Transfer of Metacognitive Skills and Hint Seeking in Monkeys

2007 ◽  
Vol 18 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Nate Kornell ◽  
Lisa K. Son ◽  
Herbert S. Terrace
Keyword(s):  
Cognitive Processes ◽  
Nonhuman Primates ◽  
Rhesus Macaques ◽  
Memory Task ◽  
Perceptual Task ◽  
Metacognitive Skills ◽  
Trial And Error ◽  
Confidence Judgments ◽  
First Time ◽  
Metacognitive Ability

Metacognition is knowledge that can be expressed as confidence judgments about what one knows (monitoring) and by strategies for learning what one does not know (control). Although there is a substantial literature on cognitive processes in animals, little is known about their metacognitive abilities. Here we show that rhesus macaques, trained previously to make retrospective confidence judgments about their performance on perceptual tasks, transferred that ability immediately to a new perceptual task and to a working memory task. We also show that monkeys can learn to request “hints” when they are given problems that they would otherwise have to solve by trial and error. This study demonstrates, for the first time, that nonhuman primates share with humans the ability to monitor and transfer their metacognitive ability both within and between different cognitive tasks, and to seek new knowledge on a need-to-know basis.

scholarly journals Sensorimotor conflicts alter perceptual and action monitoring

2018 ◽  
Author(s):  
Nathan Faivre ◽  
Laurene Vuillaume ◽  
Fosco Bernasconi ◽  
Roy Salomon ◽  
Olaf Blanke ◽  
...  
Keyword(s):  
Cognitive Processes ◽  
Perceptual Task ◽  
First Person ◽  
Intentional Binding ◽  
Action Monitoring ◽  
Confidence Judgments ◽  
Person Perspective ◽  
First Person Perspective

Bodily self-consciousness is defined as a set of prereflective representations of integrated bodily signals giving rise to self-identification, self-location and first-person perspective. While bodily self-consciousness is known to modulate perception, little is known about its influence on higher-level cognitive processes. Here, we manipulated bodily self-consciousness by applying sensorimotor conflicts while participants performed a perceptual task followed by confidence judgments. Results showed that sensorimotor conflicts altered perceptual monitoring by decreasing metacognitive performance. In a second experiment, we replicated this finding and extended our results by showing that sensorimotor conflicts also altered action monitoring, as measured implicitly through intentional binding. In a third experiment, we showed that effects on perceptual monitoring were induced specifically by sensorimotor conflicts related to the trunk and not to the hand. Taken together, our results suggest that bodily self-consciousness may serve as a scaffold for perceptual and action monitoring.

scholarly journals Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates

2020 ◽  
Vol 117 (45) ◽  
pp. 28452-28462 ◽  
Author(s):  
Alizée Lopez-Persem ◽  
Léa Roumazeilles ◽  
Davide Folloni ◽  
Kévin Marche ◽  
Elsa F. Fouragnan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Processes ◽  
Nonhuman Primates ◽  
Rhesus Macaques ◽  
Reward Processing ◽  
Functional Specialization ◽  
Related Activity ◽  
Left And Right ◽  
Lesion Studies ◽  
The Right

The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using resting-state and reward-related functional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion showing the highest reward-related asymmetry (RRA) overlapped with the region showing the highest functional connectivity asymmetry (FCA). Furthermore, the two types of asymmetries were found to be significantly correlated across individuals. In both species, the right lateral OFC was more connected to the default mode network compared to the left lateral OFC. Altogether, our results suggest a functional specialization of the left and right lateral OFC in primates.

scholarly journals Clindamycin Protects Nonhuman Primates Against Inhalational Anthrax But Does Not Enhance Reduction of Circulating Toxin Levels When Combined With Ciprofloxacin

2020 ◽  
Author(s):  
Nicholas J Vietri ◽  
Steven A Tobery ◽  
Donald J Chabot ◽  
Susham Ingavale ◽  
Brandon C Somerville ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Protective Antigen ◽  
Rhesus Macaques ◽  
Lethal Factor ◽  
Toxin Production ◽  
Protein Synthesis Inhibitors ◽  
Anthrax Lethal Factor ◽  
Bacillus Anthracis Spores ◽  
Combination Antibiotics ◽  
First Time

