Association between Type AblaZGene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus
2016 ◽
Vol 60
(11)
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pp. 6928-6932
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Keyword(s):
Type A
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ABSTRACTSome proportion of type AblaZgene-positive methicillin-susceptibleStaphylococcus aureusstrains exhibit the cefazolin inoculum effect (CIE). The type AblaZgene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P= 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by theblaZgene were closely associated with the CIE.
2013 ◽
Vol 57
(11)
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pp. 5658-5664
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2015 ◽
Vol 59
(6)
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pp. 3585-3587
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2015 ◽
Vol 59
(8)
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pp. 4930-4937
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2018 ◽
Vol 11
(2)
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pp. 417
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2015 ◽
Vol 60
(1)
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pp. 387-392
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2007 ◽
Vol 05
(06)
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pp. 1297-1318
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