal skin, lung and rib cage with lower amounts in spinal cord, spleen and muscle tissues. Tissues of the 15th day foetus accumulate the highest concentrations of transferrin. A role for the mediation of transferrin in the stimulation of growth and differentiation by interacting tissues is discussed.

scholarly journals Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner

2012 ◽  
Vol 13 (1) ◽  
pp. 132 ◽  
Author(s):  
Philipp Klaissle ◽  
Anne Lesemann ◽  
Petra Huehnchen ◽  
Andreas Hermann ◽  
Alexander Storch ◽  
...  
Keyword(s):  
Physical Activity ◽  
Substantia Nigra ◽  
Environmental Enrichment ◽  
Adult Mouse ◽  
Dependent Manner ◽  
Neural Precursors

Nuclear localization of β-catenin in adult mouse thalamus correlates with low levels of GSK-3β

Neuroreport ◽  
1999 ◽  
Vol 10 (13) ◽  
pp. 2699-2703 ◽  
Author(s):  
José J. Lucas ◽  
Félix Hernández ◽  
Jesús Avila
Keyword(s):  
Nuclear Localization ◽  
Adult Mouse ◽  
Low Levels ◽  
Gsk 3Β

scholarly journals Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons

2011 ◽  
Vol 116 (4) ◽  
pp. 646-658 ◽  
Author(s):  
Tim D. Aumann ◽  
Kate Egan ◽  
Jamie Lim ◽  
Wah C. Boon ◽  
Chris R. Bye ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Neuronal Activity ◽  
Adult Mouse ◽  
Substantia Nigra Pars Compacta

scholarly journals Regulation of proliferation and differentiation of myoblasts derived from adult mouse skeletal muscle by specific isoforms of PDGF.

1990 ◽  
Vol 111 (4) ◽  
pp. 1623-1629 ◽  
Author(s):  
Z Yablonka-Reuveni ◽  
T M Balestreri ◽  
D F Bowen-Pope
Keyword(s):  
Skeletal Muscle ◽  
Adult Mouse ◽  
Beta Subunits ◽  
Binding Assays ◽  
Mouse Skeletal Muscle ◽  
Muscle Trauma ◽  
Proliferation And Differentiation ◽  
Low Levels ◽  
High Level ◽  
Receptor Beta

The expression of receptors and the mitogenic response to PDGF by C2 myoblasts, derived from adult mouse skeletal muscle, was investigated. Employing 125I-PDGF binding assays, we showed that the cells exhibit high level binding of PDGF-BB (approximately 165 x 10(3) molecules/cell at saturation) and much lower binding of the PDGF-AA and PDGF-AB (6-12 x 10(3) molecules/cell at saturation). This indicates that the C2 myoblasts express high levels of PDGF receptor beta-subunits and low levels of alpha-subunits. PDGF-BB enhances the proliferation of C2 cells maintained in 2% FCS by about fivefold. PDGF-AB had a moderate effect on cell proliferation (less than twofold) and PDGF-AA had no effect. Inverse effects of PDGF isoforms on the frequency of differentiated myoblasts were observed; the frequency of myosin-positive cells was reduced in the presence of PDGF-BB while PDGF-AA and PDGF-AB had no effect. PDGF may thus act to increase the number of myoblasts that participate in muscle regeneration following muscle trauma by stimulating the proliferation and by inhibiting the differentiation of myogenic cells.

scholarly journals Effect of Oral Administration of Paraquat Pesticide on the Hippocampus and Substantia Nigra in Wistar Rats' Brains: تأثير التجريع الفموي للمبيد العشبي (الباراكوات) على الحصين والمادة السوداء في أدمغة جرذان الويستر

2021 ◽  
Vol 5 (3) ◽  
pp. 84-71
Author(s):  
Ebtihajah Abd Alrazaq Zaalan, Mahmoud Qassem, Muhammad Muayy Ebtihajah Abd Alrazaq Zaalan, Mahmoud Qassem, Muhammad Muayy
Keyword(s):  
Substantia Nigra ◽  
Wistar Rats ◽  
Molecular Layer ◽  
Acute Poisoning ◽  
Low Level ◽  
Pyramidal Layer ◽  
Neurotoxic Effects ◽  
Cytological Changes ◽  
Low Levels ◽  
The Brain

