Mechanical Properties and Modeling of Subcutaneous Adipose Tissue: a Comprehensive Review

Author(s):  
Zhaonan Sun ◽  
Bronislaw Gepner ◽  
Patrick S. Cottler ◽  
Sang-hyun Lee ◽  
Jason Kerrigan

Abstract Mechanical models of adipose tissue are important for various medical applications including cosmetics, injuries, implantable drug delivery systems, and plastic surgeries, and biomechanical applications such as computational human body models for surgery simulation, and blunt impact trauma. This article presents a comprehensive review of experimental approaches that aimed to characterize the mechanical properties of adipose tissue, and the resulting constitutive models and model parameters identified. In particular, this study examines the material behavior of adipose tissue, including its nonlinear stress-strain relationship, viscoelasticity, strain hardening and softening, rate-sensitivity, anisotropy, preconditioning, failure behavior, and temperature dependency.

2012 ◽  
Vol 19 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Yong Liu ◽  
Zhaofeng Chen ◽  
Jianxun Zhu ◽  
Yun Jiang ◽  
Binbin Li

Abstract(SiO2)f/SiO2 composites reinforced with three-dimensional (3D) six-directional preform were fabricated by the silicasol-infiltration-sintering method. The nominal fiber volume fraction was 47%. To characterize the mechanical properties of the composites, mechanical testing was carried out under various loading conditions, including tensile, flexural, and shear loading. The composite exhibited highly nonlinear stress-strain behavior under all the three types of loading. The results indicated that the 3D six-directional braided (SiO2)f/SiO2 composites exhibited superior flexural properties and good shear resistant as compared with other types of preform (2.5D and 3D four-directional)-reinforced (SiO2)f/SiO2 composites. 3D six-directional braided (SiO2)f/SiO2 composite exhibited graceful failure behavior under loading. The addition of 5th and 6th yarns resulted in controlled fracture and hence these 3D six-directional braided composites could possibly be suitable for thermal structure components.


2015 ◽  
Vol 137 (5) ◽  
Author(s):  
Shahrokh Zeinali-Davarani ◽  
Yunjie Wang ◽  
Ming-Jay Chow ◽  
Raphaël Turcotte ◽  
Yanhang Zhang

As major extracellular matrix components, elastin, and collagen play crucial roles in regulating the mechanical properties of the aortic wall and, thus, the normal cardiovascular function. The mechanical properties of aorta, known to vary with age and multitude of diseases as well as the proximity to the heart, have been attributed to the variations in the content and architecture of wall constituents. This study is focused on the role of layer-specific collagen undulation in the variation of mechanical properties along the porcine descending thoracic aorta. Planar biaxial tensile tests are performed to characterize the hyperelastic anisotropic mechanical behavior of tissues dissected from four locations along the thoracic aorta. Multiphoton microscopy is used to image the associated regional microstructure. Exponential-based and recruitment-based constitutive models are used to account for the observed mechanical behavior while considering the aortic wall as a composite of two layers with independent properties. An elevated stiffness is observed in distal regions compared to proximal regions of thoracic aorta, consistent with sharper and earlier collagen recruitment estimated for medial and adventitial layers in the models. Multiphoton images further support our prediction that higher stiffness in distal regions is associated with less undulation in collagen fibers. Recruitment-based models further reveal that regardless of the location, collagen in the media is recruited from the onset of stretching, whereas adventitial collagen starts to engage with a delay. A parameter sensitivity analysis is performed to discriminate between the models in terms of the confidence in the estimated model parameters.


2020 ◽  
Author(s):  
Giuseppe Dattola ◽  
Giovanni Battista Crosta ◽  
Thomas Stewart

