Histamine Metabolism in Polycythaemia Vera

2009 ◽  
Vol 15 (1) ◽  
pp. 45-57 ◽  
Author(s):  
Jan Westin ◽  
Göran Granerus ◽  
Aleksander Weinfeld ◽  
Hakon Wetterquist
Keyword(s):  
Polycythaemia Vera ◽  
Histamine Metabolism

Chronisch myeloproliferative Erkrankungen bei Kindern und Jugendlichen

2004 ◽  
Vol 04 (01) ◽  
pp. 25-30 ◽  
Author(s):  
Meinolf Suttorp
Keyword(s):  
Polycythaemia Vera ◽  
Pädiatrische Patienten ◽  
Myeloproliferative Erkrankungen ◽  
Myeloische Leukämie ◽  
Chronisch Myeloische Leukämie ◽  
Somatische Mutation ◽  
Hämatopoetische Stammzelle ◽  
Essenzielle Thrombozythämie ◽  
Who Klassifikation

ZusammenfassungAls chronisch myeloproliferative Erkrankungen (CMPE) werden die essenzielle Thrombozythämie (ET), die Polycythaemia vera (PV), die idiopathische Myelofibrose (IM) und die chronisch myeloische Leukämie (CML) zusammengefasst. Gemeinsame Ursache ist eine primäre somatische Mutation, welche eine hämatopoetische Stammzelle mit einem klonalen Proliferationsvorteil ausstattet. Die einzelnen Entitäten sind durch die Proliferation von einer oder mehreren myeloischen Zellreihen (Granulopoese, Erythropoese oder Megakarypoese) mit relativ normaler, effektiver Ausreifung charakterisiert. Der Nachweis des Philadelphia-Chromosoms trennt die CML scharf von den anderen CMPE ab. Die extreme Seltenheit einiger Entitäten und zum Teil Schwierigkeiten bei der Klassifikation bedingen für pädiatrische Patienten schwankende Angaben zur Inzidenz von 0,05-0,40 pro 100 000. Eine moderne WHO-Klassifikation der CMPE wurde in den letzten Jahren für die internistische Hämatologie etabliert, welcher auch die pädiatrische Einteilung folgt.

Histamine metabolism disorder in pathogenesis of chronic pelvic pain in patients with external genital endometriosis

2017 ◽  
pp. 56-60
Author(s):  
М.Р. Оразов ◽  
В.Е. Радзинский ◽  
М.Б. Хамошина ◽  
Е.Н. Носенко ◽  
Э.С. Токаева ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pelvic Pain ◽  
Peripheral Blood ◽  
Chronic Pelvic Pain ◽  
Pain Syndrome ◽  
Histamine Level ◽  
Life Assessment ◽  
Assay Method ◽  
Histamine Metabolism

