Effect of BMI on Knee Joint Torques in Ergometer Rowing

2013 ◽  
Vol 29 (6) ◽  
pp. 763-768 ◽  
Author(s):  
Karen Roemer ◽  
Tibor Hortobagyi ◽  
Chris Richter ◽  
Yolanda Munoz-Maldonado ◽  
Stephanie Hamilton
Keyword(s):  
Knee Joint ◽  
Weight Bearing ◽  
Normal Weight ◽  
Obese Adults ◽  
Joint Kinetics ◽  
Joint Torques ◽  
Ergometer Rowing ◽  
Lower Extremity Biomechanics ◽  
High Bmi

Although an authoritative panel recommended the use of ergometer rowing as a non-weight-bearing form of exercise for obese adults, the biomechanical characterization of ergometer rowing is strikingly absent. We examined the interaction between body mass index (BMI) relative to the lower extremity biomechanics during rowing in 10 normal weight (BMI 18–25), 10 overweight (BMI 25–30 kg·m−2), and 10 obese (BMI > 30 kg·m−2) participants. The results showed that BMI affects joint kinematics and primarily knee joint kinetics. The data revealed that high BMI leads to unfavorable knee joint torques, implying increased loads of the medial compartment in the knee joint that could be avoided by allowing more variable foot positioning on future designs of rowing ergometers.

The association between external-ground-reaction force and knee-joint kinetics during partial- and full-weight-bearing gait

2010 ◽  
Vol 25 (4) ◽  
pp. 359-364 ◽  
Author(s):  
Jay R. Ebert ◽  
David G. Lloyd ◽  
Anne Smith ◽  
Timothy Ackland ◽  
David J. Wood
Keyword(s):  
Knee Joint ◽  
Ground Reaction Force ◽  
Weight Bearing ◽  
Reaction Force ◽  
Full Weight Bearing ◽  
Joint Kinetics

scholarly journals High body mass index is associated with increased risk for osteoarthritis of the first carpometacarpal joint during more than 30 years of follow-up

RMD Open ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e001368
Author(s):  
Mattias Rydberg ◽  
Lars B Dahlin ◽  
Anders Gottsäter ◽  
Peter M Nilsson ◽  
Olle Melander ◽  
...  
Keyword(s):  
Cox Regression ◽  
Weight Bearing ◽  
High Body Mass Index ◽  
Population Based ◽  
Continuous Variable ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Increased Risk ◽  
High Bmi

IntroductionOsteoarthritis (OA) of the first carpometacarpal (CMC-1) joint is a common hand disorder with symptoms including pain and weakness of the thumb. Previous studies have associated high BMI with OA of weight-bearing joints, whereas studies regarding non-weight-bearing joints have shown conflicting results. Thus, the aim of this study was to investigate the influence of overweight and obesity on incident OA of the CMC-1 joint.MethodDuring 1974 to 1992, 33 346 participants aged 26–61 years were included in the population-based cohort Malmö Preventive Project. Endpoint data were retrieved from Swedish national registers until end of 2018. Sex-stratified Cox regression models adjusted for potential confounders were calculated using BMI as a continuous variable and stratified for normal weight, overweight and obesity.ResultsMedian follow-up was 36 years for men and 32 years for women. A one-unit increment of BMI was independently associated with incident OA of the CMC-1 joint in men (HR 1.12; 95% CI 1.09 to 1.15, p<0.001) and women (HR 1.05; 95% CI 1.03 to 1.08, p<0.001). Stratifying for BMI groups, obesity was independently associated with OA of the CMC-1 joint in men (HR 3.57; 95% CI 2.68 to 4.77, p<0.001) and women (HR 1.98; 95% CI 1.44 to 2.73, p<0.001).ConclusionHigh BMI and obesity are major risk factors for OA of the CMC-1 joint. The association was stronger among men but could be demonstrated also among women. Future studies are warranted to clarify underlying pathophysiological mechanisms for this association, enabling identification of potential therapeutic targets related to obesity in order to prevent the development of OA of the CMC-1 joint.

scholarly journals Proprioception of Knee Joint in Athletes and Non-Athletes Obese

2016 ◽  
Vol 9 (2) ◽  
pp. 286 ◽  
Author(s):  
Hajar Moravveji ◽  
Ali Ghanbari ◽  
Fahimeh Kamali
Keyword(s):  
Knee Joint ◽  
Weight Bearing ◽  
Knee Extension ◽  
Normal Weight ◽  
Obese Group ◽  
Significant Difference ◽  
Angle Reproduction Test ◽  
Reproduction Test ◽  
Proprioceptive Function ◽  
Weight Groups