Abstract Background Inhalational anthrax is rare and clinical experience limited. Expert guidelines recommend treatment with combination antibiotics including protein synthesis-inhibitors to decrease toxin production and increase survival, although evidence is lacking. Methods Rhesus macaques exposed to an aerosol of Bacillus anthracis spores were treated with ciprofloxacin, clindamycin, or ciprofloxacin + clindamycin after becoming bacteremic. Circulating anthrax lethal factor and protective antigen were quantitated pretreatment and 1.5 and 12 hours after beginning antibiotics. Results In the clindamycin group, 8 of 11 (73%) survived demonstrating its efficacy for the first time in inhalational anthrax, compared to 9 of 9 (100%) with ciprofloxacin, and 8 of 11 (73%) with ciprofloxacin + clindamycin. These differences were not statistically significant. There were no significant differences between groups in lethal factor or protective antigen levels from pretreatment to 12 hours after starting antibiotics. Animals that died after clindamycin had a greater incidence of meningitis compared to those given ciprofloxacin or ciprofloxacin + clindamycin, but numbers of animals were very low and no definitive conclusion could be reached. Conclusion Treatment of inhalational anthrax with clindamycin was as effective as ciprofloxacin in the nonhuman primate. Addition of clindamycin to ciprofloxacin did not enhance reduction of circulating toxin levels.

The Role of Perfectionism and Autobiographical Memory in a Sample of Parasuicide Patients

Crisis ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 64-72 ◽  
Author(s):  
Susan A. Rasmussen ◽  
Rory C. O’Connor ◽  
Dallas Brodie
Keyword(s):  
Suicidal Ideation ◽  
Autobiographical Memory ◽  
Memory Task ◽  
Self Report ◽  
Hierarchical Regression ◽  
Overgeneral Autobiographical Memory ◽  
Socially Prescribed Perfectionism ◽  
Hopelessness Depression ◽  
Self Harm ◽  
First Time

The main objective of this study was to investigate the relationship between social perfectionism, overgeneral autobiographical memory recall, and psychological distress (hopelessness, depression/anxiety, and suicidal ideation) in a sample of parasuicide patients. Forty patients who had been admitted to a Scottish hospital following an episode of deliberate self-harm participated in the study. The participants completed the autobiographical memory task and a battery of self-report measures (multidimensional perfectionism, hopelessness, depression/anxiety, and suicidal ideation). The results showed that repetitive self-harmers were more overgeneral in their recall of positive autobiographical memories than were first-time self-harmers. Hierarchical regression analyses showed that socially prescribed perfectionism interacted with overgeneral recall of both positive and negative memories to predict suicidal ideation/depression. The findings are discussed in relation to previous research.

Self-Regulation and Human Progress

2018 ◽  
Author(s):  
Evan Osborne
Keyword(s):  
Scientific Method ◽  
Mutual Influence ◽  
Free Market ◽  
Self Regulation ◽  
Free Expression ◽  
Trial And Error ◽  
Human History ◽  
Economic Context ◽  
The Right ◽  
First Time

Does humanity progress primarily through leaders organizing and directing followers, or through trial and error by individuals free to chart their own path? For most of human history ruling classes had the capacity and the desire to tightly regiment society, to the general detriment of progress. But beginning in the 1500s, Europeans developed a series of arguments for simply leaving well enough alone. First in the form of the scientific method, then in the form of free expression, and finally in the form of the continuously, spontaneously reordered free market, people began to accept that progress is hard, and requires that an immense number of mistakes be tolerated so that we may learn from them. This book tells the story of the development of these three ideas, and for the first time tells of the mutual influence among them. It outlines the rise, and dramatic triumph, of each of these self-regulating systems, followed by a surprising rise in skepticism, especially in the economic context. Such skepticism in the 20th century was frequently costly and sometimes catastrophic. Under the right conditions, which are more frequent than generally believed, self-regulating systems in which participants organize themselves are superior. We should accept their turbulence in exchange for the immense progress they generate.

