Improved Prosthetic Bone Implants

2003 ◽  
Author(s):  
Bhavin V. Mehta ◽  
Robert J. Setlock
Keyword(s):  
Structural Properties ◽  
Weight Distribution ◽  
Material Selection ◽  
Patient Comfort ◽  
Scaffold Material ◽  
Improved Method ◽  
Bone Implants ◽  
Biodegradable Scaffold ◽  
Natural Bone ◽  
Scaffold Materials

An improved method for manufacturing prosthetic bones is examined. We are developing a new improved method for designing and manufacturing prosthetic bones that have a porous interior core covered by a solid outer shell, more closely matching the morphology of natural bone. The new method is compatible with a wide variety of materials, including polymers, metals, composites, and biodegradable scaffold materials. Use of biodegradable scaffold material holds the potential for eventual bone regeneration within and throughout the prosthesis. Regardless of the material selection, this improved type of prosthesis is expected to more closely mimic the overall material and structural properties of natural bone, including shape, strength, weight, and weight distribution. By fabricating prosthetic bones that duplicate the material and structural properties of natural bone, implants could be made to operate as precision replacements, feeling and functioning exactly like natural bone. In addition to improving patient comfort, these new prostheses are expected to reduce the occurrence of unnatural secondary wear patterns caused by current style prosthetic bones that function in unnatural fashions due to their non-matching material and structural properties.

Development and characterization of novel biodegradable scaffold materials

2014 ◽  
Author(s):  
Tristan Fowler ◽  
Carina Kampleitner ◽  
Leander Poocza ◽  
Andrea Markus ◽  
Christian Dullin ◽  
...  
Keyword(s):  
Biodegradable Scaffold ◽  
Scaffold Materials

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

Remodeling and Compaction in Tissue Engineered Small Vessels

2009 ◽  
Author(s):  
Ana L. F. Soares ◽  
Maria Stekelenburg ◽  
Frank Baaijens
Keyword(s):  
Tissue Engineering ◽  
Environmental Factors ◽  
Small Diameter ◽  
Scaffold Material ◽  
Biodegradable Scaffold ◽  
Mechanical Integrity ◽  
Small Vessels ◽  
Biomechanical Stimuli

Small-diameter vessels tissue engineering (TE) seeks to provide viable replacements to the native ones. The approach involves seeding autologous cells onto a biodegradable scaffold material and delivering the suitable environmental factors (biochemical and biomechanical stimuli) during culture via a conditioning protocol. Still, these replacements appear to lack the native mechanical integrity. TE protocols should then be improved and optimized.

Research Findings

2005 ◽  
Vol 09 (05) ◽  
pp. 179-184 ◽  
Keyword(s):  
Genetic Selection ◽  
Human Diseases ◽  
Bone Implants ◽  
Natural Bone ◽  
Research Findings

Vitamin Fortification Could Play a Role in Genetic Selection. Using the Zebrafish to Study Human Diseases. New Bone Implants That Resemble Natural Bone.

scholarly journals Recombinant collagen polypeptide as a versatile bone graft biomaterial

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Hideo Fushimi ◽  
Takahiro Hiratsuka ◽  
Ai Okamura ◽  
Yoshitaka Ono ◽  
Izumi Ogura ◽  
...  
Keyword(s):  
Type I Collagen ◽  
Casting Process ◽  
Bone Grafts ◽  
Type I ◽  
Scaffold Material ◽  
Biodegradation Rate ◽  
Recombinant Polypeptide ◽  
Biodegradable Scaffold ◽  
Aging Societies ◽  
Mature Bone

AbstractAutografts and allografts are currently considered the gold standard for grafting surgery; however, to meet the growing demand in fast-aging societies, synthetic biomaterials will play an increasingly important role. Here we report a biodegradable scaffold material composed of recombinant polypeptide based on the human type I collagen alpha 1 chain (RCPhC1) as a source of hydrogel-based graft materials. The flexibility to engineer ideal characteristics for bone grafts was demonstrated. The critical internal isotropic pore structure was generated through a designed thin-layer freeze casting process. The optimized biodegradation rate was controlled by dehydrothermal crosslinking by adjusting the amino acid composition of RCPhC1. As a result, RCPhC1 bone grafts manufactured by a highly scalable streamlined production protocol induced robust regeneration of mature bone tissue while being completely resorbed in pre-clinical animal models.

Osteoblast Behavior at the Surface of CO3Ap-Collagen Sponges

2006 ◽  
Vol 309-311 ◽  
pp. 989-992
Author(s):  
M. Okazaki ◽  
Y. Tieliewuhan ◽  
I. Hirata
Keyword(s):  
Cell Invasion ◽  
Inner Core ◽  
3D Structure ◽  
Collagen Gel ◽  
Collagen Sponge ◽  
Carbonate Apatite ◽  
X Ray ◽  
Biodegradable Scaffold ◽  
Natural Bone ◽  
Bone Properties

Carbonate apatite (CO3Ap) was synthesized at 60+1°C and pH 7.4+0.2, to develop a new biodegradable scaffold biomaterial. The synthetic CO3Ap was mixed with a neutralized collagen gel and the CO3Ap-collagen mixtures with different kinds of CO3Ap contents and porosity were frozen and dried in lyophilized into the sponges. CO3Ap-collagen mixtures were also lyophilized into sponges in a HAp frame ring with 0.5 mm pores. To examine the degree of cell invasion, mouse MC3T3-E1 cells were grown in αMEM with 10% heat-inactivated FBS in 96-well plates containing the CO3Ap-collagen sponges at 37°C in a 5% humidified atmosphere. Under pentobarbital anesthesia, samples of UV-irradiated CO3Ap-collagen sponges with frames were surgically implanted beneath the periosteum cranii of rats. SEM observation of CO3Ap-collagen sponges showed favorable pores for cell invasion. Approximately 50~300 µm size pores seemed to continue into the deep bottom. X-ray high-resolution microtomography revealed a clear image of 3D structure of the sponges. 70 wt% CO3Ap-collagen sponge seemed to be most favorable biomaterial from the viewpoint of the natural bone properties. Then, to avoid the shrinkage of the sponges, we successfully made a hybridized CO3Ap-collagen sponge with a frame. When these sponge-frame complexes were implanted beneath the periosteum cranii of rats, newly created bone was observed toward the inner core of the complex from the surface of the periosteum cranii.

