In VivoEfficacy of Apramycin in Murine Infection Models
2014 ◽
Vol 58
(11)
◽
pp. 6938-6941
◽
Keyword(s):
ABSTRACTApramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection,Mycobacterium tuberculosisaerosol infection andStaphylococcus aureussepticemia. In both infection models, the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug-resistant pathogens and support further development of this promising unique aminoglycoside.
2013 ◽
Vol 57
(6)
◽
pp. 2506-2510
◽
2016 ◽
Vol 54
(12)
◽
pp. 2969-2974
◽
2014 ◽
Vol 9
(8)
◽
pp. 1934578X1400900
◽
2016 ◽
Vol 55
(2)
◽
pp. 457-469
◽
2014 ◽
Vol 59
(1)
◽
pp. 414-420
◽