<p>The prediction of a landslide behavior is fundamental for the design of early warning system (EWS) as well for the hazard and risk assessment. The evaluation of expected landslide volume (or extent), displacement, velocity and acceleration is mandatory. Very often empirical formulas are used for landslide volume determination whereas semi-empirical methods like the inverse velocity approach are used for time to failure definition.</p><p>Various approaches have been proposed in the literature to reproduce the landslide behavior in terms of displacement for landslides which are already in an active state or for which displacement data are available for calibration. Some approaches introduce the material viscosity to reproduce the slow motion of the landslide when the driving factor is the fluctuation of the ground water table. Another strategy consists in using numerical methods in which the material strength reduction is introduced. In other cases more sophisticated constitutive models are employed to reproduce the material behavior.</p><p>In this work, we propose an extension of a simple one dimensional mathematical model which reproduces the post failure behavior considering the landslide as an assembly of blocks interacting between each other and moving along the bedrock. In particular, the model takes into account the shear band mechanical behavior by means of a viscous-plastic model based on the Perzyna’s approach with strain-hardening. The interactions between blocks are modelled by formulating an interaction law which takes into consideration also the tangential effects due to friction along the lateral block boundaries. The forcing factors can be the piezometric level oscillation, the seismic shaking and the oscillation of external water reservoir level.</p><p>To validate the mathematical model the numerical results are compared with the Little Chief Landslide located in the North Western Canada along the upper Columbia River valley. The landslide involves a mass of about 800 million of m<sup>3</sup> with the stable bedrock depth ranging between 100 and 300 meters. This is an extremely slow landslide which has been investigated since 1960’s and for which displacements, piezometric levels and their evaluation in time are available for long time out-wards allowing to test the model. The landslide shows a periodic trend for displacements with cyclic accelerations and stable creeping. This allows for the calibration of the model parameters.</p>


2000 ◽  
Vol 7 (3) ◽  
pp. 121-138 ◽  
Author(s):  
B. Langrand ◽  
E. Markiewicz ◽  
E. Deletombe ◽  
P. Drazétic

Many different types of rivets need to be modeled to analyze the crashworthiness of aircraft structures. A numerical procedure based on FE modeling and characterization of material failure constitutive models is proposed herein with the aim of limiting the costs of experimental procedures otherwise necessary to obtain these data. Quasi-static and dynamic experiments were carried out on elementary tension (punched) and shear (riveted) specimens. No strain rate sensitivity was detected in the failure behavior of the riveted joint assemblies. Experimental data were used to identify the Gurson damage parameters of each material (2024-T351 and 7050 aluminum alloys for the sheet metal plate and the rivet respectively) by an inverse method. Characterization gave rise to satisfactory correlation between FE models and experiments. Optimized parameters were validated for each material by means of a uniaxial tension test for the sheet metal plate and an ARCAN type specimen in pure tension for the rivet.


Author(s):  
Ali A. Abbasi ◽  
M. T. Ahmadian

In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanical properties of mouse oocyte cell. It has been assumed that the cell behavior is continues, isotropic, nonlinear and homogenous material. Then, by matching the experimental data with finite element (FE) simulation result and using the Levenberg–Marquardt optimization algorithm, the nonlinear hyperelastic model parameters have been extracted. Experimental data of mouse oocyte captured from literatures. Advantage of the developed model is that it can be used to calculate accurate reaction force on surgical instrument or it can be used to compute deformation or force in virtual reality based medical simulations.


Author(s):  
Munshi Basit ◽  
Mohammad Motalab ◽  
Jeffrey C. Suhling ◽  
Pradeep Lall

