scholarly journals Development of oil-in-water microemulsion encapsulating Vitamin E for thermal and hydrolysis degradation study

2020 ◽  
Vol 16 (3) ◽  
pp. 277-280
Author(s):  
Khairun Nisa Abdul Rahman ◽  
Vicit Rizal Eh Suk ◽  
Khalisanni Khalid ◽  
Nurhazirah Mohd Ihsan ◽  
Zainurin Md Dom ◽  
...  
Keyword(s):  
Particle Size ◽  
Vitamin E ◽  
Encapsulation Efficiency ◽  
Low Cost ◽  
Bioactive Compound ◽  
Small Particle Size ◽  
Degradation Study ◽  
Oil In Water ◽  
The Mean ◽  
Vitamin E Homologs

Vitamin E is widely used for medicinal and cosmeceuticals purposes. However, it is easy to degrade by the environment. In this study, the degradation of Gold Tri.E™ was studied and determined. Gold Tri.E™ is a mixture of Vitamin E homologs (tocotrienol and tocopherol) extracted from palm oil (Elais Guineensis). A nanocarrier system has been optimized to encapsulate Gold Tri.E™ from degrading and increasing its stability as a bioactive compound. An oil-in-water (o/w) microemulsion was formulated and optimized as the best carrier to encapsulate Gold Tri.E™ with the mean particle size of 32.60±3.60 nm and 99.99±0.01% encapsulation efficiency (EE). Degradation of the Gold Tri.E™ in o/w microemulsion was significantly reduced as compared to the bare Gold Tri.ETM. This suggested that the system could protect Gold Tri.E™ from thermal and hydrolysis degradation. Thus, the ease of preparation, low-cost production, and small particle size obtained when Gold Tri.E™ encapsulated in this system give promising drug delivery system to encapsulate, protect, and increase the shelf life of Gold Tri.E™.

scholarly journals Design and characterization of oil-in-water nanoemulsion for enhanced oil recovery stabilized by amphiphilic copolymer, nonionic surfactant, and LAPONITE® RD

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1952-1959
Author(s):  
Yi Zhao ◽  
Fangfang Peng ◽  
Yangchuan Ke
Keyword(s):  
Particle Size ◽  
Nonionic Surfactant ◽  
Enhanced Oil Recovery ◽  
Oil Recovery ◽  
Small Particle ◽  
Amphiphilic Copolymer ◽  
Good Stability ◽  
Small Particle Size ◽  
Oil In Water

Emulsion with small particle size and good stability stabilized by emulsifiers was successfully prepared for EOR application.

Preparation and Research of Oil in Water Microemulsion

2020 ◽  
Vol 1001 ◽  
pp. 110-114
Author(s):  
Xiao Qi Chen ◽  
Meng Meng Zhou ◽  
Zheng Zheng Wang ◽  
Hai Jun Zhou ◽  
Shu Lan Yang ◽  
...  
Keyword(s):  
Particle Size ◽  
Constant Temperature ◽  
Polydispersity Index ◽  
Stable System ◽  
Mass Ratio ◽  
Drop Method ◽  
Mean Particle Size ◽  
Oil In Water ◽  
The Mean ◽  
The Stability

A series of oil in water (O/W) microemulsions were prepared through drop by drop method at constant temperature, taking Span80/Tween80 as a composite emulsifying system and Macol-52 as oil phase. Effects of the mass ratio of composite emulsifying system and oil/emulsifier ratio on the particle size were studied. Finally, the best technological conditions were selected and the stability of the microemulsion was also researched. Results showed that the most suitable Span80/Tween80 mass ratio was 1:1 and the oil/emulsifier ratio is 1:1. Under this condition, the mean particle size of the o/w microemulsion was 71.1 nm and the polydispersity index was 0.151. Moreover, the microemulsion maintain a bright and uniform stable system after 20minutes’ centrifugation at the speed of 4000r/min and the particle size increased slightly.

Influence of Electrical Parameter on the Size of Superalloy Powders Prepared by Spark Plasma Discharge Process

2007 ◽  
Vol 561-565 ◽  
pp. 403-406
Author(s):  
Jun Yu ◽  
Chang Chun Ge ◽  
Guo Hua Ni ◽  
Lu Lu Meng ◽  
Wei Ping Shen ◽  
...  
Keyword(s):  
Particle Size ◽  
Pulse Duration ◽  
Electrical Parameter ◽  
Spherical Shape ◽  
Plasma Discharge ◽  
Discharge Process ◽  
Small Particle Size ◽  
Spark Plasma ◽  
Mean Size ◽  
The Mean

Superalloy powders, which have a small particle size and spherical shape, were prepared by a spark plasma discharge process. The electrical parameter, spark voltage, current and pulse duration have very important effects on the size distribution of produced superalloy powders. When current or pulse duration changed the mean size significantly changed.