scholarly journals Experiential and Strategic Emotional Intelligence Are Implicated When Inhibiting Affective and Non-Affective Distractors: Findings from Three Emotional Flanker N-Back Tasks

2021 ◽  
Vol 9 (1) ◽  
pp. 12
Author(s):  
Ming D. Lim ◽  
Damian P. Birney
Keyword(s):  
Working Memory ◽  
Emotional Intelligence ◽  
Experimental Evidence ◽  
Cognitive Processes ◽  
Response Times ◽  
Memory Task ◽  
Low Load ◽  
Affective Information ◽  
Accuracy Rates

Emotional intelligence (EI) refers to a set of competencies to process, understand, and reason with affective information. Recent studies suggest ability measures of experiential and strategic EI differentially predict performance on non-emotional and emotionally laden tasks. To explore cognitive processes underlying these abilities further, we varied the affective context of a traditional letter-based n-back working-memory task. In study 1, participants completed 0-, 2-, and 3-back tasks with flanking distractors that were either emotional (fearful or happy faces) or non-emotional (shapes or letters stimuli). Strategic EI, but not experiential EI, significantly influenced participants’ accuracy across all n-back levels, irrespective of flanker type. In Study 2, participants completed 1-, 2-, and 3-back levels. Experiential EI was positively associated with response times for emotional flankers at the 1-back level but not other levels or flanker types, suggesting those higher in experiential EI reacted slower on low-load trials with affective context. In Study 3, flankers were asynchronously presented either 300 ms or 1000 ms before probes. Results mirrored Study 1 for accuracy rates and Study 2 for response times. Our findings (a) provide experimental evidence for the distinctness of experiential and strategic EI and (b) suggest that each are related to different aspects of cognitive processes underlying working memory.

scholarly journals Brain hemodynamic response in Examiner–Examinee dyads during spatial short-term memory task: an fNIRS study

2021 ◽  
Author(s):  
Francesco Panico ◽  
Stefania De Marco ◽  
Laura Sagliano ◽  
Francesca D’Olimpio ◽  
Dario Grossi ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Processes ◽  
Short Term Memory ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Task ◽  
Neural Correlates ◽  
Short Term ◽  
Term Memory ◽  
The Real

AbstractThe Corsi Block-Tapping test (CBT) is a measure of spatial working memory (WM) in clinical practice, requiring an examinee to reproduce sequences of cubes tapped by an examiner. CBT implies complementary behaviors in the examiners and the examinees, as they have to attend a precise turn taking. Previous studies demonstrated that the Prefrontal Cortex (PFC) is activated during CBT, but scarce evidence is available on the neural correlates of CBT in the real setting. We assessed PFC activity in dyads of examiner–examinee participants while completing the real version of CBT, during conditions of increasing and exceeding workload. This procedure allowed to investigate whether brain activity in the dyads is coordinated. Results in the examinees showed that PFC activity was higher when the workload approached or reached participants’ spatial WM span, and lower during workload conditions that were largely below or above their span. Interestingly, findings in the examiners paralleled the ones in the examinees, as examiners’ brain activity increased and decreased in a similar way as the examinees’ one. In the examiners, higher left-hemisphere activity was observed suggesting the likely activation of non-spatial WM processes. Data support a bell-shaped relationship between cognitive load and brain activity, and provide original insights on the cognitive processes activated in the examiner during CBT.

scholarly journals A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

2015 ◽  
Vol 7 (290) ◽  
pp. 290ra90-290ra90 ◽  
Author(s):  
Fabiano Oliveira ◽  
Edgar Rowton ◽  
Hamide Aslan ◽  
Regis Gomes ◽  
Philip A. Castrovinci ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Nonhuman Primates ◽  
Mononuclear Cells ◽  
Rhesus Macaques ◽  
Parasite Burden ◽  
Salivary Protein ◽  
Sand Fly ◽  
Protein Vaccine ◽  
Peripheral Blood Mononuclear ◽  
Phlebotomus Duboscqi

Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly–exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4+IFN-γ+ lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.

