scholarly journals Interleukin-1 Receptor Antagonist Gene Polymorphism, Vaginal Interleukin-1 Receptor Antagonist Concentrations, and Vaginal Ureaplasma urealyticum Colonization in Pregnant Women

2003 ◽  
Vol 71 (1) ◽  
pp. 271-274 ◽  
Author(s):  
Parrin T. Barton ◽  
Stefan Gerber ◽  
Daniel W. Skupski ◽  
Steven S. Witkin
Keyword(s):  
Pregnant Women ◽  
Receptor Antagonist ◽  
Ureaplasma Urealyticum ◽  
Interleukin 1 ◽  
First Trimester ◽  
Enzyme Linked Immunosorbent Assay ◽  
Interleukin 1 Receptor Antagonist ◽  
First Trimester Of Pregnancy ◽  
The Relationship ◽  
Uneventful Pregnancy

ABSTRACT Ureaplasma urealyticum is the microorganism most frequently isolated from amniotic fluids of women in preterm labor. The relationship between vaginal colonization with U. urealyticum, vaginal interleukin-1 receptor antagonist (IL-1ra) levels, and the IL-1ra genotype in pregnant women was examined. Vaginal specimens, obtained with a cotton swab from 207 women in their first trimester of pregnancy, were tested for IL-1ra concentrations by enzyme-linked immunosorbent assay and for U. urealyticum and IL-1ra genotypes by PCR. U. urealyticum was detected in 85 (41.1%) women. The median IL-1ra level was 450 ng/ml in women positive for U. urealyticum, as opposed to 225 ng/ml in women negative for this microorganism (P < 0.0001). Sixty-two percent of the 16 women who were homozygous for allele 2 of the IL-1ra gene (IL-1RN*2) were colonized with U. urealyticum, as opposed to 47% of the 49 women who were IL-1RN*1/IL-1RN*2 heterozygotes and 34% of the 133 women who were IL-1RN*1 homozygotes (P < 0.05). Median IL-1ra levels were 750 ng/ml in IL-1RN*2 homozygotes, 300 ng/ml in IL-1RN*1/IL-1RN*2 heterozygotes, and 250 ng/ml in IL-1RN*1 homozygotes (P = 0.02). The vast majority of subjects had an uneventful pregnancy and delivered a healthy infant at term. The IL-1ra genotype or U. urealyticum colonization was unrelated to birth weight. Pregnant women who are colonized with U. urealyticum during the first trimester have elevated vaginal IL-1ra concentrations and a higher prevalence of the IL-1RN*2 homozygote genotype than do noncolonized women.

scholarly journals Clinical and Pathogenetic Causes of Developing Complications in Multiple Pregnancy

2020 ◽  
Vol 27 (1) ◽  
pp. E202016
Author(s):  
Iryna Nikitina ◽  
Volodymyr Boiko ◽  
Tetiana Babar ◽  
Natalia Kalashnik ◽  
Nataliia Ikonopistseva ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pregnant Women ◽  
Multiple Pregnancy ◽  
First Trimester ◽  
Placental Growth Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Full Time ◽  
Singleton Pregnancy ◽  
Placental Dysfunction ◽  
First Trimester Of Pregnancy

To assess the role of the placental growth factor in the development of gestational complications during multiple pregnancy, there was conducted a study of this indicator in serum of 320 pregnant women with multiple pregnancy in the first trimester and 40 pregnant women with singleton pregnancy (the control group).          The objective of the research was to study the effect of placental growth factors on the gestational process in multiple pregnancy.          Materials and Methods. There was conducted a prospective study of pregnancy and childbirth in 320 females with multiple pregnancy (the main group) and 40 healthy women with singleton pregnancy. The level of serum placental growth factor was determined by enzyme-linked immunosorbent assay using monoclonal antibodies in the first trimester of pregnancy. The indicators of the hemostasis system (vascular, platelet and coagulation components) were evaluated according to generally accepted methods. Doppler ultrasound of the placental and fetal blood flow was performed in the uterine arteries, the umbilical artery and vein, the fetal middle cerebral artery.          Results. Women with multiple pregnancy were at high risk of developing gestational complications such as preterm deliveries (67.8%, p<0.01), placental dysfunction, pre-eclampsia (17.5%, p<0.05). The disorders of the vascular platelet and coagulation hemostasis in the first trimester of pregnancy were the main risk factors for early termination of pregnancy. Low level of serum placental growth factor in pregnant women with multiple pregnancy in case of preterm delivery, placental dysfunction and pre-eclampsia (111.23 ± 8.4, 203.24 ± 6.4 and 305.86 ± 7.4 pg/ml), in comparison with the corresponding indicators in singleton pregnancy (418.2 ± 10.4 pg/ml), was proven to be a prognostic marker for the development of gestational complications.          Conclusions. Timely correction of gestational complications in multiple pregnancy with micronized progesterone, low molecular weight heparins, angio-protective agents allowed us to prolong pregnancy with monochorionic placentation type for 3.2 weeks (up to 34.2 ± 2.4 weeks) and provide full-time delivery of dichorionic twin pregnancy.

