Study on the Mechanical Properties of Tissue-Mimicking Phantom Composites Using Ultrasound Indentation

2007 ◽  
Vol 334-335 ◽  
pp. 133-136
Author(s):  
Hang Yin Ling ◽  
P. Carrie Choi ◽  
Y.P. Zheng ◽  
Alan Kin Tak Lau
Keyword(s):  
Mechanical Properties ◽  
Genetic Algorithm ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Load Cell ◽  
Indentation Technique ◽  
Deformation Curves ◽  
Ultrasound Indentation ◽  
Indentation Process

This paper demonstrates the use of ultrasound (US) indentation technique for estimating the mechanical properties of tissue- mimicking phantom composites. A tissue-mimicking phantom composite is used to simulate two-layer soft tissue in human. Investigation on the mechanical properties of the phantom composites is extremely important for the understanding of the viscoelastic behaviours of soft tissues and the validation of our proposed US indentation system. The hand-held indentation probe embedded with a US transducer and a load cell together with a US pulser/ receiver. The output of the whole indentation process can be illustrated as force-deformation curves. The mechanical properties of the phantom composites can be estimated by analyzing the force-deformation curves using genetic algorithm (GA).

Reliability Investigation of Tissue Resonator Indenter Device

2010 ◽  
Author(s):  
Ming Jia ◽  
Jean W. Zu ◽  
Alireza Hariri
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Tissue Properties ◽  
University Of Toronto ◽  
In Vivo Measurements ◽  
Disease Diagnostics ◽  
Working Principle ◽  
The University

Knowledge of tissue mechanical properties is widely required by medical applications, such as disease diagnostics, surgery operation, simulation, planning, and training. A new portable device, called Tissue Resonator Indenter Device (TRID), has been developed for measurement of regional viscoelastic properties of soft tissues at the Bio-instrument and Biomechanics Lab of the University of Toronto. As a device for soft tissue properties in-vivo measurements, the reliability of TRID is crucial. This paper presents TRID’s working principle and the experimental study of TRID’s reliability with respect to inter-reliability, intra-reliability, and the indenter misalignment effect as well. The experimental results show that TRID is a reliable device for in-vivo measurements of soft tissue mechanical properties.

scholarly journals Revisión de Modelos Hiperelásticos utilizados en Tejidos

2018 ◽  
Vol 3 (1) ◽  
pp. 100
Author(s):  
Miguel Moreno ◽  
Carlos Plazaola ◽  
Guadalupe González ◽  
Mayteé Zambrano ◽  
Carmenza Spadafora
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Literature Review ◽  
Soft Tissues ◽  
Mathematical Formulation ◽  
Medical Applications ◽  
Surgical Simulations ◽  
Mechanical Nature ◽  
Hyperelastic Models

This work is related to the hyperelastic models most used in soft tissue. The importance of obtaining accurate mechanical properties of tissues are of great interest for various medical applications, for example: in treatment of diseases and surgical simulations in real time. The aim of this literature review is to evaluate the models used for proposing a mathematical formulation and modelling the mechanical behaviour of a sequence of layers of soft tissues and your reply to undergo external actions of mechanical nature, in order to improve the techniques of characterization of soft tissues.Keywords: Biomechanical, Hyperelasticity, Mechanical Properties, Nonlinear elasticity, Soft Tissues.

Immediate soft-tissue adhesion and the mechanical properties of the Ti–6Al–4V alloy after long-term acid treatment

2021 ◽  
Vol 9 (39) ◽  
pp. 8348-8354
Author(s):  
Yaming Wang ◽  
Masahiro Okada ◽  
Shi Chao Xie ◽  
Yu Yang Jiao ◽  
Emilio Satoshi Hara ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Solid State ◽  
Soft Tissue ◽  
Acid Treatment ◽  
Soft Tissues ◽  
Tissue Adhesion ◽  
Β Phase ◽  
Α Phase

A metallic solid-state adhesive for biological soft tissues was fabricated using Ti–6Al–4V alloys, and the influence of the minor β phase and the small amount of Al in the α phase are reported.

