The Effects of Choline Supplementation on Physical Performance

2000 ◽  
Vol 10 (2) ◽  
pp. 170-181 ◽  
Author(s):  
John P. Warber ◽  
John F. Patton ◽  
William J. Tharion ◽  
Steven H. Zeisel ◽  
Robert P. Mello ◽  
...  
Keyword(s):  
Physical Performance ◽  
Perceived Exertion ◽  
Performance Measure ◽  
Load Carriage ◽  
Strenuous Exercise ◽  
Time To Exhaustion ◽  
Double Blind ◽  
Total Load ◽  
And Performance ◽  
Heavy Loads

It has been reported that plasma choline levels decrease following certain types of strenuous exercise. Preliminary findings also suggest that a drop in plasma choline may limit physical performance, while choline supplementation may delay fatigue during prolonged efforts. A double-blind crossover design was used to determine the relationship between plasma choline and performance during and after 4 hr of strenuous exercise. Volunteers (N = 14) received either a placebo or treatment beverage (8.425 g choline citrate) prior to and midway through a 4-hr load carriage treadmill exercise (3% grade at 5.6 km/h × 20 km) carrying a total load of 34.1 kg. Following the treadmill test, run time-to-exhaustion and squat tests were performed, and perceived exertion, plasma choline, glycerophosphocholine, and phosphatidylcholine were measured. Plasma choline levels increased 128% after the run-to-exhaustion with the choline supplemented beverage but remained unchanged with the placebo beverage. No significant effects were seen with choline supplementation on any outcome performance measure. Consequently, soldiers conditioned to carry heavy loads over long distances do not deplete plasma choline as a result of a prolonged exhaustive exercise under a placebo beverage, nor do they benefit from choline supplementation to delay fatigue under the same conditions.

Increased Cardiorespiratory Stress During Submaximal Cycling After Ketone Monoester Ingestion in Endurance-Trained Adults

2021 ◽  
Author(s):  
Devin Goddard McCarthy ◽  
William Bostad ◽  
Fiona Jane Powley ◽  
Jonathan P. Little ◽  
Douglas Richards ◽  
...  
Keyword(s):  
Body Mass ◽  
Ketone Body ◽  
Perceived Exertion ◽  
Bolus Dose ◽  
Ventilatory Threshold ◽  
Time Trial ◽  
Rating Of Perceived Exertion ◽  
Threshold Intensity ◽  
Double Blind ◽  
And Performance

There is growing interest in the effect of exogenous ketone body supplementation on exercise responses and performance. The limited studies to date have yielded equivocal data, likely due in part to differences in dosing strategy, increase in blood ketones, and participant training status. Using a randomized, double-blind, counterbalanced design, we examined the effect of ingesting a ketone monoester (KE) supplement (600 mg/kg body mass) or flavour-matched placebo in endurance-trained adults (n=10 males, n=9 females; VO2peak=57±8 ml/kg/min). Participants performed a 30-min cycling bout at ventilatory threshold intensity (71±3% VO2peak), followed 15 min later by a 3 kJ/kg body mass time-trial. KE versus placebo ingestion increased plasma [β-hydroxybutyrate] before exercise (3.9±1.0 vs 0.2±0.3 mM, p<0.0001, dz=3.4), ventilation (77±17 vs 71±15 L/min, p<0.0001, dz=1.3) and heart rate (155±11 vs 150±11 beats/min, p<0.001, dz=1.2) during exercise, and rating of perceived exertion at the end of exercise (15.4±1.6 vs 14.5±1.2, p<0.01, dz=0.85). Plasma [β-hydroxybutyrate] remained higher after KE vs placebo ingestion before the time-trial (3.5±1.0 vs 0.3±0.2 mM, p<0.0001, dz=3.1), but performance was not different (KE: 16:25±2:50 vs placebo: 16:06±2:40 min:s, p=0.20; dz=0.31). We conclude that acute ingestion of a relatively large KE bolus dose increased markers of cardiorespiratory stress during submaximal exercise in endurance-trained participants. Novelty bullets: •Limited studies have yielded equivocal data regarding exercise responses after acute ketone body supplementation. •Using a randomized, double-blind, placebo-controlled, counterbalanced design, we found that ingestion of a large bolus dose of a commercial ketone monoester supplement increased markers of cardiorespiratory stress during cycling at ventilatory threshold intensity in endurance-trained adults.

