Oleate Hydratase (OhyA) Is a Virulence Determinant in Staphylococcus aureus
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The oleate hydratase protein family was discovered in commensal bacteria that utilize host unsaturated fatty acids as the substrates to produce a spectrum of hydroxylated products. These hydroxy fatty acids are thought to act as signaling molecules that suppress the inflammatory response to create a more tolerant environment for the microbiome. S. aureus is a significant human pathogen, and defining the mechanisms used to evade the immune response is critical to understanding pathogenesis. S. aureus expresses an OhyA that produces at least three 10-hydroxy fatty acids from host unsaturated fatty acids at the infection site, and an S. aureus strain lacking the ohyA gene has compromised virulence in an immunocompetent infection model.
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2012 ◽
Vol 62
(Pt_9)
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pp. 2133-2139
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2013 ◽
Vol 57
(7)
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pp. 3240-3249
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2021 ◽
Vol 16
(2)
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pp. 132-143
1977 ◽
Vol 23
(9)
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pp. 1145-1150
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