Antitumour metastasis and the antiangiogenic and antitumour effects of a Eimeria stiedae soluble protein

Structural and physiological responses of chrysanthemum to repeated osmotic stress were studied. Plants were cultured for 2 weeks (for each stress1 and stress 2) on half MS supplemented with mannitol 100 mM (Treatment I) and 200 mM (Treatment II). First stress inhibited growth parameters stronger than second stress in treatment I. In treatment II both stress events strongly inhibited growth parameters of micro‐shoots. Proline content exceeded control 6 ‐ 8 times after 1st stress, and 2 ‐ 5 times after the 2nd stress in treatments I and II, respectively. Soluble protein was accumulated in leaves during both stress exposures, and 2 ‐ 2.5 times exceeded control after the 2nd stress. Relative water content in both treatments increased after the 2nd stress exposure. In treatment II chlorophyll а and carotenoids contents were 8.78 and 4.62 mg/g comparing to control (4.21 and 2.25 mg/g, respectively) after the 1st stress. But after the 2nd stress there was no difference with control.Plant Tissue Cult. & Biotech. 27(2): 161-169, 2017 (December)

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Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity

International Journal of Molecular Sciences ◽

10.3390/ijms22094953 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4953

Author(s):

Natalie M. Zahr ◽

Kilian M. Pohl ◽

Allison J. Kwong ◽

Edith V. Sullivan ◽

Adolf Pfefferbaum

Keyword(s):

White Matter ◽

Proinflammatory Cytokines ◽

Soluble Protein ◽

Subcortical White Matter ◽

Control Group ◽

White Matter Volume ◽

Brain Volumes ◽

Protein Levels ◽

Matter Volume ◽

Patient Groups

Classical inflammation in response to bacterial, parasitic, or viral infections such as HIV includes local recruitment of neutrophils and macrophages and the production of proinflammatory cytokines and chemokines. Proposed biomarkers of organ integrity in Alcohol Use Disorders (AUD) include elevations in peripheral plasma levels of proinflammatory proteins. In testing this proposal, previous work included a group of human immunodeficiency virus (HIV)-infected individuals as positive controls and identified elevations in the soluble proteins TNFα and IP10; these cytokines were only elevated in AUD individuals seropositive for hepatitis C infection (HCV). The current observational, cross-sectional study evaluated whether higher levels of these proinflammatory cytokines would be associated with compromised brain integrity. Soluble protein levels were quantified in 86 healthy controls, 132 individuals with AUD, 54 individuals seropositive for HIV, and 49 individuals with AUD and HIV. Among the patient groups, HCV was present in 24 of the individuals with AUD, 13 individuals with HIV, and 20 of the individuals in the comorbid AUD and HIV group. Soluble protein levels were correlated to regional brain volumes as quantified with structural magnetic resonance imaging (MRI). In addition to higher levels of TNFα and IP10 in the 2 HIV groups and the HCV-seropositive AUD group, this study identified lower levels of IL1β in the 3 patient groups relative to the control group. Only TNFα, however, showed a relationship with brain integrity: in HCV or HIV infection, higher peripheral levels of TNFα correlated with smaller subcortical white matter volume. These preliminary results highlight the privileged status of TNFα on brain integrity in the context of infection.

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Gibberellic acid and nitrogen efficiently protect early seedlings growth stage from salt stress damage in Sorghum

Scientific Reports ◽

10.1038/s41598-021-84713-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Adam Yousif Adam Ali ◽

Muhi Eldeen Hussien Ibrahim ◽

Guisheng Zhou ◽

Nimir Eltyb Ahmed Nimir ◽

Aboagla Mohammed Ibrahim Elsiddig ◽

...

Keyword(s):

Chlorophyll Content ◽

Seedling Growth ◽

Soluble Protein ◽

Dry Weight ◽

Sod Activity ◽

Seedling Length ◽

Relative Water ◽

Emergence Percentage ◽

Negative Impacts ◽

Stress Damage

AbstractSalinity one of environmental factor that limits the growth and productivity of crops. This research was done to investigate whether GA3 (0, 144.3, 288.7 and 577.5 μM) and nitrogen fertilizer (0, 90 and 135 kg N ha−1) could mitigate the negative impacts of NaCl (0, 100, and 200 mM NaCl) on emergence percentage, seedling growth and some biochemical parameters. The results showed that high salinity level decreased emergence percentage, seedling growth, relative water content, chlorophyll content (SPAD reading), catalase (CAT) and peroxide (POD), but increased soluble protein content, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. The SOD activity was decreased by nitrogen. However, the other measurements were increased by nitrogen. The interactive impact between nitrogen and salinity was significant in most parameters except EP, CAT and POD. The seedling length, dry weight, fresh weight, emergence percentage, POD, soluble protein and chlorophyll content were significantly affected by the interaction between GA3 and salinity. The GA3 and nitrogen application was successful mitigating the adverse effects of salinity. The level of 144.3 and 288.7 μm GA3 and the rate of 90 and 135 kg N ha−1 were most effective on many of the attributes studied. Our study suggested that GA3 and nitrogen could efficiently protect early seedlings growth from salinity damage.

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