scholarly journals Legionnaires disease: historical perspective.

1988 ◽  
Vol 1 (1) ◽  
pp. 60-81 ◽  
Author(s):  
W C Winn
Keyword(s):  
Respiratory Disease ◽  
Pathogenic Bacteria ◽  
Potable Water ◽  
Cell Mediated Immunity ◽  
New Family ◽  
The Family ◽  
Legionnaires Disease ◽  
Intensive Investigation ◽  
Definition Of

In the summer of 1976, a mysterious epidemic of fatal respiratory disease in Philadelphia launched an intensive investigation that resulted in the definition of a new family of pathogenic bacteria, the Legionellaceae. In retrospect, members of the family had been isolated from clinical specimens as early as 1943. Unsolved epidemics of acute respiratory disease dating to the 1950s were subsequently attributed to the newly described pathogens. In the intervening years, the Legionellaceae have been firmly established as important causes of sporadic and epidemic respiratory disease. The sources of the infecting bacteria are environmental, and geographic variation in the frequency of infection has been documented. Airborne dissemination of bacteria from cooling towers and evaporative condensers has been responsible for some epidemics, but potable water systems are perhaps more important sources. The mode of transmission from drinking water is unclear. The Legionellaceae are gram-negative, facultative, intracellular pathogens. The resident alveolar macrophage, usually an effective antibacterial defense, is the primary site of growth. Cell-mediated immunity appears to be the most important immunological defense; the role of humoral immunity is less clear. Erythromycin remains the antibiotic of choice for therapy of infected patients, but identification and eradication of environmental sources are also essential for the control of infection.

REGULATION OF MARRIAGE RELATIONS IN THE TURKESTAN REGION

2019 ◽  
Vol 22 (2) ◽  
pp. 27-32
Author(s):  
Khurshida Tillahodjaeva ◽  
Keyword(s):  
The Family ◽  
Role Of Women ◽  
Family And Marriage ◽  
Material Conditions ◽  
Definition Of

In this article we will talk about the scale of family and marriage relations in the early XX century in the Turkestan region, their regulation, legislation. Clearly reveals the role of women and men in the family, the definition of which is based on the material conditions of society, equality of rights and freedoms and its features.

Therapeutic role of vegetables in Respiratory Diseases – A critical review from Ayurvedic classics.

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Dr. Raghavendra Naik ◽  
Shweta Vekariya ◽  
R. N. Acharya ◽  
Sneha D. Borkar
Keyword(s):  
Clinical Practice ◽  
Respiratory Disease ◽  
Respiratory System ◽  
Critical Review ◽  
Critical Analysis ◽  
Respiratory Diseases ◽  
Unique Contribution ◽  
Pharmacological Activities ◽  
The Family

The concept of Pathya (wholesome diet) is an unique contribution of Ayurveda, which plays an important role in prevention and management of many diseases. “Shakavarga”, a category under dietetics in classical texts of Ayurveda enlisted different vegetables with their properties and indications in different disease conditions. These vegetables can be prescribed as Pathya (wholesome diet) in clinical practice. In the present review, plants described under Shakavarga, indicated as Pathya in different diseases related to Pranavaha Srotas (Respiratory system) were compiled from 15 different Ayurvedic classical texts. Critical analysis of the compiled data reveals that out of 332 vegetables described under Shakavarga, 44 are indicated in respiratory disease like Shvasa (Dyspnoea/Asthma), Kasa (Cough), Peenasa (Chronic rhinitis) and Hikka (Hiccup). Among them, botanical identity of 42 classical plants has been established and maximum number of vegetables belongs to the family cucurbitaceae (10) followed by solanaceae (4). Some of these vegetables have been reported for their various pharmacological activities related to prevention and management of diseases related to Pranavaha Srotas (Respiratory system). These vegetables are reported for their anti-inflammatory (16), antioxidant (14), anti-allergic (6) and antitussive (3) activities. The observed result may be helpful in use of vegetables as Pathya (wholesome diet) and planning further scientific studies about the efficacy of these plants on prevention as well as management of respiratory diseases.

It's about Family: The Death of a Close Family Friend

2009 ◽  
Vol 90 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Joan Beder
Keyword(s):  
Family Structure ◽  
Family Member ◽  
Family Relationships ◽  
Extended Family ◽  
Entire System ◽  
The Family ◽  
Counseling Interventions ◽  
Definition Of ◽  
Close Family

When an individual dies, the role of the family member(s) is clearly prescribed by society: support, presence, caring, and remembrance. Traditionally, the definition of “family” has broadened to create the “extended family” or “expanded family” with members defined by deep bonds, relationships, and friendships. Currently, close friends who become the extended/expanded family, can be as central as kin to family structure and stability. Therefore, when one member of an extended family dies, the death resonates throughout the entire system affecting not only the lives of the immediate family members, but also those in the expanded circle of family relationships. This article describes the relationships in one extended family and discusses the struggles and counseling interventions used when one member of an extended family suddenly dies.

scholarly journals Legionella pneumophila CRISPR-Cas suggests recurrent encounters with one or more phages in the family Microviridae .

