scholarly journals Detection of Phthalates in Packages and Monitoring Their Migration Into Products

2015 ◽  
Vol 63 (5) ◽  
pp. 1459-1464 ◽  
Author(s):  
Soňa Bogdanovičová ◽  
Alžbeta Jarošová
Keyword(s):  
Thermal Treatment ◽  
High Performance ◽  
Meat Products ◽  
Sample Surface ◽  
Legal Limits ◽  
Materials Used ◽  
Butyl Phthalate ◽  
Ethylhexyl Phthalate ◽  
Migration Limit

The report is focused on determining the level of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) in materials used for packaging meat products and monitoring the extent of PAE migration into meat products after thermal treatment. Was analyzed 50 samples of packaging. The DBP concentration ​​ranged from 0.19 to 23.95 µg.dm−2 and that of DEHP was between 0.01 and 103.33 µg.dm−2. Analysed packages containing higher concentrations of phthalates (5 samples) were subsequently used for monitoring the phthalate migration into the product due to thermal treatment. The determination of phthalates was conducted using high-performance liquid chromatography (HPLC) with UV detection at a wavelength of 224 nm. The DBP concentration ​​ranged from 0.19 to 23.95 µg.dm−2 of the sample surface and that of DEHP was between 0.01 and 103.33 µg.dm−2 of sample surface. With regard to the specific migration limit (1.5 mg.kg−1 for DEHP and 0.3 mg.kg−1 for DBP), four of the analysed samples packages (a total of 5 samples) ceased to meet legal limits after thermal treatment, i.e. 70 °C in the product core for 10 minutes. Our analysis has confirmed that the migration of phthalates is influenced by temperature.

scholarly journals Detection of phthalic acid esters in the packaging films of meat products

2014 ◽  
Vol 83 (10) ◽  
pp. S59-S64
Author(s):  
Soňa Bogdanovičová ◽  
Alžbeta Jarošová ◽  
Josef Kameník
Keyword(s):  
Phthalic Acid ◽  
High Performance ◽  
Meat Products ◽  
Phthalic Acid Esters ◽  
Packaging Films ◽  
Materials Used ◽  
Butyl Phthalate ◽  
Ethylhexyl Phthalate ◽  
Acid Esters

The contents of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) were monitored in materials used for packaging films of meat products. A printed sample and a non-printed sample were taken from each of the packaging films analysed, the sample area being 1 dm2, to determine whether or not there is increased presence of phthalates in printed packaging films compared to non-printed packaging films, and to assess possible risks arising from their use. The determination of DBP and DEHP was conducted using high-performance liquid chromatography (HPLC) with the Zorbax Eclipse C8 column and UV detection at a wavelength of 224 nm. Concentrations of phthalates ranged from 2.18 to 81.33 µg∙dm-2 in printed samples and from 2.25 to 69.88 µg∙dm-2 in those without printing. This study shows different contents of phthalates in printed and non-printed areas of packaging films. The printed area had in most cases a higher content of phthalates probably due to the content of the substances in the printing colours.

Determination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV

2020 ◽  
Vol 23 (10) ◽  
pp. 1010-1022
Author(s):  
Emrah Dural
Keyword(s):  
High Performance ◽  
Phthalate Esters ◽  
High Sensitivity ◽  
Hplc Method ◽  
Cosmetic Products ◽  
Limit Of Quantification ◽  
Nail Polish ◽  
Accuracy And Precision ◽  
Butyl Phthalate

