Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones
2010 ◽
Vol 54
(7)
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pp. 3011-3014
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Keyword(s):
ABSTRACT Bacterial resistance presents a difficult issue for fluoroquinolone treatment of bacterial infections. In previous work, we reported that 8-methoxy-quinazoline-2,4-diones are active against quinolone-resistant mutants of Escherichia coli. Here, we demonstrate the activity of a representative 8-methoxy-quinazoline-2,4-dione against quinolone-resistant gyrases. Furthermore, 8-methoxy-quinazoline-2,4-dione and other diones are shown to inhibit Staphylococcus aureus gyrase and topoisomerase IV with similar degrees of efficacy, suggesting that the diones might act as dual-targeting agents against S. aureus.
2008 ◽
Vol 52
(7)
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pp. 2313-2323
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Keyword(s):
2007 ◽
Vol 51
(7)
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pp. 2445-2453
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Keyword(s):
1996 ◽
Vol 40
(12)
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pp. 2691-2697
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Keyword(s):
2013 ◽
Vol 2013
◽
pp. 1-7
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Keyword(s):