<p><strong>BACKGROUND</strong><strong>: </strong>Proprioception plays an integral role in the neuromotor control of the knee joint. The objective of this study was to evaluate the relationship of knee joint proprioception deficit and regular exercise activities with obesity.</p><p><strong>MATERIAL/METHOD</strong><strong>: </strong>In this case control study, we had 60 participants, aged 18 to 35 in four groups (15 athletes obese; 15 athletes with normal weight; 15 non-athletes obese; 15 non-athletes with normal weight). The average Body Mass Index for the obese groups was 33.50±(3.10) kg/m<sup>2</sup> and for the normal weight groups was 23.77±(2.94) kg/m<sup>2</sup>. We used a Biodex Multi-Joint System 4 Isokinetic Dynamometer to examine proprioception acuity as the amount of a subject's error when trying to reproduce a test knee extension angle (a measure of the joint position sense). We tested proprioception actively (active reproduction test; AAR) and passively (passive reproduction test; PAR) in the right leg.</p><p><strong>RESULTS: </strong>The non-athlete obese group had significantly poorer proprioception acuity in the knee extension movement compared to the normal weight groups and also compared to the athlete obese group. For knee active angle reproduction test AAR, a significant difference was found (p=0.011). The results for passive angle reproduction test PAR, revealed no significant differences between the four groups (p=0.596).</p><p><strong>CONCLUSIONS:</strong> The obese groups showed a deficit in the proprioception function in knee extension movement. Furthermore, the findings suggest that doing regular weight bearing training is associated with better proprioceptive function, even in obese groups. It could manifest that the deleterious effect of obesity on the knee joint proprioception might be stronger than the beneficial influence of exercise training.</p>

scholarly journals OP0083 DORSAL ROOT GANGLIA INFILTRATING MACROPHAGES MAINTAIN OSTEOARTHRITIS PAIN

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 55.2-56
Author(s):  
R. Raoof ◽  
C. Martin ◽  
H. De Visser ◽  
J. Prado ◽  
S. Versteeg ◽  
...  
Keyword(s):  
Knee Joint ◽  
Dorsal Root Ganglia ◽  
Immune Cells ◽  
Dorsal Root ◽  
Weight Bearing ◽  
Joint Damage ◽  
Osteoarthritis Pain ◽  
Knee Pathology ◽  
Femoral Condyles ◽  
Over Time

Background:Pain is a major debilitating symptom of knee osteoarthritis (OA). However, the extent of joint damage in OA does not correlate well with the severity of pain. The mechanisms that govern OA pain are poorly understood. Immune cells infiltrating nervous tissue may contribute to pain maintenance.Objectives:Here we investigated the role of macrophages in the initiation and maintenance of OA pain.Methods:Knee joint damage was induced by an unilateral injection of mono-iodoacetate (MIA) or after application of a groove at the femoral condyles of rats fed on high fat diet. Pain-like behaviors were followed over time using von Frey test and dynamic weight bearing. Joint damage was assessed by histology. Dorsal root ganglia (DRG) infiltrating immune cells were assessed over time using flow cytometry. To deplete monocytes and macrophages, Lysmcrex Csfr1-Stop-DTR were injected intrathecal or systemically with diptheria toxin (DT).Results:Intraarticular monoiodoacetate injection induced OA and signs of persistent pain, such as mechanical hyperalgesia and deficits in weight bearing. The persisting pain-like behaviors were associated with accumulation of F4/80+macrophages with an M1-like phenotype in the lumbar DRG appearing from 1 week after MIA injection, and that persisted till at least 4 weeks after MIA injection. Macrophages infiltrated DRG were also observed in the rat groove model of OA, 12 weeks after application of a groove at the femoral condyles. Systemic or local depletion of DRG macrophages during established MIA-induced OA completely ablated signs of pain, without affecting MIA-induced knee pathology. Intriguingly when monocytes/macrophages were depleted prior to induction of osteoarthritis, pain-like behaviors still developed, however these pain-like behaviors did not persist over time.In vitro,sensory neurons innervating the affected OA joint programmed macrophages into a M1 phenotype. Local repolarization of M1-like DRG macrophages towards M2 by intrathecal injection of M2 macrophages or anti-inflammatory cytokines resolved persistent OA-induced pain.Conclusion:Overall we show that macrophages infiltrate the DRG after knee damage and acquire a M1-like phenotype and maintain pain independent of the lesions in the knee joint. DRG-infiltrating macrophages are not required for induction of OA pain. Reprogramming M1-like DRG-infiltrating macrophages may represent a potential strategy to treat OA pain.Acknowledgments:This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreements No 814244 and No 642720. Dutch Arthritis SocietyDisclosure of Interests:Ramin Raoof: None declared, Christian Martin: None declared, Huub de Visser: None declared, Judith Prado: None declared, Sabine Versteeg: None declared, Anne Heinemans: None declared, Simon Mastbergen: None declared, Floris Lafeber Shareholder of: Co-founder and shareholder of ArthroSave BV, Niels Eijkelkamp: None declared