Цель исследования - изучение особенностей обмена гистамина при хронической тазовой боли у пациенток с наружным генитальным эндометриозом. Методика. В сыворотке крови 100 пациенток методом высокоточного (в нг/мл) иммуноферментного твердофазного анализа определяли концентрацию гистамина. Использованы реактивы «Histamine ЕLISA», аппарат BAE-1000 Гистамин (Labor Diagnostika Nord - LDN, Германия). Оценка выраженности болевого синдрома осуществлялась по шкале ВАШ, оценка качества жизни - на основании опросника для оценки качества жизни при эндометриозе (EHR-30), оценка тревожности - опросника Спилбергера-Ханина. Результаты. Показано статистически значимое повышение уровня гистамина у пациенток с высокой интенсивностью болевого синдрома. Женщины с наружным генитальным эндометриозом, сопровождающимся интенсивным болевым синдромом в 100% случаев обнаруживали высокие уровни ситуативной и личностной тревожности, тогда как, лишь у 40% женщин (n = 16) контрольной группы выявлен умеренный уровень тревожности. Депрессивные расстройства выявлены у 58,3% женщин с хронической тазовой болью (n = 35), из них основную часть (n = 20) составили женщины с выраженной степенью болевого синдрома по ВАШ. Заключение. Психоэмоциональное состояние женщин с тазовой болью, ассоциированной с наружным генитальным эндометриозом, характеризуется высокими уровнями депрессивных и тревожных расстройств, значительным снижением уровня качества жизни. Выявлена прямая связь между интенсивностью болевого синдрома и уровнем гистамина в периферической крови пациенток с наружным генитальным эндометриозом. Objective. To study features of histamine metabolism in patients with chronic pelvic pain associated with external genital endometriosis. Methods. For quantitative assessment of histamine level in peripheral blood was taken from 100 patients which than was centrifuged. In blood serum histamine concentration was determined by enzyme-linked immunosorbent assay method with reagents «Histamine ЕLISA» on the machine BAE-1000 Histamine (Labor Diagnostika Nord - LDN, Hermany). A pain syndrome was assessed by Visual Analog Scale (VAS), quality of life assessment - by Endometriosis Health Profile Questionnaire (EHR-30), level of anxiety was determined by Spielberger-Khanin questionnaire. The results. Showed statistically higher histamine level in patients with severe pain according to VAS. After assessment of results obtained from Spielberger-Khanin questionnaire 100% experimental group’s women with external genital endometriosis (n = 60) were noted to be have high level of state and trait anxiety, then 40% women of control group (n = 16) have moderate level of anxiety. The incidence of depression in women with chronic pelvic pain was 58.3% (n = 35) and the main part (n = 20) were women with severe stage of pelvic pain according to VAS. Conclusions. Psycho emotional condition of women with external genital endometriosis associated pelvic pain characterized by higher depression and anxiety levels, with significant decrease quality of life. Direct relationship also was found between pain syndrome intensity and histamine level in peripheral blood in patients with external genital endometriosis.

scholarly journals JAK-Inhibitoren für die Behandlung hämatoonkologischer Erkrankungen

2020 ◽  
Vol 45 (06) ◽  
pp. 559-567
Author(s):  
Torsten Steinbrunn ◽  
Josip Zovko ◽  
Sabrina Kraus
Keyword(s):  
Phase Iii ◽  
Polycythaemia Vera ◽  
Jak Inhibitor ◽  
Graft Versus Host ◽  
Pharmakologische Behandlung

ZusammenfassungDie konstitutive Aktivierung des JAK-STAT-Signalwegs ist charakteristisch für die Pathogenese der myeloproliferativen Neoplasien, speziell der primären Myelofibrose, der Polycythaemia vera und der essentiellen Thrombozythämie. Die Einführung von oral verfügbaren JAK-Inhibitoren in die Klinik brachte einen entscheidenden Fortschritt für die pharmakologische Behandlung der Myelofibrose und der Polycythaemia vera, wenngleich damit noch keine Heilung verbunden ist. Im Vordergrund steht die Verbesserung der Lebensqualität der meist älteren Patienten durch Kontrolle krankheitsbedingter konstitutioneller Symptome, Reduktion einer bestehenden Splenomegalie und Vermeidung insbesondere von thromboembolischen Folgekomplikationen. Darüber hinaus kann die Therapie von Myelofibrose-Patienten mit JAK-Inhibitoren jedoch auch deren Krankheitsverlauf verlangsamen und ihr Gesamtüberleben verlängern. Der bislang einzige in Europa zugelassene JAK-Inhibitor Ruxolitinib hemmt die Isoformen JAK1 und JAK2 und besitzt sowohl antiinflammatorisches als auch antiproliferatives Potenzial. Damit zeigt dieser Inhibitor überdies eine gute Wirkung in der Therapie der Graft-versus-Host-Erkrankung nach allogener hämatopoetischer Stammzelltransplantation. Mit Fedratinib, Pacritinib und Momelatinib befinden sich derzeit 3 weitere vielversprechende JAK-Inhibitoren mit etwas unterschiedlichen Wirkprofilen in der klinischen Phase III-Testung. Diese zeigen auch bei Patienten mit unwirksamer oder unverträglicher Vorbehandlung mit Ruxolitinib Wirksamkeit, sodass eine kontinuierliche Weiterentwicklung der entsprechenden Therapiestrategien abzusehen ist.