scholarly journals Differential Vaginal Expression of Interleukin-1 System Cytokines in the Presence ofMycoplasma hominisandUreaplasma urealyticumin Pregnant Women

2004 ◽  
Vol 12 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Kunihiko Doh ◽  
Parrin T. Barton ◽  
Irina Korneeva ◽  
Sriram C. Perni ◽  
Ann Marie Bongiovanni ◽  
...  
Keyword(s):  
Black Women ◽  
Pregnant Women ◽  
White Women ◽  
Ureaplasma Urealyticum ◽  
Hispanic Women ◽  
Interleukin 1 ◽  
Mycoplasma Hominis ◽  
First Trimester ◽  
Vaginal Colonization ◽  
Polymerase Chain

Objective:The genital mycoplasmas,Ureaplasma urealyticumandMycoplasma hominis, are commonly identified in the vagina of healthy pregnant women. However, these microorganisms are the most common isolates from the amniotic fluids of women in preterm labor. The mechanisms responsible for vaginal colonization and ascent to the uterus remain undetermined. We evaluated the association betweenU. urealyticumandM. hominisvaginal colonization and the presence of pro-inflammatory and anti-inflammatory interleukin-1 system components in asymptomatic pregnant women of different ethnicities.Methods:Vaginal specimens, obtained from 224 first trimester pregnant women, were assayed for interleukin- 1β(IL-1β) and IL-1 receptor antagonist (IL-1ra) concentrations by ELISA.U. urealyticumandM. hominisvaginal colonization were identified by polymerase chain reaction (PCR).Results:Vaginal colonization withM. hominiswas identified in 37 (16.5%) women, and was more prevalent in black (18.9%) and Hispanic (20.9%) than in white (4.2%) women (p= 0.01).U. urealyticumwas present in 84 (37.5%) women and there was no ethnic disparity in its detection.M. hominiscolonization was associated with elevated median vaginal IL-1βconcentrations in both black women (p=0.02) and Hispanic women (p= 0.04), and was unrelated to vaginal IL-1ra concentrations. In marked contrast,U. urealyticumcolonization was associated with elevations in vaginal IL-1ra levels, but not with IL-1βconcentrations, in black women (p= 0.02) and Hispanic women (p< 0.0001) and marginally in white women (p= 0.06).Conclusion:M. hominiscolonization in healthy pregnant women is associated with localized pro-inflammatory immune activation, whileU. urealyticumcolonization is associated with immune suppression.

scholarly journals The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder

2013 ◽  
Vol 29 (6) ◽  
pp. 635-644 ◽  
Author(s):  
Francis E. Lotrich ◽  
Meryl A. Butters ◽  
Howard Aizenstein ◽  
Megan M. Marron ◽  
Charles F. Reynolds ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Cognitive Function ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
The Relationship

Relationship between Gravidity and Severity of Emesis Gravidarum in Trimester I Pregnant Women at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java

2020 ◽  
Author(s):  
Rahma Kusuma Dewi ◽  
◽  
Halimatus Saidah ◽  
Keyword(s):  
Pregnant Women ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Nausea And Vomiting ◽  
Chi Square ◽  
Cross Sectional ◽  
Midwifery Care ◽  
First Trimester Pregnancy ◽  
First Trimester Of Pregnancy ◽  
The Relationship

ABSTRACT Background: Emesis gravidarum or nausea and vomiting has commonly occurred during pregnancy. However, excessive nausea and vomiting in early pregnancy have a potentially adverse effect on pregnancy outcomes. This study aimed to investigate the relationship between gravidity and severity of emesis gravidarum in women with first-trimester of pregnancy at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java. Subjects and Method: This was a cross-sectional study conducted at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java, from July to August 2020. A sample of 32 women with first-trimester of pregnancy was selected for this study. The dependent variable was severity of emesis gravidarum categorized into mild to moderate and severe. The independent variable was the number of gravidities categorized into primigravida and multigravida. The data were collected using questionnaire. The data were analyzed by chi-square. Results: Multigravida reduced the severity of emesis gravidarum (OR= 0.14; 95% CI= 0.02 to 0.85; p= 0.034). Conclusion: Multigravida reduces the severity of emesis gravidarum in women with first-trimester pregnancy. Keywords: emesis gravidarum, first trimester, gravidity, severity, pregnant women Correspondence: Rahma Kusuma Dewi. Faculty of Health Sciences, Universitas Kadiri. Jl. Selomangleng No 1, Kediri, East Java. Email: [email protected]. Mobile: +6281229440101. DOI: https://doi.org/10.26911/the7thicph.03.77

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