The effect of obesity and smoking status on lung age in Japanese men

Background: Asymmetric dimethylarginine (ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it remains unclear whether ADMA levels are related to the risk of stroke in the general Japanese population. Methods and Results: In this cross-sectional study, we examined 769 Japanese men (mean, 47 ± 5 years) who underwent health examinations. Each patient’s ADMA level and various vascular risk factors were assessed, and the predicted 10-year risk of stroke was calculated using the point-based prediction model for incident total stroke for Japanese from the Japan Public Health Center Study. In a multiple linear regression analysis, age, body mass index, estimated glomerular filtration rate, and current smoking status were significant independent determinants of the ADMA level. A significant odds ratio (OR) for high predicted stroke risk (10-year risk ≥ 5%) was noted in the highest quartile of ADMA level (OR, 2.47; 95% CI, 1.00-6.07) as compared to the lowest quartile, even after adjusting for potential confounding factors. A significant OR for high predicted stroke risk was also found for each standard-deviation increment in ADMA level (adjusted OR, 1.46; 95% CI, 1.10-1.92). Conclusions: An elevated ADMA level was significantly associated with an increase in predicted stroke risk, suggesting that the measurement of ADMA level may be useful for identifying middle-aged Japanese men at high risk for stroke.

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Abstract P060: A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers’ Cohort Study

Circulation ◽

10.1161/circ.135.suppl_1.p060 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Yuanying Li ◽

Hiroshi Yatsuya ◽

Yoshihisa Hirakawa ◽

Atsuhiko Ota ◽

Masaaki Matsunaga ◽

...

Keyword(s):

Prediction Model ◽

Prediction Models ◽

Smoking Status ◽

Fasting Blood Glucose ◽

Japanese Men ◽

Family History Of Diabetes ◽

Current Smoking Status ◽

History Of

Objective: Preventive services including screening for diabetes and its potential risk factorsare available to more Americans under Obamacare Preventive Care. Stratifying individuals by the predicted risk of developing type 2 diabetes mellitus (T2DM) would be useful for improving public health with efficient interventions. Although a number of T2DM prediction models have been reported, there is little evidence in East Asians, especially that from long-term follow-up studies. They are reported to have lower ability of innate insulin secretion and develop diabetes at much lower body mass index (BMI) than Caucasians and African Americans. Thus, this study aims to develop a point-based prediction model for 10-year risk of developing T2DM incidence in middle-aged Japanese men. Method: We followed 3,540 males in a worksite in Japan who were aged 35-64 years and free of diabetes in 2002 until March 31, 2015. Relationships of baseline age (continuous), BMI (<23, 23- <25 [reference category (Ref)], 25- <27.5, ≥27.5 kg/m 2 ), current smoking status (yes, no [Ref]), alcohol consumption(0 [Ref], <23, 23- <46, ≥46 g/day), regular exercise of a moderate or higher intensity, an interval of ≥3 days per week, and a duration of ≥30 minutes per time (yes [Ref], no), medication use for dyslipidemia (yes, no [Ref]), family history of diabetes (having the first degree’s relatives with diabetes, not having [Ref]), serum triglycerides (<150 [Ref], ≥150 mg/dl), high density lipoprotein cholesterol(≥40 [Ref], <40 mg/dl), and fasting blood glucose (<100 [Ref], 100- <110, 110- <126 mg/dl) with incidence of T2DM were examined by Cox proportional hazard model. Variables significantly associated with T2DM (p<0.10) in the univariate models were simultaneously entered into a multivariate model, and backward variable selection procedure was done to determine the final multivariate model. Points were assigned for each predictor according to the method used in the Framingham Study. Result: During the median follow-up of 12.2 years, 342 males developed T2DM. The point-based model employing BMI, current smoking status, family history of diabetes, and blood levels of triglycerides and fasting blood glucose showed reasonable discrimination (c-statistics: 0.73) and goodness of fit (Hosmer-Lemeshow p=0.22). Conclusion: Our point-based prediction model showed applicability in terms of identifying middle-aged Japanese men at high risk of developing T2DM. The present findings warrants further investigations to determine whether using the point-based prediction models is effective to reduce T2DM incidence.

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Smoking status and endothelial function in Japanese men

Scientific Reports ◽

10.1038/s41598-020-80012-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Haruki Hashimoto ◽

Tatsuya Maruhashi ◽

Takayuki Yamaji ◽

Takahiro Harada ◽

Yiming Han ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Endothelial Function ◽

Vascular Function ◽

Reference Group ◽

Smoking Status ◽

Critical Role ◽

Heavy Smoker ◽

Japanese Men ◽

Light Smoker ◽

Never Smoker

AbstractIt is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoking status and endothelial function in detail in men. We measured flow-mediated vasodilation (FMD) in 2209 Japanese men including 1181 men who had never smoked and 1028 current smokers. All of the participants were divided into five groups by smoking pack-years: never smoker group (= 0), light smoker group (> 0 to 10), moderate smoker group (> 10 to 20), heavy smoker group (> 20 to 30) and excessive smoker group (> 30). FMD significantly decreased in relation to pack-years (6.6 ± 3.4% in the never smoker group, 6.8 ± 3.0% in the light smoker group, 6.5 ± 2.9% in the moderate smoker group, 5.9 ± 2.9% in the heavy smoker group, and 4.9 ± 2.7% in the excessive smoker group; P < 0.001). After adjustment for age (≥ 65 years), body mass index, systolic blood pressure, low-density lipoprotein cholesterol, glucose, and year of recruitment, FMD was significantly smaller in the excessive smoker group than in the never smoker group as a reference group (OR 1.95, 95% CI 1.42 to 2.67; P < 0.001). These findings suggest that FMD decreases with an increase in the number of cigarettes smoked and that excessive smoking is associated with endothelial dysfunction. Cigarette smoking is harmful to vascular function in men who are heavy smokers.