Preparation of Barije (Ferula gummosa) Essential Oil–Loaded Liposomes and Evaluation of Physical and Antibacterial Effect on Escherichia coli O157:H7

2020 ◽  
Vol 83 (3) ◽  
pp. 511-517 ◽  
Author(s):  
MASOUD NAJAF NAJAFI ◽  
ANITA ARIANMEHR ◽  
ALI MOHAMMADI SANI
Keyword(s):  
Escherichia Coli ◽  
Particle Size ◽  
Essential Oil ◽  
Encapsulation Efficiency ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Escherichia Coli O157 ◽  
Before And After ◽  
The Mean ◽  
Electrostatic Stability

ABSTRACT The aim of this study was to load liposomes with Barije (Ferula gummosa) essential oil (EO) and to evaluate their physical and antibacterial properties. Liposomes were produced with specific ratios of lecithin/cholesterol by thin-film hydration and sonication. The chemical composition of the EO was analyzed by gas chromatography and mass spectroscopy. The physical properties of the liposomes (particle size, polydispersity index, zeta potential, and encapsulation efficiency) were evaluated. The antimicrobial effects of these liposomes against Escherichia coli O157:H7 were determined based on the MIC and disk diffusion results. The effect of subinhibitory concentrations (sub-MICs) of EO against the growth of the bacterium over 24 h was evaluated before and after encapsulation. The major components of EO were β-pinene (60.84%) and α-pinene (9.14%). The mean liposome radius of EO-loaded liposomes was 74.27 to 99.93 nm, which was significantly different from that of the empty liposomes (138.76 nm) (P < 0.05). Addition of cholesterol to the lecithin bilayer increased the particle size and reduced the encapsulation efficiency (P < 0.05). The electrostatic stability of the empty liposomes was improved by adding cholesterol, but when the EO was replaced in the liposomes, there was no significant change in electrostatic stability of liposomes with cholesterol (P < 0.05). MICs were 14.5 μg/mL for the EO-loaded nanoliposomes containing 30 mg of lecithin and 30 mg of cholesterol and 10 μg/mL for nonencapsulated EO. This trend was confirmed by measuring the inhibition zone diameter. Sub-MICs of liposomal EO (containing 60 mg of lecithin) decreased bacterial levels to a greater degree than did free EO, especially at 50 and 75% of the MIC. HIGHLIGHTS

Preparation and Application of VE Microcapsules with Polyurethane Shell for Skin-Care Textiles

2011 ◽  
Vol 331 ◽  
pp. 402-406 ◽  
Author(s):  
Guo Ping Yao ◽  
Jin Huan Zheng ◽  
Hui Fen Chen
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Vitamin E ◽  
Interfacial Polymerization ◽  
Chain Extender ◽  
Skin Care ◽  
Transmission Electron ◽  
Particle Size Analyzer ◽  
Skin Care Product ◽  
The Mean

Vitamin E (VE) microcapsules with polyurethane (PU) shell are successfully prepared via interfacial polymerization of polyurethane with toluene-2,4-diisocyanate (TDI) as the isocyanate, polyethylene glycol as the polyol, and 1,4-butanediol (BD) as the chain extender. In the preparation process, VE emulsion, prepolymer and microencapsulation of VE are studied using a particle size analyzer, butylamine titration, optical microscopy (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Based on the present research, VE microcapsules prepared have smooth surfaces and spherical appearances, the mean particle size of about 550 nm. Vitamin E microcapsules have been glued effectively to textiles, and a kind of skin-care product has been developed.

Preparation and characterization of palm oil in water microemulsion for application in the food industry

2020 ◽  
Vol 122 (10) ◽  
pp. 3077-3088
Author(s):  
Parichehr Fatehi ◽  
Ahmad Salihin Baba ◽  
Vicit Rizal Eh suk ◽  
Misni Misran
Keyword(s):  
Particle Size ◽  
Vitamin E ◽  
Palm Oil ◽  
Food Industry ◽  
Room Temperature ◽  
Average Particle Size ◽  
Average Particle ◽  
Content Type ◽  
Oil In Water ◽  
Span 60

