Prolonged Vitamin C Supplementation and Recovery from Demanding Exercise

2001 ◽  
Vol 11 (4) ◽  
pp. 466-481 ◽  
Author(s):  
Dylan Thompson ◽  
Clyde Williams ◽  
Stephen J. McGregor ◽  
Ceri W. Nicholas ◽  
Frank McArdle ◽  
...  
Keyword(s):  
Vitamin C ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Plasma Concentrations ◽  
Serum Creatine Kinase ◽  
Post Exercise ◽  
Beneficial Effects ◽  
Vitamin C Supplementation ◽  
Group 2 ◽  
Male Subjects

The aim of the present study was to investigate whether 2 weeks of vitamin C supplementation affects recovery from an unaccustomed bout of exercise. Sixteen male subjects were allocated to either a placebo (P; n = 8) or vitamin C group (VC; n = 8). The VC group consumed 200 mg of ascorbic acid twice a day, whereas the P group consumed identical capsules containing 200 mg of lactose. Subjects performed a prolonged (90-min) intermittent shuttle-running test 14 days after supplementation began. Post-exercise serum creatine kinase activities and myoglobin concentrations were unaffected by supplementation. However, vitamin C supplementation had modest beneficial effects on muscle soreness, muscle function, and plasma concentrations of malondialdehyde. Furthermore, although plasma interleukin-6 increased immediately after exercise in both groups, values in the VC group were lower than in the P group 2 hours after exercise (p < .05). These results suggest that prolonged vitamin C supplementation has some modest beneficial effects on recovery from unaccustomed exercise.

Effect of High Dose Vitamin C Supplementation on Muscle Soreness, Damage, Function, and Oxidative Stress to Eccentric Exercise

2006 ◽  
Vol 16 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S.C. Bryer ◽  
A.H. Goldfarb
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Eccentric Exercise ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Damage Function ◽  
High Dose ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Glutathione Oxidation

This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P ≥ 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Gluta-thione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.

scholarly journals Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix

1999 ◽  
Vol 82 (3) ◽  
pp. 203-212 ◽  
Author(s):  
Karin H. van het Hof ◽  
Lilian B. M. Tijburg ◽  
K. Pietrzik ◽  
Jan A. Weststrate
Keyword(s):  
Vitamin C ◽  
Plasma Levels ◽  
Vegetable Intake ◽  
Block Design ◽  
Plasma Concentrations ◽  
Carotene Content ◽  
Beneficial Effects ◽  
Incomplete Block Design ◽  
Β Carotene ◽  
Green Peas

Carotenoids, folate and vitamin C may contribute to the observed beneficial effects of increased vegetable intake. Currently, knowledge on the bioavailability of these compounds from vegetables is limited. We compared the efficacy of different vegetables, at the same level of intake (i.e. 300 g/d), in increasing plasma levels of carotenoids, folate and vitamin C and we investigated if disruption of the vegetable matrix would enhance the bioavailability of these micronutrients. In an incomplete block design, sixty-nine volunteers consumed a control meal without vegetables and three out of four vegetable meals (i.e. broccoli, green peas, whole leaf spinach, chopped spinach; containing between 1·7 and 24·6 mg β-carotene, 3·8 and 26 mg lutein, 0·22 and 0·60 mg folate and 26 and 93 mg vitamin C) or a meal supplemented with synthetic β-carotene (33·3 mg). Meals were consumed for 4 d and fasting blood samples were taken at the end of each period. Consumption of the spinach-supplemented meal did not affect plasma levels of β-carotene, although the β-carotene content was 10-fold those of broccoli and green peas, which induced significant increases in plasma β-carotene levels (28 (95 % CI 6·4, 55) % and 26 (95 % CI 2·6, 54) % respectively). The β-carotene-supplemented meal increased plasma concentrations of β-carotene effectively (517 (95 % CI 409, 648) %). All vegetable meals increased the plasma concentrations of lutein and vitamin C significantly. Broccoli and green peas were, when expressed per mg carotenoid consumed, also more effective sources of lutein than spinach. A significant increase in plasma folate concentration was found only after consumption of the spinach-supplemented meal, which provided the highest level of folate. Disruption of the spinach matrix increased the plasma responses to both lutein (14 (95 % CI 3·7, 25) %) and folate (10 (95 % CI 2·2, 18) %), whereas it did not affect the response to β-carotene. We conclude that the bioavailabilities of β-carotene and lutein vary substantially among different vegetables and that the bioavailabilities of lutein and folate from spinach can be improved by disruption of the vegetable matrix.