scholarly journals The effect of low- vs high-cadence interval training on the freely chosen cadence and performance in endurance-trained cyclists

2016 ◽  
Vol 41 (6) ◽  
pp. 666-673 ◽  
Author(s):  
Anthony G. Whitty ◽  
Aron J. Murphy ◽  
Aaron J. Coutts ◽  
Mark L. Watsford
Keyword(s):  
Perceived Exertion ◽  
Average Power ◽  
Time Trial ◽  
Interval Training ◽  
Performance Measure ◽  
Rating Of Perceived Exertion ◽  
Superior Performance ◽  
Strength Development ◽  
And Performance ◽  
High Cadence

The aim of this study was to determine the effects of high- and low-cadence interval training on the freely chosen cadence (FCC) and performance in endurance-trained cyclists. Sixteen male endurance-trained cyclists completed a series of submaximal rides at 60% maximal power (Wmax) at cadences of 50, 70, 90, and 110 r·min−1, and their FCC to determine their preferred cadence, gross efficiency (GE), rating of perceived exertion, and crank torque profile. Performance was measured via a 15-min time trial, which was preloaded with a cycle at 60% Wmax. Following the testing, the participants were randomly assigned to a high-cadence (HC) (20% above FCC) or a low-cadence (LC) (20% below FCC) group for 18 interval-based training sessions over 6 weeks. The HC group increased their FCC from 92 to 101 r·min−1 after the intervention (p = 0.01), whereas the LC group remained unchanged (93 r·min−1). GE increased from 22.7% to 23.6% in the HC group at 90 r·min−1 (p = 0.05), from 20.0% to 20.9% at 110 r·min−1 (p = 0.05), and from 22.8% to 23.2% at their FCC. Both groups significantly increased their total distance and average power output following training, with the LC group recording a superior performance measure. There were minimal changes to the crank torque profile in both groups following training. This study demonstrated that the FCC can be altered with HC interval training and that the determinants of the optimal cycling cadence are multifactorial and not completely understood. Furthermore, LC interval training may significantly improve time-trial results of short duration as a result of an increase in strength development or possible neuromuscular adaptations.

Effects of Caffeine Ingestion on Exercise-induced Change during High-Intensity Intermittent Exercise

1995 ◽  
Vol 5 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Isaiah Trice ◽  
Emily M. Haymes
Keyword(s):  
Blood Glucose ◽  
Perceived Exertion ◽  
Intermittent Exercise ◽  
Time To Exhaustion ◽  
Double Blind ◽  
Serum Free Fatty Acid ◽  
Caffeine Ingestion ◽  
Serum Free ◽  
Placebo Trial ◽  
Double Blind Design

In this study a double-blind design was used to determine the effect of caffeine on time to exhaustion and on associated metabolic and circulatory measures. Eight male subjects ingested either caffeine (5 mg/kg body weight) or a placebo 1 hr prior to exercise at 85-90% of maximum workload. Subjects were encouraged to complete three 30-min intermittent cycling periods at 70 rpm with 5 min rest between each. The exercise was terminated when the subject failed to complete three 30-min periods or failed to maintain 70 rpm for at least 15 s consecutively. Serum free fatty acids, glycerol, blood glucose, lactate, perceived exertion, heart rate, andcost were measured. The time to exhaustion was significantly longer during the caffeine trial than during the placebo trial. Serum free fatty acid levels were significantly different between trials. The decline in blood glucose levels was significantly less during the caffeine trial than during the placebo trial. There were no significant differences between trials for the other measures. It was concluded that caffeine increases time to exhaustion when trained subjects cycled intermittently at high levels of intensity.

