Maternal exposure to tobacco smoke, alcohol and caffeine, and risk of anorectal atresia: National Birth Defects Prevention Study 1997-2003

The purpose of this study was to estimate the association between 2nd and 3rd degree hypospadias and maternal exposure to disinfection by-products (DBPs) using data from a large case-control study in the United States. Concentration estimates for total trihalomethanes (TTHMs), the sum of the five most prevalent haloacetic acids (HAA5), and individual species of each were integrated with data on maternal behaviors related to water-use from the National Birth Defects Prevention Study (NBDPS) to create three different exposure metrics: (1) household DBP concentrations; (2) estimates of DBP ingestion; (3) predicted uptake (i.e., internal dose) of trihalomethanes (THMs) via ingestion, showering, and bathing. The distribution of DBP exposure was categorized as follows: (Q1/referent) < 50%; (Q2) ≥ 50% to < 75%; and (Q3) ≥ 75%. Logistic regression was used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Generally, null associations were observed with increasing TTHM or HAA5 exposure. An increased risk was observed among women with household bromodichloromethane levels in the second quantile (aOR: 1.8; 95% CI: 1.2, 2.7); however, this association did not persist after the inclusion of individual-level water-use data. Findings from the present study do not support the hypothesis that maternal DBP exposures are related to the occurrence of hypospadias.

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Maternal exposure to outdoor air pollution and congenital limb deficiencies in the National Birth Defects Prevention Study

Environmental Research ◽

10.1016/j.envres.2019.108716 ◽

2019 ◽

Vol 179 ◽

pp. 108716 ◽

Cited By ~ 1

Author(s):

Giehae Choi ◽

Jeanette A. Stingone ◽

Tania A. Desrosiers ◽

Andrew F. Olshan ◽

Wendy N. Nembhard ◽

...

Keyword(s):

Air Pollution ◽

Birth Defects ◽

Maternal Exposure ◽

Outdoor Air ◽

Prevention Study ◽

Outdoor Air Pollution ◽

Congenital Limb ◽

Limb Deficiencies

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Hypospadias and maternal exposure to atrazine via drinking water in the National Birth Defects Prevention study

Environmental Health ◽

10.1186/s12940-016-0161-9 ◽

2016 ◽

Vol 15 (1) ◽

Cited By ~ 11

Author(s):

Jennifer J. Winston ◽

◽

Michael Emch ◽

Robert E. Meyer ◽

Peter Langlois ◽

...

Keyword(s):

Drinking Water ◽

Birth Defects ◽

Maternal Exposure ◽

Prevention Study

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Propensity score analysis of the association between maternal exposure to second-hand tobacco smoke and birth defects in Northwestern China

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174421000714 ◽

2022 ◽

pp. 1-8

Author(s):

Jing Li ◽

Yujiao Du ◽

Fengyi Qu ◽

Hui Jing ◽

Hong Yan ◽

...

Keyword(s):

Propensity Score ◽

Birth Defects ◽

Tobacco Smoke ◽

Circulatory System ◽

Maternal Exposure ◽

Shaanxi Province ◽

Sensitivity Analyses ◽

Control Group ◽

Exposure Group ◽

Shs Exposure

Abstract Previous studies have suggested that maternal active smoking can increase the risk of birth defects, but evidence on second-hand tobacco smoke (SHS) is limited. We aimed to assess the association between maternal exposure to SHS and birth defects in a Chinese population. The data were based on a large-scale cross-sectional survey conducted in Shaanxi Province, China. Considering the characteristics of survey design and the potential impact of confounding factors, we adopted propensity score matching (PSM) to match the SHS exposure group and the non-exposure group to attain a balance of the confounders between the two groups. Subsequently, conditional logistic regression was employed to estimate the effect of SHS exposure on birth defects. Furthermore, sensitivity analyses were conducted to verify the key findings. After nearest neighbor matching of PSM with a ratio of 2 and a caliper width of 0.03, there were 6,205 and 12,410 participants in the exposure and control group, respectively. Pregnant women exposed to SHS were estimated to be 58% more likely to have infants with overall birth defects (OR = 1.58, 95% CI: 1.30–1.91) and 75% more likely to have infants with circulatory system defects (OR = 1.75, 95% CI: 1.26–2.44). We also observed that the risk effect of overall birth defects had an increasing trend as the frequency of exposure increased. Additionally, sensitivity analyses suggested that our results had good robustness. These results indicate that maternal exposure to SHS likely increases the risk of overall birth defects, especially circulatory system defects, in Chinese offspring.