scholarly journals Awareness and knowledge about weight status and management: results from the 1 d sensitization campaign ‘Obesity Day’ in northern Italy

2011 ◽  
Vol 14 (10) ◽  
pp. 1813-1822 ◽  
Author(s):  
Michela Barichella ◽  
Alexis E Malavazos ◽  
Giuseppe Fatati ◽  
Emanuele Cereda
Keyword(s):  
Physical Activity ◽  
Weight Management ◽  
Health Care Professionals ◽  
Weight Control ◽  
Weight Status ◽  
Normal Weight ◽  
Cross Sectional Survey ◽  
Obese Adults ◽  
Cross Sectional

AbstractObjectiveTo evaluate the awareness and knowledge about weight status and its management.DesignA 1 d cross-sectional survey. Basic anthropometric assessments (weight, height, BMI and waist circumference) and a self-administered questionnaire were considered.SettingNineteen Clinical Nutrition or Endocrinology and Metabolic Disorders Units or Dietetics Services in the Italian region of Lombardy.SubjectsAll adults attending the ‘Obesity Day’ initiative.ResultsA total of 914 participants (605 female and 309 male) were recruited. Although most of the participants (83·5 %) considered obesity to be a disease, 38·5 % were likely to misperceive their weight status. In particular, 38·8 % of normal-weight adults believed themselves to be overweight, whereas 71·1 % and 37·5 % of classes I and II/III obese adults classified themselves as being overweight and mildly obese, respectively. However, most of the overweight (90·2 %), mildly (96·8 %) and moderately/severely obese adults (99·1 %) recognized the need to lose weight. In all, 37·8 % of the sample underestimated the role of physical activity in weight management. Interestingly, only 17·2 % of dieters (previous or current) declared being advised by their doctor to lose weight. Multivariate models revealed that higher age, low education and higher BMI were important determinants of poor weight control and management. In addition, previous dieting appeared not to provide better knowledge, whereas the role of physical activity was recognized mainly by those practising it.ConclusionsThe present study suggests that in Italy knowledge about weight management should be improved not only in the general population but also among health-care professionals. To confirm this finding, there is now the rationale for a nationally representative survey. New educational programmes can be designed on the basis of the information collected.

scholarly journals Effects of prophylactic knee bracing on knee joint kinetics and kinematics during netball specific movements

2017 ◽  
Vol 23 ◽  
pp. 93-98 ◽  
Author(s):  
Jonathan K. Sinclair ◽  
Hayley Vincent ◽  
Jim D. Richards
Keyword(s):  
Knee Joint ◽  
Joint Kinetics

scholarly journals Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults

2003 ◽  
Vol 28 (1) ◽  
pp. 72-79 ◽  
Author(s):  
A Bosy-Westphal ◽  
U Reinecke ◽  
T Schlörke ◽  
K Illner ◽  
D Kutzner ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Normal Weight ◽  
Obese Adults ◽  
Resting Energy

Association of BMI, body composition and outcomes in Chinese patients with metastatic renal cell carcinoma treated with immunotherapy: A retrospective, multicohort analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16563-e16563
Author(s):  
Jun Wang ◽  
Yuanyuan Qu ◽  
Wenhao Xu ◽  
Chunping Yu ◽  
Zhiling Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Body Composition ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Normal Weight ◽  
Chinese Patients ◽  
Tissue Area ◽  
Subcutaneous Adipose ◽  
High Bmi