Biodegradable networks for soft tissue engineering by thiol–yne photo cross-linking of multifunctional polyesters

RSC Advances ◽  
2014 ◽  
Vol 4 (60) ◽  
pp. 32017-32023 ◽  
Author(s):  
Adrien Leroy ◽  
Assala Al Samad ◽  
Xavier Garric ◽  
Sylvie Hunger ◽  
Danièle Noël ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Cross Linking ◽  
Soft Tissue Engineering

Degradable and biocompatible networks have been prepared via thiol–yne photochemistry from novel alkyne multifunctional PCL. The mechanical properties of these cross-linked biomaterials could make them good candidates for soft tissues scaffolds.

scholarly journals Quantitative Imaging of Young’s Modulus of Soft Tissues from Ultrasound Water Jet Indentation: A Finite Element Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Min-Hua Lu ◽  
Rui Mao ◽  
Yin Lu ◽  
Zheng Liu ◽  
Tian-Fu Wang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Finite Element ◽  
Soft Tissue ◽  
Young’S Modulus ◽  
Soft Tissues ◽  
Young's Modulus ◽  
Quantitative Imaging ◽  
Element Model ◽  
Water Jet ◽  
High Frequency Ultrasound

Indentation testing is a widely used approach to evaluate mechanical characteristics of soft tissues quantitatively. Young’s modulus of soft tissue can be calculated from the force-deformation data with known tissue thickness and Poisson’s ratio using Hayes’ equation. Our group previously developed a noncontact indentation system using a water jet as a soft indenter as well as the coupling medium for the propagation of high-frequency ultrasound. The novel system has shown its ability to detect the early degeneration of articular cartilage. However, there is still lack of a quantitative method to extract the intrinsic mechanical properties of soft tissue from water jet indentation. The purpose of this study is to investigate the relationship between the loading-unloading curves and the mechanical properties of soft tissues to provide an imaging technique of tissue mechanical properties. A 3D finite element model of water jet indentation was developed with consideration of finite deformation effect. An improved Hayes’ equation has been derived by introducing a new scaling factor which is dependent on Poisson’s ratiosv, aspect ratioa/h(the radius of the indenter/the thickness of the test tissue), and deformation ratiod/h. With this model, the Young’s modulus of soft tissue can be quantitatively evaluated and imaged with the error no more than 2%.

scholarly journals High Throughput Manufacturing of Bio-Resorbable Micro-Porous Scaffolds Made of Poly(L-lactide-co-ε-caprolactone) by Micro-Extrusion for Soft Tissue Engineering Applications

Polymers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 34 ◽  
Author(s):  
Xabier Mendibil ◽  
Rocío Ortiz ◽  
Virginia Sáenz de Viteri ◽  
Jone M. Ugartemendia ◽  
Jose-Ramon Sarasua ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
High Throughput ◽  
Dimensional Stability ◽  
Soft Tissues ◽  
Porous Scaffolds ◽  
Elastomeric Materials ◽  
Soft Tissue Engineering ◽  
Tunable Mechanical Properties

Porous scaffolds made of elastomeric materials are of great interest for soft tissue engineering. Poly(L-lactide-co-ε-caprolactone) (PLCL) is a bio-resorbable elastomeric copolymer with tailorable properties, which make this material an appropriate candidate to be used as scaffold for vascular, tendon, and nerve healing applications. Here, extrusion was applied to produce porous scaffolds of PLCL, using NaCl particles as a leachable agent. The effects of the particle proportion and size on leaching performance, dimensional stability, mechanical properties, and ageing of the scaffolds were analyzed. The efficiency of the particle leaching and scaffold swelling when wet were observed to be dependent on the porogenerator proportion, while the secant moduli and ultimate tensile strengths were dependent on the pore size. Porosity, swelling, and mechanical properties of the extruded scaffolds were tailorable, varying with the proportion and size of porogenerator particles and showed similar values to human soft tissues like nerves and veins (E = 7–15 MPa, σu = 7 MPa). Up to 300-mm length micro-porous PLCL tube with 400-µm thickness wall was extruded, proving extrusion as a high-throughput manufacturing process to produce tubular elastomeric bio-resorbable porous scaffolds of unrestricted length with tunable mechanical properties.