2021 ◽  
Author(s):  
Shayna R. Deecker ◽  
Malene L. Urbanus ◽  
Beth Nicholson ◽  
Alexander W. Ensminger
Keyword(s):  
Legionella Pneumophila ◽  
Sequence Similarity ◽  
Mobile Element ◽  
Current Data ◽  
Significant Sequence Similarity ◽  
Remediation Strategies ◽  
The Family ◽  
Legionnaires Disease ◽  
Outstanding Question

Legionella pneumophila is a ubiquitous freshwater pathogen and the causative agent of Legionnaires’ disease. L. pneumophila growth within protists provides a refuge from desiccation, disinfection, and other remediation strategies. One outstanding question has been whether this protection extends to phages. L. pneumophila isolates are remarkably devoid of prophages and to date no Legionella phages have been identified. Nevertheless, many L. pneumophila isolates maintain active CRISPR-Cas defenses. So far, the only known target of these systems is an episomal element that we previously named Legionella Mobile Element-1 (LME-1). The continued expansion of publicly available genomic data promises to further our understanding of the role of these systems. We now describe over 150 CRISPR-Cas systems across 600 isolates to establish the clearest picture yet of L. pneumophila ’s adaptive defenses. By searching for targets of 1,500 unique CRISPR-Cas spacers, LME-1 remains the only identified CRISPR-Cas targeted integrative element. We identified 3 additional LME-1 variants - all targeted by previously and newly identified CRISPR-Cas spacers - but no other similar elements. Notably, we also identified several spacers with significant sequence similarity to microviruses, specifically those within the subfamily Gokushovirinae . These spacers are found across several different CRISPR-Cas arrays isolated from geographically diverse isolates, indicating recurrent encounters with these phages. Our analysis of the extended Legionella CRISPR-Cas spacer catalog leads to two main conclusions: current data argue against CRISPR-Cas targeted integrative elements beyond LME-1, and the heretofore unknown L. pneumophila phages are most likely lytic gokushoviruses. IMPORTANCE Legionnaires’ disease is an often-fatal pneumonia caused by Legionella pneumophila , which normally grows inside amoebae and other freshwater protists. L. pneumophila trades diminished access to nutrients for the protection and isolation provided by the host. One outstanding question is whether L. pneumophila is susceptible to phages, given the protection provided by its intracellular lifestyle. In this work, we use Legionella CRISPR spacer sequences as a record of phage infection to predict that the “missing” L. pneumophila phages belong to the microvirus subfamily Gokushovirinae . Gokushoviruses are known to infect another intracellular pathogen, Chlamydia . How do gokushoviruses access L. pneumophila (and Chlamydia ) inside their “cozy niches”? Does exposure to phages happen during a transient extracellular period (during cell-to-cell spread) or is it indicative of a more complicated environmental lifestyle? One thing is clear, 100 years after their discovery, phages continue to hold important secrets about the bacteria upon which they prey.

Geographers and sexual difference: feminist contributions

2003 ◽  
Author(s):  
Linda McDowell
Keyword(s):  
Social Life ◽  
Power Relations ◽  
Sexual Difference ◽  
Daily Lives ◽  
Men And Women ◽  
Geographical Knowledge ◽  
The Public ◽  
The Family ◽  
Definition Of

Divisions based on the assumption that men and women are different from one another permeate all areas of social life as well as varying across space and between places. In the home and in the family, in the classroom or in the labour market, in politics, and in power relations, men and women are assumed to be different, to have distinct rights and obligations that affect their daily lives and their standard of living. Thirty years ago, there were no courses about gender in British geography departments. This chapter discusses the challenges to geographical knowledge, and to the definition of knowledge more generally, that have arisen from critical debates about the meaning of difference and diversity in feminist scholarship. It examines a number of significant conceptual ideas, namely: the public and the private; sex, gender and body; difference, identity and intersectionality; knowledge; and justice. Finally, it comments on the role of feminism in the academy as a set of political practices as well as epistemological claims.

