Deformation Characterization of Mouse Oocyte Cell Using Inverse Finite Element and Levenberg–Marquardt Optimization Algorithm in Needle Injection Experiment

Author(s):  
Ali A. Abbasi ◽  
M. T. Ahmadian

In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanical properties of mouse oocyte cell. It has been assumed that the cell behavior is continues, isotropic, nonlinear and homogenous material. Then, by matching the experimental data with finite element (FE) simulation result and using the Levenberg–Marquardt optimization algorithm, the nonlinear hyperelastic model parameters have been extracted. Experimental data of mouse oocyte captured from literatures. Advantage of the developed model is that it can be used to calculate accurate reaction force on surgical instrument or it can be used to compute deformation or force in virtual reality based medical simulations.

Author(s):  
Ali A. Abbasi ◽  
M. T. Ahmadian

Analysis and investigation of the relation between different parts of biological cells such as biomembrane, cytoplasm and nucleus can help to better understand their behaviors and material properties. In this paper, first, the whole elastic properties of mouse oocyte and embryo cells have been computed by inverse finite element and Levenberg–Marquardt optimization algorithm and second, using the derived mechanical properties and the mechanical properties of its bio membrane from the literature, the mechanical properties of its cytoplasm has been characterized. It has been assumed that the cell behavior is as continues, isotropic, nonlinear and homogenous material for modeling. Matching the experimental forces with the forces from the finite element (FE) simulation by the Levenberg–Marquardt optimization algorithm, gives the nonlinear hyperelastic model parameters for the whole cell. Experimental data of mouse oocyte and embryo cells captured from the literatures.


1990 ◽  
Vol 112 (3) ◽  
pp. 287-291 ◽  
Author(s):  
F. A. Kolkailah ◽  
A. J. McPhate

In this paper, results from an elastic-plastic finite-element model incorporating the Bodner-Partom model of nonlinear time-dependent material behavior are presented. The parameters in the constitutive model are computed from a leastsquare fit to experimental data obtained from uniaxial stress-strain and creep tests at 650°C. The finite element model of a double-notched specimen is employed to determine the value of the elastic-plastic strain and is compared to experimental data. The constitutive model parameters evaluated in this paper are found to be in good agreement with those obtained by the other investigators. However, the parameters determined by the numerical technique tend to give response that agree with the data better than do graphically determined parameters previously used. The calculated elastic-plastic strain from the model agreed well with the experimental strain.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10975
Author(s):  
Nicos Haralabidis ◽  
Gil Serrancolí ◽  
Steffi Colyer ◽  
Ian Bezodis ◽  
Aki Salo ◽  
...  

Biomechanical simulation and modelling approaches have the possibility to make a meaningful impact within applied sports settings, such as sprinting. However, for this to be realised, such approaches must first undergo a thorough quantitative evaluation against experimental data. We developed a musculoskeletal modelling and simulation framework for sprinting, with the objective to evaluate its ability to reproduce experimental kinematics and kinetics data for different sprinting phases. This was achieved by performing a series of data-tracking calibration (individual and simultaneous) and validation simulations, that also featured the generation of dynamically consistent simulated outputs and the determination of foot-ground contact model parameters. The simulated values from the calibration simulations were found to be in close agreement with the corresponding experimental data, particularly for the kinematics (average root mean squared differences (RMSDs) less than 1.0° and 0.2 cm for the rotational and translational kinematics, respectively) and ground reaction force (highest average percentage RMSD of 8.1%). Minimal differences in tracking performance were observed when concurrently determining the foot-ground contact model parameters from each of the individual or simultaneous calibration simulations. The validation simulation yielded results that were comparable (RMSDs less than 1.0° and 0.3 cm for the rotational and translational kinematics, respectively) to those obtained from the calibration simulations. This study demonstrated the suitability of the proposed framework for performing future predictive simulations of sprinting, and gives confidence in its use to assess the cause-effect relationships of technique modification in relation to performance. Furthermore, this is the first study to provide dynamically consistent three-dimensional muscle-driven simulations of sprinting across different phases.


2012 ◽  
Vol 184-185 ◽  
pp. 534-537
Author(s):  
Jing Jing Zhou ◽  
Ai Dong Guo ◽  
Chun Hui Li ◽  
Zhen Jiang Lin ◽  
Tie Zhuang Wu

By setting contact sets, achieved overall analysis results of the mechanical properties with omni-direction side-loading forklift truck lifting system based on COSMOSWorks. And made an experimental measurements to omni-direction side-loading forklift truck lifting system by electrometric methods. There was a good relevance between experimental data and calculation values, and the deviation was basically within the 10 percent allowed. Finally, in this way it verified the correctness and reliability of the finite element analysis by experimental measurements. Ensured the omni-direction side-loading forklift truck lifting system could be safe and efficient to work. And also it laid a foundation for subsequent structural optimization.