Mechanical Characterization of Biological Tissue: Finite Element Modeling

2010 ◽  
Author(s):  
Yue Xuan ◽  
Wei Tong
Keyword(s):  
Thin Film ◽  
Mechanical Properties ◽  
Finite Element ◽  
Soft Tissue ◽  
Contact Area ◽  
Soft Tissues ◽  
Surface Deformation ◽  
Indentation Test ◽  
Biological Tissues ◽  
Test System

Indentation, in addition to the traditional tensile testing, has been widely used for evaluating mechanical properties of hard materials such as metals and bone as well as soft materials like polymer and soft tissues. However, it is difficult to measure the contact area and surface deformation in conventional indentation tests of soft tissue which will bring large errors to the evaluation of the material properties. Also the assumption of isotropic property limited the usage of indentation test in characterizing the nonlinear, anisotropic properties of soft tissue thin film. In this project, 2D and 3D finite element analyses has been carried out to predict hyperelastic material response under indentation and punch tests. A novel indentation test system was developed, which made the direct measurement of local deformation and contact area possible. The apparatus consists of a transparent indenter, a digital microscope, and a computer based control and data acquisition system. The proposed testing system and associated finite element analysis are used to characterize the mechanical properties of multiscale (bulk and thin film) biological tissues.

scholarly journals Mathematical modeling and computer simulation of needle insertion into soft tissue

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0242704
Author(s):  
Adam Wittek ◽  
George Bourantas ◽  
Benjamin F. Zwick ◽  
Grand Joldes ◽  
Lionel Esteban ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mechanical Properties ◽  
Computer Simulation ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Needle Insertion ◽  
Tissue Deformations ◽  
The Brain ◽  
Total Lagrangian Explicit Dynamics ◽  
Kinematic Approach

In this study we present a kinematic approach for modeling needle insertion into soft tissues. The kinematic approach allows the presentation of the problem as Dirichlet-type (i.e. driven by enforced motion of boundaries) and therefore weakly sensitive to unknown properties of the tissues and needle-tissue interaction. The parameters used in the kinematic approach are straightforward to determine from images. Our method uses Meshless Total Lagrangian Explicit Dynamics (MTLED) method to compute soft tissue deformations. The proposed scheme was validated against experiments of needle insertion into silicone gel samples. We also present a simulation of needle insertion into the brain demonstrating the method’s insensitivity to assumed mechanical properties of tissue.

scholarly journals Semianalytical Solution for the Deformation of an Elastic Layer under an Axisymmetrically Distributed Power-Form Load: Application to Fluid-Jet-Induced Indentation of Biological Soft Tissues

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Minhua Lu ◽  
Shuai Huang ◽  
Xianglong Yang ◽  
Lei Yang ◽  
Rui Mao
Keyword(s):  
Mechanical Properties ◽  
Mathematical Model ◽  
Finite Element ◽  
Soft Tissue ◽  
Finite Element Modeling ◽  
Excellent Agreement ◽  
Elastic Layer ◽  
Soft Tissues ◽  
Rigid Base ◽  
Form Function

Fluid-jet-based indentation is used as a noncontact excitation technique by systems measuring the mechanical properties of soft tissues. However, the application of these devices has been hindered by the lack of theoretical solutions. This study developed a mathematical model for testing the indentation induced by a fluid jet and determined a semianalytical solution. The soft tissue was modeled as an elastic layer bonded to a rigid base. The pressure of the fluid jet impinging on the soft tissue was assumed to have a power-form function. The semianalytical solution was verified in detail using finite-element modeling, with excellent agreement being achieved. The effects of several parameters on the solution behaviors are reported, and a method for applying the solution to determine the mechanical properties of soft tissues is suggested.

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