Impact of blood storage duration on hematologic, blood gas, biochemical, and oxidative stress variables in sheep undergoing allogeneic blood transfusions

2020 ◽  
Author(s):  
Rejane S. Sousa ◽  
Antonio H. H. Minervino ◽  
Francisco Leonardo C. Oliveira ◽  
Carolina Akiko Sato C. Araújo ◽  
Frederico Augusto M. L. Rodrigues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Allogeneic Blood ◽  
Blood Transfusions ◽  
Blood Gas ◽  
Blood Storage ◽  
Storage Duration ◽  
And Oxidative Stress

scholarly journals Effect of continuous administration of low-medium flow oxygen for non-ventilated lung during one lung ventilation surgery on blood gas analysis and oxidative stress response in lung tissue of tumor patient：A randomized controlled trial

2020 ◽  
Author(s):  
Tang-Jing Wu ◽  
Jia Zhan ◽  
Jian-Juan Ke ◽  
Zong-Ze Zhang ◽  
Yan-Lin Wang
Keyword(s):  
Oxidative Stress ◽  
Lung Tissue ◽  
Lung Ventilation ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
One Lung Ventilation ◽  
Continuous Administration ◽  
Medium Flow ◽  
And Oxidative Stress

Abstract Background: One-lung ventilation (OLV) induces hypoxia during the operation and oxidative stress to the non-ventilated lung (NVL) which may cause acute lung injury (ALI). Aims: We sought to find out whether continuous administration of low-medium flow oxygen for NVL during OLV can mitigate the oxidative stress in lung tissue of patient. Methods: After local Ethics Committee approval and informed consent, we randomly allocated fifty-seven patients scheduled for elective pulmonary tumor resection. The F14 tube was placed at 2-3cm beyond the carina of trachea in the NVL at the time of the beginning of the OLV in group O, administrating continuously with oxygen. Blood samples were taken from radial artery and internal jugular vein simultaneously for blood gas analysis, immediately after induction of anesthesia (T 1 ), 30min (T 2 ), 1h (T 3 ) and 2h (T 4 ) after OLV. Lung tissue was taken 5cm distant from the tumor for determination of superoxide dismutase(SOD) and malondialdehyde(MDA), and expression of heme oxygenase-1(HO-1) . Result: Compared with group C, the PaO 2 was significantly increased at T 2-4 and the PaCO 2 was significantly decreased at T 2,3 , the PvO 2 was significantly increased at T 2,3 and the PvCO 2 was significantly decreased at T 2-4 , the lung concentration of MDA was significantly lower and the local expression level of HO-1 in lung was significantly elevated in group O （ P <0.05）. Conclusion: The administration of continuous low-medium flow oxygen for NVL during OLV has shown the effect of pulmonary protection. The possible mechanism is related with the inhibition of the oxidative stress response in lung tissue.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress

2014 ◽  
Vol 17 (5) ◽  
pp. 271 ◽  
Author(s):  
Murat Bicer ◽  
Tunay Senturk ◽  
Murat Yanar ◽  
Ahmet Tutuncu ◽  
Arzu Yilmaztepe Oral ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemia Reperfusion ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Cabg Surgery ◽  
Off Pump ◽  
Pump Cabg ◽  
Hs Crp ◽  
And Oxidative Stress

<strong>Background</strong>: It has been suggested that off-pump coronary<br />artery bypass grafting (CABG) surgery reduces myocardial<br />ischemia-reperfusion injury, postoperative systemic<br />inflammatory response, and oxidative stress. The aim of this<br />study was to measure serum malondialdehyde (MDA), highsensitivity<br />C-reactive protein (hs-CRP), M30, and M65 levels<br />and to investigate the relationship between M30 levels and<br />oxidative stress and inflammation in patients undergoing onand<br />off-pump CABG surgery.<br /><strong>Methods</strong>: Fifty patients were randomly assigned to onpump<br />or off-pump CABG surgery (25 patients off-pump and<br />25 on-pump CABG surgery), and blood samples were collected<br />prior to surgery, and 30 minutes, 60 minutes, 6 hours,<br />and 24 hours after CABG surgery.<br /><strong>Results</strong>: Compared to the on-pump group, serum MDA<br />levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after<br />the CABG surgery were significantly lower in the off-pump<br />group (P = .001, P = .001, P = .001, and P = .001, respectively).<br />Serum M30 levels were found to be elevated in both groups,<br />returning to baseline at 24 hours. When compared to baseline,<br />the hs-CRP level reached its peak at 24 hours at 13.28 ±<br />5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dL<br />in the off-pump group.<br /><strong>Conclusion</strong>: CABG surgery is associated with an increase<br />in inflammatory markers and serum M30 levels, indicating<br />epithelial/endothelial apoptosis in the early period.

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