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Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study

Environmental Health Perspectives ◽

10.1289/ehp.1307289 ◽

2014 ◽

Vol 122 (8) ◽

pp. 863-872 ◽

Cited By ~ 57

Author(s):

Jeanette A. Stingone ◽

Thomas J. Luben ◽

Julie L. Daniels ◽

Montserrat Fuentes ◽

David B. Richardson ◽

...

Keyword(s):

Birth Defects ◽

Congenital Heart Defects ◽

Air Pollutants ◽

Congenital Heart ◽

Heart Defects ◽

Maternal Exposure ◽

Prevention Study ◽

Criteria Air Pollutants

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Demographic Characteristics, Care, and Outcomes for Children with Oral Clefts in Three States Using Participants from the National Birth Defects Prevention Study

The Cleft Palate-Craniofacial Journal ◽

10.1597/07-237.1 ◽

2009 ◽

Vol 46 (6) ◽

pp. 575-582 ◽

Cited By ~ 5

Author(s):

Peter Damiano ◽

Margaret Tyler ◽

Paul A. Romitti ◽

Charlotte Druschel ◽

April A. Austin ◽

...

Keyword(s):

Health Care ◽

New York ◽

Health Status ◽

Birth Defects ◽

Population Based ◽

Primary Objective ◽

Demographic Characteristics ◽

Prevention Study ◽

Care Needs ◽

Oral Clefts

Objective: The primary objective of this study was to evaluate whether there were differences in the characteristics and outcomes of care for children with oral clefts (OCs) among population-based samples in three states. Design: Data on the health status and on speech and esthetic outcomes were collected using structured telephone interviews conducted during 2005–2006 with mothers of children with OCs aged 2 to 7 in Arkansas, Iowa, and New York. Participants: Mothers of children born with nonsyndromic OCs on or after January 1, 1998, and on or before December 31, 2003, in Arkansas, Iowa, or New York. Subjects were identified through their participation in the ongoing National Birth Defects Prevention Study. Main Outcome Measures: Demographic characteristics, rating of cleft care, severity of condition, health status, esthetic outcomes, and speech problems were evaluated by state of residence. Results: Children with OCs from Arkansas were from lower income families, and their parents were less likely to be married. Children with OCs from Arkansas were more likely to have special health care needs and to require mental health care. Few differences were found across states in type of cleft, severity of cleft, or outcomes of cleft care. Conclusions: Combining results from population-based samples across multiple studies increases the variability of sample characteristics. Including multiple states can be an efficient way to learn more about the outcomes of medical care for less common conditions such as oral cleft.

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Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011

The Journal of Pediatrics ◽

10.1016/j.jpeds.2021.09.005 ◽

2021 ◽

Author(s):

Elijah H. Bolin ◽

Yevgeniya Gokun ◽

Paul A. Romitti ◽

Sarah C. Tinker ◽

April D. Summers ◽

...

Keyword(s):

Birth Defects ◽

Congenital Heart Defects ◽

Maternal Smoking ◽

Congenital Heart ◽

Heart Defects ◽

Prevention Study

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Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2021-107561 ◽

2021 ◽

pp. oemed-2021-107561

Author(s):

Miriam R Siegel ◽

Carissa M Rocheleau ◽

Kendra Broadwater ◽

Albeliz Santiago-Colón ◽

Candice Y Johnson ◽

...