This study aimed to detect the neurohistological damages of chronic exposure to low levels of pesticide (paraquat) in the hippocampus, and substantia nigra in Wistar rats' brains. The neurotoxic effects of acute poisoning are well established but the possibility that low level exposure causes different diseases is controversialIt is important to get a clear answer to this question as more individuals are at risk of low level exposure than acute poisoning. The anatomical and histological of current study to affected brains showed cells display the cytological changes of herbisecticides-lesioned brain tissue, such as a significant decrease in the size of the brain was observed, as most of its external features disappeared. in addition, we detected vacuolization around cells that degenerated because many reasons like apoptosis or necrosis, and the intracellular neurofibrillary tangles were observed at many regions such as the hippocampus and substantia nigra. Moreover extracellular amyloid plaques take fibers form were detected. we also observed degenerated in CA1, CA2 and CA3 regions (molecular layer, polymorphic layer and pyramidal layer) by pigmenting degenerated neurons with silver nitrate with increased astrocytes of glia cells.

Low levels of citrin (SLC25A13) expression in adult mouse brain restricted to neuronal clusters

2009 ◽  
Vol 88 (5) ◽  
pp. 1009-1016 ◽  
Author(s):  
Laura Contreras ◽  
Almudena Urbieta ◽  
Keiko Kobayashi ◽  
Takeyori Saheki ◽  
Jorgina Satrústegui
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Low Levels

Expression of SPARC/osteonectin in tissues of bony and cartilaginous vertebrates

1991 ◽  
Vol 69 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Maurice Ringuette ◽  
Sashko Damjanovski ◽  
Donna Wheeler
Keyword(s):  
Tissue Distribution ◽  
Adult Mouse ◽  
Single Copy ◽  
Rat Tissues ◽  
Diverse Group ◽  
Biological Functions ◽  
Copy Gene ◽  
Liver And Kidney ◽  
Low Levels ◽  
Extracellular Glycoprotein

To explore the biological functions of SPARC (secreted protein, acidic, rich in cysteine), a Ca2+-binding extracellular glycoprotein, we have examined its expression in an evolutionary diverse group of organisms. Similar patterns of SPARC mRNA expression were observed in adult mouse and rat tissues. SPARC transcripts represented 0.0002–0.0025% of the total RNA found in calvarium, lung, brain, and heart, whereas relatively low levels of SPARC RNA were detected in liver and kidney. Within nonmuscular tissues, a statistically significant correlation was observed between the tissue distribution of SPARC and cytoskeletal actin transcripts. Southern blot analysis revealed SPARC as a low or single-copy gene in an evolutionary diverse group of vertebrates. No hybridization signal was observed with the invertebrates examined. The tissue distribution of SPARC transcripts in the vertebrates examined was similar, except for sea lamprey and sea skate, two vertebrates that do not form mineralized bone. These data suggest that SPARC has multiple functions in mineralized and nonmineralized tissues of vertebrates.Key words: SPARC, osteonectin, vertebrate expression.

LH and testosterone cause the development of seminiferous tubule contractile activity and the appearance of testicular oxytocin in hypogonadal mice

1986 ◽  
Vol 110 (1) ◽  
pp. 159-167 ◽  
Author(s):  
H. D. Nicholson ◽  
R. T. S. Worley ◽  
H. M. Charlton ◽  
B. T. Pickering
Keyword(s):  
Seminiferous Tubule ◽  
Adult Mouse ◽  
Contractile Activity ◽  
Normal Adult ◽  
Seminiferous Tubules ◽  
Releasing Hormone ◽  
Adult Mice ◽  
Low Levels ◽  
Lh Releasing Hormone ◽  
The Relationship

ABSTRACT Immunoreactive oxytocin is present in the testis and it has been shown that this hormone increases the contractility of seminiferous tubules. We have investigated the relationship between testicular oxytocin, tubular movements and the effects of LH and testosterone using, as a model, the hypogonadal (hpg/hpg) mouse, which is deficient in hypothalamic LH-releasing hormone (LHRH). Whilst both testicular oxytocin and seminiferous tubule movements, resembling those seen in the rat, can be found in normal adult mice, neither can be found in hypogonadal mice. After 2 weeks of treatment with LH (200 ng to 100 μg daily) low levels of testicular oxytocin and tubular movements were observed. Treatment with large doses of testosterone for 2–12 weeks led to higher concentrations of testicular oxytocin and tubular movements resembling those seen in the normal adult mouse. The results support the evidence that testicular oxytocin modulates seminiferous tubule movements. We suggest that testosterone may play a part in the accumulation of oxytocin in the testis. J. Endocr. (1986) 110, 159–167

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