scholarly journals Diabetes duration and obesity matter in autologous mesenchymal stem/stromal cell transplantation in type 2 diabetes patients

2021 ◽  
Author(s):  
Joonyub Lee ◽  
Kun‐Ho Yoon
Keyword(s):  
Type 2 Diabetes ◽  
Cell Transplantation ◽  
Stromal Cell ◽  
Diabetes Duration ◽  
Diabetes Patients

scholarly journals The Association Between Age at Diagnosis of Type 2 Diabetes and Albuminuria in Chinese Adults

2020 ◽  
Author(s):  
Shujing Wu ◽  
Shanshan Liu ◽  
Zhiyun Zhao ◽  
Mian Li ◽  
Tiange Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Duration ◽  
Age At Diagnosis ◽  
Diabetes Diagnosis ◽  
Chinese Adults ◽  
Younger Age ◽  
Study Sites ◽  
Normal Controls ◽  
Diabetes Patients

Abstract Background: Type 2 diabetes is increasingly diagnosed at a younger age worldwide and in China. Limited data are available regarding the association between age at diabetes diagnosis and risks of albuminuria, which is a common microvascular complication in diabetes patients. In addition, few studies on age at diagnosis and outcomes have fully accounted for the complex interplay between age at diagnosis and the actual age or diabetes duration, all of which are independently associated with vascular risks.Methods: We used data from a nationwide multicenter study with 207,961 participants recruited from 25 communities across mainland China during 2010-2012. Age, sex, and study sites were matched for 31,366 screen-detected type 2 diabetes and 31,366 normal controls. Age, sex, study sites, and diabetes duration were matched for 7,490 self-reported type 2 diabetes and 7,490 normal controls. Risks of having albuminuria in matched type 2 diabetes vs. normal controls were examined using multivariable logistic regression analysis in strata of age at type 2 diabetes diagnosis (<50, 50-59, 60-69, or ≥70 years). Albuminuria was defined as urinary albumin-to-creatinine ratio ≥30 mg/g.Results: Percentages of albuminuria were significantly higher among type 2 diabetes patients compared with normal controls in each stratum of age at diagnosis. Although the absolute rate of albuminuria is higher in older adults, the odds ratio of albuminuria in type 2 diabetes vs. matched controls decreased with increasing age at diagnosis. For participants with diabetes diagnosed at an age of <50, 50-59, 60-69, or ≥70 years, the multivariable adjusted risk of albuminuria increased by 81%, 60%, 45%, and 33% for screen-detected diabetes, and 135%, 121%, 90%, and 58% for self-reported diabetes compared with their normal controls, respectively. Conclusions: A younger age at diagnosis of type 2 diabetes is associated with a more significantly elevated risk of albuminuria than an older age at diagnosis in Chinese adults.

scholarly journals National Eye Institute Visual Function Scale in Type 2 Diabetes Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Sezen Akkaya ◽  
Sinay Düzova ◽  
Özlem Şahin ◽  
Haluk Kazokoğlu ◽  
Tayfun Bavbek
Keyword(s):  
Type 2 Diabetes ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Diabetes Duration ◽  
Ophthalmological Examination ◽  
Near Vision ◽  
Snellen Visual Acuity ◽  
Clinically Significant ◽  
Diabetes Patients

Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages.Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divided into 5 groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale (ICDRS).Results. The diabetes duration in general health scores (p=0.029); the stage (p=0.011); and clinically significant macular edema (CSME) (p=0.019) in general vision were found to be the most efficient factors. In near vision activities the most efficient factors were near vision acuity (NVA) (p=0.0001) and DRP stage (p=0.020). EDTRS visual acuity was found to be the most efficient factor in vision specific role difficulties (p=0.034) and dependency (p=0.011) whereas Snellen visual acuity was found to be among the most effective factors in distance activities (DA) (p=0.014) and total scores (p=0.026).Discussion. Difference was based not on the diabetes duration, clinically significant cataract (CSCat), CSME presence, and DRP stage but on thevisual acuitylevels of the better seeing eye of the patients.

