The Mdm2 Ubiquitin Ligase Enhances Transcriptional Activity of Human Papillomavirus E2
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ABSTRACT The regulation of human papillomavirus (HPV) gene expression by the E2 protein is a critical feature of the viral life cycle. Previous studies have shown an important role in transcription for the ubiquitin-proteasome pathway, but its role in HPV gene expression has not been addressed. We now show that HPV E2 requires an active proteasome for its optimal transcriptional activator function. This involves an interaction with the Mdm2 ubiquitin ligase, which together with E2 acts synergistically to activate the HPV type 16 promoter. We also show that HPV E2 recruits Mdm2 onto HPV promoter sequences, providing an explanation for this cooperative activity.
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2007 ◽
Vol 31
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pp. 1-14
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2012 ◽
Vol 59
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pp. E999
2005 ◽
Vol 289
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pp. C766-C773
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2011 ◽
Vol 286
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pp. 24426-24433
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Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercise and Statins
2005 ◽
Vol 25
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pp. 2560-2566
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2002 ◽
Vol 22
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pp. 4463-4476
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2001 ◽
Vol 12
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pp. 1431-1443
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