Functional modulation of an aquaporin to intensify photosynthesis and abrogate bacterial virulence in rice

2021 ◽  
Author(s):  
Xiaochen Chen ◽  
Jinbiao Ma ◽  
Xuan Wang ◽  
Kai Lu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Bacterial Virulence ◽  
Functional Modulation

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Characterization and functional modulation of HBV-specific CD4+ T cell responses

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
F Jacobi ◽  
T Flecken ◽  
R Thimme ◽  
T Boettler
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Functional Modulation

scholarly journals Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation

2020 ◽  
Author(s):  
Kaat Schroven ◽  
Abram Aertsen ◽  
Rob Lavigne
Keyword(s):  
Small Molecules ◽  
Bacterial Infections ◽  
Bacterial Virulence ◽  
Arms Race ◽  
Control Mechanisms ◽  
Human Pathogens ◽  
Vaccine Candidates ◽  
Cargo Proteins ◽  
Genes Encoding ◽  
Mutualistic Relationship

ABSTRACT Bacteria-infecting viruses (phages) and their hosts maintain an ancient and complex relationship. Bacterial predation by lytic phages drives an ongoing phage-host arms race, whereas temperate phages initiate mutualistic relationships with their hosts upon lysogenization as prophages. In human pathogens, these prophages impact bacterial virulence in distinct ways: by secretion of phage-encoded toxins, modulation of the bacterial envelope, mediation of bacterial infectivity and the control of bacterial cell regulation. This review builds the argument that virulence-influencing prophages hold extensive, unexplored potential for biotechnology. More specifically, it highlights the development potential of novel therapies against infectious diseases, to address the current antibiotic resistance crisis. First, designer bacteriophages may serve to deliver genes encoding cargo proteins which repress bacterial virulence. Secondly, one may develop small molecules mimicking phage-derived proteins targeting central regulators of bacterial virulence. Thirdly, bacteria equipped with phage-derived synthetic circuits which modulate key virulence factors could serve as vaccine candidates to prevent bacterial infections. The development and exploitation of such antibacterial strategies will depend on the discovery of other prophage-derived, virulence control mechanisms and, more generally, on the dissection of the mutualistic relationship between temperate phages and bacteria, as well as on continuing developments in the synthetic biology field.

Interference of quorum sensing regulated bacterial virulence factors and biofilms by Plumbago zeylanica extract

2021 ◽  
Author(s):  
Faizan Abul Qais ◽  
Iqbal Ahmad ◽  
Fohad Mabood Husain ◽  
Suliman Y. Alomar ◽  
Naushad Ahmad ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Virulence Factors ◽  
Bacterial Virulence ◽  
Plumbago Zeylanica
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