scholarly journals Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women

2020 ◽  
Vol 21 (18) ◽  
pp. 6469
Author(s):  
Małgorzata Żychowska ◽  
Agata Grzybkowska ◽  
Monika Wiech ◽  
Robert Urbański ◽  
Wanda Pilch ◽  
...  
Keyword(s):  
Vitamin C ◽  
Iron Homeostasis ◽  
Elderly Women ◽  
Mrna Levels ◽  
Oral Supplementation ◽  
Ferritin Heavy Chain ◽  
Health Related ◽  
Vitamin C Supplementation ◽  
Group 2 ◽  
Group 1

Physical training and antioxidant supplementation may influence iron metabolism through reduced oxidative stress and subsequent lowering of mRNA levels of genes that are easily induced by this stress, including those responsible for iron homeostasis. Fifteen elderly women participated in our 12-week experiment, involving six weeks of training without supplementation and six weeks of training supported by oral supplementation of 1000 mg of vitamin C daily. The participants were divided into two groups (n = 7 in group 1 and n = 8 in group 2). In group 1, we applied vitamin C supplementation in the first six weeks of training, while in group 2 during the remaining six weeks of training. In both phases, the health-related training occurred three times per week. Training accompanied by vitamin C supplementation did not affect prooxidative/antioxidative balance but significantly decreased ferritin heavy chain (FTH) and ferritin light chain (FTL) mRNA in leukocytes (for FTH mRNA from 2^64.24 to 2^11.06, p = 0.03 in group 1 and from 2^60.54 to 2^16.03, p = 0.01 in group 2, for FTL mRNA from 2^20.22 to 2^4.53, p = 0.01 in group 2). We concluded that vitamin C supplementation might have caused a decrease in gene expression of two important antioxidative genes (FTH, FTL) and had no effect on plasma prooxidative/antioxidative balance.

The Effect of Vitamin C Supplementation on Coagulability and Lipid Levels in Healthy Male Subjects

2000 ◽  
Vol 100 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Geoffrey H Tofler ◽  
James J Stec ◽  
Ingo Stubbe ◽  
Jeanne Beadle ◽  
Dali Feng ◽  
...  
Keyword(s):  
Vitamin C ◽  
Lipid Levels ◽  
Healthy Male ◽  
Vitamin C Supplementation ◽  
Male Subjects

Post-exercise vitamin C supplementation and recovery from demanding exercise

2003 ◽  
Vol 89 (3) ◽  
pp. 393-400 ◽  
Author(s):  
D. Thompson ◽  
C. Williams ◽  
P. Garcia-Roves ◽  
S. J. McGregor ◽  
F. McArdle ◽  
...  
Keyword(s):  
Vitamin C ◽  
Post Exercise ◽  
Vitamin C Supplementation

scholarly journals The Effects of Spirulina Supplementation on Redox Status and Performance Following a Muscle Damaging Protocol

2021 ◽  
Vol 22 (7) ◽  
pp. 3559
Author(s):  
Aggelos Pappas ◽  
Athanasios Tsiokanos ◽  
Ioannis Fatouros ◽  
Athanasios Poulios ◽  
Dimitris Kouretas ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Muscle Soreness ◽  
Peak Torque ◽  
Redox Status ◽  
Muscle Performance ◽  
Protein Carbonyls ◽  
Post Exercise ◽  
Beneficial Effects ◽  
Total Antioxidant ◽  
And Performance

