scholarly journals Evolutionary toxicology: Toward a unified understanding of life's response to toxic chemicals

2017 ◽  
Vol 10 (8) ◽  
pp. 745-751 ◽  
Author(s):  
Steven P. Brady ◽  
Emily Monosson ◽  
Cole W. Matson ◽  
John W. Bickham
Keyword(s):  
Toxic Chemicals ◽  
Evolutionary Toxicology

Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

1987 ◽  
Vol 45 ◽  
pp. 718-719
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat
Keyword(s):  
Low Dose ◽  
Fetal Liver ◽  
Late Pregnancy ◽  
Toxic Chemicals ◽  
Control Group ◽  
High Dose ◽  
Over The Counter ◽  
Liver And Kidney ◽  
Neonatal Liver ◽  
Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

Rapid, Non-Toxic Synthesis of Beta Zeolites

2018 ◽  
Author(s):  
Felix Hemmann ◽  
Jonathan Hackebeil ◽  
Andreas Lißner ◽  
Florian Mertens
Keyword(s):  
Hydrofluoric Acid ◽  
Molecular Sieves ◽  
Toxic Chemicals ◽  
Lewis Acidity ◽  
Beta Zeolite ◽  
Seeded Growth ◽  
Related Research ◽  
Beta Zeolites ◽  
Growth Method ◽  
Fast Synthesis

Molecular sieves with beta zeolite topology are promising catalysts for various reactions as they exhibits extraordinary Lewis acidity. However, their industrial application and related research in academica is hindered because their synthesis is time consuming and typically involves toxic chemicals as hydrofluoric acid. Therefore, tetraethylammonium fluorid was tested as a non-toxic fluotide source for the synthesis of beta zeolites. In combination with the previously reported nano-seeded growth method, a fast synthesis of beta zeolites only involving non-toxic chemicals was possible. Synthesized zeolites show comparable selectivity in the Bayer-Villinger oxidation as conventional zeolites synthesized with hydrofluoric acid.<br>

Principles for construction of bioluminescent enzyme biotests for analysis of complex media

2019 ◽  
Vol 485 (2) ◽  
pp. 229-233
Author(s):  
V. P. Kalyabina ◽  
E. N. Esimbekova ◽  
I. G. Torgashina ◽  
K. V. Kopylova ◽  
V. A. Kratasyuk
Keyword(s):  
Fruits And Vegetables ◽  
Rapid Assessment ◽  
Test System ◽  
Maximum Sensitivity ◽  
Toxic Chemicals ◽  
Complex Media ◽  
Luminescent Bacterium ◽  
Chemical Safety ◽  
Minimal Impact

We formulated the principles of designing bioluminescent enzyme tests for assessing the quality of complex media which consist in providing the maximum sensitivity to potentially toxic chemicals at a minimal impact of uncontaminated complex media. The developed principles served as a basis for designing a new bioluminescent method for an integrated rapid assessment of chemical safety of fruits and vegetables which is based on using the luminescent bacterium enzymes (NAD(P)H:FMN oxidoreductase and luciferase) as a test system.

Chemical Hazards

2017 ◽  
Author(s):  
Michael Gochfeld ◽  
Robert Laumbach
Keyword(s):  
Heavy Metals ◽  
Carbon Monoxide ◽  
Target Organ ◽  
Toxic Chemicals ◽  
Detailed Understanding ◽  
Adverse Health Effects ◽  
Chemical Hazards ◽  
Environmental Properties ◽  
Organ Level ◽  
Source Use

Building on the principles of toxicology, this chapter describes chemicals by structure, source, use, mechanism of action, environmental properties, and target organ. Major advances in toxic effects include more detailed understanding of the mechanisms by which toxic chemicals damage receptors at the subcellular, cellular, and organ level. The chapter describes properties of various types of inorganic and organic chemicals and their adverse health effects. It discusses asphyxiants, such as carbon monoxide and hydrogen sulfide; heavy metals, such as lead, mercury, and cadmium; organic solvents, such as benzene and trichlorethylene; pesticides, including chlorinated hydrocarbons and organophosphates; and a variety of other toxic chemicals to which people are exposed in the home, community, or workplace environment. Several cases are presented to illustrate various concepts concerning chemical hazards in occupational and environmental health.

scholarly journals The Interactions of Absorptive Capacity, Buffer Inventory, and Toxic Emissions on Firm Value

