Djulis supplementation against oxidative stress and ultraviolet radiation‐induced cell damage: The influence of antioxidant status and aging of skin in healthy subjects

2021 ◽  
Author(s):  
Tsung‐Yi Tsai ◽  
Rong‐Jyh Lin ◽  
Cheng Liu ◽  
Ya‐Ping Tseng ◽  
Leong‐Perng Chan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ultraviolet Radiation ◽  
Healthy Subjects ◽  
Antioxidant Status ◽  
Cell Damage ◽  
Radiation Induced

Parameters of protection against ultraviolet radiation-induced skin cell damage

2009 ◽  
Vol 220 (2) ◽  
pp. 277-284 ◽  
Author(s):  
Cong Cao ◽  
Yinsheng Wan
Keyword(s):  
Ultraviolet Radiation ◽  
Cell Damage ◽  
Skin Cell ◽  
Radiation Induced

scholarly journals Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 836 ◽  
Author(s):  
Jinjoo Lee ◽  
Myung In Jeong ◽  
Hyo-Rim Kim ◽  
Hyejin Park ◽  
Won-Kyoung Moon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plant Extracts ◽  
Cell Damage ◽  
Antioxidant Properties ◽  
B Cell Lymphoma ◽  
Cancer Therapies ◽  
Cancer Proliferation ◽  
Monocyte Chemoattractant Protein 1 ◽  
Radiation Induced ◽  
Factor Α

Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.

Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation – hospital-based study

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Towseef Amin Rafeeqi ◽  
Farhat Jabeen ◽  
M A Waheed ◽  
Gulam Mohammed Husain ◽  
Alokananda Chakraborthy
Keyword(s):  
Oxidative Stress ◽  
Healthy Subjects ◽  
Skin Disorder ◽  
Antioxidant Status ◽  
The Body ◽  
Oxygen Species ◽  
Statistical Significant Difference ◽  
Significant Difference ◽  
Gpx Activity

AbstractBackgroundVitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.MethodsHerein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.ResultsThere was significant difference in the parameters viz., SOD (p<0.001) and CAT (p<0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.ConclusionsThe results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.

scholarly journals Effects of oral vitamin E and β-carotene supplementation on ultraviolet radiation–induced oxidative stress in human skin

2004 ◽  
Vol 80 (5) ◽  
pp. 1270-1275 ◽  
Author(s):  
Frank McArdle ◽  
Lesley E Rhodes ◽  
Richard AG Parslew ◽  
Graeme L Close ◽  
Catherine IA Jack ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Ultraviolet Radiation ◽  
Human Skin ◽  
Oral Vitamin ◽  
Radiation Induced ◽  
Β Carotene

Radioprotective effect of Curcuma longa extract on γ-irradiation-induced oxidative stress in rats

2012 ◽  
Vol 90 (4) ◽  
pp. 415-423 ◽  
Author(s):  
Ahmed S. Nada ◽  
Asrar M. Hawas ◽  
Nour El-Din Amin ◽  
Magdy M. Elnashar ◽  
Zakaria Y. Abd Elmageed
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Antioxidant Status ◽  
Curcuma Longa ◽  
Radioprotective Effect ◽  
Male Rats ◽  
Sublethal Dose ◽  
Γ Irradiation ◽  
Protein Levels ◽  
Radiation Induced

This study was conducted to evaluate the modulatory effect of aqueous extract of Curcuma longa (L.) against γ-irradiation (GR), which induces biochemical disorders in male rats. The sublethal dose of GR was determined in primary hepatocytes. Also, the effect of C. longa extract was examined for its activity against GR. In rats, C. longa extract was administered daily (200 mg/kg body mass) for 21 days before, and 7 days after GR exposure (6.5 Gy). The lipid profile and antioxidant status, as well as levels of transaminases, interleukin-6 (IL-6), and tumour necrosis factor α (TNFα) were assessed. The results showed that in hepatocytes, the aqueous extract exhibited radioprotective activity against exposure to GR. Exposure of untreated rats to GR resulted in transaminase disorders, lipid abnormalities, elevation of lipid peroxidation, trace element alterations, release of IL-6 and TNF, and decrease in glutathione and protein level of superoxide dismutase-1 (SOD-1) and peroxiredoxin-1 (PRDX-1). However, treatment of rats with this extract before and after GR exposure improved antioxidant status and minimized the radiation-induced increase in inflammatory cytokines. Changes occurred in the tissue levels of trace elements, and the protein levels of SOD-1 and PRDX-1 were also modulated by C. longa extract. Overall, C. longa exerted a beneficial radioprotective effect against radiation-induced oxidative stress in male rats by alleviating pathological disorders and modulating antioxidant enzymes.