The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise

2012 ◽  
Vol 302 (8) ◽  
pp. E972-E978 ◽  
Author(s):  
Luigi Di Luigi ◽  
Paolo Sgrò ◽  
Carlo Baldari ◽  
Maria Chiara Gallotta ◽  
Gian Pietro Emerenziani ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Double Blind ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Adrenal Axis ◽  
Free Cortisol ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
And Performance ◽  
Pituitary Adrenal Axis

Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day with a 36-h interval) before a maximal exercise was performed. After a 2-wk washout, the volunteers were crossed over. Blood samples were collected at −30 and −15 min and immediately before exercise, immediately after, and during recovery (+15, +30, +60, and +90 min) for adrenocorticotropin (ACTH), β-endorphin, growth hormone (GH), prolactin, cortisol (C), corticosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol binding globulin (CBG) assays. C-to-CBG (free cortisol index, FCI) and DHEAS-to-C ratios were calculated. Exercise intensity, perceived exertion rate, O2 consumption, and CO2 and blood lactate concentration were evaluated. ACTH, GH, C, corticosterone, and CBG absolute concentrations and/or areas under the curve (AUC) increased after exercise after both placebo and tadalafil. Exercise increased DHEAS only after placebo. Compared with placebo, tadalafil administration reduced the ACTH, C, corticosterone, and FCI responses to exercise and was associated with higher β-endorphin AUC and DHEAS-to-C ratio during recovery, without influencing cardiorespiratory and performance parameters. Tadalafil reduced the activation of the hypothalamus-pituitary-adrenal axis during exercise by probably influencing the brain's nitric oxide- and cGMP-mediated pathways. Further studies are necessary to confirm our results and to identify the involved mechanisms, possible health risks, and potential clinical uses.

Monitoring Training Load, Recovery, and Performance of Brazilian Professional Volleyball Players During a Season

2018 ◽  
Vol 13 (9) ◽  
pp. 1182-1189 ◽  
Author(s):  
Paula B. Debien ◽  
Marcelly Mancini ◽  
Danilo R. Coimbra ◽  
Daniel G.S. de Freitas ◽  
Renato Miranda ◽  
...  
Keyword(s):  
Physical Performance ◽  
Perceived Exertion ◽  
Training Session ◽  
Training Load ◽  
Rating Of Perceived Exertion ◽  
Total Quality ◽  
Volleyball Players ◽  
Monitoring Training ◽  
And Performance ◽  
Difficulty Score

Purpose: To describe and analyze the distribution of internal training load (ITL), recovery, and physical performance of professional volleyball players throughout 1 season. Methods: Fifteen male professional Brazilian volleyball players participated in this study. The session rating of perceived exertion (s-RPE) and Total Quality Recovery (TQR) score were collected daily for 36 wk. s-RPE was collected after each training session, and TQR, before the first session of the day. The sum of the ITL of each session during the week, training monotony, strain, acute∶chronic workload ratio, match difficulty score, and average of the TQR scores were recorded for the analysis. In addition, the athletes performed countermovement-jump (CMJ) tests with and without the use of the arms 4 times over the season. Results: The season mean weekly ITL was 3733 (1228) AU and the TQR was 15.02 (0.71). The ITL and recovery demonstrated undulating dynamics over the 36 wk, with higher weekly ITL in the preparatory periods (F = 50.32; P < .001) and worse recovery during the main competition (F = 6.47; P = .004). Negative correlations were found between TQR and ITL variables (P < .05). There was improvement and maintenance in CMJ tests without (F = 11.88; P < .001) and with (F = 16.02; P < .001) the use of the arms after the preparatory periods. Conclusions: The ITL variables, recovery, and physical performance changed significantly throughout a professional volleyball season. Despite the decrease in ITL during the main competitive period, the correct distribution of weekly ITL seems to be very important to guarantee the best recovery of athletes.