scholarly journals RING N METHYLATION; A MAJOR ROUTE OF HISTAMINE METABOLISM

1956 ◽  
Vol 221 (1) ◽  
pp. 307-313
Author(s):  
Richard W. Schayer ◽  
S.A. Karjala ◽  
K. Jane Davis ◽  
Rosa L. Smiley
Keyword(s):  
Histamine Metabolism ◽  
Major Route

Role of erythrocytes and platelets in the hypercoagulable status in polycythemia vera through phosphatidylserine exposure and microparticle generation

2013 ◽  
Vol 109 (06) ◽  
pp. 1025-1032 ◽  
Author(s):  
Chunyan Gao ◽  
Xue Yang ◽  
Jianan Li ◽  
Wei Wang ◽  
Jinxiao Hou ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Blood Cells ◽  
Significant Inhibition ◽  
Polycythaemia Vera ◽  
Factor V ◽  
Healthy Controls ◽  
Clotting Time ◽  
Thrombotic Risk ◽  
Few Data

SummaryThe development of thrombosis in polycythaemia vera (PV) involves multifactorial processes including pathological activation of blood cells. Release of microparticles (MPs) by activated cells in diseases is associated with thrombotic risk, but relatively few data are available in PV. The aim of the present study was to investigate the increase in MP release and exposure of phosphatidylserine (PS) on the outer membrane of MP-origin cells in patients with PV, and to analyse their procoagulant activity (PCA). PS-positive MPs and cells were detected by flow cytometry, while PCA was assessed with clotting time and purified coagulation complex assays. We found that PV patients had elevated circulating lactadherin+ MPs, which mostly originating from erythrocytes, platelets, granulocytes, and endothelial cells, as well as increased PS exposing erythrocytes/platelets as compared to secondary polycythaemia patients or healthy controls. These PS-bearing MPs and cells were highly procoagulant. Moreover, lactadherin competed factor V and VIII to PS and inhibited about 90% of the detected PCA in a dose-response manner while anti-TF antibody did no significant inhibition. Treatment with hydroxyurea is associated with a decrease in PS exposure and lactadherin+ MP release of erythrocytes/platelets. Our data demonstrate that PV patients are characterised by increased circulating procoagulant MPs and PS exposing erythrocytes/platelets, which could contribute to the hypercoagulable state in these patients.

Histamine metabolism is altered in nasal polyposis

2004 ◽  
Vol 53 (0) ◽  
pp. S93-S94
Author(s):  
A. Falus ◽  
A. Hirschberg ◽  
Zs. Darvas ◽  
A. J�k�ti ◽  
H. Schwellberger ◽  
...  
Keyword(s):  
Nasal Polyposis ◽  
Histamine Metabolism

Effects of Guanethidine and Related Compounds on Histamine Excretion

1972 ◽  
Vol 50 (6) ◽  
pp. 539-544 ◽  
Author(s):  
J. LeBlanc ◽  
J. Côté ◽  
F. Doré ◽  
S. Rousseau
Keyword(s):  
Peritoneal Fluid ◽  
Fold Increase ◽  
Female Rats ◽  
Male Rats ◽  
Daily Injection ◽  
Histamine Metabolism ◽  
Methyl Transferase ◽  
Single Intraperitoneal Injection ◽  
Urinary Histamine ◽  
Related Compounds

The basic nature of guanethidine and some of its effects suggested a possible action of this drug on histamine metabolism. A single intraperitoneal injection of guanethidine (10 mg/kg) in male rats was found to double the daily urinary excretion of free histamine; daily injection for three weeks caused a 10-fold increase. In male rats, guanethidine increased the number of mast cells in the peritoneal fluid and, in both peritoneal fluid and mesentery, caused a significant degranulation of these cells; this action was not observed in female rats. This finding may indicate that guanethidine blocks methylation of histamine by inhibiting imidazole methyl transferase since this enzyme is found in male but not in female rats. Bethanidine and reserpine had no effect on histamine excretion. Imidazole was found to be even more potent than guanethidine in causing an increase in urinary histamine. Guanethidine and imidazole neither potentiated nor mimicked the action of histamine on the isolated ileum.

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