Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes
1999 ◽
Vol 43
(4)
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pp. 937-939
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Keyword(s):
ABSTRACT We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates ofK. pneumoniae, 4 presented ISs in their ompK36gene.
2019 ◽
Vol 74
(11)
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pp. 3211-3216
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2004 ◽
Vol 72
(3)
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pp. 1767-1774
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1996 ◽
Vol 40
(12)
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pp. 2848-2853
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2017 ◽
Vol 17
(2)
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pp. 200-209
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2007 ◽
Vol 51
(4)
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pp. 1481-1486
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Keyword(s):
2014 ◽
Vol 59
(3)
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pp. 1797-1801
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Keyword(s):