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Dietary Inflammatory Index Is Associated With Inflammation in Japanese Men

Frontiers in Nutrition ◽

10.3389/fnut.2021.604296 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ayaka Kotemori ◽

Norie Sawada ◽

Motoki Iwasaki ◽

Taiki Yamaji ◽

Nitin Shivappa ◽

...

Keyword(s):

Screening Program ◽

Smoking Status ◽

Geometric Mean ◽

Low Grade ◽

Dietary Inflammatory Index ◽

Japanese Men ◽

Men And Women ◽

Inflammatory Index ◽

Inflammatory Status ◽

Hs Crp

Background: Dietary components are known to affect chronic low-grade inflammation status. The dietary inflammatory index (DII®) was developed to measure the potential impact of a diet on an individual's inflammatory status, and it has been validated mainly in Western countries.Objective: This study aimed to examine the validity of the energy-adjusted DII (E-DIITM) using high-sensitivity C-reactive protein (hs-CRP) concentration in Japanese men and women.Methods: In total, 6,474 volunteers from a cancer-screening program (3,825 men and 2,649 women) completed a food frequency questionnaire (FFQ) and their hs-CRP concentrations were evaluated. E-DII scores were calculated on the basis of 30 food parameters derived from the FFQ. Higher E-DII scores reflect a greater pro-inflammatory potential of the diet. The associations between E-DII quartiles and hs-CRP concentration were assessed using regression models adjusted for age, body mass index, smoking status, and amount of physical activity.Results: Mean E-DII in men and women was + 0.62 ± 1.93 and −1.01 ± 2.25, respectively. The proportion of men and women who had hs-CRP concentration >3 mg/L was 4.7 and 3.1%, respectively. A significant positive association was observed between E-DII score and hs-CRP concentration in men; geometric mean of hs-CRP concentration in the lowest and highest E-DII quartiles was 0.56 mg/L and 0.67 mg/L (Ptrend < 0.01), respectively. The odds ratio (95% confidence interval) of having an elevated hs-CRP concentration (>3 mg/L) was 1.72 (1.10–2.67) in the highest E-DII quartile (Ptrend = 0.03) in men. However, no association was observed between E-DII score and hs-CRP concentration in women, except in those not taking prescription medications.Conclusions: DII was associated with inflammation status in Japanese men, but the association was limited in Japanese women.

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The Association of Lung Age with Smoking Status in Korean Men

Korean Journal of Family Medicine ◽

10.4082/kjfm.2014.35.1.35 ◽

2014 ◽

Vol 35 (1) ◽

pp. 35 ◽

Cited By ~ 1

Author(s):

Hye Young Oh ◽

Hong Soo Lee ◽

Sang Wha Lee ◽

Kyung Won Shim ◽

Hyejin Chun ◽

...

Keyword(s):

Smoking Status ◽

Lung Age

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Abstract P308: γ-Glutamyltransferase and Mortality from Cardiovascular Disease: EPOCH-JAPAN

Circulation ◽

10.1161/circ.125.suppl_10.ap308 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Yuanying Li ◽

Hiroyasu Iso ◽

Renze Cui ◽

Shinya Nagasawa ◽

Yoshitaka Murakami ◽

...

Keyword(s):

Cardiovascular Disease ◽

Coronary Heart Disease ◽

Heart Disease ◽

Smoking Status ◽

Cardiovascular Prevention ◽

Health Examination ◽

Multivariable Model ◽

Japanese Men ◽

Men And Women ◽

Cvd Mortality

Background: Recently, γ-Glutamyltransferase (γ-GTP) has been positively associated with risk of cardiovascular disease (CVD), especially among non-drinkers. But the evidence is limited in Asian populations. The present study investigated the association between γ-GTP with mortality from ischemic stroke, hemorrhagic stroke and coronary heart disease in Japanese men and women, and further in non-drinkers. Methods: A total of 41,040 Japanese (men/women: 15,987/25,053) aged 40-79 years with no self-reported history of CVD at baseline from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) which is a pooled analysis comprising 13 well-qualified Japanese cohorts for examining the relationship between health examination measures and CVD mortality. Sex-specific hazard ratios(HRs) and their 95% confident intervals(CIs) of CVD mortality for one-standardized deviation increment of log-transformed γ-GTP were calculated by Cox hazard models, adjusting for age (continuous), smoking status (never, past, 1–20/day and ≥21/day), drinking status (never, past and current), and sex-specific quintiles of body mass index, triglycerides, total cholesterol, systolic blood pressure, aspartate transaminase and alanine transaminase in multivariable model. Results: During an average 8.7-year follow-up, there were 314 (146 men and 168 women) deaths from stroke, 154 (101men and 53 women) deaths from coronary heart disease, and 701 (361 men and 340 women) deaths from total CVD. A significant association was found in the multivariable model between γ-GTP and mortality form stroke and total CVD in men, and mortality from coronary heart disease and total CVD in women. The respective multivariable HRs (95% CI) were 1.36 (1.13–1.65) and 1.17 (1.03–1.33) in men, and 1.76 (1.36–2.28) and 1.33 (1.19–1.49) in women. Because the proportion of current drinkers was 73% in men and 29% in women, we further examined the associations in non-drinkers. The respective multivariable HRs (95% CI) were 1.58 (1.08–2.31) and 1.42 (1.13–1.80) in male non-drinkers and 1.72 (1.28–2.33) and 1.32 (1.16–1.51) in female non-drinkers. Conclusions: γ-GTP was positively associated with CVD mortality in both Japanese men and women, specifically in non-drinkers.

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