Optimal material selection for the construction of a paediatric prosthetic knee

2015 ◽  
Vol 232 (2) ◽  
pp. 137-147 ◽  
Author(s):  
Taahirah Mangera ◽  
Frank Kienhöfer ◽  
Kristian J Carlson ◽  
Mariette Conning ◽  
Ashley Brown ◽  
...  
Keyword(s):  
Structural Strength ◽  
Material Selection ◽  
Comfort Level ◽  
Structural Testing ◽  
Patient Comfort ◽  
Electre Iii ◽  
Prosthetic Knee ◽  
Material Cost ◽  
Multiple Attribute ◽  
Selection Of

The material selection of prostheses in developing countries is currently biased towards what is readily available and ignores important criteria such as patient comfort and structural strength. In this study, the ELECTRE III multiple attribute decision-making method was applied to the material selection of a paediatric prosthetic knee. Light metals were considered as candidates for selection. While composites are light, they are not suitable for use in components with sliding and mating surfaces such as a prosthetic knee. Plastics are prone to failure. Candidate materials were evaluated on criteria related to patient fatigue and comfort, structural stability and material cost. The patient fatigue and comfort requirement was evaluated using material density as the weight of the prosthesis affects the comfort level. Finite element analyses simulating the ISO 10328:2006 standard for structural testing of lower limb prostheses were used to evaluate the structural strength suitability of the candidate materials. The present day prices of the raw material of the candidates were used as an index of material cost. Wrought aluminium alloy aluminium 7175 was ranked highest while titanium alloys were ranked below these due to their higher cost. Cast aluminium alloys ranked lowest due to their poor structural performance. The study, using ELECTRE III, a rigorous multi-criteria decision analysis method, shows that aluminium 7175 is the optimal light metal material for a paediatric prosthetic knee.

scholarly journals An Incremental and Backward-Conflict Guided Method for Unfolding Petri Nets

Symmetry ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 392
Author(s):  
Dongming Xiang ◽  
Xiaoyan Tao ◽  
Yaping Liu
Keyword(s):  
State Space ◽  
Structural Properties ◽  
Petri Net ◽  
Concurrent Systems ◽  
Improved Method ◽  
Key Factors ◽  
State Space Explosion ◽  
Series Of Experiments ◽  
Recursive Relations

The unfolding technique of Petri net can characterize the real concurrency and alleviate the state space explosion problem. Thus, it is greatly suitable to analyze/check some potential errors in concurrent systems. During the unfolding process of a Petri net, the calculations of configurations, cuts, and cut-off events are the key factors for the unfolding efficiency. However, most of the unfolding methods do not specify a highly efficient calculations on them. In this paper, we reveal some recursive relations and structural properties of these factors. Subsequently, we propose an improved method for computing configurations and cuts. Meanwhile, backward conflicts are used to guide the calculations of cut-off events. Moreover, a case study and a series of experiments are done to illustrate the effectiveness and application scenarios of our methods.

scholarly journals Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Isabella Caroline Pereira Rodrigues ◽  
Andreas Kaasi ◽  
Rubens Maciel Filho ◽  
André Luiz Jardini ◽  
Laís Pellizzer Gabriel
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Material Selection ◽  
Cardiac Tissue Engineering ◽  
Tissue Formation ◽  
Scaffold Material ◽  
Interdisciplinary Field ◽  
Current State ◽  
Whole Heart

ABSTRACT Cardiovascular diseases are the major cause of death worldwide. The heart has limited capacity of regeneration, therefore, transplantation is the only solution in some cases despite presenting many disadvantages. Tissue engineering has been considered the ideal strategy for regenerative medicine in cardiology. It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue and giving rise to a fully functional heart, without causing side effects, such as immunogenicity. In this review, we systematically present and compare the techniques that have drawn the most attention in this field and that generally have focused on four important issues: the scaffold material selection, the scaffold material production, cellular selection and in vitro cell culture. Many studies used several techniques that are herein presented, including biopolymers, decellularization and bioreactors, and made significant advances, either seeking a graft or an entire bioartificial heart. However, much work remains to better understand and improve existing techniques, to develop robust, efficient and efficacious methods.

Strategies for skeletal muscle tissue engineering: seed vs. soil

2015 ◽  
Vol 3 (40) ◽  
pp. 7881-7895 ◽  
Author(s):  
Brian M. Sicari ◽  
Ricardo Londono ◽  
Stephen F. Badylak
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Ex Vivo ◽  
Three Dimensional ◽  
Scaffold Material ◽  
Cell Recruitment ◽  
Soil P ◽  
Tissue Replacement ◽  
Tissue Engineering Approach ◽  
Scaffold Materials

The most commonly used tissue engineering approach includes theex vivocombination of site-appropriate cell(s) and scaffold material(s) to create three-dimensional constructs for tissue replacement or reconstruction. Biologic scaffold materials facilitate endogenous cell recruitment.

Sign in / Sign up

Export Citation Format

Share Document