Influence of Carbohydrate Ingestion on Blood Glucose and Performance in Runners

1992 ◽  
Vol 2 (4) ◽  
pp. 317-327 ◽  
Author(s):  
Randall L. Wilber ◽  
Robert J. Moffatt
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Perceived Exertion ◽  
Treadmill Exercise ◽  
Blood Glucose Concentration ◽  
Endurance Performance ◽  
Time To Exhaustion ◽  
Experimental Conditions ◽  
Double Blind ◽  
Carbohydrate Ingestion

Ten trained male runners performed a treadmill exercise test at 80%under two experimental conditions, carbohydrate (CHO, 7% carbohydrate) and placebo (P), to determine the effect of carbohydrate ingestion on endurance performance (treadmill run time), blood glucose concentration, respiratory exchange ratio (RER), and subjective ratings of perceived exertion (RPE). Treatment order was randomized and counterbalanced and test solutions were administered double-blind. Ingestion took place 5 min preexercise (250 ml) and at 15-min intervals during exercise (125 ml). Performance was enhanced by 29.4% (p~ 0.05) during CHO (115 ±25 min) compared to P (92 ± 27 min). Blood glucose concentration was significantly greater during CHO (5.6 ± 0.9 mM) relative to P (5.0 ±0.7 mM). There was a significant increase in mean RER following CHO ingestion (.94±.01) compared to P (.90±.01). Average RPE was significantly less during CHO (14.5±2.3) relative to P (15.4±2.4). These data suggest that time to exhaustion of high-intensity treadmill exercise is delayed as a result of carbohydrate ingestion and that this effect is mediated by favorable alterations in blood glucose concentration and substrate utilization.

scholarly journals The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Chloe Gao ◽  
Saurabh Gupta ◽  
Taranah Adli ◽  
Winston Hou ◽  
Reid Coolsaet ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Time Trial ◽  
Cochrane Collaboration ◽  
Performance Measure ◽  
Time To Exhaustion ◽  
Cochrane Central Register ◽  
Endurance Sports ◽  
Dietary Nitrate ◽  
Significant Difference ◽  
Nitrate Supplementation

Abstract Background Nitrate supplementation is thought to improve performance in endurance sports. Objective To meta-analyze studies evaluating the effect of nitrate supplementation on endurance sports performance among adults. Data sources We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science and CINAHL without language restrictions. Methods We included studies that: 1) compared nitrate supplementation with placebo; 2) enrolled adults engaging in an endurance-based activity; and 3) reported a performance measure or surrogate physiologic outcome. We evaluated risk of bias using the Cochrane Collaboration tool and pooled data with a random-effects model. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to evaluate confidence in estimates. Results We included 73 studies (n = 1061). Nitrate supplementation improved power output (MD 4.6 watts, P < 0.0001), time to exhaustion (MD 25.3 s, P < 0.00001), and distance travelled (MD 163.7 m, P = 0.03). We found no significant difference on perceived exertion, time trial performance and work done. Nitrate supplementation decreased VO2 (MD − 0.04 L/min, P < 0.00001) but had no significant effect on VO2max or blood lactate levels. Conclusion The available evidence suggests that dietary nitrate supplementation benefits performance-related outcomes for endurance sports.

scholarly journals Analysis of the ergogenic effect of asynchronous music on physiological, psychophysiological and performance parameters obtained in an incremental runing test

2019 ◽  
Author(s):  
Felipe Marroni Rasteiro ◽  
Fulvia de Barros Manchado Gobatto ◽  
Leonardo Henrique Dalcheco Messias ◽  
João Pedro da Cruz ◽  
Rafael Lucas Cetein ◽  
...  
Keyword(s):  
Anaerobic Threshold ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Physiological Parameters ◽  
Ergogenic Effect ◽  
Time To Exhaustion ◽  
Threshold Intensity ◽  
Perceived Effort ◽  
And Performance

