scholarly journals Efeito da suplementação de ômega 3 isolado ou associado em pacientes com doença de Alzheimer: uma revisão sistemática da literatura científica

HU Revista ◽  
2020 ◽  
Vol 45 (4) ◽  
pp. 452-464
Author(s):  
Christianne Rosiak Gonzaga dos Santos ◽  
Camila Kellen De Souza Cardoso
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Elderly People ◽  
Omega 3

Introdução: O envelhecimento da população está associado ao aumento da incidência da doença de Alzheimer (DA), a qual causa graves complicações ao paciente. Os nutrientes imunomoduladores, como os ácidos graxos poli-insaturados (PUFAs) da série ômega 3 (w-3) podem auxiliar na melhora do quadro clínico da DA. Objetivo: Analisar o efeito da suplementação de PUFAs w-3 isolado ou associado na população idosa com DA. Material e métodos: Trata-se de uma revisão sistemática de literatura científica nas bases de dados Pubmed e Science Direct, que englobou ensaios clínicos em idosos com provável e/ou comprovado diagnóstico de DA e suplementados com PUFAS w-3 isolado ou associado, no idioma inglês e com os seguintes descritores em saúde (DECs): brain, Alzheimer’s disease, fatty docosahexaenoic acid (DHA), polyunsaturated fatty acids (PUFA), older and elderly people e termo de pesquisa: eicosapentaenoic acid (EPA). O recorte temporal das publicações foi delimitado de 2006 a 2017. Resultados: foram selecionados 10 ensaios clínicos, cuja suplementação de w-3 favoreceu menor declínio no score de miniexame de estado mental (MEEM), retardo da disfunção, melhora no domínio de agitação do inventário neuropsiquiátrico (NPI) e melhora dos sintomas depressivos pela Escala de Depressão de Montgomery-Asberg (MADRS). Foram observadas mudanças significativas como aumento de apetite, peso, índice de massa corporal (IMC), EPA e DHA, além de reduções nos níveis séricos de albumina, ácido araquidônico (AA), ácido mirístico, interleucina-6 (IL- 6), interleucina 1 ß (IL-1ß) e fator estimulante de colônias de granulócitos (G-CSF) e redução na liberação de prostaglandina F2α (PGF2α). Foram relatadas alterações positivas em alguns genes e em outros, redução de sua expressão, além de hipometilação de importantes genes. Conclusão: A suplementação de PUFAs w-3 exerceu efeito positivo em pacientes com DA grau leve a moderado.

THE RELATIONSHIP OF OMEGA 3 POLYUNSATURATED FATTY ACIDS IN RED BLOOD CELL MEMBRANES WITH COGNITIVE FUNCTION AND BRAIN STRUCTURE: A REVIEW FOCUSSED ON ALZHEIMER’S DISEASE

2017 ◽  
pp. 1-7
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Blood Cell ◽  
Polyunsaturated Fatty Acids ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Research Attention ◽  
Pufa Supplementation

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci

scholarly journals Rapeseeds a Rich Source of Polyunsaturated Fatty Acids

Proceedings ◽  
2019 ◽  
Vol 29 (1) ◽  
pp. 115
Author(s):  
Cristina Emanuela Enăşcuţă ◽  
Elena Emilia Oprescu ◽  
Adrian Radu ◽  
Elena Radu ◽  
Marian Deaconu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Stroke Prevention ◽  
Essential Role ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Human Diet ◽  
Brain Functions

In human diet, polyunsaturated fatty acids (PUFA), have an essential role in optimal brain functions and stroke prevention, specially, omega-3 fatty acids, e.g., 9,12,15-linolenic acid (ALA, 18:3), 5,8,11,14,17-eicosapentaenoic acid (EPA, 20:5), and 4,7,10,13,16,19-docosahexaenoic acid (DHA, 22:6). [...]

scholarly journals Comparative Nutrient Profiling of Retail Goat and Cow Milk

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2282 ◽  
Author(s):  
Sokratis Stergiadis ◽  
Natalja P. Nørskov ◽  
Stig Purup ◽  
Ian Givens ◽  
Michael R. F. Lee
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Vaccenic Acid ◽  
Goat Milk ◽  
Cow Milk ◽  
Omega 3 ◽  
Nutrient Profiling ◽  
Nutritional Profiling

