scholarly journals Modeling the impact on virus transmission ofWolbachia-mediated blocking of dengue virus infection ofAedes aegypti

2015 ◽  
Vol 7 (279) ◽  
pp. 279ra37-279ra37 ◽  
Author(s):  
Neil M. Ferguson ◽  
Duong Thi Hue Kien ◽  
Hannah Clapham ◽  
Ricardo Aguas ◽  
Vu Tuan Trung ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Virus Transmission ◽  
Dengue Virus Infection ◽  
The Impact

Effects of Ascogregarina culicis (Eugregarinorida: Lecudinidae) on Mosquito Size and Dengue Virus Infection in Aedes aegypti (Diptera: Culicidae)

2020 ◽  
Author(s):  
Panpim Thongsripong ◽  
Dawn M Wesson
Keyword(s):  
Virus Infection ◽  
Aedes Aegypti ◽  
Dengue Virus ◽  
Infection Rate ◽  
Wing Length ◽  
The Body ◽  
Global Public Health ◽  
Dengue Virus Infection ◽  
Significant Difference ◽  
The Impact

Abstract Dengue virus infection, transmitted via mosquito bites, poses a substantial risk to global public health. Studies suggest that the mosquito’s microbial community can profoundly influence vector-borne pathogen transmissions, including dengue virus. Ascogregarina culicis (Ross) of the phylum Apicomplexa is among the most common parasites of Aedes aegypti (Linnaeus), the principal vector of dengue. Despite a high prevalence worldwide, including in the areas where dengue is endemic, the impact of A. culicis on Ae. aegypti vector competence for dengue virus is unknown. This study aimed to investigate the effects of A. culicis infection on mosquito size and fitness, as measured by wing length, and the susceptibility to dengue virus infection in Ae. aegypti. Our results showed that there was no statistically significant difference in wing lengths between Ae. aegypti infected and not infected with A. culicis. Furthermore, A. culicis infection did not significantly affect dengue virus infection or disseminated infection rate. However, there was a significant association between shorter wings and higher dengue virus infection rate, whereby a 0.1-mm increase in wing length decreased the odds of the mosquito being infected by 32%. Thus, based on our result, A. culicis infection does not influence the body size and dengue virus infection in Ae. aegypti. This study helps to shed light on a common but neglected eukaryotic mosquito parasite.

scholarly journals Commercial Dengue Rapid Diagnostic Tests for Point-of-Care Application: Recent Evaluations and Future Needs?

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Stuart D. Blacksell
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Diagnostic Tests ◽  
Point Of Care ◽  
Virus Transmission ◽  
Dengue Shock Syndrome ◽  
Rapid Diagnostic Tests ◽  
Dengue Virus Infection ◽  
Future Needs ◽  
Appropriate Treatment

Dengue fever, dengue haemorrhagic fever, and dengue shock syndrome (DF/DHF/DSS) are tropical diseases that cause significant humanitarian and economic hardship. It is estimated that more than 2.5 billion people are at risk of infection and more than 100 countries have endemic dengue virus transmission. Laboratory tests are essential to provide an accurate diagnosis of dengue virus infection so that appropriate treatment and patient management may be administered. In many dengue endemic settings, laboratory diagnostic resources are limited and simple rapid diagnostic tests (RDTs) provide opportunities for point-of-care diagnosis. This paper addresses current issues relating to the application of commercial dengue RDTs for the diagnosis of acute dengue virus infection, recent diagnostic evaluations, and identifies future needs.

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