Spirulina plantensis is a popular supplement which has been shown to have antioxidant and performance enhancing properties. The purpose of this study was to evaluate the effects of spirulina supplementation on (a) redox status (b) muscle performance and (c) muscle damage following an eccentric bout of exercise that would induce muscle damage. Twenty-four healthy, recreationally trained males participated in the study and were randomly separated into two groups: a spirulina supplementation (6 g per day) and a placebo group. Both groups performed an eccentric bout of exercise consisting of 5 sets and 15 maximum reps per set. Blood was collected at 24, 48, 72 and 96 h after the bout and total antioxidant capacity (TAC) and protein carbonyls (PC) were assessed in plasma. Delayed onset muscle soreness (DOMS) was also assessed at the same aforementioned time points. Eccentric peak torque (EPT) was evaluated immediately after exercise, as well as at 24, 48, 72 and 96 h post exercise. Redox status indices (TAC and PC) did not change significantly at any time point post exercise. DOMS increased significantly 24 h post exercise and remained elevated until 72 h and 96 h post exercise for the placebo and spirulina group, respectively. EPT decreased significantly and immediately post exercise and remained significantly lower compared to baseline until 72 h post exercise. No significant differences between groups were found for DOMS and EPT. These results indicate that spirulina supplementation following a muscle damaging protocol does not confer beneficial effects on redox status, muscle performance or damage.

Muscle Soreness and Damage Parameters after Prolonged Intermittent Shuttle-Running Following Acute Vitamin C Supplementation

2001 ◽  
Vol 22 (1) ◽  
pp. 68-75 ◽  
Author(s):  
D Thompson ◽  
C Williams ◽  
M Kingsley ◽  
C W Nicholas ◽  
H KA Lakomy ◽  
...  
Keyword(s):  
Vitamin C ◽  
Muscle Soreness ◽  
Vitamin C Supplementation

Influence of Acute Vitamin C and/or Carbohydrate Ingestion on Hormonal, Cytokine, and Immune Responses to Prolonged Exercise

2005 ◽  
Vol 15 (5) ◽  
pp. 465-479 ◽  
Author(s):  
Glen Davison ◽  
Michael Gleeson
Keyword(s):  
Vitamin C ◽  
Prolonged Exercise ◽  
Plasma Concentrations ◽  
High Dose ◽  
Carbohydrate Ingestion ◽  
Post Exercise ◽  
Plasma Antioxidant Capacity ◽  
Neutrophil Degranulation ◽  
Plasma Antioxidant ◽  
Single Blind

The aim of the present study was to investigate the effect of vitamin C with or without carbohydrate consumed acutely in beverages before and during prolonged cycling on immunoendocrine responses. In a single blind, randomized manner six healthy, moderately trained males exercised for 2.5 h at 60% VO2max and consumed either placebo (PLA), carbohydrate (CHO, 6% w/v), vitamin C (VC, 0.15% w/v) or CHO+VC beverages before and during the bouts; trials were separated by 1 wk. CHO and CHO+VC significantly blunted the post-exercise increase in plasma concentrations of cortisol, ACTH, total leukocyte, and neutrophil counts and limited the decrease in plasma glucose concentration and bacteria-stimulated neutrophil degranulation. VC increased plasma antioxidant capacity (PAC) during exercise (P < 0.05) but had no effect on any of the immunoendocrine responses (P > 0.05). CHO+VC increased PAC compared to CHO but had no greater effects, above those observed with CHO alone, on any of the immunoendocrine responses. In conclusion, acute supplementation with a high dose of VC has little or no effect on the hormonal, interleukin-6, or immune response to prolonged exercise and combined ingestion of VC with CHO provides no additional effects compared with CHO alone.

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