Aim and scope: Due to the serious toxicological risks and their widespread use, quantitative determination of phthalates in cosmetic products have importance for public health. The aim of this study was to develop a validated simple, rapid and reliable high-performance liquid chromatography (HPLC) method for the determination of phthalates which are; dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), di(2- ethylhexyl) phthalate (DEHP), in cosmetic products and to investigate these phthalate (PHT) levels in 48 cosmetic products marketing in Sivas, Turkey. Materials and Methods: Separation was achieved by a reverse-phase ACE-5 C18 column (4.6 x 250 mm, 5.0 μm). As the mobile phase, 5 mM KH2PO4 and acetonitrile were used gradiently at 1.5 ml min-1. All PHT esters were detected at 230 nm and the run time was taking 21 minutes. Results: This method showed the high sensitivity value the limit of quantification (LOQ) values for which are below 0.64 μg mL-1 of all phthalates. Method linearity was ≥0.999 (r2). Accuracy and precision values of all phthalates were calculated between (-6.5) and 6.6 (RE%) and ≤6.2 (RSD%), respectively. Average recovery was between 94.8% and 99.6%. Forty-eight samples used for both babies and adults were successfully analyzed by the developed method. Results have shown that, DMP (340.7 μg mL-1 ±323.7), DEP (1852.1 μg mL-1 ± 2192.0), and DBP (691.3 μg mL-1 ± 1378.5) were used highly in nail polish, fragrance and cream products, respectively. Conclusion: Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and our research in general, are DEP (1852.1 μg mL-1 ± 2192.0), DBP (691.3 μg mL-1 ± 1378.5) and DMP (340.7 μg mL-1 ±323.7), respectively. Phthalates were found in the content of all 48 cosmetic products examined, and the most detected phthalates in general average were DEP (581.7 μg mL-1 + 1405.2) with a rate of 79.2%. The unexpectedly high phthalate content in the examined cosmetic products revealed a great risk of these products on human health. The developed method is a simple, sensitive, reliable and economical alternative for the determination of phthalates in the content of cosmetic products, it can be used to identify phthalate esters in different products after some modifications.

scholarly journals Determination of Di(2-ethylhexyl phthalate) released in the blood from PVC line during the hemodialysis procedure

2018 ◽  
Vol 23 (1) ◽  
Author(s):  
Beatriz Luci Fernandes ◽  
Fernanda Maria ◽  
Lia Sumie Nakao ◽  
Max Ingberman ◽  
Marcia Regina Cubas
Keyword(s):  
Healthy Volunteers ◽  
Body Mass ◽  
High Performance ◽  
Average Concentration ◽  
International Standards ◽  
Human Beings ◽  
Alternative Materials ◽  
Ethics In Research ◽  
Ethylhexyl Phthalate

ABSTRACT The objective of the work is to demonstrate the applicability of the High-Performance Liquid Chromatography (HPLC) on the quantification of the Di(2-ethylhexyl phthalate) (DEHP) released from the Polyvinyl Chloride (PVC) line into the circulating blood during the hemodialysis procedure. As the proposal is not to validate the method, blood samples from five patients and three healthy volunteers were collected, and the plasmas were isolated, prepared and analyzed. The average concentration of DEHP in the patient's plasma was 0.19±0.12 mg/kg of body mass, while in the plasma of the healthy volunteers was 0.003±0.002 µg/kg of body mass. The results showed that the method presented is an alternative to quantify the DEHP in the blood and could assist in the search for alternative materials to apply to extracorporeal circulation equipment. The study was performed according to the national and international standards of ethics in research involving human beings (CEP PUCPR Prot. n.5802).

scholarly journals Determination of acrolein, ethanol, volatile acidity, and copper in different samples of sugarcane spirits

2012 ◽  
Vol 32 (3) ◽  
pp. 568-572 ◽  
Author(s):  
José Masson ◽  
Maria das Graças Cardoso ◽  
Lidiany Mendonça Zacaroni ◽  
Jeancarlo Pereira dos Anjos ◽  
Adelir Aparecida Sackz ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Minas Gerais ◽  
Volatile Acidity ◽  
Legal Limits ◽  
Brazilian Legislation ◽  
Significant Difference ◽  
Average Size

Seventy-one samples of sugarcane spirits from small and average size stills produced in the northern and southern Minas Gerais (Brazil) were analyzed for acrolein using HPLC (High Performance Liquid Chromatography). Ethanol and copper concentrations and volatile acidity were also determined according to methods established by the Ministry of Agriculture, Livestock and Supply (MAPA). A total of 9.85% of the samples tested showed levels of acrolein above the legal limits, while the copper concentrations of 21.00% of the samples and the volatile acidity of 8.85% of the samples were higher than the limits established by the Brazilian legislation. The concentration of acrolein varied from 0 to 21.97 mg.100 mL-1 of ethanol. However, no significant difference at 5% of significance was observed between the samples produced in the northern and southern Minas Gerais. The method used for determination of acrolein in sugarcane spirits involved the formation of a derivative with 2,4-dinitrophenylhydrazine (2,4-DNPH) and subsequent analysis by HPLC.

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