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

2011 ◽  
Vol 301 (4) ◽  
pp. L415-L426 ◽  
Author(s):  
Yasuhiro Terasaki ◽  
Ikuroh Ohsawa ◽  
Mika Terasaki ◽  
Mikiko Takahashi ◽  
Shinobu Kunugi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Damage ◽  
A549 Cells ◽  
Lung Damage ◽  
Epithelial Cell Line ◽  
Type Iii Collagen ◽  
Treatment Groups ◽  
Human Lung Epithelial Cell ◽  
Spin Resonance ◽  
Radiation Induced

Molecular hydrogen (H2) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from damaging effects of irradiation, we investigated the possibility that H2 could serve as a radioprotector in the lung. Cells of the human lung epithelial cell line A549 received 10 Gy irradiation with or without H2 treatment via H2-rich PBS or medium. We studied the possible radioprotective effects of H2 by analyzing ROS and cell damage. Also, C57BL/6J female mice received 15 Gy irradiation to the thorax. Treatment groups inhaled 3% H2 gas and drank H2-enriched water. We evaluated acute and late-irradiation lung damage after H2 treatment. H2 reduced the amount of irradiation-induced ROS in A549 cells, as shown by electron spin resonance and fluorescent indicator signals. H2 also reduced cell damage, measured as levels of oxidative stress and apoptotic markers, and improved cell viability. Within 1 wk after whole thorax irradiation, immunohistochemistry and immunoblotting showed that H2 treatment reduced oxidative stress and apoptosis, measures of acute damage, in the lungs of mice. At 5 mo after irradiation, chest computed tomography, Ashcroft scores, and type III collagen deposition demonstrated that H2 treatment reduced lung fibrosis (late damage). This study thus demonstrated that H2 treatment is valuable for protection against irradiation lung damage with no known toxicity.

Empetrum nigrum var. japonicum Extract Suppresses γ-Ray Radiation-Induced Cell Damage via Inhibition of Oxidative Stress

2011 ◽  
Vol 39 (01) ◽  
pp. 161-170 ◽  
Author(s):  
Ki Cheon Kim ◽  
In Kyung Lee ◽  
Kyoung Ah Kang ◽  
Bum Joon Kim ◽  
Daeshin Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Modification ◽  
Cell Damage ◽  
Membrane Lipid ◽  
Mitogen Activated Protein Kinase ◽  
Γ Radiation ◽  
Empetrum Nigrum ◽  
Mitogen Activated Protein ◽  
Radiation Induced ◽  
Cellular Dna

The ethylacetate fraction of Empetrum nigrum var. japonicum (ENE) was shown to reduce intracellular reactive oxygen species (ROS) generated by γ-radiation and activate antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and gluthathion peroxidase (GPx). ENE protected cells against radiation-induced cellular DNA damage, membrane lipid peroxidation, and protein modification, which are the main points of radiation-induced damage. In addition, ENE recovered cell viability by inhibiting apoptosis after cells were treated with radiation. ENE treatment also reduced γ-radiation induced Bax, and caspase 9 and 3 expression in irradiated cells. However, irradiated cells with ENE recovered Bcl-2 expression, which was reduced by radiation. This anti-apoptotic effect of ENE was due to the inhibition of mitogen-activated protein kinase kinase-4 (MKK4/SEK1)-c-Jun NH2-terminal kinase (JNK) cascades induced by γ-radiation. In summary, these results suggest that ENE protects cells against γ-radiation-induced oxidative stress via the reduction of ROS and attenuation of apoptosis.

Assessment of DNA damage profile and oxidative/antioxidative biomarkers level in patients with inflammatory bowel disease

2020 ◽  
Vol 92 (4) ◽  
pp. 1-5
Author(s):  
Małgorzata Mrowicka ◽  
Jerzy Mrowicki ◽  
Michał Mik ◽  
Łukasz Dziki ◽  
Adam Dziki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Bowel Disease ◽  
Dna Damage ◽  
Bowel Disease ◽  
Healthy Subjects ◽  
Antioxidant Status ◽  
Oxidative Dna Damage ◽  
Spectrophotometric Methods ◽  
Inflammatory Bowel ◽  
Repair Genes

Aim: The purpose of this study was to investigate the oxidative DNA damage, pro- antioxidant status in Polish patients with inflammatory bowel disease (IBD). Method: Oxidative DNA damage were measured by comet assay techniques; nitric oxide (NO) and plasmatic lipid peroxidation (MDA) as oxidative stress were valuated by colometric methods; superoxide dismutase (SOD1), catalase (CAT) and glutathione peroxidase (GPx1) as antioxidative defence were determined by spectrophotometric methods. Results: The level of oxidative DNA damage in IBD patients was significantly higher in relation to controls (P = 0.01). Alike, in control subject as well as in patients with IBD, lymphocytes are characterized by complete repair of DNA damage. A significant decrease of SOD (P = 0.031), CAT (P = 0.006), GPx1 (P = 0.001) activity was seen in IBD patients vs control. MDA (P = 0.001) and NO (P = 0.001) concentrations were significantly increased in IBD patients than in healthy subjects. Conclusion: Our results may be due to induction of DNA repair genes may occur at the stage of the pathological changes pathway (IBD), that may be caused by excessive oxidative stress. However, the reasons for these relationship, and whether it is direct or indirect, remains to be explored.

scholarly journals Inhibitory Effects of Shimotsu-to, a Traditional Chinese Herbal Prescription, on Ultraviolet Radiation-Induced Cell Damage and Prostaglandin E2 Release in Cultured Swiss 3T3 Cells

1998 ◽  
Vol 118 (6) ◽  
pp. 241-247 ◽  
Author(s):  
Katsuya SAKUMA ◽  
Masayuki OGAWA ◽  
Mitsutoshi KIMURA ◽  
Katsumi YAMAMOTO ◽  
Masahiko OGIHARA
Keyword(s):  
Ultraviolet Radiation ◽  
Cell Damage ◽  
Prostaglandin E ◽  
Inhibitory Effects ◽  
3T3 Cells ◽  
Chinese Herbal ◽  
Radiation Induced ◽  
Swiss 3T3 ◽  
Herbal Prescription
Sign in / Sign up

Export Citation Format

Share Document