2021 ◽  
Vol 18 (4) ◽  
pp. 1979
Author(s):  
Lik Man Daphne Yiu ◽  
Ka Yui Karl Wu
Keyword(s):  
Absorptive Capacity ◽  
Firm Value ◽  
Market Value ◽  
Organizational Capabilities ◽  
Toxic Chemicals ◽  
External Information ◽  
Sustainable Competitive Advantage ◽  
Toxic Emissions ◽  
Organizational Mechanism ◽  
Low Toxic

A significant amount of research has been conducted on the impacts of emissions reduction, absorptive capacity, and buffer inventory on firm performance. According to the resource-based view (RBV), absorptive capacity and buffer inventory are organizational capabilities and resources to create sustainable competitive advantages. Yet, the resource orchestration perspective (ROP) of the RBV emphasizes that firms need to develop a new capability to orchestrate and deploy their existing capabilities and resources. From an organizational learning perspective, firms with the low-level release of toxic chemicals have established a structured system and systematic organizational routines, strengthening their learning capabilities to share and use internal and external information across functional areas for continuous improvements. This study explores and seeks to understand toxic emissions through systematic operational routines as an organizational mechanism. These routines orchestrate and deploy the firm-specific absorptive capacity and buffer inventory to generate a sustainable competitive advantage. We examine the impacts of the absorptive capacity and buffer inventory on firm value in terms of Tobin’s Q, respectively. We also explore how such impacts are moderated by toxic emissions. Our results show that the absorptive capacity significantly enhances the market value of firms. However, the relationship between the buffer inventory and firm value is insignificant. Our additional analyses indicate that the impacts of the absorptive capacity and buffer inventory on the firm value are both significantly positive when firms release low toxic chemicals. Our results further suggest that firms can maximize their market value with a high absorptive capacity, high buffer inventory, and low toxic emissions.

A critical innovation of photocatalytic degradation for toxic chemicals and pathogens in air

2021 ◽  
Author(s):  
Phuoc Loc Truong ◽  
Alemayehu Kidanemariam ◽  
Juhyun Park
Keyword(s):  
Photocatalytic Degradation ◽  
Toxic Chemicals

scholarly journals Implication of ferroptosis in aging

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Maryam Mazhar ◽  
Ahmad Ud Din ◽  
Hamid Ali ◽  
Guoqiang Yang ◽  
Wei Ren ◽  
...  
Keyword(s):  
Cell Death ◽  
Neurological Disorders ◽  
Accelerated Aging ◽  
Underlying Mechanism ◽  
Toxic Chemicals ◽  
Whole Body ◽  
Regulated Cell Death ◽  
Age Related ◽  
The Subject ◽  
Conventional Cell

AbstractLife is indeed continuously going through the irreversible and inevitable process of aging. The rate of aging process depends on various factors and varies individually. These factors include various environmental stimuli including exposure to toxic chemicals, psychological stress whereas suffering with various illnesses specially the chronic diseases serve as endogenous triggers. The basic underlying mechanism for all kinds of stresses is now known to be manifested as production of excessive ROS, exhaustion of ROS neutralizing antioxidant enzymes and proteins leading to imbalance in oxidation and antioxidant processes with subsequent oxidative stress induced inflammation affecting the cells, tissues, organs and the whole body. All these factors lead to conventional cell death either through necrosis, apoptosis, or autophagy. Currently, a newly identified mechanism of iron dependent regulated cell death called ferroptosis, is of special interest for its implication in pathogenesis of various diseases such as cardiovascular disease, neurological disorders, cancers, and various other age-related disorders (ARD). In ferroptosis, the cell death occur neither by conventional apoptosis, necrosis nor by autophagy, rather dysregulated iron in the cell mediates excessive lipid peroxidation of accumulated lethal lipids. It is not surprising to assume its role in aging as previous research have identified some solid cues on the subject. In this review, we will highlight the factual evidences to support the possible role and implication of ferroptosis in aging in order to declare the need to identify and explore the interventions to prevent excessive ferroptosis leading to accelerated aging and associated liabilities of aging.

Mechanistic Insight into Charge and Energy Transfers of Luminescent Metal–Organic Frameworks Based Sensors for Toxic Chemicals

2021 ◽  
pp. 2000293
Author(s):  
Brij Mohan ◽  
Sandeep Kumar ◽  
Shixuan Ma ◽  
Hengzhi You ◽  
Peng Ren
Keyword(s):  
Metal Organic Frameworks ◽  
Toxic Chemicals ◽  
Mechanistic Insight ◽  
Energy Transfers ◽  
Metal Organic ◽  
Insight Into
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