Docosahexaenoic Acid and Eicosapentaenoic Acid Antagonize the Proinflammatory Interactions of Pneumolysin with Human Neutrophils
2004 ◽
Vol 72
(7)
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pp. 4327-4329
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Keyword(s):
Omega 3
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ABSTRACT Pneumolysin (4.18 ng/ml)-mediated influx of Ca2+ and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 μg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.