In the electronic packaging industry, it is important to be able to make accurate predictions of board level solder joint reliability during thermal cycling exposures. The Anand viscoplastic constitutive model is often used to represent the material behavior of the solder in finite element simulations. This model is defined using nine material parameters, and the reliability prediction results are often highly sensitive to the Anand parameters. In this work, an investigation on the Anand constitutive model and its application to SAC solders of various Ag contents (i.e. SACN05, with N = 1, 2, 3, 4) has been performed. For each alloy, both water quenched (WQ) and reflowed (RF) solidification profiles were utilized to establish two unique specimen microstructures, and the same reflow profile was used for all four of the SAC alloys so that the results could be compared and the effects of Ag content could be studied systematically. In addition, we have performed tensile testing on reflowed specimens subjected to 6 months of aging at 100 C. After this level of aging, any further changes in the mechanical response and properties will be rather small. Thus, the results for these tests can be regarded as approaching the highest level of mechanical behavior degradation possible for a “severely aged” lead free solder material. The nine Anand parameters were determined for each unique solder alloy and microstructure from a set of stress strain tests performed at several strain rates and temperatures. Testing conditions included strain rates of 0.001, 0.0001, and 0.00001 (sec−1), and temperatures of 25, 50, 75, 100, and 125 C. As expected, the mechanical properties (modulus and strength) increase with the percentage of Ag content, and these changes strongly affect the Anand parameters. The sensitivity of the mechanical properties and Anand parameters to silver content is higher at lower silver percentages (1–2%). Also, the observed mechanical properties of water quenched samples were better (higher in magnitude) than the corresponding mechanical properties of the reflowed samples. Although the differences in elastic modulus between the water quenched and reflowed samples are relatively small, significant differences are present for the yield and ultimate tensile stresses of all four SAC alloys. The changes in the Anand model parameters after severe aging (6 months at 100 °C) were significant. The measured experimental results have been used to illustrate the range of values possible for Anand parameters for the SACN05 alloys. The upper extreme was the water quenched limit, where the materials have extremely fine microstructures and high mechanical properties. The lower extreme was the severely aged limit, where the materials have extremely coarsened microstructures and highly degraded mechanical properties. While further degradations are certainly possible with even further aging, the limiting values found for a severely aged SAC alloy can be used by designers as a conservative set of constitutive parameters representing the lower end of the material properties for that alloy. After deriving the Anand parameters for each alloy and microstructure, the stress-strain curves have been calculated for various conditions, and excellent agreement was found between the predicted results and experimental stress-strain curves.


RSC Advances ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5659-5697 ◽  
Author(s):  
Namsheer K ◽  
Chandra Sekhar Rout

Conducting polymers are extensively studied due to their outstanding properties, including tunable electrical property, optical and high mechanical properties, easy synthesis and effortless fabrication and high environmental stability over conventional inorganic materials.


2021 ◽  
Vol 11 (7) ◽  
pp. 2898
Author(s):  
Humberto C. Godinez ◽  
Esteban Rougier

Simulation of fracture initiation, propagation, and arrest is a problem of interest for many applications in the scientific community. There are a number of numerical methods used for this purpose, and among the most widely accepted is the combined finite-discrete element method (FDEM). To model fracture with FDEM, material behavior is described by specifying a combination of elastic properties, strengths (in the normal and tangential directions), and energy dissipated in failure modes I and II, which are modeled by incorporating a parameterized softening curve defining a post-peak stress-displacement relationship unique to each material. In this work, we implement a data assimilation method to estimate key model parameter values with the objective of improving the calibration processes for FDEM fracture simulations. Specifically, we implement the ensemble Kalman filter assimilation method to the Hybrid Optimization Software Suite (HOSS), a FDEM-based code which was developed for the simulation of fracture and fragmentation behavior. We present a set of assimilation experiments to match the numerical results obtained for a Split Hopkinson Pressure Bar (SHPB) model with experimental observations for granite. We achieved this by calibrating a subset of model parameters. The results show a steady convergence of the assimilated parameter values towards observed time/stress curves from the SHPB observations. In particular, both tensile and shear strengths seem to be converging faster than the other parameters considered.


2006 ◽  
Vol 503-504 ◽  
pp. 31-36 ◽  
Author(s):  
Johannes Mueller ◽  
Karsten Durst ◽  
Dorothea Amberger ◽  
Matthias Göken

The mechanical properties of ultrafine-grained metals processed by equal channel angular pressing is investigated by nanoindentations in comparison with measurements on nanocrystalline nickel with a grain size between 20 and 400 nm produced by pulsed electrodeposition. Besides hardness and Young’s modulus measurements, the nanoindentation method allows also controlled experiments on the strain rate sensitivity, which are discussed in detail in this paper. Nanoindentation measurements can be performed at indentation strain rates between 10-3 s-1 and 0.1 s-1. Nanocrystalline and ultrafine-grained fcc metals as Al and Ni show a significant strain rate sensitivity at room temperature in comparison with conventional grain sized materials. In ultrafine-grained bcc Fe the strain rate sensitivity does not change significantly after severe plastic deformation. Inelastic effects are found during repeated unloading-loading experiments in nanoindentations.


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