PurposeRed palm oil contains both tocopherol (∼30%) and tocotrienol (∼70%) with the latter having better antioxidant potency than the former by a factor of 60 times. The microemulsion is one of the most suitable carriers to protect this vitamin E from environmental stress due to food processing and storage. However, the instability of microemulsion might limit the presentation of vitamin E in the food industry. In the present study, we demonstrated the preparation of microemulsions from different ratios of palm oil and Span 60 to achieve potential carrier formulations for vitamin E delivery.Design/methodology/approachThe microemulsions with the different ratios of palm oil and water (o/w) and Span 60 were prepared by using homogenization technique, incubated and observed at 45.0 ± 0.1 °C, room temperature (25 °C ± 0.1) or 8.0 ± 0.1 °C. The microemulsion formed was analyzed by Fourier transforms infrared (FTIR) spectroscopy to observe the molecular composition and the functional groups in the employed oil and emulsifier. Back-scattered dynamic light scattering (DLS) method was employed to determine the stability of microemulsion by measuring the average particle size and polydispersity index (PDI). The zeta potential values of microemulsion were measured by Shape Zeta sizer Nano ZS. The shape and dynamic properties of the microemulsion were observed by Leica optical polarizing microscope (OPM). The creaming, sedimentation, the ratio of aqueous separation and clarification of the microemulsions were evaluated visually whereas the changes in pH were determined using pH meter.FindingsThe morphological study showed the presence of spherical-shaped particles. The average particle size was found to be the smallest in the presence of 7% Span 60 in the 70/30 (o/w) formulation, and the zeta potential was less than −30 mV for most of the formulations. The most stable pH (the least amount of changes in the pH at room temperature) prevailed for 7% Span 60. Accelerated stability test showed that formulations 30:70 and 50:50 (o/w), in the presence of 5% and 7% Span 60, were the most stable throughout the incubation period.Originality/valueThe palm oil in water microemulsion in the presence of 7% Span 60 has the potential to be further developed as a delivery system for hydrophobic nutrients such as vitamin E, proteins or peptides and antioxidants in the food and beverage industry.

scholarly journals A Novel Aerosol Method for the Production of Hydrogel Particles

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Diana Guzman-Villanueva ◽  
Hugh D. C. Smyth ◽  
Dea Herrera-Ruiz ◽  
Ibrahim M. El-Sherbiny
Keyword(s):  
Particle Size ◽  
Low Cost ◽  
Polymer Concentration ◽  
Air Pressure ◽  
Mean Particle Size ◽  
Cost System ◽  
Hydrogel Particles ◽  
Alginate Concentration ◽  
Novel Method ◽  
The Mean

A novel method of generating hydrogel particles for various applications including drug delivery purposes was developed. This method is based on the production of hydrogel particles from sprayed polymeric nano/microdroplets obtained by a nebulization process that is immediately followed by gelation in a crosslinking fluid. In this study, particle synthesis parameters such as type of nebulizer, type of crosslinker, air pressure, and polymer concentration were investigated for their impact on the mean particle size, swelling behavior, and morphology of the developed particles. Spherical alginate-based hydrogel particles with a mean particle size in the range from 842 to 886 nm were obtained. Using statistical analysis of the factorial design of experiment it was found that the main factors influencing the size and swelling values of the particles are the alginate concentration and the air pressure. Thus, it was demonstrated that the method described in the current study is promising for the generation of hydrogel particles and it constitutes a relatively simple and low-cost system.

Novel Formulation Development and Evaluation of Nanoparticles Based in Situ Gelling System for The Ophthalmic Delivery of Ciprofloxacin Hydrochloride

2015 ◽  
Vol 5 (4) ◽  
Author(s):  
Kranti Singh ◽  
Surajpal Verma ◽  
Shyam Prasad ◽  
Indu Bala
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Drug Loading ◽  
In Vitro Release ◽  
Formulation Development ◽  
Ciprofloxacin Hydrochloride ◽  
Potential Value ◽  
The Mean ◽  
In Situ Gelling

Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanoparticles was evaluated for particle size, zeta potential value and loading efficiency; nanoparticle incorporated in situ gelling system was evaluated for pH, clarity, gelling strength, rheological studies, in-vitro release studies and ex-vivo precorneal permeation studies. The nanopaticle showed the mean particle size varying between 263.5nm - 325.9 nm with the mean zeta potential value of -5.91 mV to -8.13 mV and drug loading capacity varied individually between 72.50% to 98.70% w/w. The formulation was clear with no suspended particles, showed good gelling properties. The gelling was quick and remained for longer time period. The developed formulation was therapeutically efficacious, stable and non-irritant. It provided the sustained release of drug over a period of 8-10 hours.

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