scholarly journals Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation

Author(s):  
Da Cheng ◽  
Zhenwu Luo ◽  
Xiaoyu Fu ◽  
Sophie Stephenson ◽  
Clara Di Germanio ◽  
...  

This study reports that an autoantibody presents in the CNS of HIV patients and that its levels in the CSF correlate with some markers of neuroinflammation.

2016 ◽  
Vol 74 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Ronald Salamano ◽  
Raquel Ballesté ◽  
Abayubá Perna ◽  
Natalia Rodriguez ◽  
Diego Lombardo ◽  
...  

ABSTRACT Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity. Thirty-two patients were selected for this study. VDRL was positive in five of them. The number of diagnoses reached 14 when the other techniques were added. It was not determined whether cellularity and increased protein levels were auxiliary tools in the diagnosis. According to our investigation, CSF analysis using the abovementioned techniques may be useful in diagnosing neurosyphilis in these patients.


AIDS ◽  
2014 ◽  
Vol 28 (11) ◽  
pp. 1579-1591 ◽  
Author(s):  
Edana Cassol ◽  
Vikas Misra ◽  
Anupriya Dutta ◽  
Susan Morgello ◽  
Dana Gabuzda

Ciencia Unemi ◽  
2016 ◽  
Vol 9 (20) ◽  
pp. 63
Author(s):  
Valeria Barcia Castilla ◽  
Sunny Sanchez Giler

De la prueba de tinta china como tamizaje para esta infección. Se obtuvieron los datos del líquido cefalorraquídeo de 252 pacientes VIH positivos admitidos de mayo a octubre del 2014 en el Hospital de Infectología de Guayaquil, Ecuador. Los análisis se realizaron por cultivo y tinta china en 81 pacientes, cuyos resultados de sensibilidad y valor predictivo negativo fueron 80% y 93,55% respectivamente. Como conclusión se consideró la tinta china como una prueba de tamizaje relativamente buena por su buen valor predictivo negativo pero medianamente buen valor sensitivo.  ABSTRACTMeningitis by Cryptococcus spp is a serious public health problem in HIV + patients, therefore the Indian ink utility as screening test for this infection was determined. Cerebrospinal fluid data of 252 HIV + patients admitted from May to October 2014 at the Hospital de Infectología de Guayaquil was collected. Analysis from this cerebrospinal fluid was performed by Indian ink and culture in 81 patients, whose sensibility and negative predictive value were 80% and 93,55%, respectively. As conclusion the Indian ink was considered a relatively good screening test because of its good negative predictive value but moderately good sensibility.


1997 ◽  
Vol 3 (3) ◽  
pp. 192-196 ◽  
Author(s):  
M Portolani ◽  
M Meacci ◽  
Amt Sabbatini ◽  
P Pietrosemoli ◽  
M Pecorari ◽  
...  

2019 ◽  
Vol 5 (2) ◽  
pp. 62-66
Author(s):  
Ryan Halleyantoro ◽  
Yunilda Andriyani ◽  
Ika Puspa Sari ◽  
Agnes Kurniawan

Background: Toxoplasmosis is a disease caused by infection of Toxoplasma gondii, Which may cause a life-threatening condition in immunocompromised patients, for example, Toxoplasma encephalitis (TE). It is challenging to diagnose Toxoplasma as a cause of central nervous system (CNS) infection in HIV patient, so we need an alternative method, which is a PCR detection of Toxoplasma gondii B1 gene.Objective: This research aimed to find association between PCR methods for Toxoplasma gondii B1 gene and anti-Toxoplasma IgG from cerebral spinal fluid patient HIV AIDS.Methods: A cross-sectional study was conducted to Cerebrospinal fluid (CSF) samples of HIV patients with neurological symptoms to determine Toxoplasma gondii infection using nested PCR methods for the B1 gene and detection of anti-Toxoplasma IgG.Results: 88 CSF samples from HIV patients tested using nested PCR showed 23 samples (26,1%) were positive. Serologic test for IgG Toxoplasma showed 34 samples were positive (28,6%). There was a significant correlation (p=0.000(<0.05) between PCR result and a serologic test for IgG Toxoplasma.Conclusion: Nested PCR methods to detect B1 gene increased the accuracy of diagnosis for toxoplasma encephalitis.


1997 ◽  
Vol 4 (6) ◽  
pp. 576-585 ◽  
Author(s):  
R. Pirskanen ◽  
K. Samuelsson ◽  
A. Sönnerborg ◽  
L. Waldenlind ◽  
E. Sandström

2012 ◽  
Vol 39 (3) ◽  
pp. 768-770 ◽  
Author(s):  
K.-H. Park ◽  
O.-H. Cho ◽  
E. M. Lee ◽  
S.-O. Lee ◽  
S.-H. Choi ◽  
...  

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