Keyword(s):

Birth Defects ◽

Cleft Lip ◽

Population Based ◽

Small Samples ◽

Prevention Study ◽

Control Data ◽

Reproductive Effects ◽

Race Ethnicity ◽

Maternal Occupation ◽

Pregnancy And Birth

ObjectiveNail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investigated associations between selected birth defects and maternal occupation as a nail technician or hairdresser versus a non-cosmetology occupation during pregnancy.MethodsWe analysed population-based case–control data from the multisite National Birth Defects Prevention Study, 1997–2011. Cases were fetuses or infants with major structural birth defects; controls were live-born infants without major birth defects. Expert raters classified self-reported maternal jobs as nail technician, combination nail technician-hairdresser, hairdresser, other cosmetology work or non-cosmetology work. We used logistic regression to calculate adjusted ORs and 95% CIs for associations between occupation during pregnancy and birth defects, controlling for age, smoking, education and race/ethnicity.ResultsSixty-one mothers worked as nail technicians, 196 as hairdressers, 39 as combination nail technician-hairdressers and 42 810 as non-cosmetologists. The strongest associations among nail technicians included seven congenital heart defect (CHD) groups (ORs ranging from 2.7 to 3.5) and neural tube defects (OR=2.6, CI=0.8 to 8.4). Birth defects most strongly associated with hairdressing included anotia/microtia (OR=2.1, CI=0.6 to 6.9) and cleft lip with cleft palate (OR=2.0, CI=1.1 to 3.7). All oral cleft groups were associated with combination nail technician-hairdresser work (ORs ranging from 4.2 to 5.3).ConclusionsSmall samples resulted in wide CIs. Still, results suggest associations between maternal nail technician work during pregnancy and CHDs and between hairdressing work and oral clefts.

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Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997–2011

Public Health Nutrition ◽

10.1017/s1368980018002641 ◽

2018 ◽

Vol 22 (2) ◽

pp. 336-343

Author(s):

Renata H Benjamin ◽

Laura E Mitchell ◽

Mark A Canfield ◽

Adrienne T Hoyt ◽

Dejian Lai ◽

...

Keyword(s):

Preterm Birth ◽

Birth Defects ◽

Pregnancy Outcomes ◽

Fish Consumption ◽

Large Population ◽

Population Based ◽

Prevention Study ◽

Preparation Methods ◽

The Usa ◽

Early Preterm Birth

AbstractObjectiveTo evaluate the relationships between maternal fish consumption and pregnancy outcomes in a large, population-based sample of women in the USA.DesignWe collected average fish consumption prior to pregnancy using a modified version of the semi-quantitative Willett FFQ. We estimated adjusted OR (aOR) and 95 % CI for associations between different levels of fish consumption and preterm birth (<37 weeks), early preterm birth (<32 and <35 weeks) and small-for-gestational-age infants (SGA; <10th percentile).SettingThe National Birth Defects Prevention Study (NBDPS).SubjectsControl mother–infant pairs with estimated delivery dates between 1997 and 2011 (n 10 919).ResultsNo significant associations were observed between fish consumption and preterm birth or early preterm birth (aOR = 0·7–1·0 and 0·7–0·9, respectively). The odds of having an SGA infant were elevated (aOR = 2·1; 95 % CI 1·2, 3·4) among women with daily fish consumption compared with women consuming fish less than once per month. No associations were observed between other levels of fish consumption and SGA (aOR = 0·8–1·0).ConclusionsHigh intake of fish was associated with twofold higher odds of having an SGA infant, while moderate fish consumption prior to pregnancy was not associated with preterm or SGA. Our study, like many other studies in this area, lacked information regarding preparation methods and the specific types of fish consumed. Future studies should incorporate information on nutrient and contaminant contents, preparation methods and biomarkers to assess these relationships.

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