e16563 Association of BMI, body composition and outcomes in Chinese patients with metastatic renal cell carcinoma treated with immunotherapy: a retrospective, multicohort analysis. Background: Obesity (body-mass index [BMI] ≥30 kg/m) is associated with a higher risk of developing clear cell renal cell carcinoma (RCC) but, paradoxically, obesity is also associated with better outcome in renal cell carcinoma (RCC) patients treated with immunotherapy. Whether BMI associate outcomes in Chinese RCC patients treated with immunotherapy considering Asian population has a lower BMI? In this study, we aimed to investigate the relationship between BMI, body composition and outcomes of Chinese patients with RCC treated with immunotherapy. Methods: We evaluated clinical data of metastatic RCC patients treated with immunotherapy from five major centers in China. Despite using the Chinese standard, only 6 people met the obese standard (BMI ≥28 kg/m, as per WHO's BMI categories), so we divided the patients into high BMI gourps (BMI ≥24.0 kg/m), and normal weight groups (BMI 18.5-23·9 kg/m). We assessed overall survival, defined as the time from treatment initiation to the date of any-cause death or of censoring on the day of the last follow-up, in high BMI patients and in patients with a normal weight. We also investigative the relationship between body composition (skeletal muscle index (SMI = skeletal muscle area/height2), skeletal muscle density (SMD), and subcutaneous adipose distribution index (SADI = subcutaneous adipose tissue area / subcutaneous adipose tissue area + visceral adipose tissue area) of each patient at the third lumbar vertebrae) and overall survival using CT or MRI scan at the treatment initiation. Results: Out of a total of 222 patients, 203 had evaluable CT or MRI radiographs, pretreatment BMI measurements, and overall survival data for analyses, and we excluded 4 (1.7%) underwetight patients, leaving a final cohort of 199 patients from this study for our analyses. There were 79 (39.7%) high BMI patients and 120 (65.3%) normal weight patients. There was no difference in overall survival between the high BMI and normal weight groups (HR:1.36, CI 0.83-2.21). In addition, SMI and SMD were not associated with outcome of patients. Interestingly, although there was no statistical difference, subcutaneous fat was associated with better outcomes, while visceral fat was associated with poor outcomes. Thus, the combination of the two indicators, SADI, showed a significant prognostic correlation after adjustment for International Metastatic RCC Database risk score (aHR:0.314, CI 0.19-0.51). Conclusions: BMI is not a good predictor of the outcome of immunotherapy in Chinese patients with RCC. Evaluation of body composition may be a better tool for predicting prognosis in RCC patients treated with immunotherapy.

scholarly journals Peak force and maximal shortening velocity of soleus fibers after non-weight-bearing and resistance exercise

1997 ◽  
Vol 82 (1) ◽  
pp. 189-195 ◽  
Author(s):  
Jeffrey J. Widrick ◽  
Robert H. Fitts
Keyword(s):  
Resistance Exercise ◽  
Elevated Level ◽  
Fiber Diameter ◽  
Weight Bearing ◽  
Normal Weight ◽  
Peak Force ◽  
Type I ◽  
Shortening Velocity ◽  
Adult Rats ◽  
Cross Sectional

Widrick, Jeffrey J., and Robert H. Fitts. Peak force and maximal shortening velocity of soleus fibers after non-weight-bearing and resistance exercise. J. Appl. Physiol. 82(1): 189–195, 1997.—This study examined the effectiveness of resistance exercise as a countermeasure to non-weight-bearing-induced alterations in the absolute peak force, normalized peak force (force/fiber cross-sectional area), peak stiffness, and maximal shortening velocity ( V o) of single permeabilized type I soleus muscle fibers. Adult rats were subjected to one of the following treatments: normal weight bearing (WB), non-weight bearing (NWB), or NWB with exercise treatments (NWB+Ex). The hindlimbs of the NWB and NWB+Ex rats were suspended for 14 days via tail harnesses. Four times each day, the NWB+Ex rats were removed from suspension and performed 10 climbs (∼15 cm each) up a steep grid with a 500-g mass (∼1.5 times body mass) attached to their tail harness. NWB was associated with significant reductions in type I fiber diameter, absolute force, normalized force, and stiffness. Exercise treatments during NWB attenuated the decline in fiber diameter and absolute force by almost 60% while maintaining normalized force and stiffness at WB levels. Type I fiber V oincreased by 33% with NWB and remained at this elevated level despite the exercise treatments. We conclude that in comparison to intermittent weight bearing only (J. J. Widrick, J. J. Bangart, M. Karhanek, and R. H. Fitts. J. Appl. Physiol. 80: 981–987, 1996), resistance exercise was more effective in attenuating alterations in type I soleus fiber absolute force, normalized force, and stiffness but was less effective in restoring type I fiber V oto WB levels.

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