Islamic Reform, the Family, and Knowledge Networks Linking Mecca to Southeast Asia in the Nineteenth Century

2014 ◽  
Vol 73 (1) ◽  
pp. 89-111
Author(s):  
Francis R. Bradley
Keyword(s):  
Nineteenth Century ◽  
Southeast Asia ◽  
Spiritual Leadership ◽  
Knowledge Networks ◽  
Islamic Reform ◽  
Social Actions ◽  
Refugee Community ◽  
The Family ◽  
Definition Of

Through a study of over 1,300 previously unanalyzed Malay Islamic manuscripts, this article examines the role of the Patani community in the construction of transoceanic knowledge networks between Mecca and Southeast Asia in the nineteenth century. Set against the backdrop of the destruction of prevailing symbols of authority, as well as the displacement and scattering of the community after 1200/1786, the present study investigates the manner by which scholars established new cultural unities for the community and addressed social concerns by translating and spreading Islamic writings, teachings, and schools. With its spiritual leadership centered now in Mecca, influential members of the community began producing works that were contingent upon political circumstances, but also directed at the problems facing the refugee community. Of foremost importance were the place and definition of the family, and related issues such as inheritance, divorce, and visible social actions, including ritual purity, fasting, almsgiving, and criminal punishments.

Anorexia Nervosa and Dysmorphobia

1986 ◽  
Vol 149 (6) ◽  
pp. 780-782 ◽  
Author(s):  
P. Sturmey ◽  
P. D. Slade
Keyword(s):  
Anorexia Nervosa ◽  
The Family ◽  
External Cues ◽  
History Of ◽  
Definition Of ◽  
Control Behaviour

Anorexia nervosa is frequently associated with neurotic traits and symptoms. The symptomatology and history of a housebound 20-year-old woman with anorexia nervosa and dysmorphophobia are described. The role of the family In maintaining the problems, use of external cues to control behaviour, overvalued somatic ideas and the definition of dysmorphophobia are discussed.

Feature-Based Modeling of Product Families

1994 ◽  
Author(s):  
Timo Laakko ◽  
Martti Mäntylä
Keyword(s):  
Product Family ◽  
Design History ◽  
Product Modeling ◽  
Product Families ◽  
New Family ◽  
The Family ◽  
Feature Based ◽  
Definition Of ◽  
Language Description

Abstract A feature-based product modeling system is introduced where the user can incrementally create and modify product families. Product family and feature descriptions are coded in a special definition language and can be easily added and modified by the user. The descriptions include dynamically maintained constraints. The definition language description of a new family can be automatically created on the basis of a recognized prototypical instance. A stored design history can be used for generating the geometry definition of the family.

scholarly journals The role of the Family Health Program in the organization of primary care in municipal health systems

2009 ◽  
Vol 25 (5) ◽  
pp. 1153-1167 ◽  
Author(s):  
Maria Guadalupe Medina ◽  
Zulmira Maria de Araújo Hartz
Keyword(s):  
Primary Care ◽  
Health Systems ◽  
Health Program ◽  
Family Health ◽  
Family Health Program ◽  
The Family ◽  
Institutional Contexts ◽  
Definition Of ◽  
Municipal Health

The contribution of primary care to population health and health systems organization has been well documented, but some authors have highlighted that in Third World countries it has gained more ground in discourse than in facts and practices, with different possible configurations. The objectives of the current study were to evaluate and correlate organizational and local contextual characteristics to the degree of implementation of primary care in two municipalities (counties) in the State of Bahia State, Brazil, that had adopted the Family Health Program (FHP) as the system's central thrust. The research was based on two case studies with interwoven levels of analysis, using as the point of departure the underlying goal-image of primary care in the definition of criteria and standards for degree of implementation. The total scores for Municipalities A and B were 66 and 81, respectively (maximum total score = 100), while differences were observed between the urban and rural teams. The political and institutional contexts helped explain differences in the degree of implementation of primary care, but regardless of the municipal context, the study showed the emergence of organizational innovations closely related to the FHP.

scholarly journals Liberal outcomes through undemocratic means: the reform of the Code de statut personnel in Morocco

2009 ◽  
Vol 47 (4) ◽  
pp. 487-506 ◽  
Author(s):  
Francesco Cavatorta ◽  
Emanuela Dalmasso
Keyword(s):  
Civil Society ◽  
Theoretical Work ◽  
Individual Decision ◽  
Policy Makers ◽  
Associational Life ◽  
Whole Process ◽  
New Family ◽  
The Family ◽  
Family Code

ABSTRACTThe 2004 reform of the family code in Morocco has been held as one of the most significant liberal reforms undertaken in the country, and has led scholars and policy makers to argue that this demonstrates the democratic progress Morocco and the King are making. At the same time, the role of the women's movement in getting the reform approved has seemingly confirmed that associational life is crucial in promoting democratisation. This paper, building on theoretical work questioning the linkage between a strong civil society and democratic outcomes, argues that civil society activism does not necessarily lead to democratisation, and may reinforce authoritarian practices. Far from demonstrating the centrality of civil society, the process through which the new family code was passed highlights the crucial institutional role of the monarch, whose individual decision-making power has driven the whole process. Authoritarianism finds itself strengthened in Morocco despite the liberal nature and outcome of the reform.

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