The characteristics of fluid flows confined within microscale space are of theoretical and practical interest [1]. Such flow includes the thin lubrication films, the liquid flow between biological cells, and the flow of polymer melts in a micro-injection molding machines, etc. A pressure-driven radial flow microrheometry (PDRFM) is used to characterize high-shear microscale fluids. The shear-dependent viscosity of the pressure-driven radial flow is modeled to investigate the possible size effect on the fluid viscosity. In the modeling, the surface shear rate and surface shear stress at the edge of the radial flow are expressed in terms of three measurable parameters, i.e. the flow rate, the loading force, and the fluid film thickness. By decreasing the fluid film thickness to microscale level, this model can be used to study the microscale effect of any homogeneous fluids. The analysis has been verified by using CFD simulations as digital testing platforms. Furthermore, the preliminary experimental results of Newtonian and non-Newtonian flows also proved the rheological modeling.