SPE Journal ◽  
2006 ◽  
Vol 11 (01) ◽  
pp. 5-17 ◽  
Author(s):  
Guohua Gao ◽  
Albert C. Reynolds

Summary For large scale history matching problems, where it is not feasible to compute individual sensitivity coefficients, the limited memory Broyden-Fletcher-Goldfarb-Shanno (LBFGS) is an efficient optimization algorithm, (Zhang and Reynolds, 2002; Zhang, 2002). However, computational experiments reveal that application of the original implementation of LBFGS may encounter the following problems:converge to a model which gives an unacceptable match of production data;generate a bad search direction that either leads to false convergence or a restart with the steepest descent direction which radically reduces the convergence rate;exhibit overshooting and undershooting, i.e., converge to a vector of model parameters which contains some abnormally high or low values of model parameters which are physically unreasonable. Overshooting and undershooting can occur even though all history matching problems are formulated in a Bayesian framework with a prior model providing regularization. We show that the rate of convergence and the robustness of the algorithm can be significantly improved by:a more robust line search algorithm motivated by the theoretical result that the Wolfe conditions should be satisfied;an application of a data damping procedure at early iterations orenforcing constraints on the model parameters. Computational experiments also indicate thata simple rescaling of model parameters prior to application of the optimization algorithm can improve the convergence properties of the algorithm although the scaling procedure used can not be theoretically validated. Introduction Minimization of a smooth objective function is customarily done using a gradient based optimization algorithm such as the Gauss- Newton (GN) method or Levenberg-Marquardt (LM) algorithm. The standard implementations of these algorithms (Tan and Kalogerakis, 1991; Wu et al., 1999; Li et al., 2003), however, require the computation of all sensitivity coefficients in order to formulate the Hessian matrix. We are interested in history matching problems where the number of data to be matched ranges from a few hundred to several thousand and the number of reservoir variables or model parameters to be estimated or simulated ranges from a few hundred to a hundred thousand or more. For the larger problems in this range, the computer resources required to compute all sensitivity coefficients would prohibit the use of the standard Gauss- Newton and Levenberg-Marquardt algorithms. Even for the smallest problems in this range, computation of all sensitivity coefficients may not be feasible as the resulting GN and LM algorithms may require the equivalent of several hundred simulation runs. The relative computational efficiency of GN, LM, nonlinear conjugate gradient and quasi-Newton methods have been discussed in some detail by Zhang and Reynolds (2002) and Zhang (2002).


Author(s):  
Pieter F. J. Henning ◽  
Leon Pretorius ◽  
Rudolph F. Laubscher

In this research the effect of geometric changes introduced on Al 6063-T6 circular tubes in the form of horizontal and spiral grooves, (Fig. 2 and Fig. 3) is assessed. The horizontal and spiral grooves were cut into the tube to a depth of half the wall thickness of the tubes, while the pitch was varied for both the horizontal and spiral grooves, and the cut width was kept constant. These tubes were axially compressed, and load vs. displacement and Energy vs. displacement graphs were generated from the captured experimental data for the tubes. A Finite Element Method model is presented for each of the experimentally tested tubes. 2D models for the uncut and horizontally grooved tubes and a 3D model for the spiral cut tube were generated and analyzed. Reaction force vs. displacement and energy vs. displacement graphs are presented for the different analyses. A comparison is made between the numerically and experimentally determined gradients of the energy vs. displacement graphs for each of the tubes analyzed. This forms the basis for an energy absorber design with application in the transport industry currently under consideration.


Author(s):  
Zahari Taha ◽  
Mohd Hasnun Arif Hassan

The soccer ball is one of the important pieces of equipment in the game of soccer. It undergoes various forms of impact during the game. In order to numerically investigate the occasions of ball impact such as soccer heading, a validated finite element model of a soccer ball is required. Therefore, a model was developed incorporating material properties obtained from literature. To ensure the accuracy of the model, it was validated against an established soccer ball model and experimental data of the coefficient of restitution, contact time, longitudinal deformation and reaction force. In addition, a parametric study of the mesh density was also performed to determine the optimal number of elements. The developed soccer ball model was found to be in a good agreement with the literature and experimental data. This suggests that, the soccer ball model is capable of replicating the impacts of interest. This article details the development of the model and the validation processes.


2014 ◽  
Vol 659 ◽  
pp. 57-62 ◽  
Author(s):  
Vlad Carlescu ◽  
Gheorghe Prisacaru ◽  
Dumitru Olaru

Modeling large nonlinear elastic deformation of elastomers is an important issue for developing new materials. Particularly, this is very promising for design and performance analysis of dielectric elastomers (DEs). These “smart materials” are capable of responding to an external electric field by displaying significant change in shape and size. In this paper, finite element method (FEM) was used to simulate the mechanical behavior of soft elastomers on uniaxial tension. Experimental data from uniaxial tensile tests were used in order to calibrate hyperelastic constitutive models of the material behavior. The constitutive model parameters were evaluated in ABAQUS/CAE. The 3D-model simulation results of a dumbbell shaped specimen at uniaxial tension shows very good correspondence with experimental data.


Author(s):  
Zhaonan Sun ◽  
Bronislaw Gepner ◽  
Patrick S. Cottler ◽  
Sang-hyun Lee ◽  
Jason Kerrigan

Abstract Mechanical models of adipose tissue are important for various medical applications including cosmetics, injuries, implantable drug delivery systems, and plastic surgeries, and biomechanical applications such as computational human body models for surgery simulation, and blunt impact trauma. This article presents a comprehensive review of experimental approaches that aimed to characterize the mechanical properties of adipose tissue, and the resulting constitutive models and model parameters identified. In particular, this study examines the material behavior of adipose tissue, including its nonlinear stress-strain relationship, viscoelasticity, strain hardening and softening, rate-sensitivity, anisotropy, preconditioning, failure behavior, and temperature dependency.


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