scholarly journals Correlation between kidney and peripheral nerve functions in Type 2 diabetes

QJM ◽  
2019 ◽  
Author(s):  
Y-R Lai ◽  
B-C Cheng ◽  
C-C Huang ◽  
W-C Chiu ◽  
N-W Tsai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Kidney Diseases ◽  
Medical Center ◽  
Linear Regression Analysis ◽  
Diabetes Duration ◽  
Diabetic Patients ◽  
The Impact ◽  
Diabetes Patients

Abstract Background Although greater impairments in nerve functions parameters are most likely to occur with a lower kidney function, there is a paucity of information on the relationship between the kidney and peripheral nerve functions parameters in Type 2 diabetes. Aim To address the impact of peripheral nerve functions in Type 2 diabetes patients in different stages of chronic kidney diseases (CKD). Design This prospective study enrolled 238 patients with Type 2 diabetes at a tertiary medical center. Method We designed composite amplitude scores of nerve conductions (CAS) as a measure of severity of peripheral neuropathy (PN), and used estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) parameters to stage CKD in Type 2 diabetes patients. The intrapersonal mean, standard deviation and coefficient of variation of eGFR for 238 patients were obtained in the 3 years prior to the study. Results The patients who had lower eGFR and higher UACR were older, with longer diabetes duration, a greater percentage of retinopathy and PN and higher CAS. Multiple linear regression analysis revealed that diabetes duration and eGFR were independently associated with CAS, and a cut-off value of eGFR in the presence of PN was 65.3 ml/min/1.73 m2. Conclusion We observed a close relationship between the severity of kidney and peripheral nerve function in patients with diabetes. If a patient’s eGFR value is below 65.3 ml/min/1.73 m2 or the UACR value is above 98.6 mg/dl, caution is needed with the presence of PN even in diabetic patients who are asymptomatic.

Serum Ferritin Status of Patients with Type 2 DM Attending OPD of BIRDEM General Hospital

2020 ◽  
Vol 11 (1) ◽  
pp. 7-10
Author(s):  
Khadiza Begum ◽  
Fahmida Islam ◽  
Farjana Aktar ◽  
Murshida Aziz ◽  
Tohfa E Ayub Tahiya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Study Groups ◽  
Acute Phase Reactant ◽  
The Body ◽  
Iron Stores ◽  
Normal Healthy Individual ◽  
Diabetes Patients

Background: In recent times much is talked about of serum ferritin, an acute phase reactant a marker of iron stores in the body and its association with diabetes mellitus. Studies implicate that increased body iron stores and subclinical hemochromatosis has been associated with the development of glucose intolerance, type 2 diabetes and its micro as well as macrovascular complications. Material & Methods: This study was carried out to examine and to observe for any relationship between serum ferritin with Type 2 diabetes mellitus. Our study populations were included 163. Among them 81 type 2 diabetes patients as a case (M=49,F=32, mean 44.68 age in years)and 82 normal healthy individual as a control ( M=35, F=47 , mean 34.71 in years). Results: Majority were healthy outpatients who had come for regular checkup and were matched with controls. Serum ferritin and FBS were estimated and other investigations. Results showed that although Serum ferritin was in the normal range value it was increased in type 2 diabetes patients than in controls and was statistically significant, we did get a positive correlation with duration of diabetes. It can be concluded that there were positive associations between serum ferritin and FBG, age, sex among study groups. Conclusion: In conclusion our study shows that there is significant correlation between increased serum ferritin in diabetes compared to individuals with normal blood sugars in this part and hyper ferritinemia may be one of the causes for development of insulin resistance before overt diabetes. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 7-10

Clinical and safety profile of empagliflozin in nepalese type 2 diabetes patients

2020 ◽  
Author(s):  
Ansumali Joshi ◽  
Priyadarshini Yonzon ◽  
Luna Thapa ◽  
Ritika Karki
Keyword(s):  
Type 2 Diabetes ◽  
Safety Profile ◽  
Diabetes Patients
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