Goat milk is globally consumed but nutritional profiling at retail level is scarce. This study compared the nutrient composition of retail cow and goat milk (basic solids, fatty acids, minerals, and phytoestrogens) throughout the year and quantified the potential implications on the consumers’ nutrient intakes. When compared to cow milk, goat milk demonstrated nutritionally desirable traits, such as lower concentrations of C12:0, C14:0, C16:0 and Na: K ratio, and the higher concentrations of cis polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isoflavones, B, Cu, Mg, Mn, P and I, although the latter may be less desirable in cases of high milk intakes. However, in contrast with nutritional targets, it had lower concentrations of omega-3 PUFA, vaccenic acid, lignans, Ca, S and Zn. The extent of these differences was strongly influenced by season and may demonstrate a combination of differences on intrinsic species metabolism, and farm breeding/husbandry practices.

COMPARATIVE ANALYSIS OF UNSATURATED INDICATORS FATTY ACIDS IN ELDERLY PATIENTS IN INITIAL STAGES OF ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA

2020 ◽  
pp. 265-272
Author(s):  
Е. Е. Дубинина ◽  
Л. В. Щедрина ◽  
К. В. Ющин ◽  
Е. В. Светкина ◽  
Н. М. Залуцкая ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Comparative Analysis ◽  
Polyunsaturated Fatty Acids ◽  
Vascular Dementia ◽  
Cognitive Functions ◽  
Control Group ◽  
Omega 3

Снижение когнитивных функций вплоть до развития деменции у пожилых людей связывают с уменьшением в крови уровня полиненасыщенных жирных кислот, особенно Омега-3, которое происходит на фоне окислительного стресса. В работе представлен сравнительный анализ спектра полиненасыщенных жирных кислот и активности отдельных компонентов ферментативной антиоксидантной системы в крови у лиц пожилого возраста с нарушением показателей когнитивного функционирования до уровня «мягкое когнитивное снижение» первично-атрофической (MCI БА, продромальная болезнь Альцгеймера) или васкулярной этиологии (MCI СД, продромальная сосудистая деменция) по сравнению с пожилыми людьми без признаков нарушений когнитивных функций. Выявлено снижение концентрации Омега-3 полиненасыщенных жирных кислот в крови обеих групп обследованных больных по сравнению с контрольной группой. У пациентов с MCI БА обнаружено резкое снижение концентрации арахидоновой кислоты (Омега-6) по сравнению с больными MCI СД и контрольной группой. Выявленное нами снижение активности антиоксидантной ферментативной системы и снижение полиненасыщенных жирных кислот за счет их пероксидации свидетельствует об интенсификации процессов окислительного стресса у пациентов с нарушением когнитивных функций. Обсуждается вопрос о патогенетической роли арахидоновой кислоты у больных, предрасположенных в будущем к развитию болезни Альцгеймера. A decrease in cognitive functions up to the development of dementia in the elderly is associated with a decrease in the blood level of polyunsaturated fatty acids, especially Omega-3, which occurs against the background of oxidative stress. The paper presents a comparative analysis of the spectrum of polyunsaturated fatty acids and the activity of individual components of the enzymatic antioxidant system in the blood of elderly people with impaired cognitive performance to the level of «mild cognitive decline» (MCI AD, prodromal Alzheimer’s disease) or vascular etiology (MCI VaD, prodromal vascular dementia) compared with older people without signs of cognitive impairment. A decrease in the concentration of Omega-3 polyunsaturated fatty acids in the blood of both groups of the examined patients was revealed compared with the control group. In patients with AD MCI, a sharp decrease in the concentration of arachidonic acid (Omega-6) was detected compared with patients with MCI VaD and the control group. The decrease in the activity of the antioxidant enzymatic system and the decrease in polyunsaturated fatty acids due to their peroxidation revealed in this study indicate an intensification of the OS processes in patients with impaired cognitive functions. The question of the pathogenetic role of arachidonic acid in patients predisposed in the future to the development of AD is discussed.

scholarly journals Docosahexaenoic Acid and Eicosapentaenoic Acid Antagonize the Proinflammatory Interactions of Pneumolysin with Human Neutrophils

2004 ◽  
Vol 72 (7) ◽  
pp. 4327-4329 ◽  
Author(s):  
Riana Cockeran ◽  
Annette J. Theron ◽  
Charles Feldman ◽  
Timothy J. Mitchell ◽  
Ronald Anderson
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Human Neutrophils ◽  
Omega 3 ◽  
Reactive Oxidants

ABSTRACT Pneumolysin (4.18 ng/ml)-mediated influx of Ca2+ and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 μg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

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