Realistic hardening-to-softening transition effects of metals over the finite strain range up to failure

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Zi-Han Xu ◽  
Lin Zhan ◽  
Si-Yu Wang ◽  
Hui-Feng Xi ◽  
Heng Xiao
Keyword(s):  
Finite Strain ◽  
Plastic Work ◽  
Uniaxial Tensile ◽  
Uniaxial Tensile Test ◽  
Trial And Error ◽  
Content Type ◽  
Transition Effects ◽  
Iterative Procedures ◽  
First Time ◽  
Hardening And Softening

PurposeA new approach is proposed toward accurately matching any given realistic hardening and softening data from uniaxial tensile test up to failure and moreover, toward bypassing usual tedious implicit trial-and-error iterative procedures in identifying numerous unknown parameters.Design/methodology/approachFinite strain response features of metals with realistic hardening-to-softening transition effects up to eventual failure are studied for the first time based on the self-consistent elastoplastic J2-flow model with the logarithmic stress rate. As contrasted with usual approximate and incomplete treatments merely considering certain particular types of hardening effects such as power type hardening, here a novel and explicit approach is proposed to obtain a complete form of the plastic-work-dependent yield strength over the whole hardening and softening range.FindingsA new multi-axial evolution equation for both hardening and softening effects is established in an explicit form. Complete results for the purpose of model validation and prediction are presented for the finite strain responses of monotonic uniaxial stretching up to failure.Originality/valueNew finite strain elastoplastic equations are established with a new history-dependent variable equivalently in place of the usual plastic work. With these equations, a unified and accurate simulation of both gardening and softening effects up to failure is achieved for the first time in an explicit sense without involving usual tedious implicit trial-and-error iterative procedures.

scholarly journals Plasma Derived Exosomal Biomarkers of Exposure to Ionizing Radiation in Nonhuman Primates

2018 ◽  
Vol 19 (11) ◽  
pp. 3427 ◽  
Author(s):  
Amrita Cheema ◽  
Charles Hinzman ◽  
Khyati Mehta ◽  
Briana Hanlon ◽  
Melissa Garcia ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Nonhuman Primates ◽  
Rhesus Macaques ◽  
Ultra Performance Liquid Chromatography ◽  
Molecular Signature ◽  
Detection And Identification ◽  
Molecular Events ◽  
Plasma Metabolome ◽  
Radiation Induced ◽  
Hydroxyl Fatty Acids

Exposure to ionizing radiation induces a cascade of molecular events that ultimately impact endogenous metabolism. Qualitative and quantitative characterization of metabolomic profiles is a pragmatic approach to studying the risks of radiation exposure since it provides a phenotypic readout. Studies were conducted in irradiated nonhuman primates (NHP) to investigate metabolic changes in plasma and plasma-derived exosomes. Specifically, rhesus macaques (Macaca mulatta) were exposed to cobalt-60 gamma-radiation and plasma samples were collected prior to and after exposure to 5.8 Gy or 6.5 Gy radiation. Exosomes were isolated using ultracentrifugation and analyzed by untargeted profiling via ultra-performance liquid chromatography mass spectrometry (UPLC-MS) based metabolomic and lipidomic analyses, with the goal of identifying a molecular signature of irradiation. The enrichment of an exosomal fraction was confirmed using quantitative ELISA. Plasma profiling showed markers of dyslipidemia, inflammation and oxidative stress post-irradiation. Exosomal profiling, on the other hand, enabled detection and identification of low abundance metabolites that comprise exosomal cargo which would otherwise get obscured with plasma profiling. We discovered enrichment of different classes of metabolites including N-acyl-amino acids, Fatty Acid ester of Hydroxyl Fatty Acids (FAHFA’s), glycolipids and triglycerides as compared to the plasma metabolome composition with implications in mediation of systemic response to radiation induced stress signaling.

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