Ten healthy male individuals were randomly evaluated in two exercise sessions (with or without music during the tests). They were submited to an incremental running test (3-min stages; initial intensity equal to 7 km.h-1 and 1 km.h-1 increments; treadmill inclination equal to 1%). The music´s motivation were adressed by the Brunel Rating Music Inventory- 2, considering the most motivation on top of the playlist, and then yours subsequents. Anaerobic threshold intensity (iAnT), blood lactate concentration ([Lac]iAnT) and heart rate (HRiAnT) at anaerobic threshold intensity were considered as physiological parameters. Psychophysiological scales such as Perceived Exertion (PSEBorg), Perceived Effort (PSEFoster) and Estimation of Time Limit (ETL) were used for psychophysiological analyses. Time to exhaustion (T.T) was considered as performance parameter. No differences were found between iAnT (p=0.248), [Lac]iAnT (p=0.786), HRiAnT (p=1.000) an T.T (p=0.055). However, 70% of the sample presented better performance with asynchronous music was inserted (p=0.003). Significant differences were visualized for PSEBorg (AM= ;WM= ;0,042) and ETL (AM= ;WM= ;p=0.015). In sumary, for 70% of the evaluated sample asynchronous music exerted ergogenic effect on the physical performance in an incremental running protocol attenuating the psychophysiological responses without changing physiological parameters.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual and Performance Parameters

2020 ◽  
Author(s):  
Philip J. Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Perceived Exertion ◽  
Ketone Bodies ◽  
Rating Of Perceived Exertion ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, heart rate (HR), rating of perceived exertion (RPE), affect, respiratory exchange ratio (RER), oxygen consumption (VO2), carbon dioxide production (VCO2), and ventilation (VE) were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, HR , affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, HR, affect, RPE, and exercise performance.

Sex-Specific Physical Performance Adaptive Responses Are Elicited After 10 Weeks of Load Carriage Conditioning

2021 ◽  
Author(s):  
Jodie A Wills ◽  
David J Saxby ◽  
Daniel J Glassbrook ◽  
Timothy L A Doyle
Keyword(s):  
Training Program ◽  
Physical Performance ◽  
Test Performance ◽  
Perceived Exertion ◽  
Load Carriage ◽  
Adaptive Responses ◽  
Ratings Of Perceived Exertion ◽  
Squat Jump ◽  
Before And After ◽  
Squat Jumps

ABSTRACT Introduction The purpose of this study was to identify and characterize sex-specific physical and psychophysical performance adaptations in response to a novel 10-week training program. Materials and Methods Fifteen males and thirteen females completed a standardized load carriage task (5 km at 5.5 km.h−1, wearing a 23 kg torso-borne vest) before and after 10 weeks of resistance and load carriage training. Psychophysical responses (i.e., heart rate and ratings of perceived exertion) were measured throughout the load carriage task. Physical performance (i.e., countermovement and squat jumps, push-ups, sit-ups, and beep test) was measured at before, mid-way, and after the training program (weeks 0, 6, and 11, respectively). Results Training elicited significant improvements in squat jump maximal force, push-ups, and beep test performance (P &lt; .05). Males outperformed females in all performance measures, with interactions (time, sex) for push-ups, sit-ups, and beep test performance. After training, aerobic capacity improved by 5.4% (42.9 mL· kg−1· min−1 to 45.2 mL· kg−1· min−1) in males but did not improve in females. Psychophysical responses decreased for both sexes (P &lt; .05) during the load carriage task post-training. Conclusion While 10 weeks of standardized training elicited positive adaptations in both physical and psychophysical performance, sex-specific differences were still evident. To lessen these differences, sex-specific training should be considered to optimize load carriage performance.

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